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drmichaelmarks.bsky.social
NIHR Research Professor Professor of Medicine at LSHTM. Lead for Integrated Academic Training at LSHTM. Consultant in Infectious Diseases at UCLH. Syphilis & STIs, Neglected Tropical Diseases, Emerging Infectious Diseases, Group A Strep, Pragmatic Trials
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A timely example of why we should do trials of interventions rather than just use them in an observational fashion even for most emerging infections. I hope this will alter approach to to use in UK.

submitted 4 days ago • 0 comments

Negative pressure wound therapy versus usual care in patients with surgical wound healing by secondary intention in the UK (SWHSI-2): an open-label, multicentre, parallel-group, randomised controlled trial No difference in infection rates too. #IDSky #ClinMicro www.thelancet.com/journals/lan...

submitted 4 days ago • 4 comments

Two weeks until this application for Infectious Diseases ACLs @lshtm.bsky.social closes. Do get in touch if you are interested of applying.

submitted 4 days ago • 0 comments

Great to see the funding for the STRAP trial. A linked UK funding application should be going in imminently.

submitted 5 days ago • 1 comment

Fabulous talk @seanong.bsky.social Used BALANCE data developed & validated multi-variable risk scores which accurately predict outcome bacteramia. Showed results hold true across all risk groups. Paper: www.thelancet.com/journals/ecl... #ESCMID2026 @steventong.bsky.social @drtoddlee.bsky.social

submitted 6 days ago • 1 comment

Interesting data Barista showing diversity in S. aureus isolates from sterile sites. Some evidence isolates become enriched for mutations over time. Wonder if really evolution over time or if samples from deeper sites would differ at baseline from those in blood? @steventong.bsky.social #ESCMID2025

submitted 6 days ago • 2 comments

Great session on viral haemorrhagic fever #ESCMID2025 - one of my conference highlights. Learnt a lot about Venezuelan Equine Encephalitis and Kyasanur forest disease in particular. #IDSky

submitted 6 days ago • 1 comment

HARVEST Trial - largest trial high dose (35mg/kg) Rifampicin for TBM. Phase 2 data suggested benefit & dose-response effect. Sadly no evidence of benefit & some suggestion of sub-groups who did worse. More trials coming & clear we need interventions beyond just killing bug #ESCMID2025 #IDSky

submitted 7 days ago • 2 comments

Does adding NGS testing improve sepsis outcomes? Gave more positive micro. No impact primary outcome. Many secondary outcomes better but ?appropriate report p values if primary null. Clinicians didnt change Abx in response to NGS. Unclear if some analysis were pre-planned or post-hoc. #ESCMID2025

submitted 7 days ago • 1 comment

Lovely piece of work. Strong recommend.

submitted 7 days ago • 1 comment

Vancomycin Taper trial presented by @dremilymcd.bsky.social #ESCMID2025. In people who get better by day 10 should we stop or give taper? Reduced recurrences by primary outcome timepoint but the KM suggests it may be just delaying rather than truly preventing recurrence? #IDSky

submitted 7 days ago • 0 comments

Depressing but unsurprising that only 1 out of 24 UK Emergency Medicine trials between 2010-23 reported sex-disaggregated outcome data. #ESCMID2025 #IDSky pubmed.ncbi.nlm.nih.gov/39266055/

submitted 7 days ago • 2 comments

Lovely data from Galicia #ESCMIDGlobal showing nisrevimab huge impact on infant admissions with RSV-LRTI. Looking forward to seeing planned data on impact on antibiotic use & broader outcomes. #IDSky

submitted 7 days ago • 1 comment

Random Reflections #ESCMID2025 It is mad to me how many 'plug & play' PCR systems there are now available. I am glad to see alternatives to Cepheid but having 20+ essentially identical systems which are closed, proprietary and have no inter-operability just seems totally mad. #IDSky

submitted 7 days ago • 2 comments

Interesting study suggesting a role for Lymphatic Filariasis in altering risk of HIV acquisition. @thelancet.bsky.social I need to mull over a bit how I think this might work biologically....

submitted 8 days ago • 1 comment

In collaboration with great team in DRC & Spain we present data MPOX both in regions of DRC where disease traditionally been reported & areas where has emerged recently @thelancet.bsky.social Hopefully provides useful insights into relative severity & clinical features of MPOX across region #IDSky

submitted 8 days ago • 0 comments

A reminder we have 2 Academic Clinical Lecturer Posts in Infection @lshtm.bsky.social shorturl.at/EIUIz Open to people training in ID in UK & hold/imminently completing PhD. Open to people with broad range of infection research interests. If interested get in touch. Applications close April 28

submitted 18 days ago • 0 comments

A reminder we have 2 Academic Clinical Lecturer Posts in Infection @lshtm.bsky.social shorturl.at/EIUIz Open to people training in ID in UK & hold/imminently completing PhD. Open to people with broad range of infection research interests. If interested get in touch. Applications close April 28

submitted 18 days ago • 0 comments

Academic Clinical Lecturer Posts in Infection now out: for people training in ID in UK & hold/imminently completing PhD. 2 posts @lshtm.bsky.social shorturl.at/EIUIz 1 at St Georges & 1 at Kings shorturl.at/8kDY3 If interested in @lshtm.bsky.social posts get in touch. UK ID people please share!!

submitted 23 days ago • 0 comments

Academic Clinical Lecturer Posts in Infection now out: for people training in ID in UK & hold/imminently completing PhD. 2 posts @lshtm.bsky.social shorturl.at/EIUIz 1 at St Georges & 1 at Kings shorturl.at/8kDY3 If interested in @lshtm.bsky.social posts get in touch. UK ID people please share!!

submitted 23 days ago • 0 comments

I think it is a 30% drop in RSV related admissions? Still very important but not quite what this implies - Think really important we are clear when describing these types of programmes and their impact. @smhopkins.bsky.social any chance this type of messaging could be looked at to reflect this?

submitted 26 days ago • 2 comments

Incredible opportunity apply to be the new Director of the MRC Unit in the Gambia - part of @lshtm.bsky.social. A world leading research unit with fantastic links across the region. This is an opportunity to shape health and research capacity across the region. Deadline is 2nd May to apply.

submitted 30 days ago • 0 comments

BRTI is seeking a Study Coordinator for the PROMISE Study in Harare. This 6-month, full-time role focuses on improving maternal and newborn health by integrating diagnostic-led STI screening into antenatal care. Details here ⤵️

submitted 31 days ago • 0 comments