gruberlab.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

Still hard to believe but Béla Novák died suddenly on Saturday. We've lost a fantastic colleague, mentor & great friend to many. There was really no-one else like him. Working with him was so much fun & I owe him a lot. All my thoughts are with his family. www.merton.ox.ac.uk/news/remembe...

submitted 2 days ago • 8 comments

Roche's SBX sequencing by expansion - preprint out! www.biorxiv.org/content/10.1...

submitted 2 days ago • 2 comments

Excited to share our work on archaeal 3D genome! This paper revealed how an archaeal SMC complex sculpts TAD-like domains by cooperating with a roadblock NAP and physical properties of DNA. Many congrats to our talented PhD student Kodai! www.nature.com/articles/s41...

submitted 8 days ago • 1 comment

🔴⚠CNIO-CaixaResearch Frontiers Meetings: Machines acting on DNA and RNA, a molecular mechanistic perspective. 📆May 28-30th 👥 @oscarllorca.bsky.social, @rfleiro.bsky.social and @nogaleslab.bsky.social. 🔗https://www.cnio.es/eventos/machines-acting-on-dna-and-rna-a-molecular-mechanistic-perspective/

submitted 21 days ago • 0 comments

The plasmids described in our recent ‘4G-cloning’ paper for multi-subunit complex expression (www.life-science-alliance.org/content/8/1/...) are now available from @addgene.bsky.social (www.addgene.org/search/catal...). Thanks to Addgene for distribution in this convenient and affordable format!

submitted 34 days ago • 2 comments

Grateful for the opportunity to contribute a little to this great study! Step by step we are beginning to understand how these wonderful machines work....

submitted 40 days ago • 1 comment

New discovery from our #CDlab reported in Cell @cp-cell.bsky.social today: SMC motor proteins have a left-right ‘gearbox’ and can switch direction in DNA loop extrusion! www.sciencedirect.com/science/arti... 1/

submitted 41 days ago • 2 comments

Interested in the plasmidverse? Then, don't think twice and join the International Society for Plasmid Biology Virtual Seminars Series. 👇

submitted 42 days ago • 1 comment

We are still waiting for applications to join us as a group leader in the department of Chromosome Biology! Apply until the first of Feb.

submitted 52 days ago • 1 comment

Do you know who Douglas Prasher is? Many don't, even though he is the person who cloned the original #GFP gene in the late 1980s. In my short history of plant light #microscopy I also cover a bit of his story - & why he is relatively unknown today, despite the importance of his work. See this 🧵👇

submitted 282 days ago • 3 comments

Unicore identifies single-copy protein structures across genomes using Foldseek, bypassing slow structure predictions by utilizing 3Di predictions from ProstT5, enabling rapid phylogenetic inference at the tree-of-life scale. 1/n 📄 www.biorxiv.org/content/10.1... 💾 github.com/steineggerla...

submitted 65 days ago • 2 comments

Pervasive phosphorylation by phage T7 kinase disarms bacterial defenses https://www.biorxiv.org/content/10.1101/2024.12.20.629319v1

submitted 68 days ago • 0 comments

Topoisomerases aficionados, Save the date! The Topo Club is back! February 20th and 21st in ENS - PSL Paris. Registration is free and all are welcome, but for organizational reasons, registration on the website is compulsory. Please log on to indico.in2p3.fr/event/34994/....

submitted 68 days ago • 0 comments

🧪1/ 🚨New paper on ecDNAs from our lab! We reveal a strategy to engineer extrachromosomal DNA (ecDNA) amplifications in cells & mice. Let's dive in! Let’s dive in! 🧵👇 www.nature.com/articles/s41...

submitted 70 days ago • 12 comments

Happy to see this out before the end of the year. Fantastic work by Lily Wang with help from our wonderful technologists in the Discovery Platform Proteomics Core managed by Christos Spanos. Great publishing experience @embojournal.bsky.social www.embopress.org/doi/full/10....

submitted 71 days ago • 1 comment

Shareable link to @carlzimmer.bsky.social article in NYTimes on serious concerns over mirror bacteria, published in Science today. www.nytimes.com/2024/12/12/s...

submitted 76 days ago • 9 comments

The structure of Zorya is mind-blowing 🙀 www.nature.com/articles/s41...

submitted 77 days ago • 0 comments

www.biochemistry.org/events-and-t...

submitted 78 days ago • 0 comments

Registration now open for the EMBO Workshop: Immune System of Bacteria !!!! www.sisb2025.conferences-pasteur.org/home Joins us in Institut Pasteur, Paris, April 8-10th.

submitted 79 days ago • 1 comment

Institut Pasteur 2025 call for group leader ! A fantastic place to do science in a great city. Have a look, repost and don't hesitate to reach out for more info...

submitted 80 days ago • 0 comments

We are opening a call for applications 2025 – Creation of new junior research groups at the Institut Pasteur in Paris @pasteur.fr all details on our web site : research.pasteur.fr/en/call/call...

submitted 80 days ago • 1 comment

Awesome poster!

