fmattiroli.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

SAVE THE DATE! The next EMBO | EMBL Symposium on 'DNA replication and genome maintenance: from basic biology to disease' will be held October 20-23, 2026. Organized by Helle Ulrich (IMB), Johannes Walter (Harvard) and Anja Groth (Danish Cancer Institute). www.embl.org/about/info/c...

submitted 6 hours ago • 1 comment

𝐇𝐨𝐰 𝐝𝐨 𝐜𝐞𝐥𝐥𝐬 𝐫𝐞𝐦𝐞𝐦𝐛𝐞𝐫 𝐰𝐡𝐨 𝐭𝐡𝐞𝐲 𝐚𝐫𝐞 𝐚𝐟𝐭𝐞𝐫 𝐃𝐍𝐀 𝐫𝐞𝐩𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧? Our new study “Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability” is out in 𝘚𝘤𝘪𝘦𝘯𝘤𝘦 𝘈𝘥𝘷𝘢𝘯𝘤𝘦𝘴. Led by @lleonie.bsky.social @biranalva.bsky.social 🧵 More below👇

submitted 7 days ago • 5 comments

Researchers at Fred Hutch have discovered an overlooked mechanism driving aggressive breast and brain tumors involving genes so ancient — more than 2 billion years old — that they fly under the radar of standard genetic sequencing methods. 1/9 www.science.org/doi/10.1126/...

submitted 13 days ago • 1 comment

Prof Joe Marsh and I have a PhD project as part of the 2025 Edinburgh Doctoral College Scholarship: "Integrating AI, Biophysical Modelling and Experimental Validation for Enhancer Variant Interpretation". Closing date for applications is 25 April 2025. Please get in touch if you are interested! 🧬🧠

submitted 17 days ago • 0 comments

4-year PhD studentship available in my lab to study helper helicase function in eukaryotic DNA replication. Happy to receive any enquiries directly to me. Come join us and add your figure to the lab lego collection! institute-genetics-cancer.ed.ac.uk/igc-graduate...

submitted 19 days ago • 0 comments

Dead line is approaching. Have a look on the prg.

submitted 21 days ago • 0 comments

Please RT. Join the sixth edition of our Training Unit @institut_curie international course on Genome Instability & Human Disease open to master students, PhDs and researchers! Amazing program. Registration dead line 2nd March 2025 at training.institut-curie.org/courses/geno...

submitted 53 days ago • 0 comments

Happy to share this concise review and outlook for single-cell sequencing methods to unravel cell biology of the nucleus! Big shoutout to my friend and former colleague Peter Zeller for sharing the work! www.sciencedirect.com/science/arti...

submitted 22 days ago • 0 comments

Our paper on Stopless-ORF Circular RNAs (socRNAs) is now out in Cell. By high-res tracking and comparing translation by either single or multiple ribosomes, we find that ribosomes cooperate to overcome pausing to ensure fast and efficient translation www.cell.com/cell/fulltex...

submitted 23 days ago • 4 comments

Seeing ribosomes in action? Thanks to researchers from the @marvintanenbaum.bsky.social lab this is now possible. They created a technology to track individual ribosomes during mRNA translation. The team found that ribosomes ‘help’ each other in difficult situations www.hubrecht.eu/ribosomes-te...

submitted 26 days ago • 0 comments

Amid concerning times, sharing a bit of positivity: our 1st preprint of 2025 (funded VIA NIH COMMON FUND), heroically led by Marty Yang (@martyyang.bsky.social) w/ huge assist from @genophoria.bsky.social lab. Lots to cover so let’s get this tweetorial started (1/n)! www.biorxiv.org/content/10.1...

submitted 33 days ago • 4 comments

We’re hiring! 🚨 We’re looking for motivated postdocs to join our team and help us advance the frontiers of chromatin simulations Learn more and apply here: www.jobs.cam.ac.uk/job/50052/ Women and underrepresented profiles in STEM are encouraged to apply Please repost to help us spread the word!

submitted 33 days ago • 0 comments

we are recruiting a postdoc to work on a collaborative project with the lab of Nynke Dekker in Oxford @nynkedekkerlab.bsky.social. Please RT www.hubrecht.eu/job/postdoc-...

submitted 33 days ago • 0 comments

I am really excited to have the opportunity to continue to do science at the Hubrecht Institute @hubrechtinstitute.bsky.social! Thank you for the support!

submitted 33 days ago • 6 comments

Is chromatin ordered or disordered? It all depends on the linker DNA length. Check our latest work with Mike Rosen and Sy Redding. We explore how changes in linker DNA length (as small as 1 bp) fine-tune chromatin structure, between order and disorder, and the properties of chromatin droplets

submitted 64 days ago • 6 comments

Happy New Year, blue-sci-peeps! My piece in Annual Review of Biophysics on chromatin replication is now available online. doi.org/10.1146/annu... If you have paywall issues, try this link: madhanilab.ucsf.edu/s/annurev-bi...

submitted 50 days ago • 1 comment

In one of our first publications in 2025, with colleagues from St. Louis, Leiden and Boston, we shed light on the molecular mechanisms of motile cilia, structures used by cells to propel themselves through fluid or to move fluid across their surfaces. www.nature.com/articles/s41...

submitted 50 days ago • 0 comments

I have received a Wellcome Discovery Award to study the initiation of eukaryotic DNA replication, with 8 years of funding at the Francis Crick Institute. Looking for a postdoc in molecular mechanisms, cryo-EM, cryo-FIB and in situ structure? Contact me now! 3 postdoc positions advertised soon.

submitted 77 days ago • 17 comments

"Structural diversity of axonemes across mammalian motile cilia" www.nature.com/articles/s41...

submitted 56 days ago • 0 comments

Really cool work, demonstrating TRF2-RAP1 mediated inhibition of the NHEJ machinery at chromosome ends! www.biorxiv.org/content/10.1...

submitted 55 days ago • 0 comments

I wrote some thoughts about why peer review matters It shapes scientific standards, maintains field coherence & trains new researchers Yes, it needs improvement—but it's the glue that holds scientific progress together briscoelab.org/2024/12/11/i...

submitted 77 days ago • 12 comments

Don’t miss this opportunity!!

submitted 75 days ago • 0 comments

This work from the Zaret lab is so elegant and systematic! Very interesting too 👏 www.nature.com/articles/s41...

submitted 77 days ago • 1 comment

Looking for a PhD position? Interested in understanding gene regulation using live-cell single-molecule imaging technologies? Apply for the NKI PhD program to join our lab or other NKI labs. bit.ly/3O4bOjq

submitted 86 days ago • 0 comments

Another masterpiece on understanding how human cells prepare for genome replication

submitted 90 days ago • 0 comments

Very excited to see our work on genome-wide mapping DNA repair in single cells out @naturecomms.bsky.social Amazing work by Kim de Luca & Pim Rullens. Wonderful collaboration with the Legube lab, @mariekeoudelaar.bsky.social & @jjachowicz.bsky.social . rdcu.be/d0ZAM

submitted 91 days ago • 1 comment

Powerful new method to study chromatin replication! 🤩 check it out!

submitted 102 days ago • 0 comments