ferag.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

The US will depart the World Health Organization in 2026. Nature spoke to senior figures in global health to gauge what might be next for the WHO and the field. 🧪

submitted 4 days ago • 1 comment

The great joy of writing a review paper is finding good quality papers in society journals from 20-40 years ago that show the same basic result as papers being published in high profile journals today.

submitted 11 days ago • 2 comments

With @jrpenades.bsky.social, we challenged Google AI co-scientist to generate hypotheses. In just 2 days, it recapitulated our unpublished, experimentally confirmed mechanism for how cf-PICIs spread between bacterial species! @imperialcollegeldn.bsky.social tinyurl.com/3byyaeh2

submitted 7 days ago • 0 comments

That fact that serious fungal infections are still treated with Amphotericin B (approved in 1958) is solid evidence here.

submitted 8 days ago • 3 comments

Who figured out what stars are made of? Cecilia Payne. 1925, her research proved that stars are mostly hydrogen & helium overturning old assumptions. Changed astrophysics but was stuck with the title “technical asst” for decades. Time to make her name harder to forget. https://tinyurl.com/2p9ebubh 🗃️

submitted 14 days ago • 0 comments

THREAD Things that didn't make the news that will likely change our lives for the better The news is not an accurate reflection of the world. Good news doesn't get reported as much. Here are the wonderful things researchers have achieved recently. 1/24

submitted 11 days ago • 2 comments

Are you curious about how LLMs can be applied to bioinformatics? This series of four webinars covers fundamentals through to cutting-edge applications in knowledge extraction & summarisation. Registration is free but essential for each webinar: www.ebi.ac.uk/training/eve... #GeneSky 🖥️🧬🧪

submitted 14 days ago • 0 comments

🔬🎤 As pre-announced a few days ago... please let us proudly present to you: 𝑴𝒊𝒄𝒓𝒐𝕊𝒑𝒍𝒊𝒕 - your ticket to imaging more, imaging more gentle, and/or imaging more efficient. 🔬 doi.org/10.1101/2025... Like ❤️, repost 🔂, and most importantly... please send feedback ✉️ our way! 🙏

submitted 16 days ago • 2 comments

🚨Preprint Alert!🚨 #ProteinDesign is advancing rapidly—wouldn't it be great to seamlessly combine design tools to achieve more than what each can do alone?🤔 Here, we introduce AI.zymes: A modular platform for evolutionary #EnzymeDesign.♻️🖥️ biorxiv.org/content/10.1... 1/🧵

submitted 15 days ago • 1 comment

How long does it take to predict ligand binding sites for all 220k proteins in the PDB? P2Rank 2.5 does it in 3 hours on a single CPU (16-core amd 5950x)—2x faster than the previous version 🚀. (1/n)

submitted 17 days ago • 1 comment

Writers and aspiring writers! We're launching a writing fellowship on scientific progress, jointly hosted by Works in Progress and Asimov Press. We'd like you to produce richly detailed articles about a selected area of scientific progress. We'll pay, mentor, and give editorial feedback. Apply:

submitted 15 days ago • 4 comments

Making intrabodies from antibodies just got easier! Learn how we made 𝟭𝟵 intrabodies to bind and light up peptides and histone modifications in live cells. And thanks to Academia, all sequences are freely available. (video credit: Yuko Sato @YukoSatoT2) (1/15) www.biorxiv.org/content/10.1...

submitted 15 days ago • 12 comments

Optical tweezers reveal MoA of 3 small-molecule inhibitor classes against #tuberculosis #RNA #polymerase, suggesting combining two of the three antibiotics (Stl & D-IX216) to induce complete transcription arrest and therapeutic effect.

submitted 17 days ago • 0 comments

“The good thing about science is that it’s true whether or not you believe in it.” — Neil deGrasse Tyson

submitted 17 days ago • 0 comments

The new #RDKit blog post is another tutorial. This time it's about some advanced substructure search functionality. greglandrum.github.io/rdkit-blog/p...

