genomestability.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

Really cool new cryoEM structure of RAD51 caught in the act of recombination initiation at a D-loop. elifesciences.org/reviewed-pre...

submitted 4 days ago • 0 comments

💥🛟Wow cyclic peptides are cool! So excited to share a new publication on "Potent Cyclic Peptide Inhibitors Disrupt the FANCM–RMI Interaction". Work led by @yuhenglau.bsky.social to which we contributed structures and ideas. The top hits mimic native MM2...but in reverse! pubs.acs.org/doi/10.1021/...

submitted 9 days ago • 0 comments

BRCA2 C-terminal clamp restructures RAD51 dimers to bind B-DNA for replication fork stability: Molecular Cell www.cell.com/molecular-ce...

submitted 14 days ago • 0 comments

Andrew Deans @genomestability.bsky.social and collaborators show that #FANCM helicase has evolved from an ancient repair motor into a specialized sensor coupling DNA-damage recognition to Fanconi Anemia pathway activation www.embopress.org/doi/full/10....

submitted 18 days ago • 0 comments

🧬 New from crystal structures from our lab in EMBO Journal! We reveal how the FANCM enzyme, an emerging therapeutic target it cancer, has evolved to specifically recognise branched DNA and activate the Fanconi anaemia pathway of DNA repair. doi.org/10.1038/s443... 🧵👇

submitted 18 days ago • 2 comments

CST complex blocks end resection by BLM-DNA2 or EXO1, therefore promoting non-homologous endjoining and inhibiting repair templated DNA repair. www.science.org/doi/10.1126/...

submitted 25 days ago • 0 comments

Due to great enthusiasm, we are extending the early bird registration deadline, at a reduced rate, until 25 May. After this date, the rate will increase by 1500NOK (approx. 135USD). We look forward to seeing you in Trondheim! www.endodnadamage.com

submitted 53 days ago • 0 comments

NHMRC has decided to replace the standard scale of 1-7 with something a bit more nuanced for the next round of Investigator grants. Score descriptors to be released soon.

submitted 32 days ago • 2 comments

I'm super excited to announce that registrations are now open for the 19th Australian Cell Cycle, DNA Repair and Telomere Workshop. Awesome international speaker line-up, with plenty of locals being invited! Book now to secure your earlybird rate. www.australiancellcycle.org

submitted 36 days ago • 1 comment

Some seriously nice biochemistry and cryo-EM of FAN1-PCNA-flapDNA complexes! www.nature.com/articles/s41...

submitted 36 days ago • 0 comments

Excited to share our latest from my postdoc at @mskcancercenter.bsky.social in the Sfeir Lab, in collaboration with the Simon Powell Lab! We uncovered a novel genome repair mechanism in human cells: RNA-templated DNA double-strand break repair (RT-DSBR). (1/5)

submitted 39 days ago • 3 comments

What governs where DNA replication begins in human cells? Here, we show that origins of replication in human DNA are epigenetically specified and that crucially, this epigenetic mark is required for both DNA replication and cell proliferation! @narjournal.bsky.social academic.oup.com/nar/article/...

submitted 44 days ago • 2 comments

Excited to see this out in @science.org today!! www.science.org/doi/10.1126/...

submitted 50 days ago • 6 comments

🚨 new preprint from the lab. Combining modeling, new Hi-C data in yeast and data analysis, our study offers new insights into the spatial and dynamic organization of chromatin during replication in eukaryotes. Check the tweetorial below ⬇️ www.biorxiv.org/content/10.1...

submitted 52 days ago • 1 comment

🧬 New research discovers sequential phosphorylation of MRE11 by ATM and ATR prevents extensive DNA degradation at stalled replication forks www.pnas.org/doi/abs/10.1...

submitted 52 days ago • 1 comment

FANCX=FAAP100, new Fanconi Anemia gene Two new papers identify 3 families with FAAP100 homozygous mutations leading to severe developmental and hematologic abnormalities leading to death in utero or in early life. www.jci.org/articles/vie... www.jci.org/articles/vie...

submitted 56 days ago • 0 comments

Super cool new preprint: FANCD2:FANCI is a sensor of open chromatin, independent of DNA damage, but further increased at double strand breaks. www.biorxiv.org/content/10.1...

submitted 57 days ago • 0 comments

Today, we report that APOBEC3B targets unprotected single-stranded DNA at replication forks upon ATR inhibition, triggering a reaction cascade involving UNG2 and APE1 that leads to fork collapse and hyperactivation of PARP1, causing replication catastrophe. www.science.org/doi/10.1126/...

submitted 64 days ago • 1 comment

So excited to share our new paper out today in @nature.com. We repurposed R2 retrotransposons to create STITCHR, a tool that can make virtually any kind of edit in mammalian genomes including the scarless multi-kilobase scale insertions 🧵 www.nature.com/articles/s41...

