genomestability.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

🚀 New Paper Alert! Our latest @natrevmcb.bsky.social explores how nuclear and genome organization drive DNA double-strand break repair! 🧬 📖 Free access: rdcu.be/edViW Please 🔄 ❤️

submitted 7 days ago • 1 comment

Happy to share our new collaboration paper in Cell Reports. We show that translation synthesis in cancer cells occurs predominantly behind the replication fork, to fill ssDNA gaps, rather than to restart stalled replication forks “on the fly”. www.sciencedirect.com/science/arti...

submitted 26 days ago • 2 comments

𝐇𝐨𝐰 𝐝𝐨 𝐜𝐞𝐥𝐥𝐬 𝐫𝐞𝐦𝐞𝐦𝐛𝐞𝐫 𝐰𝐡𝐨 𝐭𝐡𝐞𝐲 𝐚𝐫𝐞 𝐚𝐟𝐭𝐞𝐫 𝐃𝐍𝐀 𝐫𝐞𝐩𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧? Our new study “Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability” is out in 𝘚𝘤𝘪𝘦𝘯𝘤𝘦 𝘈𝘥𝘷𝘢𝘯𝘤𝘦𝘴. Led by @lleonie.bsky.social @biranalva.bsky.social 🧵 More below👇

submitted 33 days ago • 5 comments

We are delighted to share our latest work, characterising the role of BRCA2 and its binding partner PALB2 at centromeres, just out in the latest issue of Cell Reports. ⬇️ www.cell.com/cell-reports...

submitted 27 days ago • 3 comments

Transcription termination sites, particularly at 5'-CCTTTTTT transcription-terminator-like sequences, are hotspots for DNA damage, independent of R-loops or replication conflicts. This represents a fourth mechanism of transcription-associated genomic instability. www.nature.com/articles/s41...

submitted 29 days ago • 1 comment

Apply Now for the 2025 Samuel H. Wilson Award for Studies on DNA Repair - emgs-us.org/general/cust... @emgsus.bsky.social @weldeiry.bsky.social @ianywonglab.bsky.social

submitted 39 days ago • 1 comment

Beautiful work showing how DSBs trigger de novo cohesin loops, positioned perfectly at break sites. RAD51 spreads ~Mb within TAD limits & loop extrusion actively drives homology search - distant HR repair drops when you kill cohesin loading by NIPBL! #DNArepair www.biorxiv.org/content/10.1...

submitted 36 days ago • 0 comments

New #preprint from the lab! Do you want to see the invisible? So did we! When DNA genomes get broken, cells somehow find related sequences to fix the break. But how do they find it? We developed a way to look at sequence search, not just sequence usage. doi.org/10.1101/2025...

submitted 41 days ago • 2 comments

Excited to present Social DNAing tomorrow. I’ll talk about our work led by @szmyd-radoslaw.bsky.social in collaboration with @radoncdocgee.bsky.social. 12 pm Eastern USA Thanks Shan Zha for the invite. www.cancer.columbia.edu/research/pro...

submitted 47 days ago • 0 comments

Check out our lab’s latest work on the regulation of transcription by RECQL5 helicase! This work was co-led by @alfredo0712.bsky.social and @nlue8.bsky.social, with contributions from Patricia Grob, Ben Kaeser, Jie Fang, and Susanne Kassube. 1/7 www.biorxiv.org/content/10.1...

submitted 53 days ago • 1 comment

@science.org Genome recombination on demand | Science www.science.org/doi/10.1126/... a Perspective by @seczmarta.bsky.social Lars Steinmetz @stanford.edu on two studies bit.ly/4hzFRMg + bit.ly/4jyT4Hf that generate large genome rearrangements in mammalian cells @ unprecedented scale #synbio #genome

submitted 51 days ago • 1 comment

Join us on Tuesday, February 4th from 5-6 PM Rome Time for a lively discussion on genome integrity maintenance with great speakers Lumír Krejčí and Giulia Bastianello. Link: uniroma1.zoom.us/j/95149984403

submitted 54 days ago • 0 comments

Registration now open for the 2025 EMBO workshop on Meiosis! June 22-26, 2025, Engelberg, Switzerland. Deadline for abstract submissions and registration is Feb 15th, 2025. Lots of speaker slots will be selected from abstracts, so apply now! meetings.embo.org/event/25-mei...

submitted 105 days ago • 0 comments

Adaptive replication origin activation alters chromatin dynamics and stability in cancer cells https://www.biorxiv.org/content/10.1101/2024.12.03.626323v1

submitted 109 days ago • 0 comments

Announcing the NAR Cancer virtual 5th anniversary symposium: "Manipulating DNA repair and the DNA damage response to improve cancer therapy." First webinar Jan 9. In cooperation with Social DNAing at Columbia University. Read the program and register for free! academic.oup.com/narcancer/pa...

submitted 109 days ago • 0 comments

Online today @science.org 👀Molecular basis of FIGNL1 in dissociating RAD51 from #DNA and #chromatin by @alexcarver.bsky.social @layates.bsky.social et al. in @imperialcollegeldn.bsky.social @mskcancercenter.bsky.social www.science.org/doi/10.1126/...