submitted 85 days ago • 1 comment

“Don’t feed the trolls” also extends to bad opinion pieces in papers of record. They run them bc people react to them the most. If we stop linking to bad columns and instead post thinkers we find valuable (& generate convo around it), incentives change. It’s not easy and takes constant practice!

submitted 86 days ago • 2303 comments

Congrats @bislightyear.bsky.social, Amar, Kevin, Eugene and co!

submitted 86 days ago • 1 comment

Latest #CDlab paper in Nucleic Acid Research: academic.oup.com/nar/article/... Great work by Alejandro Martin-Gonzalez, @tismaa.bsky.social ea collaboring with @gruberlab.bsky.social, showing the interplay of DNA supercoiling & ParB condensation, 2 processes that set bacterial genome organization.

submitted 91 days ago • 0 comments

Out today in Nucleic Acids Research! My final publication from @ceesdekker.bsky.social lab together with A.M. Gonzalez ! Together with @gruberlab.bsky.social in Lausanne, we show the interaction between supercoiled DNA and partitioning protein ParB. Read full: doi.org/10.1093/nar/...

submitted 91 days ago • 0 comments

Exciting times! Our latest preprint is now live 🤩! After nearly 16 yrs of running my lab, I truly believe this is one of the most significant contributions we've made. It offers fresh hypotheses about how pandemic Vibrio cholerae spreads globally. Let’s dive in!🧵..1/n www.biorxiv.org/content/10.1...

submitted 93 days ago • 4 comments

PubPeer has received the 2024 Einstein Foundation Award. This recognition celebrates the contributions of our community to scientific discourse. award.einsteinfoundation.de/award-winner... This award provides a financial boost that we’re reinvesting back into the platform and its users. See below:

submitted 94 days ago • 1 comment

Sign of the times, no more bluebird on the biorxiv engagement tab..

submitted 95 days ago • 6 comments

"Many human behaviors seem maladaptive. e.g. some of us have devoted more energy to writing scientific papers than raising a fitness-optimizing number of children." 🤣 www.pnas.org/doi/10.1073/...

submitted 97 days ago • 0 comments

We strongly suggest that academic publishers and other platforms that host research rapidly implement a Share to Bluesky button for their articles. Here's how: docs.bsky.app/docs/advance... #AcademicSky #HigherEd #Altmetrics

submitted 100 days ago • 176 comments

If you work on bacterial immune systems, this founding paper by Burroughs and Aravind is a must-read (and must-cite). pubmed.ncbi.nlm.nih.gov/32868406/

submitted 101 days ago • 0 comments

The Institute for Integrative Biology of the Cell (I2BC) is seeking to recruit new group leaders in cell biology. The application deadline is February 28, 2025 www.i2bc.paris-saclay.fr

submitted 104 days ago • 2 comments

1/AlphaFold 3 code now available, following researcher criticism for not providing it with the initial publication. www.nature.com/articles/d41...

submitted 107 days ago • 2 comments

Last week @ScienceMagazine Continuous evolution of user-defined genes at 1 million times the genomic mutation rate @chang_c_liu @rix_gordon www.science.org/doi/10.1126/...

submitted 107 days ago • 0 comments

We discovered the first alternative genetic code in Archaea! www.biorxiv.org/content/10.1...

submitted 110 days ago • 7 comments

Is it cool if I post videos here?

submitted 109 days ago • 163 comments

Join us in Paris on April 8th-10th for the 2025 Symposium on the Immune System of Bacteria 🥖🍷🦠🧬. Excited to welcome these amazing speakers at Institut Pasteur. Registration will open beginning of November. Abstract deadline February 28. Stay tuned. Co-organized by @soreklab.bsky.social P. Kranzusch

submitted 128 days ago • 0 comments

We are hiring again! Staff scientist expert in cryo-EM recruiting.epfl.ch/Vacancies/32...

submitted 355 days ago • 0 comments

Now online at Cell Host & Microbe! From CRISPRi-seq to a new potent pneumococcal vaccine. Great collaboration with the lab of Jean-Claude Sirard, @gruberlab.bsky.social Victor Nizet. Congrats to Xue and Laurye for their amazing work! authors.elsevier.com/a/1ig8V6t8JE...

submitted 365 days ago • 0 comments

Our new work on the Wadjet (JET) anti-plasmid defence system is out: authors.elsevier.com/a/1iXM53vVUP... Showing structures of SMC complexes on extruded DNA (first time?) and blockage (!) of DNA extrusion by obstacles on DNA and more...

submitted 390 days ago • 0 comments

Congratulations to Julien for his BactExtract paper published and successfully defending his PhD! Many thanks to @pinholab.bsky.social and @gruberlab.bsky.social for the expert discussions! www.microbiologyresearch.org/content/jour...

submitted 396 days ago • 0 comments

A new study by the Chin lab online today in Science for the 1st time brings orthogonal replication to E coli enabling rapid continuous biomolecular evolution in this workhorse organism for molecular biology and protein engineering. Paper: bit.ly/adk1281 Perspective by Williams + Liu: bit.ly/adn3434

submitted 398 days ago • 0 comments