frezzalab.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

Molecular basis of SIFI activity in the integrated stress response www.nature.com/articles/s41...

submitted 9 hours ago • 0 comments

new out in Nature www.nature.com/articles/s41...

submitted 11 hours ago • 0 comments

Activation of lysosomal iron triggers ferroptosis in cancer www.nature.com/articles/s41...

submitted 11 hours ago • 0 comments

PLA2G15 is a BMP hydrolase and its targeting ameliorates lysosomal disease www.nature.com/articles/s41... congrats @abu-remaileh.bsky.social lab!!

submitted 11 hours ago • 0 comments

Jason Casler @jasoncasler.bsky.social, Clare Harper and Laura Lackner @lllackner.bsky.social find that mitochondria–plasma membrane contact sites regulate the ER–mitochondria encounter structure. journals.biologists.com/jcs/article/... #JCSMitoSI #OpenAccess #ReadandPublish

submitted 18 hours ago • 1 comment

I'm thrilled to be co-organizing the very first EMBO Workshop bridging mitochondria and brain research - a powerhouse of science, ideas, and amazing speakers! 🧠🔬 📅 registration closes MAY 30th, so don’t wait to snag your spot! Stay tuned - more updates about the topics and speakers coming soon! 🎙️

submitted 2 days ago • 1 comment

This review underscores the importance of #circadian rhythm maintenance for glycolipid #metabolism and its role in preventing #metabolic disorders. www.sciencedirect.com/science/arti...

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Super excited to share my latest review! In this piece, I dive into how cells cleverly reuse proteins for mitosis-specific tasks — a fascinating and still underexplored area. There’s so much more to uncover, and I hope this review sparks new ideas and discussions! pubs.acs.org/doi/10.1021/...

submitted 2 days ago • 1 comment

My weekly selection of #anticancer #therapy and #metabolic reprogramming! Enjoy 🤙 biomed.news/bims-meract/...

submitted 3 days ago • 1 comment

Better to stay far from an airport. www.sciencedirect.com/science/arti...

submitted 3 days ago • 1 comment

Good Sunday, all. Here is a summary of papers in #cancermetabolism and #mitochondrialbiology, packed with superexciting science and discoveries. Don't miss it, check it here: biomed.news/bims-camemi/... @biomednews.bsky.social "Love is the quality of attention we pay to things." -J. D. McClatchy

submitted 3 days ago • 0 comments

Metabolic signaling of ceramides through the FPR2 receptor inhibits adipocyte thermogenesis | Science www.science.org/doi/10.1126/...

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Stromal lipid species dictate melanoma metastasis and tropism: Cancer Cell www.cell.com/cancer-cell/... great work from Amaya Viros @cruk-mi.bsky.social

submitted 4 days ago • 0 comments

www.nature.com/articles/s42... congrats @jasonrcantor.bsky.social &team

submitted 5 days ago • 1 comment

"Do your own research" to decide about therapies is like asking to someone to learn to fly to get into a plane. It complete erodes the trust in each other and the essence of society.

submitted 6 days ago • 0 comments

NAD depletion in skeletal muscle does not compromise muscle function or accelerate aging: Cell Metabolism www.cell.com/cell-metabol...

submitted 7 days ago • 1 comment

Current methods for profiling #HistoneModifications require cell isolation & don't work with all tissue types. @jellevda.bsky.social &co adapt Targeted DamID (TaDa) to profile cell-type-specific #histone marks throughout the genome, in vivo, without cell isolation 🧪 @plosbiology.org plos.io/3Dw8sUD

submitted 7 days ago • 0 comments

CSCI is now on Bluesky! We're happy to share our first post as a link to a poem from postdoc Kirsty Ferguson about working in the Institute, started at the Annual Retreat this year. See Kirsty's collaborative poem here: tinyurl.com/cscipoem

submitted 147 days ago • 2 comments

The do’s and don’ts of scientific image editing Acceptable image-editing practices are partly a matter of common sense. But researchers say journals and funders could help scientists by standardizing policies. @sarareardon.bsky.social reports www.nature.com/articles/d41...

submitted 7 days ago • 4 comments

We’re back at #AACR2025 More #CRUKfunded researchers presenting in Chicago today📣👇

submitted 8 days ago • 1 comment

What sort of nudging is this?

