elias-adriaenssens.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

NAP1 switches from an activator to a limiter of interferon induction by trapping TBK1 in condensates https://www.biorxiv.org/content/10.1101/2025.05.21.655319v1

submitted 4 days ago • 0 comments

Very special feelings to announce this one... A project that started like 10 years ago is reaching the finish line, ready to shine. In a dream-team with @beckmannlab.bsky.social we solved the long-chased structure of the active membrane protein insertase SecYEG-YidC www.biorxiv.org/content/10.1...

submitted 4 days ago • 7 comments

We are happy to share that our snR30 story is finally out in @natureportfolio.nature.com 🥳 We report the first structure of a H/ACA snoRNP acting in ribosome synthesis thereby providing a detailed structural and biochemical view of the snR30 snoRNP guiding local 18S rRNA subdomain folding. 👇👇👇

submitted 5 days ago • 1 comment

Check out our latest study @natsmb.nature.com‬: Establishing a consensus model for #ubiquitin chain assembly by HECT #E3 ligases: #cryoEM structures of #TRIP12 forming K29-linked and K29/K48-branched chains! ❕ www.nature.com/articles/s41... @samuelmaiwald.bsky.social @unileiden.bsky.social

submitted 5 days ago • 0 comments

Researchers in Science have developed a tool to silence specific mitochondria-encoded mRNAs in living cells, which could help scientists understand the origins of certain mitochondria-related diseases. scim.ag/3F6Wm5d

submitted 8 days ago • 0 comments

This is just an excellent preprint by Rasmus Jensen and colleagues from Julia Mahamid's lab @embl.org - a tour de force of Cryogenic electron tomography to do in cell structural biology in which they discover a new complex and solve its structure and function! www.biorxiv.org/content/10.1...

submitted 9 days ago • 2 comments

Phosphoribosyl ubiquitination of SNARE proteins regulate autophagy in Legionella infection https://www.biorxiv.org/content/10.1101/2025.05.19.654886v1

submitted 11 days ago • 0 comments

An innovative genome-editing tool promises to do what original CRISPR systems have struggled to achieve: insert entire genes, precisely and efficiently, into human DNA https://go.nature.com/45eGzvv

submitted 15 days ago • 3 comments

Thanks to editors Amelia Glazier and Heidi McBride for the opportunity to share a little about me in this special Mitochondria issue of J Cell Science - includes how I became a scientist, some thoughts on current attacks on science/funding in the US, parenting as a PI, & more doi.org/10.1242/jcs....

submitted 15 days ago • 2 comments

Molecular machineries shaping the mitochondrial inner membrane.

submitted 16 days ago • 0 comments

mTORC1 is activated when cells are fed with amino acids. New preprint with @robzonculab.bsky.social led by Rachel Jansen shows how the massive "CastiGATOR" complex is formed when arginine-free CASTOR1 binds to the GATOR2 complex to antagonize mTORC1 starved cells. tinyurl.com/yr6en6f4

submitted 17 days ago • 3 comments

Excited that our work revealing the regulation of PINK1 by ISR pathway, is out now! A new regulatory axis in mitophagy and mitochondrial quality control #mitophagy #Pink1 #mitochondria #ISR #Neurodegeneration @mrcppu.bsky.social www.science.org/doi/10.1126/...

submitted 19 days ago • 0 comments

Metabolic immunity to infection is driven by mitochondrial one-carbon metabolism https://www.biorxiv.org/content/10.1101/2025.05.07.652698v1

submitted 18 days ago • 0 comments

One of my favorite meetings each year! 👇 #ubfriends2025

submitted 22 days ago • 0 comments

Fantastic new study from Raphael Rodriguez' lab shows that induced proximity concepts can be used to induce Ferroptosis! Inducing proximity of lysosomal iron and lipids induces lipid peroxidation! What a cool concept! Have a look at our News/Views with @olzmannlab.bsky.social shorturl.at/cbc8D

submitted 23 days ago • 1 comment

The E3 ubiquitin ligase complex SIFI has a role in terminating stress response signalling, to restore cellular homeostasis. Researchers @nature present the cryo-EM structure of this ~1.3 MDa complex providing insights into its mechanism of action. www.nature.com/articles/s41...

