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The @norwichmicro.bsky.social (CMI) Annual Conference starts tomorrow 🦠 📽️ Get a sneak peak of some of the scientific posters that will be on display with videos on microbiology research from across Norwich Research Park ⤵️

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Join the @longtrec.bsky.social doctoral network for a summer school in #longread bioinformatics, introducing masters’ students, doctoral candidates and early career fellows into the world of long-reads.

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Do you use Darwin Tree of Life (DToL) genomes for your work or grant applications? If so, can you please fill out this form? docs.google.com/forms/d/e/1F... We are gathering info on how DToL genomes are used. It will help us raise money to continue producing publicly available high-quality genomes.

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In this technical blog, Senior Research Assistant Ashleigh Lister guides you through her workflow for employing @vizgen.bsky.social MERSCOPE technologies in #plant tissues, mapping out gene activity in situ. 🧪

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Research at the Earlham Institute and The Alan Turing Institute is bringing together cellular and molecular biologists with #computerscientists, to transform the processing and analysing large scale cellular imaging data. 🖥️ 🧬 https://buff.ly/3ERe6RC #AI #datascience #genomics

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💬 “LITE2 really shines when coupled with ultra-high-throughput sequencing on the #Illumina #NovaSeq X, this has brought affordable whole-genome #sequencing to a new level.” ➡️

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Scientists at the Earlham Institute and The Alan Turing Institute are employing #AI to overcome challenges associated with the large volumes of #data generated by imaging flow cytometry. ➡️ https://buff.ly/3EFDI3M

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📣 Applications are now open for the Summer Vacation Bioscience Research Scholarships at the @uniofeastanglia.bsky.social and #NorwichResearchPark. Three projects are available at the Earlham Institute working across #AI for bioimaging, #singlecell RNAseq pipelines, and plant beneficial #microbiota.

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Another great couple of days at #NorwichScienceFestival, huge thanks to everyone who joined us and our colleagues volunteering their time on the stand. @theforumnorwich.bsky.social @uniofeastanglia.bsky.social

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See the brilliant organisations are joining us today in The Explorium and the free activities on offer, from astronomy to oceans! 🔭🐟 https://norwichsciencefestival.co.uk/whats-on/the-explorium-thursday-20 There's only 2 days left of Norwich Science Festival so don't miss your opportunity to join in!

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💬 "For better or worse, you see proportional data represented with nested circles a fair bit in the media." A guide from @rowenahill.bsky.social on plotting proportional data as nested circles in R https://buff.ly/4aW8mC3 #R #coding 🖥️ 🧬

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💬 “With this imaging #flowcytometry, we can generate a lot more #data about the #cells we’re studying, but we don’t have a fast and efficient way to process the data yet. This creates a bottleneck that can slow down our research." 🧪 ➡️ https://buff.ly/3ENjt42

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Do you want to advance in your #longReads analysis? Don't miss this course in long-reads bioinformatics at @earlhaminst.bsky.social from the hand of @longtrec.bsky.social

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💬 “We can process a large number of samples, with minimal input and without compromising on the quality of the resulting data.” Introducing the improved LITE2 protocol for affordable genome sequencing 🧬 🖥️

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MARTi: a real-time analysis and visualisation tool for nanopore metagenomics 🧬🖥️🧪 Preprint https://www.biorxiv.org/content/10.1101/2025.02.14.638261v1 Source https://github.com/richardmleggett/MARTi Docs https://marti.readthedocs.io Demo app https://marti.cyverseuk.org/

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🆕 In partnership with the The Alan Turing Institute, scientists at the Earlham Institute are employing #AI with imaging #flowcytometry to transform the processing, cataloguing, and analysis of large-scale cellular #data. 🖥️ 🧬 https://buff.ly/4i46YPV

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Interested in the latest updates and applications in #genomics and #bioinformatics? 🧬 🖥️ Our upcoming meeting will look at new technologies, tools, and approaches for UK genome science.

