faldalf.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

Speed AND less data are the real advantage of 2D projections from a Snouty light-sheet microscope! (previous post) -> Here's a zebrafish heart from the @retof.bsky.social lab. The heart beats quickly but the GFP is sparse so 2 orthogonal projections can reveal the dynamics! doi.org/10.1038/s415...

submitted 1 day ago • 1 comment

Excited to be in Genoa for the #WeberSymposium2025 A few days of all fun things fluorescence ahead 🔬🎆🌈 Starting out with an account of the seminal contributions by Gregorio Weber presented by the amazing Dave Jameson

submitted 1 day ago • 0 comments

Excited to share our latest story in Nature. We developed a high-throughput cellular stretch system to look for genes regulating membrane rupture under tension, and found an amazing small protein called NINJ1 that weakens the membrane for rupture! H/T to Zozo, my 10-y.o. for her artist's impression😃

submitted 7 days ago • 2 comments

When to design and make custom optics? The short answer is... only when absolutely necessary! -> Here's a tiny achromat and knife edge mirror combination (+ custom mechanics) that makes an image relay with a scanning microelectromechanical (MEMS) mirror at the pupil. Stock parts couldn't be found!

submitted 8 days ago • 0 comments

Very excited to share our work on mechanosensitive control of cell contractility by the putative ion channel Tmc, now online in @currentbiology.bsky.social. Very grateful for this fantastic collaboration with the Großhans lab! www.cell.com/current-biol...

submitted 48 days ago • 0 comments

Here's an autophagic punctum for you: Small but mighty: ATG9A-positive vesicles are a branch of the intracellular nanovesicle superfamily Some self-eating self-publicity... 🧪 doi.org/10.1080/2769...

submitted 12 days ago • 1 comment

Excited to share our Science paper on HaloDA1.0-the first genetically encoded far-red dopamine sensor! 🥳It enables powerful multiplex imaging in neurons, brain slices, and live animals.🧠🔬 #GRABsensors #Dopamine www.science.org/doi/10.1126/...

submitted 11 days ago • 1 comment

We are looking for a postdoc to study biomolecular condensates and/or mechanosensitive membrane proteins. Please help spread the news 🙏 sites.rutgers.edu/shi-lab/look...

submitted 18 days ago • 2 comments

Our groundbreaking Dark Sectioning technique is now published in Nature Methods! 🎉 It supercharges existing imaging systems: 🔬 Widefield → Confocal 🔬 Single-photon → Multiphoton 🔬 2D-SIM → 3D-SIM Now integrated in Airy PolarSIM and #FlexSIM! doi.org/10.1038/s415... #Microscopy #Fluorescence

submitted 32 days ago • 2 comments

Wonder doesn’t flinch. It’s our compass pulling us toward curiosity, creativity It reminds us: #science & #discovery are good. Here’s a moment that stirred mine: a new PI(3,4)P₂ probe illuminating the cell membrane & endosomes. Marvel with me. Captured on #FluorescenceFriday for #MicroscopyMonday

submitted 21 days ago • 6 comments

New UK-EU agreement just published. Promises to implement a new youth mobility scheme and resurrect the UK's membership of the Erasmus scheme

submitted 29 days ago • 27 comments

Grateful that students in my lab/department and one that I mentor were able to attend the @pair-up.bsky.social workshop at the MBL!

submitted 29 days ago • 0 comments

Science continues to move forward and @mblscience.bsky.social is a hotbed of exciting education, training research! 🧪

submitted 29 days ago • 1 comment

Back to @mblscience.bsky.social Woods Hole - teaching on the Pair Up Microscopy Course. Great experience and awesome participants. Wild - last time here I was a student (Physical Biology of the Cell Course in 2018). Now introducing my lab. Thanks Abhishek Kumar for organising and the invitation.

submitted 29 days ago • 1 comment

🧵5 Top Free Alternatives to BioRender for Scientific Illustrations! These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs. Save and share the post!

submitted 34 days ago • 34 comments

Introducing warpfield, an open source Python library for GPU-accelerated non-rigid 3D registration. Warps and aligns gigavoxel volumes within seconds (not hours). For 3D microscopy, region-to-region and cell-to-cell matching. A collaboration with @mh123.bsky.social 🚀 github.com/danionella/w...

submitted 36 days ago • 7 comments

An amazing new enabling technology. Measurements of molecular size and shape on a chip. Couldn't be prouder of our friend Madhavi Krishnan of @ox.ac.uk this was and is one among the must fun collaborations I ever had. www.science.org/doi/10.1126/...

