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Microbiota colonising the new born colon prime goblet cells producing the gut-protective mucus 📷 Åsa Johansson et al @gobletcellguy.bsky.social University of Gothenburg in @jem.org ➡️ bpod.org.uk/archive/2025...

submitted 22 days ago • 0 comments

Happy to see this finally published 🙌 Thanks to the editors and reviewers for the constructive process 😎

submitted 32 days ago • 1 comment

Abstract deadline for #GGIG2025 is approaching fast! Don’t miss your chance to share your research at the 5th Ghent Gut Inflammation Group Meeting! 🧬🦠 www.vibconferences.be/events/5th-g...

submitted 74 days ago • 0 comments

Which cells use Myd88 to control Segmented Filamentous Bacteria colonization? Here work explores the hematopoietic MyD88/IL-22 axis during SFB growth. www.mucosalimmunology.org/article/S193...

submitted 70 days ago • 1 comment

My colleague Sjoerd van der Post just quietly dropped a preprint defining the interaction of the #ETEC SPATE family enzyme EatA with intestinal Muc2, providing some fascinating insights into host specific #mucus degradation 🤯. Check it out: www.biorxiv.org/content/10.1...

submitted 77 days ago • 0 comments

Nice discussion around the ongoing #glycoRNA debate, check out the comments

submitted 78 days ago • 0 comments

In our lates review, we explore new insights into the gut-joint axis, a connection is not absolute. A causal role for the microbiota is context-dependent, and arthritis can also arise independently through sterile mechanisms: authors.elsevier.com/a/1kkn55Eb0R... #GutJointAxis

submitted 87 days ago • 0 comments

Say what now?!

submitted 100 days ago • 0 comments

So excited to share this latest work by @kelseyhuus.bsky.social !!! She shows that flagellin in the human gut affects whether or not people develop fever in response to vaccine, and the amount of flagellin reflects diet

submitted 101 days ago • 3 comments

glycowork v1.5 is now released! We're excited to see the cool things you'll be doing with it:-) Lots of new & improved functionality, check out the Release notes for the full change log:

submitted 108 days ago • 0 comments

Happy to announce that MEDI, our method to quantify dietary intake through metagenomics is out now. 🧬 🧪🧫🦠 www.nature.com/articles/s42... #metagenomics #microbiome #microbiomesky So what is MEDI? A combination of two things:

submitted 108 days ago • 1 comment

For all the #mucus fans out there who believe in our knight in slimy armour and want to join the starter pack 👇 contact @gobletcellguy.bsky.social #mucusmatters

submitted 109 days ago • 0 comments

1/ 🚨 New preprint alert! 🚨 We’re thrilled to share our latest work exploring microbiome & genomic #Bifidobacterium co-evolutionary & functional signatures across diverse animal hosts. This has been a long time coming, & huge credit to Magda for her incredible hard work as first author! 🐾✨👇

submitted 146 days ago • 1 comment

This was a fun study from Scott Hultgrens lab that we contributed to, led by Philippe Azimzadeh, looking at #UPEC interactions with colonic #mucus: www.science.org/doi/10.1126/...

submitted 109 days ago • 1 comment

New paper out today from the lab on Akkermansia muciniphila 🦠and how it breaks down host glycans! Very proud of my group, especially @cassiebakshani.bsky.social who did an amazing job. @naturemicrobiol.bsky.social www.nature.com/articles/s41...

submitted 126 days ago • 3 comments

#microsky

submitted 114 days ago • 0 comments

Discovery of a new Cu-dependent cellulose degrading enzyme for biomass conversion #glycotime (trying to overlook the extraneous proton, see if you can find it) www.nature.com/articles/s41...

submitted 113 days ago • 4 comments

Don’t miss #ASRI2025 in St. Paul Minnesota May 17-21. Check out fantastic talks on the Maternal, Fetal, and Neonatal Immunology and submit your abstract by 2/15! theasri.org/Abstracts-Po...

submitted 112 days ago • 0 comments

Still time to submit late breaking abstract to this fantastic meeting: www.perinatal-immunity.de/en/symposium...

submitted 115 days ago • 0 comments

The measles outbreak in Texas is reminding me of the public letter Roald Dahl wrote about losing his daughter to measles in 1962, just before the vaccine was publicly available.

submitted 111 days ago • 415 comments

Just in case any new #mucus, #Goblet cell or #mucin folks have joined up recently, we have a small but growing starter pack for this area - let me know if you want in 🫡 go.bsky.app/7Z84CmG

submitted 115 days ago • 1 comment

Yes

submitted 116 days ago • 0 comments

Now that we're into #GPCR biology, I get to include (what I'm sure is) a very original joke in my journal club presentation...

submitted 116 days ago • 0 comments

How do massive megaDalton-sized transmembrane mucins reach the plasma membrane in intestinal epithelial cells? 🧐 Using proximity labeling, proteomics, and CRISPR KO, we uncovered key roles for MYO1B, MYO5B, and SNX27 in mucin transport. portlandpress.com/biochemj/art... #mucins #glycotime

submitted 175 days ago • 0 comments

Biochemical characterization of 66 carbohydrate-active enzymes from the gut microorganism Akkermansia muciniphila reveals that these enzymes can break down a range of host glycans, including mucin, which they degrade to completion, according to a Nature Microbiology paper. 🧪

submitted 118 days ago • 0 comments

Its stories like this that makes me incredibly excited! A gut immune–epithelial circuit regulating tolerance to food: Goblet cell protein RELMβ disrupts tolerance by depleting microbiome-derived indoles needed for protective Tregs. #microbiome #immunity #ImmunoSky www.nature.com/articles/s41...

submitted 130 days ago • 0 comments

Dear mucosal immunologists! Registration for the European Mucosal Immunology Group (EMIG) meeting in Aachen, Germany is now open. Register and see you this July in Aachen! 👇🏼 emig2025.de @petterbrodin.bsky.social @wiag.bsky.social @mucosalimmunol.bsky.social @societymucosalimm.bsky.social

submitted 132 days ago • 0 comments

🎄 Santa came early this year!🎄 We’re unwrapping an exciting discovery from our lab that reveals the critical role of the transmembrane mucin MUC17 in protecting the small intestine against bacterial challenges. insight.jci.org/articles/vie... #mucins #glycotime #Crohns #gut

submitted 166 days ago • 8 comments

What are lumens and how do forces control tissue form and fate through lumen size? Join me, @dhirajindana.bsky.social, in this short thread to explore this question through some fascinating papers.

submitted 167 days ago • 2 comments

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

submitted 177 days ago • 24 comments

#Colorectal #Cancer #Starterpack. Patient Advocates, Scientists, Physicians, Institutes and Journals with a focus on Colorectal Cancer. Please comment/text to be added! go.bsky.app/PGqU6zP

submitted 181 days ago • 9 comments

#Medsky🧪 #oncosky The study found that aging suppresses tumorigenesis and stemness in 🫁 by promoting a functional iron insufficiency in the alveolar epithelium. via @TuomasTammela @xueqianzhang.bsky.social @naturecomms.bsky.social www.nature.com/articles/s41...

submitted 183 days ago • 2 comments