ibddoctor.bsky.social
Interested in #rstats, reproducibility of medical research, soccer, cycling, and of course, improving care in #IBD
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RAM vs ROM.
You can reboot from ROM if disaster happens.
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I don't think (as of a month ago) quarto-live and quarto books were compatible. Had to go with webr for a test book.
phiggins.quarto.pub/rmrwr-quarto/
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@grrrck.xyz Any step-by-step examples of how to do this in Quarto?
Would like to try to incorporate in a quarto book....
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does it work in quarto?
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I have found the expanded abilities with {patchwork} really help with multipanel journal figures.
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One that I am fond of as a reality check when we have multiple and varying endpoints - VWF tells us what the participants actually think of the trial drug.
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The VWF (Voting With their Feet) endpoint - who dropped out (7% w/900, 20% with 450 vs 20% PBO) makes me think they need to drop 450mg and try 900 vs. 1350 in phase 3. Compare to Upa U-Excel, only 6.3% dropout v. 11.9% PBO
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Sorry, reading the fine print now. Looks pretty usual, except for 14 weeks instead of 8.... Hmm
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FWIW, that is a surprisingly high rate of PBO CRem in UC. Usually close to 5%.
Did they use a less stringent definition of clinical remission?
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Did they use informative or noninformative priors?
If informative, what was the source of the prior data (did they borrow from tulisokibart ph2)?
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While I have burned through the center of a thick bridge w/ APC (which took ~ 15-20 min), it is a lot easier with a needleknife if you have one available. At this point when I see one at our outpatient center, I schedule a followup scope with needleknife at the hospital endo unit for treatment. 4/4
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Oresland, et al. reported an indicence of about 6% in 1989. It seems a bit lower today, but I may have been lucky. Oresland T, et al. The clinical and functional outcome after restorative proctocolectomy. A prospective study in 100 patients. Int. J. Colorectal Dis. 1989; 4: 50–56. 3/4
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Endoscopically, you can readily find a 'bridge' of tissue that goes across the body of the pouch, often near the anastomosis of the J pouch with the rectal cuff. These are usually fairly thick, around 7-13 mm in thickness, so not readily cut through with forceps. 2/4
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Learn more about the package: simonpcouch.github.io/gander/
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www.ssa.gov/forms/ssa-72...
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and/or the rvg package - ardata-fr.github.io/officeverse/
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officeverse and mschart cn help ardata-fr.github.io/mschart/
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Apparently yes, scores now posted.
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If meetings are listed here - did they actually happen (no scores posted yet) ?https://www.federalregister.gov/documents/2025/01/15/2025-00689/center-for-scientific-review-notice-of-closed-meetings
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Definitely needs a condor for the extent that folks are winging it.
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also watching the Tr1x studies.
Pardon my ignorance, but what is ST7?
(I am assuming not related to Star Trek)
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Prices for child-sized coffins going up.
RFK Jr. will leave a mark, just like he did in Samoa.
www.reuters.com/article/busi...