submitted 25 days ago • 0 comments

Uncovering ERLAD: the ER-to-Lysosome Associated Degradation of large, aggregated, disease-causing, nasty misfolded proteins that fail to enter proteasomal-driven ERAD pathways. eur02.safelinks.protection.outlook.com?url=https%3A...

submitted 26 days ago • 0 comments

Super happy to share that our work on the specific inhibition of USP30 - a clinical stage Parkinson's drug target - is now online at NSMB www.nature.com/articles/s41... Have a read if you fancy chimeric protein engineering or a framework for DUB ligandability. Huge congratulations to Nafizul & team!

submitted 26 days ago • 3 comments

We quantify the aggregation of >100,000 random protein sequences to train CANYA, a convolution-attention hybrid neural network to predict aggregation from sequence. With @bennibolo.bsky.social www.science.org/doi/10.1126/...

submitted 27 days ago • 1 comment

"That telomere phages are so prevalent means that they are a selective force, one that we know little about. We now want to understand how the telomere-toxin is secreted and also understand how this ‘telocin’ wheedles its way into unsuspecting bacterial neighbors” www.science.org/doi/10.1126/...

submitted 29 days ago • 7 comments

Join us in Engelberg, Switzerland, for an exciting #EMBO workshop on #mitochondria in the nervous system #EMBOmitoNervousSys! Great speaker line up and opportunities for short talks from early career scientists. Submit your abstract until May 30st! @jcourchet.bsky.social @tatjanakleele.bsky.social

submitted 29 days ago • 0 comments

Our work on deriving protein-protein (functional) associations across different human tissues from proteomics data is now published. There is quite a lot in this paper, so I will just touch on a few highlights: www.nature.com/articles/s41...

submitted 29 days ago • 3 comments

How do cells keep their cilia “clean” and functional? Our new study uncovers a conserved mechanism for retrieving polyubiquitinated proteins from #cilia – a process essential for cellular signaling and health. #cellbiology #ciliopathy #ubiquitin #IFT 🧵👇 1/n

submitted 32 days ago • 2 comments

I'm excited to share our latest story from the @lydiafinley.bsky.social lab, where we show that it's not just whether cells take up nutrients that matters, but how and where those metabolites are used. Out now in @naturemetabolism.bsky.social: rdcu.be/ejFTs 1/

submitted 33 days ago • 2 comments

Nickel-NTA lipid-monolayer affinity grids allow for high-resolution structure determination by cryo-EM https://www.biorxiv.org/content/10.1101/2025.04.24.650495v1

submitted 36 days ago • 0 comments

The essential co-chaperone Sgt1 regulates client dwell time in the Hsp90 chaperone cycle https://www.biorxiv.org/content/10.1101/2025.04.24.648904v1

submitted 36 days ago • 0 comments

I'm happy to share that our paper describing our novel TMEM106B overexpression mouse model is now out in Molecular Neurodegeneration 🧠📝. It’s been a project with highs and lows, and seeing it published is incredibly rewarding. Thanks to everyone who was part of the journey 🙌.

submitted 37 days ago • 1 comment

TNIP1 and Autophagy Receptors Regulate STING Signaling https://www.biorxiv.org/content/10.1101/2025.04.21.649822v1

submitted 38 days ago • 0 comments

Our PKA-autophagy story by outstanding graduate student Ashley Segura (co-led with Rose Citron) published in @embojournal.org, dissects a deep connection between autophagy and PKA in neuronal signaling, with implications for neurological disease. Great collaboration with @manciaslab.bsky.social!

submitted 38 days ago • 6 comments

At membrane contact sites, bridge-like transport proteins, e.g. LPD-3, mediate bulk lipid transfer between cellular organelles. @nature see cryo-EM structure of native LDP-3, and gain insights into its functioning and interaction with other proteins and lipids. shorturl.at/lycuz & shorturl.at/ARpUK

submitted 38 days ago • 0 comments

It's TOM season!! 😄 🥳 🎉 🔬❄️ What a perfect way to start the week after the easter weekend! Congrats to @ahmed-noor-agip.bsky.social , @pamornelas.bsky.social and colleagues! Fingers crossed! 🤞🤞

