fmattiroli.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

Exciting PhD project available in our lab (time sensitive)! 👇

submitted 4 days ago • 1 comment

This is very interesting!

submitted 4 days ago • 0 comments

What governs where DNA replication begins in human cells? Here, we show that origins of replication in human DNA are epigenetically specified and that crucially, this epigenetic mark is required for both DNA replication and cell proliferation! @narjournal.bsky.social academic.oup.com/nar/article/...

submitted 5 days ago • 2 comments

Want to learn more about chromatin and its dynamics? Read this review by Charlotte and Jolijn in our lab, aimed at giving an overview on this and the ways this is dealt with during transcription, replication and damage repair. Thanks to Biochemistry for inviting us! doi.org/10.1021/acs....

submitted 7 days ago • 2 comments

🚨 new preprint from the lab. Combining modeling, new Hi-C data in yeast and data analysis, our study offers new insights into the spatial and dynamic organization of chromatin during replication in eukaryotes. Check the tweetorial below ⬇️ www.biorxiv.org/content/10.1...

submitted 12 days ago • 1 comment

Cell scientist to watch – Hana Polasek-Sedlackova @hanasedlackova.bsky.social In this interview, we learn about Hana’s career, her insights on collaborative research and her engineering hobby. journals.biologists.com/jcs/article/...

submitted 20 days ago • 0 comments

Hello World! Are you passionate about epigenomics and evolution 🧪🧬🐭🐵 ? Are you looking for a postdoc in a stimulating and inclusive environment ? Look no further... We are seeking creative postdocs for our ERC project EvoEpi @igred.fr ! 👇Details👇 tinyurl.com/PostdocEvoEp... Repost are appreciated

submitted 41 days ago • 2 comments

Excellent opportunity available for a motivated #postdoc to join @kellythd-nguyen.bsky.social’s group investigating the roles of histones in regulating telomerase using a multi-disciplinary approach. More details: www.nature.com/naturecareer... Apply by 04 MAY #PostdocJobs #ScienceJobs

submitted 25 days ago • 0 comments

3rd edition of the fantastic UK DNA replication meeting is happening next September in Edinburgh. Don't miss out 🧬🏴󠁧󠁢󠁳󠁣󠁴󠁿 www.biochemistry.org/events-and-t...

submitted 26 days ago • 0 comments

So beautiful!! Amazing work! Congratulations to all authors 🤩

submitted 27 days ago • 0 comments

Are you a group leader within the research field Chemistry of Life? Would you like to strengthen your network? Then join us at the Chemistry of Life community day 2025 on 17 April @tudelfttnw.bsky.social Register 👇 www.nwo.nl/en/meetings/... deadline: 10 April

submitted 32 days ago • 1 comment

Thrilled to share our lab's first preprint, led by an exceptional PhD student Gita Chhetri and with the support of wonderful collaborators, we find that replisome function is rate-limited by strand-specific PCNA dynamics. Hope you will enjoy reading. www.biorxiv.org/content/10.1... Brief teaser:

submitted 52 days ago • 3 comments

Exciting seminar series from Genome integrity italian Network (GiiN), chaired by myself and Raffaella Di Micco! Short talks (2x30’), at convenient time for EU/USA attendees. Big shots and raising stars in an expanding field. See flyers + link to receive email alerts. Please repost to your network!👇

submitted 55 days ago • 3 comments

Check this beautiful study from our neighbors!! 👏

submitted 61 days ago • 0 comments

A new PhD position is available in my lab to explore DNA replication mechanisms using single-molecule approaches. Apply by 19th of March: www.crick.ac.uk/careers-stud...

submitted 68 days ago • 0 comments

SAVE THE DATE! The next EMBO | EMBL Symposium on 'DNA replication and genome maintenance: from basic biology to disease' will be held October 20-23, 2026. Organized by Helle Ulrich (IMB), Johannes Walter (Harvard) and Anja Groth (Danish Cancer Institute). www.embl.org/about/info/c...