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Great couple of days at #NorwichScienceFestival. Thanks to our volunteers and everyone who joined us at our Living Soil stand, learning about the diversity of #microbial #communities in #soil! 🌱 Join us on Wednesday and Thursday for another activity to learn about hidden medicines in our plants. 🏵️

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ICYMI last week BBSRC released a report on their long-term impact on #sequencing and #genomics, featuring significant milestones in the Earlham Institute's history, as well as looking to the future landscape of genomics. @ukri.org

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📣 Applications are now open for the Summer Vacation Bioscience Research Scholarships at the @uniofeastanglia.bsky.social and #NorwichResearchPark. Three projects are available at the Earlham Institute working across AI for bioimaging, single-cell RNAseq pipelines, and plant beneficial microbiota.

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By making small but important changes to the workflow, the Earlham Institute's Technical Genomics team have managed to make significant improvements to the LITE protocol - a low-cost method for high-throughput whole #genome #sequencing with reduced DNA input. 🖥️ 🧬

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💬 "There’s already plenty of documentation out there for how to use #ggtree, but there is the odd thing I come up against that I haven’t seen explicitly demonstrated before." A guide to plotting #phylogenetictrees in #R, and automating clade highlights, by @rowenahill.bsky.social 👇

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Scientists in the Macaulay Group are combining #singlecell methods with #longread sequencing to explore the role of alternative splicing events on cell differentiation in the haematopoietic system. 🧪 ➡️ buff.ly/4aZtXJz

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Register for our #Nanopore #Metagenomics workshop - providing comprehensive training in the workflow, from sample to analysis, including: ☑️ DNA extraction ☑️ Library preparation ☑️ Data visualisation 📆 08-09 July 2025 📍 Earlham Institute, Norwich ➡️ https://buff.ly/41dxyAr @nanoporetech.com 🖥️ 🧬

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Technological advances have transformed #sequencing, but costs and timescales can still be limiting, especially in library generation. Earlham Institute's updated Low Input, Transposase Enabled (LITE) protocol offers low-cost, high-throughput whole #genome sequencing with reduced DNA input. 💻🧬🧪

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Applications close soon for a Senior Technical #ProjectManager to join the BioFAIR Hub at the Earlham Institute. This role will: ☑️ provide key project management leadership ☑️ establish the structure, staffing, partnerships and governance 📆 Apply by: 18 February #openscience #FAIRdata

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A new report published today celebrates the long-term impact in #sequencing and #genomics from the Biotechnology and Biological Sciences Research Council, featuring significant achievements from the Earlham Institute's history, as well as looking to the future landscape of genomics.

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🚀 Master #LongReads #Transcriptomics! 🧬 #LongReads sequencing reveals full-length isoforms, splicing events, and hidden gene regulation. Enhance your #Bioinformatics research with our Summer School 🌞🏫. A hands on course covering the latest methods and tools. 📆Apply now & level up your skills!

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"There are a couple of #R packages that can produce ideograms, but in this case, I wanted something even simpler... and instead made a very basic telomere-marked ideogram using just #ggplot2." Marking telomeres on a simple ideogram in R by @rowenahill.bsky.social #coding 🖥️ 🧬

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Registration & abstract submission is now open for #EISingleCell25! Join us in June to hear from leading experts, explore innovative applications, and network with peers across the #singlecell and #spatial #genomics field. 🧪

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Last month a delegation from the Department for Science, Innovation and Technology (DSIT) visited Norwich Research Park, to see the cutting edge research in #EngineeringBiology undertaken across the campus, including at the Earlham Biofoundry. #automation #synbio

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As part of the Earlham Institute’s #CellularGenomics research programme, scientists at the Earlham Institute are combining #singlecell methods with long-read #sequencing to investigate the role of alternative splicing events on cell differentiation in both health and disease fields.

