hutchbasicsci.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

@science.org RNA polymerase II at histone genes predicts outcome in human cancer 🧬💊 @fredhutch.bsky.social @hhmi.bsky.social www.science.org/doi/10.1126/...

submitted 10 days ago • 4 comments

Next, our 2nd preprint of the week (!), this one driven by @madelouhart.bsky.social Previously: Mitochondrial inhibition impairs cell proliferation by constraining aspartate (ASP) availability. Here: we investigate the kinetics of ASP depletion/ proliferation impairments and...surprises ensue!

submitted 6 days ago • 3 comments

Excited to share a recent preprint by Oliver Newsom, where we evaluate the functional contributions of serum for cancer cell proliferation. Inside: A broadly applicable serum-free media, Quantitative lipid uptake characterization, Evidence lipid scavenging > synthesis for cancer cell proliferation.

submitted 7 days ago • 4 comments

Join us for Siegen McKellar’s defense! Title: Exploring Regulators of Tumor-immune Interactions: Chorionic Gonadotropin Beta and Major Vault Protein Lab: Bradley Lab, FH When: Tues, Feb 25, 1pm PST Where: FH O'Mack Symposium Suite, Steam Plant Building & Zoom (email [email protected] for link)

submitted 13 days ago • 0 comments

We’re excited to have Yu-Chien Chuan from the Smith Lab and Jenny Waters from Human Biology’s Hsieh Lab sharing their latest discoveries at Friday Afternoon Seminars. For everyone @fredhutch.bsky.social, join us today at 4pm for two fantastic talks!

submitted 5 days ago • 0 comments

Thank you, @repdelbene.bsky.social, for your support of NIH funding in Congress! We were grateful to have you at Fred Hutch to tour our research facilities and discuss how vital federal biomedical research funding is in turning lab discoveries into life-saving cures.

submitted 7 days ago • 0 comments

"Imaging second messenger signaling in vivo: novel tools and their applications" We’re excited to have Dr. Haining Zhong joining us from @ohsunews.bsky.social to speak at today’s Current Biology Seminar! For all our @FredHutch.bsky.social colleagues, don’t miss a great talk today at 12 in Pelton!

submitted 8 days ago • 0 comments

Huge congratulations @jbloomlab.bsky.social!

submitted 11 days ago • 0 comments

Need a last-minute Valentine’s Day card for the science geek in your life? Don't worry! We’ve got you covered!

submitted 13 days ago • 0 comments

Researchers at Fred Hutch have discovered an overlooked mechanism driving aggressive breast and brain tumors involving genes so ancient — more than 2 billion years old — that they fly under the radar of standard genetic sequencing methods. 1/9 www.science.org/doi/10.1126/...

submitted 13 days ago • 1 comment

We have two fantastic talks lined up for Friday Afternoon Seminars! For all our @fredhutch.bsky.social colleagues, join us at 4:00 in Pelton to hear about the latest discoveries from Mengqiu Jiang in the @suebiggins.bsky.social Lab and Yuji Kumagai in Human Biology’s Cheung Lab.

submitted 19 days ago • 0 comments

Grant King, a postdoc in the lab of @harmitmalik.bsky.social, has been named a Hanna H. Gray Fellow by @hhmi.bsky.social — investing up to $1.5 million for up to eight years to help King achieve his goal of running his own lab. Read more: bit.ly/4hlRWFo @hutchbasicsci.bsky.social

submitted 23 days ago • 0 comments

"Safeguarding Human Chromosome Ends: Homologs RPA and CST’s Distinct Roles in Telomere Maintenance" We’re excited to have Dr. @cijilim.bsky.social speaking at today’s Current Biology Seminar! For all our @fredhutch.bsky.social colleagues, don’t miss a great talk today at noon in Pelton!

submitted 22 days ago • 0 comments

In a new study led by Caelan Radford, we use deep mutational scanning to systematically compare the escape mutations from two broadly neutralizing antibodies in a clade A versus clade B HIV Envelope. www.biorxiv.org/content/10.1...

submitted 26 days ago • 2 comments

Congrats to @memerman.bsky.social for winning the @fredhutch.bsky.social faculty conclave award for education, training, and mentorship. I cannot think of someone more deserving for three decades of transforming lives of trainees (and naive junior colleagues)!

submitted 27 days ago • 6 comments

Our progress over the past 50 years progress only makes me more excited for what’s yet to come. We’ve launched the Campaign for Fred Hutch to seize that opportunity and to radically increase the pace and scale of innovation for the families and communities that are counting on us.

submitted 33 days ago • 0 comments

"New tools for studying mRNA methylation" We’re excited to have Dr. Kate Meyer joining us from @dukemedschool.bsky.social to speak at today’s Current Biology Seminar! For all our @fredhutch.bsky.social colleagues, don’t miss a fantastic talk today at noon in Pelton!