submitted 39 days ago • 8 comments

Why are biological membranes asymmetric, with different lipids in the two bilayer leaflets? Discovered in the 70s, lipid asymmetry is linked to many cellular processes, but why the cell needs it is largely unclear. @pavelbarahtjan.bsky.social addresses this question: www.biorxiv.org/content/10.1...

submitted 42 days ago • 6 comments

Late to the party, I know, but finally making the move to where the sky is bluer and the grass is greener.

submitted 40 days ago • 0 comments

Check out our recent progress using 🧬 PAINT kinetics to decode molecular tension in super-resolution force imaging! 🔬 Great team effort from Seongho, Adam, Irving, and Kevin! 👏 #DNA-PAINT #tension #integrin #superresolution #adhesion doi.org/10.1002/advs...

submitted 60 days ago • 1 comment

Using light to sculpt vertebrate development! OptoNodal2 converts patterns of illumination into patterns of morphogen signaling. journals.biologists.com/dev/article/...

submitted 46 days ago • 1 comment

This is one to watch 🔬Congratulations!

submitted 55 days ago • 2 comments

#newPI and time is running. It has already been a month since I officially joined the University of Warwick as Assistant Professor. I am excited to announce and build the Fluorescence and Membrane Dynamics (FMD) Lab: warwick.ac.uk/fac/sci/med/...

submitted 55 days ago • 7 comments

HaloTag-based kinase activity sensor! And it works in live cell super-res :D Congratulations @michellefrei17.bsky.social @jinzhanglab.bsky.social

submitted 56 days ago • 0 comments

📢 Fresh off the press and featuring new exciting experiments! 🧪 We show how glycolytic activity instructs germ layer proportions through regulation of Nodal and Wnt signaling - happy to finally share this 😊 doi.org/10.1016/j.st... B2B with @jesseveenvliet.bsky.social lab: doi.org/10.1016/j.st... 🤩

submitted 61 days ago • 6 comments

Gentle reminder :-)

submitted 62 days ago • 0 comments

Researchers at the @uni-muenster.de have solved a key issue in protein splicing. They traced inefficiencies in split inteins to fragment misfolding and created a new cysteine-less, monomeric intein (CLm) read full article: www.synbiobeta.com/read/why-som... #Biotech #ScienceNews

submitted 62 days ago • 0 comments

Bright and photostable yellow fluorescent proteins for extended imaging by François St-Pierre and team: www.nature.com/articles/s41...

submitted 71 days ago • 0 comments

We may not have really squared the circle — but we came close! 😉 In our @NaturePhysics paper w/ @fakhrilab.bsky.social, light-triggered membrane excitability enables programmable shapes — a step toward engineering living matter. 🔗 www.nature.com/articles/s41... #biophysics #syntheticcell #softmatter

submitted 78 days ago • 1 comment

Awkwardly sitting next to a poster of my face at the RNA Victoria symposium @hudsonresearch.bsky.social #RNAte #RNA #accidentalmodel 🧪💃

submitted 82 days ago • 0 comments

The Snouty light-sheet microscope is an ultrafast volumetric imaging system. Due to the 'fast optical scanning' (previous post) we can routinely image in 3D! -> Here we explore adherent cells. Every time the laser flashes we're acquiring a whole volume! amsikking.github.io/high_na_sing...

submitted 82 days ago • 0 comments

1/8 Exciting new work with Agu @mangiarotti.bsky.social @mpici.bsky.social ! 🚀 Our latest study explores how lipid packing and cholesterol regulate the interaction of biomolecular condensates with membranes. It turns out, it’s not just about membrane phase. Packing is the key! 🧵👇 rdcu.be/eelLq

submitted 88 days ago • 1 comment

Join the Membrane Structure and Function Subgroup will be hosting a webinar on Tuesday, March 25 at 11:00 AM ET. The presentations will explore recent breakthroughs, foundational concepts, and future directions in membrane biophysics. Register here: buff.ly/YOAPVID

submitted 86 days ago • 0 comments

NEW: Elon Musk’s X has suspended accounts of Turkish opposition groups, suppressing footage of anti-government protests. So, best we share all the footage we can here! This was last night’s massive demo against Erdogan’s government, which follows the arrest of his rival Ekrem İmamoğlu. 🇹🇷 #Turkey

submitted 86 days ago • 168 comments