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Congratulations to @cristobaluauy.bsky.social - a close collaborator with the Earlham Institute - on his appointment as the next Director of the @johninnescentre.bsky.social Great news for the future of #plant and #microbial #research in Norwich!

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📂 We develop a range of open source software and #bioinformatics tools to support research, analysis, and the management of data according to FAIR principles. Made available to the #bioscience community, our tools enable integration, analysis, and interpretation of large or complex #datasets.

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Expression of interest has just opened for our popular #Singlecell #RNAseq workshop - from lab to data analysis. This five-day course offers a comprehensive overview of single-cell #genomics, with lectures and hands-on sessions from our research faculty. 🖥️ 🧬

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📢 Calling all Signallers! Join us for this celebratory smorgasbord of signalling research on 1-2 May with sessions on #proteostasis, #PI3K, #autophagy, #redox biology and #nuclear signalling. 🧪 Latest Institute research with special guests ⤵️ www.eventbrite.co.uk/e/cellular-s...

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💬 “By using a much-expanded set of robust barcodes, we can pool more samples in the sequencing lane, making better use of our capacity and further lowering the cost per sample.” - @drkarimgharbi.bsky.social LITE2 takes affordable genome sequencing to a new level

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Plants produce a wealth of #bioactives with potential uses in medicine, agriculture, and industry. Finding the #genes that control their production could enable scalable production of these compounds. 🏵️🧬 At #NorwichScienceFestival, join us to learn more about the hidden medicines in our #plants.

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On my way to Nottingham for the first HDR UK & @elixiruknode.org Joint Hackathon! Looking forward to contributing to some of the exciting projects for the next 3 days! elixiruknode.org/event/2025-h...

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Thank you for the invite. It was great meeting students, postdocs and colleagues.

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Dr Meha Patel (@mehapatel.bsky.social) is a Wellcome Clinical Fellow in the Macaulay Group at EI. She's using the Institute's #singlecell technologies to define the tissue-resident and circulating #immune cell landscape in Primary Sclerosing Cholangitis (PSC), a rare liver disease.

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Thanks to @alperakay.bsky.social from @uniofeastanglia.bsky.social who joined us this morning for our weekly seminar, sharing his research in #alternativesplicing regulation by snRNA modifications. @norwichrnaclub.bsky.social @whaerty.bsky.social

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GUIDE: Are you assembling a #genome for a polyploid? In this blog, Dr Camilla Ryan demonstrates how to go beyond the traditional collapsed genome and retain all haplotypes in the assembly. 🖥️ 🧬

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Just over a week left to get 🎟️ for our first @pintofscience.uk 2025 event @theforumnorwich.bsky.social 💫 We have talks from @katielong.bsky.social, Jack Dorling & Prof David Andrews 🔎 & science inspired art from Edible East! 🎨🌱 🎟️⬇️ pintofscience.co.uk/event/nsf-2025 @johninnescentre.bsky.social

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ℹ️ Register to join our Transformative #Genomics User Meeting next month. 🧬 We'll discuss challenges facing the community, and explore the latest research applications of the platform, including ultra-long read #sequencing and #spatialtranscriptomics. 📆 13 March 2025 📍 Earlham Institute, Norwich

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By making small but important changes to the workflow, the Earlham Institute's Technical Genomics team have managed to make significant improvements and are now excited to present the LITE2 protocol - a low-cost method for high-throughput whole #genome #sequencing with reduced DNA input. 🖥️ 🧬

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🆕 Registration has is open for our training course '#Nanopore #Metagenomics: from sample to analysis. The course provides a thorough overview of lab and in-field, real-time @nanoporetech.com sequencing, including DNA extraction, library preparation, and data analysis and visualisation. 🖥️ 🧬

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Applications close soon for two part-time secondments to the role of BioFAIR Architects. These positions will involve supporting the initial stages of the technical design of the BioFAIR UK infrastructure. 📆 Apply by: 14 February #FAIRdata #OpenScience @elixiruknode.org

submitted 16 days ago • 0 comments