submitted 39 days ago • 1 comment

Please enjoy our (@pamornelas.bsky.social and I) work on the cryoEM structures of TOM from Chaetomium thermophilum, revealing insights into the early stages of preprotein translocation. The paper is still under review, so fingers crossed 🤞. www.biorxiv.org/content/10.1... @mpibp.bsky.social

submitted 40 days ago • 1 comment

Super excited to share this as my first post with the 🦋 world! In my first co-correspondent article, we (@Mayra Borrero @Agnieszka Chacińska @IMOL Institute) look at the roles of lipids in mitochondrial protein import complexes (spoiler: there are plenty!) &call for methods (spoiler: there are few!)

submitted 43 days ago • 2 comments

Proposed pH-dependent mechanism of the mitochondrial pyruvate carrier. In the outward-open state, positively charged K49 and H86 bind pyruvate, initiating conformational changes to the inward-open state. The high matrix pH deprotonates H86, allowing pyruvate to leave. www.science.org/doi/10.1126/...

submitted 42 days ago • 0 comments

Molecular basis of pyruvate transport and inhibition of the human mitochondrial pyruvate carrier

submitted 42 days ago • 0 comments

I'm thrilled to share that our story is now out in Science Advances! 🎉 We use quantitative imaging to map the mito central dogma, define translation hubs in the mitochondrial matrix, and show that they're replaced by Mitochondrial Stress Bodies (MSB) when mtRNA processing is perturbed 1/4

submitted 42 days ago • 8 comments

Spatial analysis of mitochondrial gene expression reveals dynamic translation hubs and remodeling in stress | Science Advances www.science.org/doi/10.1126/...

submitted 42 days ago • 8 comments

Mitochondria-organelle crosstalk in establishing compartmentalized metabolic homeostasis: Molecular Cell www.cell.com/molecular-ce...

submitted 43 days ago • 0 comments

Happy to share our most recent review on mitochondria-organelle metabolic communication with Yatrik Shah and Costas Lyssiotis now online at Molecular Cell! We explored aspect of lipid transfer, organelle membrane contacts, ROS, metabolites, and metals! www.sciencedirect.com/science/arti...

submitted 43 days ago • 1 comment

Happy to share out latest collaborative work with the groups of Ricarda Richter-Dennerlein and Peter Rehling just out in @natcomms.nature.com. Great work led by two very talented PhD students - Franziska Finke (our lab) and Marleen Heinrichs (Richter-Dennerlein lab). www.nature.com/articles/s41...

submitted 44 days ago • 1 comment

Thank you very much for this great analysis!! And for confirming what I have been saying all along, AF3 is comparable at PPI prediction, they just sample more in the original publication

submitted 45 days ago • 1 comment

www.cell.com/cell-metabol...

submitted 47 days ago • 0 comments

"The bridge-like lipid transport protein VPS13C/PARK23 mediates ER–lysosome contacts following lysosome damage" out now in Nature Cell Biology rdcu.be/ehbaL

submitted 51 days ago • 0 comments

Outstanding paper where scientists discover Mlkl isoforms that differently regulate necroptosis and a drugable target against the necroptotic activity of Mlkl. Congratulations Uris Ros, Ana Garcia Sáez and everyone involved #necroptosis kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...

submitted 46 days ago • 0 comments

Join us in Engelberg for an exciting #EMBO workshop on #mitochondria in the nervous system #EMBOmitoNervousSys. Great speaker line up and opportunities for short talks from early career scientists! Submit your abstract until May 30st! meetings.embo.org/event/25-mit...

submitted 47 days ago • 1 comment

Excited to share our preprint on the molecular architecture of heterochromatin in human cells 🧬🔬w/ @jpkreysing.bsky.social, @johannesbetz.bsky.social, @marinalusic.bsky.social, Turoňová lab, @hummerlab.bsky.social @becklab.bsky.social @mpibp.bsky.social 🔗 Preprint here tinyurl.com/3a74uanv

submitted 50 days ago • 12 comments

Nucleophagy is promoted by two autophagy receptors and inhibited by chromatin-nuclear envelope tethering in fission yeast https://www.biorxiv.org/content/10.1101/2025.04.09.648038v1

submitted 50 days ago • 0 comments