submitted 29 days ago • 0 comments

We’re excited to have Thamiya Vasanthakumar from the @melodygcampbell.bsky.social Lab and Laurel Kelnhofer-Millevolte from Human Biology’s Avgousti Lab sharing their latest discoveries at Friday Afternoon Seminars. For everyone @fredhutch.bsky.social, join us today at 4:00 for two fantastic talks!

submitted 33 days ago • 0 comments

Check out a fantastic @elife.bsky.social article highlighting @yarimura.bsky.social’s MagIC #cryoEM technique - a method using specialized magnetic beads that makes it possible to study the structure of proteins from dilute samples. elifesciences.org/articles/105...

submitted 33 days ago • 0 comments

In a new study published in Frontiers in Physiology, the Roth Lab in @hutchbasicsci.bsky.social showed that microscopic worms can survive extreme cold & low oxygen by triggering a survival mechanism. This could offer insights into how humans might endure similar conditions. bit.ly/4gZu5Lo

submitted 35 days ago • 0 comments

"Understanding Nonsense: how animals degrade mRNAs with an early stop codon" We’re excited to have Dr. Joshua Arribere joining us from @ucsantacruz.bsky.social to speak at today’s Current Biology Seminar! For all our @fredhutch.bsky.social colleagues, don’t miss a great talk today at 12 in Pelton!

submitted 36 days ago • 0 comments

In new study, we find dramatic differences in specificities of serum neutralizing antibodies in infants w single infection by a recent SARS-CoV-2 strain versus adults/children imprinted by an early viral strain. www.biorxiv.org/content/10.1...

submitted 36 days ago • 12 comments

Our latest work using TIRFM to uncover mechanisms that stabilize the centromeric nucleosome: www.embopress.org/doi/full/10....

submitted 43 days ago • 0 comments

The essential N-terminal domain (END) of yeast CENP-A homolog Cse4 stabilizes its localization at #centromeres via binding to #kinetochore proteins Okp1 and Ame1 @suebiggins.bsky.social sky.social and collaborators @hutchbasicsci.bsky.social @fredhutch.bsky.social www.embopress.org/doi/full/10....

submitted 43 days ago • 0 comments

“Synapse development and function in health and disease: insights from C. elegans” @pkurshan.bsky.social is joining us from @einsteinmededu.bsky.social to speak at today’s Current Biology Seminar and we couldn’t be more excited! For all @fredhutch.bsky.social colleagues, don’t miss a great talk!

submitted 43 days ago • 0 comments

50 years of Fred Hutch! Founded in 1975 to honor a brother, Fred Hutch Cancer Center pursued bold science, pioneered a cure for blood diseases that changed medicine and became a world-class biomedical research and clinical care institution. bit.ly/3DJq7aX #FH50

submitted 44 days ago • 1 comment

🎉 Congrats to @fredhutch.bsky.social on 50 yrs of groundbreaking biomedical #research and #clinical care! Dr. William Hutchinson’s vision led to two lasting legacies of innovation: Fred Hutch & PNRI. Here's to 50 years of impact & the discoveries ahead! Read about this milestone at: bit.ly/4jcR7zS

submitted 48 days ago • 0 comments

The best part of the week is almost here: Friday Afternoon Seminars! Can’t wait to learn about the latest research from Allie Cheney in the Talbot Lab and Darien Reed-Perino in Human Biology’s Paddison Lab. For all our @fredhutch.bsky.social colleagues, join us in Pelton at 4PM for two great talks!

submitted 47 days ago • 0 comments

Adam Nguyen, a graduate student at Fred Hutch, recently received an NIH training award to study the structure of a complex molecule called Tie2 that aids and abets cancer’s escape from blood vessels when it malfunctions. bit.ly/49ZvGhL

submitted 54 days ago • 0 comments

“New tools for multimodal precision measurement of single cells and single molecules” We’re excited to have Dr. Aaron Streets joining us from @ucberkeleyofficial.bsky.social to speak at today’s Current Biology Seminar! For all our @fredhutch.bsky.social colleagues, don’t miss a great talk at noon!

submitted 50 days ago • 0 comments

In this episode, I interviewed Dr. Harmit Malik (@harmitmalik.bsky.social), Professor and Associate Director of the Basic Sciences Division at the Fred Hutch Cancer Center (@fredhutch.bsky.social / @hutchbasicsci.bsky.social)

submitted 51 days ago • 1 comment

We have two great talks lined up for the first Friday Afternoon Seminars of 2025! For all our @fredhutch.bsky.social colleagues, join us at 4:00 in Pelton to hear about the latest discoveries from @htoure.bsky.social in the Koch Lab and Claire Mills in Human Biology’s Beronja Lab.

submitted 54 days ago • 0 comments

Get all the highlights from the Basic Sciences Division in our 2024 annual report! Hear from division director @SueBiggins.bsky.social, see event highlights, get updates from each of our labs, and so much more: https://buff.ly/4foiYKq

submitted 69 days ago • 0 comments

Great news! 4 postdocs in Basic Sciences @FredHutch.bsky.social will receive WRF fellowships. Congrats Allie Cheney in the Talbot Lab, @davemai.bsky.social in the @sanjaysrivatsan.bsky.social Lab, Sara Sunshine in the @jbloomlab.bsky.social, and Alina Lorant in the Koch Lab!