submitted 19 days ago • 1 comment

Chuck Feeney here who died in 2023. A man who made an estimated €8 billion out of Duty Free and then gave it all away to make the world a better place. A modest man too. Which is why you may never have heard of him. www.forbes.com/sites/steven...

submitted 20 days ago • 27 comments

Modern-Day Oracles or Bullshit Machines? Jevin West (@jevinwest.bsky.social) and I have spent the last eight months developing the course on large language models (LLMs) that we think every college freshman needs to take. thebullshitmachines.com

submitted 23 days ago • 125 comments

I've gone through about half of Carl and Jevin's materials for this course, and they are excellent. My own summary: Many thought that AI would be dangerous because it would be too smart. That worry turns out to be false. Instead, the danger is that AI is too stupid.

submitted 20 days ago • 1 comment

NEW Publication!😄 Here, we show how #PhyKIT — a broadly applicable toolkit for #phylogenomics — can be used to construct phylogenomic data matrices (& quantify biases therein), detect anomalies in predicted orthology, calculate gene-gene coevolution, & more! 🔗: tinyurl.com/yc5ja4xz

submitted 94 days ago • 2 comments

submitted 21 days ago • 2 comments

Do you work on parasites and reside in an LMIC? Consider applying for a 2025 MPM LMIC award. The deadline is March 3rd, 2025—details on the website. www.parasitesrule.com/mpm-xxxvi/tr...

submitted 22 days ago • 0 comments

Rotary Tool xkcd.com/3047

submitted 22 days ago • 75 comments

We're changing the field of #compchem by creating free and open-source software for performing alchemical free energy calculations. Our flagship protocol calculates relative binding free energies of protein-ligand systems. Try it out in your browser: colab.research.google.com/github/OpenF...

submitted 23 days ago • 0 comments

Want to help build capacity public health pathogen bioinformatics in the Asia Pacific region? 🦘 Based in Melbourne Australia with me ✈️ Travel to and work internationally 🧠 Lead strategy, training & infrastructure Applications close soon! jobs.unimelb.edu.au/caw/en/job/9...

submitted 22 days ago • 0 comments

Here is a quick thread to promote my research! After years of dedicated research, I'm thrilled to share our article just published at Nature Communications :) www.nature.com/articles/s41... #metabolism #CRISPRscreens #mitochondria

submitted 33 days ago • 19 comments

Drs Sugandika Bullumulla, Lihua Xiao, Yaoyu Feng, Amanda Ash, Una Ryan & Amanda Barbosa provide an update on #transmission of #zoonotic #Giardia in #cattle. #Typing #PublicHealth @murdoch.edu.au authors.elsevier.com/a/1kXJ55Eb1x...

submitted 24 days ago • 0 comments

Do you know Daisy Roulland-Dussoix? She is one of the discoverers of restriction enzymes, who’s findings paved the way for the development of recombinant DNA and cloning technologies. Accordingly, the finding was rewarded with a #NobelPrize. But the prize didn’t go to her. 🧵👇

submitted 26 days ago • 7 comments

Here is the link platinum-crispr.bham.ac.uk/predict.pl

submitted 84 days ago • 1 comment

Thrilled to take a break from doom and gloom to share our latest work collaborating with the DeGrado lab! We took a de novo designed protein, screened it for ligand binding using X-rays, and used the hits to evolve two wildly different functions: fluorescent turn-on and Kemp elimination catalysis. 🧵

submitted 27 days ago • 3 comments

The world is full of crazy and sad news, but here is a protein that localizes to only one of the two flagella

submitted 26 days ago • 8 comments

We see you. WHO is grateful for the love 💙 and messages of support we received. We stand by you. #HealthForAll

submitted 30 days ago • 118 comments

🧪Two more days to apply to @dev-journal.bsky.social's Pathway to Independence programme. Apply by 31 January. #ECR #DevBio