submitted 109 days ago • 0 comments

"The oestrous cycle stage affects mammary tumour sensitivity to chemotherapy" 🧪 www.nature.com/articles/s41...

submitted 110 days ago • 0 comments

Excited to see the final published form of this amazing @drewberry.bsky.social‬ animation of DNA repair go live! Watch your favourite friends BRCA1/2, RPA, RAD51, Exo1, BLM, PCNA, MRN, primase and DNA polymerase perform their recombination magic. Cool educational & scientific tool for our community.

submitted 111 days ago • 2 comments

DNA nicks in either the leading or lagging strand templates can trigger break-induced replication (although nicks are introduced with Cas9n, Flp or gp2 that also create an R-loop or covalent protein barrier). In yeast. www.cell.com/molecular-ce...

submitted 111 days ago • 0 comments

I love that there is a FANCL sunscreen. I wonder if it also protects against aldehyde damage? #DNArepair www.allbestbeauty.com.au/products/fan...

submitted 112 days ago • 3 comments

Our article "MCM double hexamer loading visualized with human proteins" published in Nature today! ❄️🔬🧬🎉🥳 Great collaboration with John Diffley's lab. Congratulations to Florian Weissmann, Julia Greiwe and all other authors! rdcu.be/d1F7m

submitted 117 days ago • 10 comments

The dark side of fluorescent protein tagging: the impact of protein tags on biomolecular condensation www.biorxiv.org/content/10.1...

submitted 120 days ago • 10 comments

Hey everyone! Lorne Protein Meeting here with our first post on BlueSky! Remember to check our website lorneproteins.org and that the 2025 Meeting marks the 50th Anniversary of this premier International protein meeting!

submitted 120 days ago • 0 comments

Sign of the times, no more bluebird on the biorxiv engagement tab..

submitted 121 days ago • 6 comments

From @seedgeorge.bsky.social Johann De Bono and colleagues (us !). In BRCA2m CRPC, reversion mutations emerge in 79% by end of olaparib treatment. Reversions associate with PFS and OS. Rare subclones without BRCA2-loss also emerge authors.elsevier.com/sd/article/S...

submitted 123 days ago • 1 comment

I'm honoured to speak at the upcoming Genome Instability & Cancer Conference, celebrating the legacy of Angelos Constantinou. His pioneering work transformed our understanding of DNA repair. Register now to join us near his home town in France in March! www.tribute2angelos.fr/page/home/

submitted 125 days ago • 0 comments

Hi DNA/RNA folks! With @granzhan.bsky.social @sebastien-britton.bsky.social @glowsticks.bsky.social and others we are launching an International Research Network (IRN) on nucleic acid junctions #3WJ - Thanks @cnrs.bsky.social Chimie! 1st meeting next year (May 25) in Paris Contact me if interested

submitted 131 days ago • 4 comments

Just in time for the great migration from the other place, our latest: in which the DNA helicase Srs2 / PARI, known as an anti-recombinase during S-phase, is also required to coordinate cytokinesis with chromosome segregation. Mini-thread below! www.biorxiv.org/content/10.1...

submitted 131 days ago • 2 comments

Hi BlueSky! It's great to be here. Here's a handy Starter Pack of DNA repair & genome stability groups that I found so far go.bsky.app/NvFWKvL

submitted 132 days ago • 11 comments

Since there are new followers and a new platform: here is a new study from the group showcasing how mediators promote Rad51 nucleation, not growth, on RPA-coated DNA during homologous Recombination. www.biorxiv.org/content/10.1...

submitted 132 days ago • 0 comments

The peer-reviewed version of our paper is out! Thanks to all co-authors, editor and reviewers for the smooth process 🤓🎉 And don’t miss the chromatin haiku! www.cell.com/molecular-ce...

submitted 132 days ago • 5 comments

New updates to the upcoming DNA repair/Genome Stability conferences over 2024/2025. Please let me know if you have meetings to add: docs.google.com/spreadsheets...

submitted 133 days ago • 2 comments

First post here! New paper from the lab! Profound synthetic lethality between FANCM and SMARCAL1: www.cell.com/molecular-ce...

submitted 135 days ago • 3 comments

🧬🔬 Our paper on FANCM's DNA binding mechanism is out in the final finished form in Nucleic Acids Research. FANCM is crucial for DNA repair and cancer cell survival in ALT. academic.oup.com/nar/article/...

submitted 133 days ago • 0 comments

Cool role for replication timing and ATR in aging: "IF aging is due to replication stress induced by cryptic DNA damage, it may explain the conundrum why slowly proliferating tissues, eg liver, age faster than highly proliferating tissues eg intestine."...

submitted 183 days ago • 1 comment

Huge advance in making transplantable hematopoetic stem cells in vitro from iPSC – with efficiencies similar to umbilical cord blood transplantation. I love that Aussies are leaders in this technology, that could revolutionise bone marrow transplantation....

submitted 203 days ago • 1 comment