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elizsmckenna.bsky.social
Executive Editor of Cancer Discovery, published by AACR. Harvard BBS/Dana-Farber alum. Native New Yorker. Posts are my own. She/her https://aacrjournals.org/cancerdiscovery
147 posts 3,848 followers 2,566 following
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#ICYMI: Scientists and former agency heads spoke about the crisis in public funding for cancer research at the AACR Annual Meeting 2025. Learn more in Cancer Today magazine: www.cancertodaymag.org/cancer-talk/... #AACR25

submitted 7 days ago • 1 comment

AACR on Campus empowers the next generation of cancer researchers and practitioners worldwide. Learn about the global reach in Leading Discoveries: leadingdiscoveries.aacr.org/a-global-rea...

submitted 6 days ago • 0 comments

So excited to share our latest work! An immunomechanical checkpoint PYK2 governs monocyte-to-macrophage differentiation in pancreatic cancer url:https://aacrjournals.org/cancerdiscovery/article-abstract/doi/10.1158/2159-8290.CD-24-1712/762294/An-immunomechanical-checkpoint-PYK2-governs

submitted 2 days ago • 0 comments

🎯 Delighted that the May 2025 issue of Cancer Discovery @theaacr.bsky.social features #MANIFESTuk! Check out this ‘In Focus’ piece summarising our vision and ambitions for #CancerImmunotherapy 👇 aacrjournals.org/cancerdiscov... @manifest-cirrp.bsky.social

submitted 3 days ago • 0 comments

Now online in Cancer Discovery: Trends in Cancer Incidence and Mortality Rates in Early-Onset and Older-Onset Age Groups in the United States, 2010–2019 - by Meredith Shiels and colleagues doi.org/10.1158/2159...

submitted 3 days ago • 0 comments

Today, the American Association for Cancer Research (AACR) called on Congress to reject the Administration's nearly 40% cut to the NIH budget and allocate a bipartisan funding increase to $51.3 billion for the agency to accelerate progress for patients. www.aacr.org/about-the-aa...

submitted 5 days ago • 2 comments

Now online in Cancer Discovery: An Immunomechanical Checkpoint PYK2 Governs Monocyte-to-Macrophage Differentiation in Pancreatic Cancer - by Wenyan Xie, Xin Yu, Qingxin Yang, Nengwen Ke, Ping Wang, Yun-Hua Liu, Bi-Sen Ding, Qiang Wei, Hong Jiang, and colleagues doi.org/10.1158/2159...

submitted 3 days ago • 1 comment

I also had the rare (and fun) opportunity to tell an author in person that their work was chosen to be featured on the cover of an upcoming issue when I met Dr. Toledo at #AACR25! 😊

submitted 9 days ago • 0 comments

The May issue of Cancer Discovery is now online! The cover features fascinating findings by Carlota Arenillas, Rodrigo Toledo, et al. providing evidence of convergent genetic adaptation in hypoxic tumors and in high-altitude populations. More here: aacrjournals.org/cancerdiscov... @vhio.bsky.social

submitted 9 days ago • 0 comments

Mariam is part of team CANCAN, who are tackling the @cancergrand.bsky.social cachexia challenge!

submitted 12 days ago • 0 comments

For more on CAR T cell therapy to overcome barriers in treating pediatric central nervous system tumors, read the review by #AACR25 speaker Andrea Timpanaro (along with @nickvitanza.bsky.social and colleagues) - online now in Cancer Discovery! doi.org/10.1158/2159...

submitted 12 days ago • 0 comments

Online now in Cancer Discovery concurrent with a #AACR25 poster: A RAS(ON) Multi-selective Inhibitor Combo Therapy Triggers Long-Term Tumor Control via Senescence-Associated Tumor-Immune Equilibrium in PDAC - by Caroline Broderick, @rmezzadra.bsky.social, Scott Lowe, et al. doi.org/10.1158/2159...

submitted 12 days ago • 1 comment

Online now in Cancer Discovery concurrent with the #AACR25 Major Symposium on Advances in ctDNA Minimal Residual Disease Detection by speaker Max Diehn: Integrating Circulating Tumor DNA Analysis and Radiomics for Dynamic Risk Assessment in Localized Lung Cancer doi.org/10.1158/2159...

submitted 12 days ago • 0 comments

Online now in Cancer Discovery concurrent with Victor Velculescu's #AACR25 presentation on next-gen liquid biopsies for early detection: Detection of Brain Cancer Using Genome-Wide Cell-Free DNA Fragmentomes doi.org/10.1158/2159...