submitted 72 days ago • 3 comments

Join us at the unique conference in the field on DNA and RNA - the 8th EU-US Conference on Endogenous Damage and Repair in Norway, Trondheim, 5th-8th October! www.endodnadamage.com Secure your spot, only 26 days til the early-bird deadline! Several spaces for oral presentations available. Pls share

submitted 77 days ago • 0 comments

I ❤️ this new paper on RAD52 at replication forks, just published @nature.com. Cryo-EM reveals a unique double-ring structure that blocks reversal of replication forks. www.nature.com/articles/s41...

submitted 77 days ago • 1 comment

Striking new study from @archaeon-alex.bsky.social's lab just out in @science.org on multicellular development induced by compression in Archaea: www.science.org/doi/10.1126/...

submitted 77 days ago • 6 comments

I heard that some scientists have secret stashes of DE81 paper, since it is no longer made by GE for DNA binding experiments. Well, your days of hoarding are over! You can now buy DE81 (and P81) from a new Australian manufacturer for a very reasonable price! www.svi.edu.au/research/pla...

submitted 78 days ago • 1 comment

Check out our review on DNA end resection! With Raphael Ceccaldi, www.nature.com/articles/s41...

submitted 87 days ago • 2 comments

🚀 New Paper Alert! Our latest @natrevmcb.bsky.social explores how nuclear and genome organization drive DNA double-strand break repair! 🧬 📖 Free access: rdcu.be/edViW Please 🔄 ❤️

submitted 94 days ago • 1 comment

Happy to share our new collaboration paper in Cell Reports. We show that translation synthesis in cancer cells occurs predominantly behind the replication fork, to fill ssDNA gaps, rather than to restart stalled replication forks “on the fly”. www.sciencedirect.com/science/arti...

submitted 113 days ago • 2 comments

𝐇𝐨𝐰 𝐝𝐨 𝐜𝐞𝐥𝐥𝐬 𝐫𝐞𝐦𝐞𝐦𝐛𝐞𝐫 𝐰𝐡𝐨 𝐭𝐡𝐞𝐲 𝐚𝐫𝐞 𝐚𝐟𝐭𝐞𝐫 𝐃𝐍𝐀 𝐫𝐞𝐩𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧? Our new study “Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability” is out in 𝘚𝘤𝘪𝘦𝘯𝘤𝘦 𝘈𝘥𝘷𝘢𝘯𝘤𝘦𝘴. Led by @lleonie.bsky.social @biranalva.bsky.social 🧵 More below👇

submitted 120 days ago • 5 comments

We are delighted to share our latest work, characterising the role of BRCA2 and its binding partner PALB2 at centromeres, just out in the latest issue of Cell Reports. ⬇️ www.cell.com/cell-reports...

submitted 115 days ago • 3 comments

Transcription termination sites, particularly at 5'-CCTTTTTT transcription-terminator-like sequences, are hotspots for DNA damage, independent of R-loops or replication conflicts. This represents a fourth mechanism of transcription-associated genomic instability. www.nature.com/articles/s41...

submitted 116 days ago • 1 comment

Apply Now for the 2025 Samuel H. Wilson Award for Studies on DNA Repair - emgs-us.org/general/cust... @emgsus.bsky.social @weldeiry.bsky.social @ianywonglab.bsky.social

submitted 126 days ago • 1 comment

Beautiful work showing how DSBs trigger de novo cohesin loops, positioned perfectly at break sites. RAD51 spreads ~Mb within TAD limits & loop extrusion actively drives homology search - distant HR repair drops when you kill cohesin loading by NIPBL! #DNArepair www.biorxiv.org/content/10.1...

submitted 123 days ago • 0 comments

New #preprint from the lab! Do you want to see the invisible? So did we! When DNA genomes get broken, cells somehow find related sequences to fix the break. But how do they find it? We developed a way to look at sequence search, not just sequence usage. doi.org/10.1101/2025...

submitted 128 days ago • 2 comments

Excited to present Social DNAing tomorrow. I’ll talk about our work led by @szmyd-radoslaw.bsky.social in collaboration with @radoncdocgee.bsky.social. 12 pm Eastern USA Thanks Shan Zha for the invite. www.cancer.columbia.edu/research/pro...

submitted 134 days ago • 0 comments

Check out our lab’s latest work on the regulation of transcription by RECQL5 helicase! This work was co-led by @alfredo0712.bsky.social and @nlue8.bsky.social, with contributions from Patricia Grob, Ben Kaeser, Jie Fang, and Susanne Kassube. 1/7 www.biorxiv.org/content/10.1...

submitted 140 days ago • 1 comment

@science.org Genome recombination on demand | Science www.science.org/doi/10.1126/... a Perspective by @seczmarta.bsky.social Lars Steinmetz @stanford.edu on two studies bit.ly/4hzFRMg + bit.ly/4jyT4Hf that generate large genome rearrangements in mammalian cells @ unprecedented scale #synbio #genome

submitted 138 days ago • 1 comment

Join us on Tuesday, February 4th from 5-6 PM Rome Time for a lively discussion on genome integrity maintenance with great speakers Lumír Krejčí and Giulia Bastianello. Link: uniroma1.zoom.us/j/95149984403

submitted 141 days ago • 0 comments