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interactivefly.bsky.social
The Interactive Fly (https://www.sdbonline.org/sites/fly/aimain/1aahome.htm) is a cyberspace guide to Drosophila Development. Special sites describe Drosophila as a model of human diseases, stress response, neural circuits, evolution, and behavior
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Valérie Hilgers and co-workers @hilgerslab.bsky.social @mpi-ie.bsky.social and @zmbh.uni-heidelberg.de show that the conserved #neuronal #protein Pumilio differentially binds to mRNA 3′ UTR isoforms to regulate localization of synaptic proteins. #neuroscience www.embopress.org/doi/full/10....

submitted 2 days ago • 1 comment

de Leeuw, Budhathoki, Russell, Loerke & Blankenship examine the mechanical limitations that nuclear volumes impose on epithelial remodeling in #Drosophila. https://buff.ly/4gyiW3j In #Mechanobiology 2025: https://buff.ly/3EK0uaq

submitted 3 days ago • 0 comments

Contreras, E. G., Kautzmann, S., Klmmbt, C. (2024). The Drosophila blood-brain barrier invades the nervous system in a GPCR-dependent manner. Frontiers in cellular neuroscience, 18:1397627 www.frontiersin.org/journals/cel...

submitted 3 days ago • 0 comments

Chitre, K., Kairamkonda, S., Dwivedi, M. K., Yadav, S., Kumar, V., Sikdar, S. K., Nongthomba, U. (2024). Beadex, the #Drosophila LIM only protein, is required for the growth of the larval neuromuscular junction. Journal of neurophysiology, 132(2):418-432 journals.physiology.org/doi/abs/10.1...

submitted 3 days ago • 0 comments

Ellis, K. E., Bervoets, S., Smihula, H., Ganguly, I., Vigato, E., Auer, T. O., Benton, R., Litwin-Kumar, A., Caron, S. J. C. (2024). Evolution of connectivity architecture in the Drosophila mushroom body. Nat Commun, 15(1):4872 www.nature.com/articles/s41...

submitted 3 days ago • 0 comments

Choi, K., Rosenbluth, W., Graf, I. R., Kadakia, N., Emonet, T. (2024). Bifurcation enhances temporal information encoding in the olfactory periphery. bioRxiv, www.biorxiv.org/content/10.1...

submitted 3 days ago • 0 comments

Lymer, S., Patel, K., Lennon, J., Blau, J. (2024). Circadian clock neurons use activity-regulated gene expression for structural plasticity. bioRxiv, www.biorxiv.org/content/10.1...

submitted 3 days ago • 0 comments

Meschi, E., Duquenoy, L., Otto, N., Dempsey, G., Waddell, S. (2024). Compensatory enhancement of input maintains aversive dopaminergic reinforcement in hungry #Drosophila.. Neuron, 112(14):2315-2332 www.cell.com/neuron/fullt...

submitted 3 days ago • 0 comments

Tsap, M. I., Yatsenko, A. S., ...., Tsikas, D., Shcherbata, H. R. (2024). Unraveling the link between neuropathy target esterase NTE/SWS, lysosomal storage diseases, inflammation, abnormal fatty acid metabolism, and leaky brain barrier. Elife, 13 elifesciences.org/articles/98020

submitted 4 days ago • 0 comments

Garcia, E. L., Steiner, R. E., Raimer, A. C., Herring, L. E., Matera, A. G., Spring, A. M. (2024). Dysregulation of innate immune signaling in animal models of spinal muscular atrophy. BMC Biol, 22(1):94 bmcbiol.biomedcentral.com/articles/10....

submitted 4 days ago • 0 comments

Yuan, Y., Yu, L., Zhuang, X., Wen, D., ...., Du, X., Chen, W., Wang, X. (2025). Drosophila models used to simulate human ATP1A1 gene mutations that cause Charcot-Marie-Tooth type 2 disease and refractory seizures. Neural Regen Res, 20(1):265-276 journals.lww.com/nrronline/fu...

submitted 4 days ago • 0 comments

Lobato, A. G., Ortiz-Vega, N., ...., Zhai, R. G. (2024). Copper enhances aggregational toxicity of mutant huntingtin in a Drosophila model of Huntington's Disease. Biochimica et biophysica acta Molecular basis of disease, 1870(1):166928 www.sciencedirect.com/science/arti...

submitted 4 days ago • 0 comments

Melkani, Y., Pant, A., Guo, Y., Melkani, G. C. (2024). Automated assessment of cardiac dynamics in aging and dilated cardiomyopathy #Drosophila models using machine learning. Communications biology, 7(1):702 www.nature.com/articles/s42...

submitted 4 days ago • 0 comments

Luedke, K. P., Yoshino, J., Yin, C., Jiang, N., Huang, J. M., Huynh, K., Parrish, J. Z. (2024). Dendrite intercalation between epidermal cells tunes nociceptor sensitivity to mechanical stimuli in #Drosophila larvae. PLoS Genet, 20(4):e1011237 journals.plos.org/plosgenetics...

submitted 5 days ago • 0 comments

Yoshikawa, S., Tang, P., Simpson, J. H. (2024). Mechanosensory and command contributions to the Drosophila grooming sequence. Curr Biol, 34(10):2066-2076 www.cell.com/current-biol...

