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durocher1.bsky.social
Scientist: durocherlab.org @ Lunenfeld-Tanenbaum Research Institute, Toronto. Founder: Repare Therapeutics & Induxion Therapeutics
24 posts 1,634 followers 762 following
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Posts 23 Comments 14

@mark-carney.bsky.social Mr. Carney, regarding your plan to reduce federal "spending" but increase "investments": in which category do you put federal support for research and innovation? Do you see it as an expense or an investment?

submitted 4 days ago • 0 comments

Portuguese editorial cartoonist Zez Vaz reaches back to Tiananmen Square to call on American defiance.

submitted 9 days ago • 541 comments

🧬 Join our lab in Toronto, Canada 🇨🇦! Exciting postdoc opening joint with @durocher1.bsky.social at the intersection of machine learning and cancer genomics-develop next-gen models to predict genetic interactions with in-the-loop validation. Apply ➡️ apply.interfolio.com/162929 or DM with questions!

submitted 13 days ago • 1 comment

Dear all, Postdoc positions are available to work on (1) the role of DNA strand break repair proteins during DNA replication and (2) the molecular/structural biology of XRCC1 protein complexes, as part of our work on genetic diseases & cancer. Contact me if interested: [email protected]

submitted 14 days ago • 1 comment

It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.

submitted 15 days ago • 86 comments

Delighted to share our latest paper describing a method to read the levels of hundreds of metabolites or drugs in parallel using DNA sequencing. This method, which we call ‘smol-seq’ (Small MOLecule sequencing), harnesses the power of DNA sequencing for metabolite detection: rdcu.be/d8xLv (1/6)

submitted 20 days ago • 11 comments

There is clearly enough bullshit in the US to fertilize the fields of Iowa

submitted 20 days ago • 0 comments

I wonder if my American friends understand the acute sense of collective betrayal we are experiencing in Canada right now. It's widespread and deeply felt.

submitted 22 days ago • 4 comments

⚠️DEADLINE APPROACHING ⚠️ #BGFP25 early bird and talk submission deadline closes on 30 Jan 2025! 🧬 Don't miss out on the opportunity to present at this fantastic conference in beautiful Portugal, submit your abstract now ➡️ bit.ly/3AnsVZF

submitted 27 days ago • 1 comment

Come be my boss! We're looking for a new Program Head for the Molecular Medicine Program at the Hospital for Sick Children. Toronto, Canada (the deadline has been extended from Jan 31) Please Re-post. jobs.sciencecareers.org/job/667223/p...

submitted 30 days ago • 1 comment

Dear all, over Christmas I was sadly informed that Larry Thompson died on Dec.16th. Those of you that knew Larry and his work will know how big a loss this is to the genome stability community. A brief memoriam and tribute to Larry is available in DNA Repair. authors.elsevier.com/sd/article/S...

submitted 27 days ago • 0 comments

We are recruiting! Princess Margaret Cancer Centre in Toronto is recruiting an early career cancer research scientist at Assistant Professor level. Apply! Spread the word! www.nature.com/naturecareer...

submitted 104 days ago • 0 comments

My research is finally out! Huge thanks to @thecesarelab.bsky.social, @radoncdocgee.bsky.social, and everyone involved for their invaluable support along the way. Briefly, we have demonstrated that cell cycle dependent DSB repair pathways guide death outcomes following lethal genomic damage.

submitted 42 days ago • 0 comments

The Beastie Boys’ ‘So What’cha Want’ -by The Muppets

submitted 47 days ago • 88 comments

1/n Some time ago my colleague, excellent cook, and friend Ivan told me: "Cacio e pepe is the recipe that I screw up more often. Let's make a project studying systematically the physics of that sauce". Prepare to get cheesy, I'm glad to share the Cacio e paper preprint: arxiv.org/abs/2501.00536

submitted 51 days ago • 25 comments

I sincerely hope that some of you among my football (soccer)-playing bioinformatics/computational biologists colleagues play in a team called Log2FC.

submitted 51 days ago • 2 comments

RIP David Lodge. I've only read Small World but it was such a funny book with its vivid and hilarious description of academia. I don't understand why I haven't read any of his other books yet. Something I plan to correct!

submitted 51 days ago • 1 comment

Review on synthetic lethal strategies in oncology, with a small contribution from yours truly. www.nature.com/articles/s41...

submitted 82 days ago • 2 comments

Very impressed. That would kill me.

submitted 84 days ago • 0 comments

TTF2 promotes replisome eviction from stalled forks in mitosis https://www.biorxiv.org/content/10.1101/2024.11.30.626186v1

submitted 85 days ago • 0 comments

GY!BE!!!!

submitted 101 days ago • 1 comment

Heard at the conference bar: “How many starter packs are you part of?”

submitted 101 days ago • 0 comments

First post here! New paper from the lab! Profound synthetic lethality between FANCM and SMARCAL1: www.cell.com/molecular-ce...

submitted 106 days ago • 3 comments