submitted 12 days ago • 0 comments

Online now in Cancer Discovery concurrent with today's #AACR25 Plenary, by speaker Mariam Jamal-Hanjani and colleagues - Cancer-Associated Cachexia: Bridging Clinical Findings with Mechanistic Insights in Human Studies doi.org/10.1158/2159...

submitted 12 days ago • 0 comments

Online now in Cancer Discovery concurrent with the #AACR25 Major Symposium on #Immunometabolism by session speaker Ping-Chih Ho: PLT012, a Humanized CD36-Blocking Antibody, Is Effective for Unleashing Anti-Tumor Immunity against Liver Cancer and Liver Metastasis doi.org/10.1158/2159...

submitted 13 days ago • 0 comments

Online now concurrent with the #AACR25 oral presentation by Cancer Discovery Early Career Award Winner @Sandra_Misale: Direct Inhibition of RAS Reveals the Features of Oncogenic Signaling Driven by RAS G12 and Q61 Mutations doi.org/10.1158/2159...

submitted 13 days ago • 2 comments

Online now in Cancer Discovery for the #AACR25 session on Advances in #KRAS Biology in PDAC by session speaker Andrew Aguirre: Response and Resistance to RAS inhibition in Cancer doi.org/10.1158/2159...

submitted 13 days ago • 1 comment

Online now in Cancer Discovery for the #AACR25 Late-Breaking Abstract Minisymposium: Mutant p53 Gain of Function: Why Many See It, Why some Don’t - a perspective by Gigi Lozano, Carol Prives, and Kanaga Sabapathy doi.org/10.1158/2159...

submitted 14 days ago • 0 comments

Online now in Cancer Discovery concurrent with the #AACR25 Major Symposium on Mechanisms Underlying Differences in Cancer Incidence, by speaker Jun Yu: Intrahepatic Microbial Heterogeneity in Multifocal HCC and Its Association with Host Genomic and Transcriptomic Alterations doi.org/10.1158/2159...

submitted 14 days ago • 1 comment

Online now in Cancer Discovery by #AACR25 Pezcoller–AACR Award for Extraordinary Achievement in Cancer Research winner Douglas Hanahan: HPV16-Expressing Tumors Release Multiple IL-1 Ligands to Orchestrate Systemic Immunosuppression Whose Disruption Enables Vaccine Efficacy doi.org/10.1158/2159...

submitted 14 days ago • 0 comments

Online now in Cancer Discovery concurrent with the #AACR25 Opening Plenary, by plenary speaker Catherine Wu: The Future of Personalized Cancer Vaccines doi.org/10.1158/2159...

submitted 14 days ago • 0 comments

Online now in Cancer Discovery concurrent with the #AACR25 Opening Plenary, by plenary speaker Paul Mischel: A Guide to Extrachromosomal DNA (#ecDNA): Cancer's Dynamic Circular Genome doi.org/10.1158/2159...

submitted 14 days ago • 0 comments

I’m heading to Chicago tomorrow for #AACR25! I’m ready to be both extremely inspired by the science and extremely tired from all the steps I’ll be taking running around McCormick.

submitted 17 days ago • 1 comment

Congratulations to the 2025 Cancer Discovery Early Career Award winner: Sandra Misale! @sandramisale.bsky.social #AACR25

submitted 15 days ago • 1 comment

Excited to be at #AACR25 and looking forward to meeting everyone!!

submitted 15 days ago • 1 comment

This year’s 11 NextGen Stars will share their findings on cancer cartography, the dark proteome, cancer-resistant tissues, and more at #AACR25. Learn more about their work and its future implications on the #AACRBlog: www.aacr.org/blog/2025/04...

submitted 15 days ago • 0 comments

Don't miss "The Journey of Antibody–Drug Conjugates: Lessons Learned from 40 Years of Development," a Cancer Discovery review by #AACR25 speakers Elisabeth de Vries and @raffcolo.bsky.social (along with Pat LoRusso & @ptarantinomd.bsky.social) doi.org/10.1158/2159...

submitted 15 days ago • 2 comments

Watching the #AACR25 Education Session presentation by @KenLauLab on the Hallmarks of Precancer? Read more in his Cancer Discovery perspective: doi.org/10.1158/2159...

submitted 15 days ago • 0 comments

@manelesteller.bsky.social is discussing the Epigenetic Hallmarks of Cancer now at the #AACR25 Education Session on the Evolution of Cancer Hallmarks - read the landmark Cancer Discovery review: doi.org/10.1158/2159...