submitted 29 days ago • 0 comments

🚨🚨 MEGA JOB ALERT 🚨🚨 Independent Group Leader Positions in Computational Biology @humantechnopole.bsky.social! Are you ready to start your own lab? Do you know someone who is? Repost this + share with everyone who might want to know about it. Thanks!!! 🙏 More details below... check it out! 🧵 1/3

submitted 29 days ago • 1 comment

Are we at a turning point in world history? | David Motadel

submitted 30 days ago • 22 comments

Bursary support is available to attend Applied Bioinformatics and Public Health Microbiology 2025!💰 #ABPHM25 Join us to explore the impact of data-driven #genomics on global #PublicHealth 🧬 Apply by 25 February to be considered for up to 50% off the fee. #Bursaries 📎Find out more: bit.ly/4fc0T28

submitted 30 days ago • 0 comments

The Kowalinski group's latest study on trypanosome parasites reveals significant differences between the trypanosomal and human nuclear cap-binding complex. This key player in cellular RNA metabolism could be a potential target for novel anti-parasitic drugs. www.embl.org/news/science...

submitted 37 days ago • 1 comment

Exiting insights though mysteries of cap4 remain!

submitted 39 days ago • 0 comments

NSUN6 inhibitor discovery guided by its mRNA substrate bound crystal structure doi.org/10.1016/j.st... #RNA #RNAsky #RNAbiology

submitted 30 days ago • 0 comments

Ten simple rules for developing good reading habits during graduate school and beyond To me, the most important are: Read often, read broadly (incl. older papers and outside your field), and learn to read some papers in detail and others more superficially (and quickly)

submitted 32 days ago • 5 comments

Excited to share our gene tagging toolkit! It's a protein tagging system that maintains regulatory elements. Originally built for Kinetoplastids but adaptable to any system - no parasite-specific sequences in vectors. Prefect for studying post-transcriptional control! www.biorxiv.org/content/10.1...

submitted 95 days ago • 0 comments

📢 Excited to announce that our Opinion paper on GPI-anchored proteins is now Published! 🎉 👀 If you're working in this field, be sure to check out our paper — we've highlighted some truly outstanding questions on the topic! ⚠️ www.cell.com/trends/cell-...

submitted 34 days ago • 0 comments

It's always great to collaborate in academia! And what could be better than receiving an acceptance email on January 2nd! 😂 www.nature.com/articles/s41...

submitted 34 days ago • 0 comments

Machine Learning in Drug Discovery Resources page updated for 2025. github.com/PatWalters/r...

submitted 35 days ago • 5 comments

🧵 Have you heard of leishmaniasis? This neglected tropical disease affects 700,000 to 1 million people each year, mostly in low-income communities. It’s caused by Leishmania parasites, spread by sandflies. It has three main forms ⤵️ [1/6]

submitted 35 days ago • 1 comment

Sagan was a prophet.

submitted 37 days ago • 322 comments

How is this different from posting incremental improvement articles in a blog post hosted in a version controlled repository (eg GitHub) and citing the commit unique and persistent ID? Is peer review of these tiny bits of incremental science sustainable?

submitted 35 days ago • 1 comment

Welcome to Bluesky @barcelonacollaboratorium.com! 🦋 The BCN Collaboratorium, a joint initiative between EMBL Barcelona and @crg.eu, is a space for interaction of computational biology - promoting researchers to collaborate, share ideas and synergize across disciplines and scales.

submitted 35 days ago • 0 comments

#Microbes Saving Lives & Reducing Suffering—led by KenTimmis, this is a call to action for understanding and exploiting microbes & their role in helping humans at the face of current challenges as a global society @microbiotech.bsky.social enviromicro-journals.onlinelibrary.wiley.com/doi/full/10....

submitted 35 days ago • 0 comments

Effectiveness of molecular fingerprints for exploring the chemical space of natural products - published in jcheminf. Thanks to all the co-authors involved for this nice collaboration ! @molecularML @MiChemQSAR @fragrisoni.bsky.social jcheminf.biomedcentral.com/articles/10....

submitted 37 days ago • 1 comment