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fraserlab.bsky.social
Professor and Chair @UCSF/@UCSF_BTS - dynamic structural biology and open science - (he/him) - fraserlab.com
116 posts 3,229 followers 421 following
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WHERE WILL YOU BE ON MARCH 7TH!? Head to www.standupforscience2025.org/local-event-information/ or the link in our bio to find your closest event—or add one if you're hosting one! #standupforscience2025

submitted 1 day ago • 53 comments

How do mutations far from an enzyme's active site influence catalysis? 🤔 Part 2: In collaboration with @fraserlab.bsky.social and @silviaosuna.bsky.social, we investigated this question using de novo Kemp eliminases, revealing effects of distal mutations on the catalytic cycle. 🧵 (1/6)

submitted 2 days ago • 1 comment

Structural biology is in an era of dynamics & assemblies but turning raw experimental data into atomic models at scale remains challenging. @minhuanli.bsky.social and I present ROCKET🚀: an AlphaFold augmentation that integrates crystallographic and cryoEM/ET data with room for more! 1/14.

submitted 7 days ago • 6 comments

Crystal structures are *not* God-given truth. They approximate, w/ flaws & errors, X-ray diffraction data. AlphaFold etc. have been trained on structures, not data. SFCalculator now differentiably connects structures to diffraction data. What does this enable? 🧵 1/4 www.biorxiv.org/content/10.1...

submitted 8 days ago • 1 comment

Making my first bluesky post to share information about the West Coast Structural Biology Workshop: wcsbw2025.macromolecules.xyz There's still one week left to register and submit your abstract for this exciting conference with beautiful views of the Pacific ocean. Come join us next month!!

submitted 9 days ago • 0 comments

New York Times article now up on Federal Register stuff. www.nytimes.com/2025/02/21/s... 1/n

submitted 9 days ago • 17 comments

Excited to share what I’ve been working on with @tkaraletsos.bsky.social to transform the field of drug discovery with atomistic foundation simulation models! I could not be more thrilled to be working with this dream team. achira.ai

submitted 9 days ago • 9 comments

Berg 2028!

submitted 10 days ago • 1 comment

🚨 New preprint alert! 🚨 How does SARS-CoV-2 use as much of its genome as possible to evade our immune response? Our latest study dissects how Orf9b, which is encoded in an alternate reading frame from the N(ucleocapsid) protein, can regulate interferon signaling. www.biorxiv.org/content/10.1... 🧵👇

submitted 12 days ago • 1 comment

Excited to announce here my postdoc work in Danica Fujimori's lab is published open-access. With @stirlingchurchman.bsky.social, @fraserlab.bsky.social, & Takeuchi-Tomita lab, we use biochemical & structural approaches to investigate mitoribosomal inhibition by antibiotics doi.org/10.1093/nar/...

submitted 15 days ago • 3 comments

It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.

submitted 22 days ago • 86 comments

New acknowledgement of @elife.bsky.social lack of Impact Factor in proofs... see response!

submitted 25 days ago • 0 comments

And welcome @ianseiple.bsky.social to Bluesky!

submitted 26 days ago • 0 comments

Continuing the ☘️🍪▶️📄. Yesterday I was EXTREMELY disappointed to only receive 6 preprints (🧵) for 18 Caramel deLites. We have "preprint hating cookie thieves" (great name for a rock band!) on the 4th floor! I'm trying again - this time with the innovation of Scotch tape attached to the cookie box!

submitted 26 days ago • 2 comments

Welcome @poojaasthana.bsky.social to Bluesky!

submitted 26 days ago • 0 comments

Our latest work on tackling streptogramin resistance in collaboration with the Seiple lab is now up as a preprint. We (led by Pooja Asthana) targeted a resistance enzyme, VatD, with fragment-based drug discovery! www.biorxiv.org/content/10.1...

submitted 27 days ago • 1 comment

New strategy for discovering preprints. Cookies to Offline RSS feed! 🍪🍀

submitted 27 days ago • 1 comment

Calling all Bay Area researchers for a paid opportunity: the @asterainstitute.bsky.social Open Science Program’s User Testing Day in Emeryville on Feb 11! 📍 Try cutting-edge research tools 💡 Share feedback 🍷 Network Apply by Feb 5: forms.gle/1qk4PHjbee35... #UXTesting #Biotech #OpenScience

submitted 34 days ago • 1 comment

Thrilled to take a break from doom and gloom to share our latest work collaborating with the DeGrado lab! We took a de novo designed protein, screened it for ligand binding using X-rays, and used the hits to evolve two wildly different functions: fluorescent turn-on and Kemp elimination catalysis. 🧵

submitted 30 days ago • 3 comments

A system designed around policing and thwarting bad actors will become too burdensome to work. Fake papers (fraud, marketing, mills, hoaxes, political stunts) abuse a system built on trust, but the answer isn't to make trust obsolete, it's to ensure there are consequences for violating it.

submitted 37 days ago • 1 comment