submitted 15 days ago • 1 comment

Congratulations to Charles Roberts, MD, PhD, for election to the @theaacr.bsky.social Board of Directors. Your commitment and leadership in the advancement of cures and preventions for cancer continues to drive progress. #AACR25

submitted 16 days ago • 1 comment

Congratulations to the #AACR25 NextGen Stars! Read more about the work of Edmond Chan, Yash Chhabra, Karen Dixon, Adam Durbin, Anniina Färkkilä, Anand Jeyasekharan, Zuzana Keckesova, John Prensner, Elvin Wagenblast, Stephanie Xie, Di Zhao in this Cancer Discovery commentary: doi.org/10.1158/2159...

submitted 16 days ago • 0 comments

We are getting ready to host the cancer community as #AACR25 begins tomorrow at 3:00 PM CT. We hope you will join us here in Chicago or online.

submitted 17 days ago • 0 comments

A little travel reading for those heading to #AACR25: the recent collections of special commentaries published in Cancer Discovery! Read them here: aacrjournals.org/cancerdiscov... aacrjournals.org/cancerdiscov...

submitted 17 days ago • 0 comments

Honored to Chair @theaacr.bsky.social #AACR25 Educational Session "The Evolution of Cancer Hallmarks: Insights and Moving Forward" and deliver lecture #Epigenetic #hallmarks with Chi Van Dang @ludwigcancer.bsky.social #Circadian and Ken S. Lau #Precancer www.abstractsonline.com/pp8/#!/20273...

submitted 34 days ago • 0 comments

Why do tumors tend to metastasize to lymph nodes? Super interesting insights into that question, published online in Cancer Discovery today. One of those papers that grabs you at the title.

submitted 18 days ago • 0 comments

Now online in Cancer Discovery: Intrinsic Properties of the Lymph Node Render It Immunologically Susceptible to Metastasis - by Benjamin Kahn, Ben Stanger, and colleagues doi.org/10.1158/2159... @pennmedicine.bsky.social @penncancer.bsky.social

submitted 18 days ago • 1 comment

Now online in Cancer Discovery: Depletion of Effector Regulatory T Cells Associates with Major Response to Induction Dual Immune Checkpoint Blockade - by Xianli Jiang, Ken Chen, Maura Gillison, and colleagues doi.org/10.1158/2159... @mdanderson.bsky.social

submitted 19 days ago • 0 comments

Make the most of your #AACR25 experience with in-person and virtual options, the AACR Runners for Research 5K Run/Walk, a performance by the CheckPoints, and more. Preview highlights in AACR Annual Meeting News: www.aacrmeetingnews.org/news/prepari...

submitted 28 days ago • 0 comments

Congratulations to the recipients of the 2025 AACR Scientific Achievement Awards and Lectureships. This year’s distinguished class of awardees will be recognized at #AACR25 in Chicago. www.aacr.org/about-the-aa...

submitted 26 days ago • 0 comments

Now online in Cancer Discovery: Precancerous Cells Initiate #Glioblastoma Evolution and Contribute to Intratumoral Heterogeneity - by Hyun Jung Kim, Jeong Ho Lee, and colleagues doi.org/10.1158/2159... #KAIST

submitted 25 days ago • 0 comments

#AACR25 is only 2 weeks away!! Looking forward to having one of these 🌭 and to seeing everyone in Chicago! If you or any of your colleagues are going and would like to meet to discuss your research, please reach out!!

submitted 30 days ago • 1 comment

Now in Cancer Discovery: Antitumor Activity of Vebreltinib & Characterization of Clinicogenomic Features in Tumors w/MET Rearrangements - by Seshiru Nakazawa, Federica Pecci, Igor Odintsov, Pasi Janne, Mark Awad, et al. doi.org/10.1158/2159... @danafarber.bsky.social @mskcancercenter.bsky.social

submitted 32 days ago • 0 comments

Now online in Cancer Discovery: Convergent Genetic Adaptation in Human Tumors Developed Under Systemic Hypoxia and in Populations Living at High Altitudes - by Carlota Arenillas, Rodrigo Toledo, and colleagues doi.org/10.1158/2159... @vhio.bsky.social

submitted 32 days ago • 0 comments

The cancer research community will gather in Chicago for #AACR25 to discuss the latest breakthroughs, share ideas, and forge new collaborations to accelerate progress in cancer science and medicine. Learn more about this pivotal meeting: www.aacr.org/about-the-aa... #AACRStories

submitted 35 days ago • 0 comments

Now online in Cancer Discovery: Activated T Cells Break Tumor Immunosuppression by Macrophage Re-education - by Rosa Trotta, Silvia Rivis, Shikang Zhao, Massimiliano Mazzone and colleagues doi.org/10.1158/2159...

submitted 34 days ago • 0 comments