submitted 74 days ago • 1 comment

𝐇𝐨𝐰 𝐝𝐨 𝐜𝐞𝐥𝐥𝐬 𝐫𝐞𝐦𝐞𝐦𝐛𝐞𝐫 𝐰𝐡𝐨 𝐭𝐡𝐞𝐲 𝐚𝐫𝐞 𝐚𝐟𝐭𝐞𝐫 𝐃𝐍𝐀 𝐫𝐞𝐩𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧? Our new study “Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability” is out in 𝘚𝘤𝘪𝘦𝘯𝘤𝘦 𝘈𝘥𝘷𝘢𝘯𝘤𝘦𝘴. Led by @lleonie.bsky.social @biranalva.bsky.social 🧵 More below👇

submitted 81 days ago • 5 comments

Researchers at Fred Hutch have discovered an overlooked mechanism driving aggressive breast and brain tumors involving genes so ancient — more than 2 billion years old — that they fly under the radar of standard genetic sequencing methods. 1/9 www.science.org/doi/10.1126/...

submitted 87 days ago • 1 comment

Prof Joe Marsh and I have a PhD project as part of the 2025 Edinburgh Doctoral College Scholarship: "Integrating AI, Biophysical Modelling and Experimental Validation for Enhancer Variant Interpretation". Closing date for applications is 25 April 2025. Please get in touch if you are interested! 🧬🧠

submitted 91 days ago • 0 comments

4-year PhD studentship available in my lab to study helper helicase function in eukaryotic DNA replication. Happy to receive any enquiries directly to me. Come join us and add your figure to the lab lego collection! institute-genetics-cancer.ed.ac.uk/igc-graduate...

submitted 93 days ago • 0 comments

Dead line is approaching. Have a look on the prg.

submitted 95 days ago • 0 comments

Please RT. Join the sixth edition of our Training Unit @institut_curie international course on Genome Instability & Human Disease open to master students, PhDs and researchers! Amazing program. Registration dead line 2nd March 2025 at training.institut-curie.org/courses/geno...

submitted 127 days ago • 0 comments

Happy to share this concise review and outlook for single-cell sequencing methods to unravel cell biology of the nucleus! Big shoutout to my friend and former colleague Peter Zeller for sharing the work! www.sciencedirect.com/science/arti...

submitted 96 days ago • 0 comments

Our paper on Stopless-ORF Circular RNAs (socRNAs) is now out in Cell. By high-res tracking and comparing translation by either single or multiple ribosomes, we find that ribosomes cooperate to overcome pausing to ensure fast and efficient translation www.cell.com/cell/fulltex...

submitted 97 days ago • 4 comments

Seeing ribosomes in action? Thanks to researchers from the @marvintanenbaum.bsky.social lab this is now possible. They created a technology to track individual ribosomes during mRNA translation. The team found that ribosomes ‘help’ each other in difficult situations www.hubrecht.eu/ribosomes-te...

submitted 100 days ago • 0 comments

Amid concerning times, sharing a bit of positivity: our 1st preprint of 2025 (funded VIA NIH COMMON FUND), heroically led by Marty Yang (@martyyang.bsky.social) w/ huge assist from @genophoria.bsky.social lab. Lots to cover so let’s get this tweetorial started (1/n)! www.biorxiv.org/content/10.1...

submitted 108 days ago • 4 comments

We’re hiring! 🚨 We’re looking for motivated postdocs to join our team and help us advance the frontiers of chromatin simulations Learn more and apply here: www.jobs.cam.ac.uk/job/50052/ Women and underrepresented profiles in STEM are encouraged to apply Please repost to help us spread the word!

submitted 107 days ago • 0 comments

we are recruiting a postdoc to work on a collaborative project with the lab of Nynke Dekker in Oxford @nynkedekkerlab.bsky.social. Please RT www.hubrecht.eu/job/postdoc-...

submitted 107 days ago • 0 comments

I am really excited to have the opportunity to continue to do science at the Hubrecht Institute @hubrechtinstitute.bsky.social! Thank you for the support!

submitted 107 days ago • 6 comments

Is chromatin ordered or disordered? It all depends on the linker DNA length. Check our latest work with Mike Rosen and Sy Redding. We explore how changes in linker DNA length (as small as 1 bp) fine-tune chromatin structure, between order and disorder, and the properties of chromatin droplets

submitted 138 days ago • 6 comments

Happy New Year, blue-sci-peeps! My piece in Annual Review of Biophysics on chromatin replication is now available online. doi.org/10.1146/annu... If you have paywall issues, try this link: madhanilab.ucsf.edu/s/annurev-bi...

submitted 125 days ago • 1 comment

In one of our first publications in 2025, with colleagues from St. Louis, Leiden and Boston, we shed light on the molecular mechanisms of motile cilia, structures used by cells to propel themselves through fluid or to move fluid across their surfaces. www.nature.com/articles/s41...

submitted 124 days ago • 0 comments