submitted 8 days ago • 3 comments

Very cool work from the @katajistolab.bsky.social ! Congratulations to the team!

submitted 8 days ago • 1 comment

Intracellular metabolic gradients dictate dependence on exogenous pyruvate www.nature.com/articles/s42... Congrats to @lydiafinley.bsky.social Lab!

submitted 8 days ago • 1 comment

tinyurl.com/mrce6bbb Fun to write this N&V together with Regina @hrshin.bsky.social, on the several cryoEM papers that build on her discovery of the fascinating LYCHOS protein and its role in cholesterol sensing and mTORC1 regulation!

submitted 9 days ago • 0 comments

A reviewer asked: but why is IRE1 activated when glucose is low? A committee member for Mabel Cruz's PhD asked: why is the UPR activated upon glucose deprivation? So we wrote a review about it. Here it is! @ericchevet.bsky.social @febsj.bsky.social febs.onlinelibrary.wiley.com/doi/10.1111/...

submitted 13 days ago • 2 comments

Stable isotope tracing in human plasma-like medium reveals metabolic and immune modulation of the glioblastoma microenvironment www.biorxiv.org/content/10.1...

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Selling indulgences played a significant role in medieval strategies for attaining eternal salvation. Now we pay millions for supposed drugs as strategies for eternity.

submitted 9 days ago • 0 comments

A belated weekly issue of papers in #cancermetabolism and #mitochondriabiology is ready for you! Check it out here: biomed.news/bims-camemi/... @biomednews.bsky.social "You have to do nothing to be who you are. Nothing at all." -H. W. L. Poonja

submitted 10 days ago • 0 comments

ATP - not only a fuel source! Intriguing work from Marco Terenzio and colleagues at the OIST www.science.org/doi/full/10....

submitted 11 days ago • 1 comment

What do cells undergoing #ferroptosis #celldeath release? Read all about it in our atlas on ferroptosis #secretomes out now in Cell Death and Differentiation #CDDpress Great collaboration with @cecad.bsky.social @frezzalab.bsky.social @kreuzaler.bsky.social @almutschulze.bsky.social rdcu.be/ejp9C

submitted 11 days ago • 3 comments

💥Exciting #Postdoc opportunity in my lab at @cruk-mi.bsky.social to study the role of #RNADynamics in cancer progression! ⏰Deadline: 07/05/25 Apply 👇 www.cruk.manchester.ac.uk/career/mi-24... ⏩ Please share this with your network. #CancerResearch #RNADynamics #RNAmodification #CRUK #postdoc

submitted 26 days ago • 0 comments

Short read! Read the News and Views article showcasing MAVS as a sensor of fumarate during antiviral immunity #MicroSky 🦠 www.nature.com/articles/s41...

submitted 12 days ago • 1 comment

Please repost: Deadline extended until May 1st - join us for discussing cutting-edge cardiometabolic basic and translational research! Outstanding speaker lineup, highly interactive program, ca. 35 short talks selected from abstracts, and the most beautiful venue at Lake Starnberg: eas-elc.org

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Tumor-derived erythropoietin acts as an immunosuppressive switch in cancer immunity | Science www.science.org/doi/10.1126/...

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Base-modified nucleotides mediate immune signaling in bacteria | Science www.science.org/doi/10.1126/...

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Circulating glycerate predicts resilience to fructose-induced hepatic steatosis: Cell Metabolism www.cell.com/cell-metabol...

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α-Ketoglutarate promotes trophectoderm induction and maturation from naive human embryonic stem cells www.nature.com/articles/s41...

submitted 13 days ago • 0 comments

Why do tumors tend to metastasize to lymph nodes? Super interesting insights into that question, published online in Cancer Discovery today. One of those papers that grabs you at the title.

submitted 14 days ago • 0 comments

www.nature.com/articles/s41...

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www.nature.com/articles/s41... Spatial mapping of transcriptomic plasticity in metastatic pancreatic cancer Congrats @anirbanmaitra.bsky.social!!

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Targeting PIKfyve-driven lipid metabolism in pancreatic cancer www.nature.com/articles/s41... Congrats to the @lyssiotislab.bsky.social and all the others involved

submitted 14 days ago • 1 comment

www.nature.com/articles/s41...

submitted 14 days ago • 0 comments