submitted 69 days ago • 0 comments

We need more programs like this one to bring fresh perspectives into the biological sciences. As highlighted in the fellowship link, our lab is excited to co-advise fellows eager to tackle the world’s biggest challenges using cutting-edge tools. Feel free to DM me if you’d like to talk!

submitted 70 days ago • 0 comments

In new study, we measure how all mutations to rabies G affect cell entry & antibody neutralization Sheds light on constraints on type III fusion proteins, suggests ways to stabilize G vaccine antigens, and quantifies antibody robustness to rabies variation www.biorxiv.org/content/10.1...

submitted 70 days ago • 3 comments

Could a tiny molecular soccer ball deliver vaccines and drugs to cells? The lab of UW's Dr. David Baker (2024 Nobel Prize Winner!), with Fred Hutch’s Barry Stoddard and Madison Kennedy, report the latest protein design results from their ongoing 25-year collaboration. www.nature.com/articles/s41...

submitted 70 days ago • 0 comments

2024 was an amazing year for Basic Sciences @fredhutch.bsky.social, including the opening of the @yarimura.bsky.social Lab, the Pathfinders Postdoc Symposium, a wonderful retreat, many scientific discoveries, and more. Get all the highlights in our annual report: www.fredhutch.org/en/research/...

submitted 70 days ago • 0 comments

Full stream ahead: how one couple is leveraging their love of science to inspire support for research at Fred Hutch www.fredhutch.org/en/news/cent...

submitted 73 days ago • 0 comments

Brilliant thesis defense today by Rechel Geiger; "Evolutionary strategies for MxA antiviral proteins to overcome breadth-specificity tradeoffs in Orthomyxovirus restriction" at the Fred Hutch and UW MCB Program. She is the 11th PhD student that @harmitmalik.bsky.social and I have co-mentored

submitted 77 days ago • 2 comments

“High-throughput measurements of transcriptional effectors and RNA regulators in human cells” We’re excited to have Dr. Lacra Bintu joining us from @bioe-stanford.bsky.social to speak at today’s Current Biology Seminar! For our @fredhutch.bsky.social colleagues, don’t miss it at noon in Pelton!

submitted 71 days ago • 1 comment

“Arousing astrocytes alters neural circuit computation” Can’t wait for a great talk! We’re excited to have Dr. Marc Freeman joining us from the Vollum Institute @ohsunews.bsky.social to speak at today’s Current Biology Seminar! For all our @fredhutch.bsky.social colleagues, don’t miss it!

submitted 78 days ago • 0 comments

With support from @pewtrusts.org Innovation Fund, Fred Hutch's @jbloomlab.bsky.social will pair up with K. Christopher Garcia, Ph.D., to develop a method for examining protein-protein interactions and engineering new ones. www.pewtrusts.org/en/research-...

submitted 78 days ago • 0 comments

We’re excited to have Charu Mehta from the Buck Lab and Brandon Lofts from Human Biology’s Bedalov Lab sharing their latest discoveries at Friday Afternoon Seminars. For everyone @fredhutch.bsky.social, join us today at 4:00 in Pelton for two fantastic talks!

submitted 82 days ago • 0 comments

We are excited to announce the 52nd Maine Biological and Medical Sciences Symposium (MBMSS) at the MDI Bio Lab, featuring keynote speaker @harmitmalik.bsky.social, Professor and Associate Director @hutchbasicsci.bsky.social. #AcademicSky🧪🤝 🩺 Don't miss out — register now: mdibl.org/conference/5...

submitted 83 days ago • 1 comment

“Deconstructing and reconstructing cell polarity from the molecular to tissue-scale” We’re excited to have Dr. Danelle Devenport joining us from Princeton University to speak at today’s Current Biology Seminar! For all our @fredhutch.bsky.social colleagues, don’t miss a great talk at 12 in Pelton!

submitted 85 days ago • 0 comments

The best part of the week kicks off soon: Friday Afternoon Seminars! Can’t wait to learn about the latest research from Elyse Christensen in the @nlehrbach.bsky.social Lab and Liberalis Boila in Human Biology’s Kugel Lab. For all our @FredHutch.bsky.social colleagues, join us for two great talks!

submitted 96 days ago • 0 comments

Absolutely brilliant and fascinating seminar by @jeremywilusz.bsky.social from Baylor College of Medicine on the important and pervasive role of the integrator complex in mRNA stability. Hosted by Rasi Subramaniam. @hutchbasicsci.bsky.social Relevant paper: pubmed.ncbi.nlm.nih.gov/37995689/

submitted 99 days ago • 0 comments

“Harnessing RNA endonucleases to control gene outputs” We’re thrilled to have @jeremywilusz.bsky.social joining us from Baylor College of Medicine to speak at today’s Current Biology Seminar! For all our @FredHutch.bsky.social colleagues, don’t miss a great talk at noon in Pelton!

submitted 99 days ago • 0 comments