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genejockeycas9.bsky.social
Gene Editor, Sci-fi lover
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“Why phosphates? Their unique electrostatics give them the perfect balance—stable enough to safeguard DNA, RNA & ATP, yet reactive enough to be finely controlled. Westheimer (1987) and Warshel (2013) showed us nature’s clever design!” pubmed.ncbi.nlm.nih.gov/2434996/

submitted 119 days ago • 0 comments

North Carolina - Our log house covered in snow.

submitted 140 days ago • 0 comments

1st of many -> www.fiercepharma.com/pharma/verte...

submitted 540 days ago • 0 comments

Continuing to read CRISPR classics. This week I reread Nishimasu et al., (2015) Crystal Structure of Cas9 in Comple... It's a Cell paper and yes it's long. The paper unveils the 2.5Å structure of the Cas9-sgRNA-target DNA complex, illuminating Cas9's intricate targeting mechanism for DNA cleavage...

submitted 541 days ago • 1 comment

A winter visit from a Northern Cardinal. #birds 🦉

submitted 542 days ago • 0 comments

Jimi Olaghere has lived with sickle cell disease his whole life—experiencing chronic pain, organ damage, and hopelessness. As a patient enrolled in a clinical trial for Vertex’s new exa-cel treatment, he was among the first to experience CRISPR’s transformative effects. It changed his life.

submitted 545 days ago • 0 comments

🧬 Continuing to revisit CRISPR classics: Mali et al. (2013) RNA-guided human... In this CRISPR classic authors from George Church's lab engineered the type II bacterial CRISPR system for use in human cells, showcasing significant advancements in RNA-guided genome engineering. #GenomeEditing #Thread

submitted 552 days ago • 4 comments

🧬 Just re dove into the groundbreaking study: 'A Programmable Dual-RNA–Guided DNA... from the Doudna lab. It unveils how CRISPR-Cas9, guided by custom RNA sequences, can precisely edit DNA, revolutionizing gene editing! A leap in #GeneEditing. What’s your favorite part of this classic?

submitted 558 days ago • 0 comments