submitted 5 days ago • 0 comments

Nern, A., Loesche, F., Takemura, S. Y., Burnett, L. E., Dreher, M.,..., Berg, S., Rubin, G. M., Reiser, M. B. (2024). Connectome-driven neural inventory of a complete visual system.. bioRxiv pmc.ncbi.nlm.nih.gov/articles/PMC...

submitted 5 days ago • 0 comments

Desai, M., Hemant, Deo, A., Naik, J., Dhamale, P., Kshirsagar, A., Bose, T., Majumdar, A. (2024). Mrj is a chaperone of the Hsp40 family that regulates Orb2 oligomerization and long-term memory in #Drosophila. PLoS Biol, 22(4):e3002585 journals.plos.org/plosbiology/...

submitted 5 days ago • 0 comments

Zhuravlev, A. V., Vetrovoy, O. V., ..., Nikitina, E. A., Savvateeva-Popova, E. V. (2024). Overexpression of the limk1 Gene in #Drosophila melanogaster Can Lead to Suppression of Courtship Memory in Males. Biochemistry (Mosc), 89(3):393-406 link.springer.com/article/10.1...

submitted 5 days ago • 0 comments

Tran, H., Le, L., Singh, B. N., Kramer, J., Steward, R. (2024). Tet controls axon guidance in early brain development through glutamatergic signaling. iScience, 27(5):109634 www.cell.com/iscience/ful...

submitted 5 days ago • 0 comments

cetylcholine Receptor Alpha6 Contributes to Antiviral Immunity via IMD Pathway in #Drosophila melanogaster. Viruses, 16(4) www.mdpi.com/1999-4915/16...

submitted 6 days ago • 0 comments

Ruan, Z. R., Yu, Z., Xing, C., Chen, E. H. (2024). Inter-organ steroid hormone signaling promotes myoblast fusion via direct transcriptional regulation of a single key effector gene. Curr Biol, 34(7):1438-1452 www.cell.com/current-biol...

submitted 6 days ago • 0 comments

Komori, H., Rastogi, G., Bugay, J. P., Luo, H., Lin, S., Angers, S., Smibert, C. A., Lipshitz, H. D., Lee, C. Y. (2024). Post-transcriptional regulatory pre-complex assembly drives timely cell-state transitions during differentiation. bioRxiv www.biorxiv.org/content/10.1...

submitted 6 days ago • 0 comments

Loyer, N., Hogg, E. K. J., Shaw, H. G., Pasztor, A., Murray, D. H., Findlay, G. M., Januschke, J. (2024). A CDK1 phosphorylation site on #Drosophila PAR-3 regulates neuroblast polarisation and sensory organ formation.. Elife, 13 elifesciences.org/articles/97902

submitted 6 days ago • 0 comments

Gamblin, C. L., Alende, C., Corriveau, F., ..., Majeau, N., Laurin, M., Laprise, P. (2024).. The polarity protein Yurt associates with the plasma membrane via basic and hydrophobic motifs embedded in its FERM domain. J Cell Sci, 137(10) journals.biologists.com/jcs/article/...

submitted 6 days ago • 0 comments

Lye, C. M., Blanchard, G. B., Evans, J., Nestor-Bergmann, A., Sanson, B. (2024). Polarised cell intercalation during #Drosophila axis extension is robust to an orthogonal pull by the invaginating mesoderm. PLoS Biol, 22(4):e3002611 journals.plos.org/plosbiology/...

submitted 6 days ago • 0 comments

Excited see the final portion of my PhD work with Vanessa Ruta out today in @cellpress.bsky.social, in the midst of everything. In time for valentines day, @rufeili.bsky.social and I describe how competition between males sculpt mating decisions in 🪰🫶. www.cell.com/cell/fulltex...

submitted 11 days ago • 5 comments

The FlyBoard is happy to announce the call for nominations for the Drosophila Community Service Award. Please submit your nomination by 01/17/2025 by email to: [email protected]. Please repost.

submitted 46 days ago • 2 comments

Duan, C. Y., Li, Y., ...., O'Connor, D. P., Xu, G. (2024). E3 ubiquitin ligase UBR5 modulates circadian rhythm by facilitating the ubiquitination and degradation of the key clock transcription factor BMAL1. Acta pharmacologica Sinica, 45(9):1793-1808 www.nature.com/articles/s41...

submitted 11 days ago • 0 comments

Lee, J. E., Lee, H., Baek, E., ...., Lee, Y. S., Song, G. J., Cho, K. S. (2024). The role of glial and neuronal Eph/ephrin signaling in #Drosophila mushroom body development and sleep and circadian behavior. Biochem Biophys Res Commun, 720:150072 www.sciencedirect.com/science/arti...

submitted 11 days ago • 0 comments

hlers, S. F., Manikowski, D., Steffes, G., Ehring, K., Gude, F., Grobe, K. (2024). A Residual N-Terminal Peptide Enhances Signaling of Depalmitoylated Hedgehog to the Patched Receptor. Journal of developmental biology, 12(2) www.mdpi.com/2221-3759/12...

submitted 11 days ago • 0 comments

Pandey, A., Roy, J. K. (2024). Rab11 maintains the undifferentiated state of adult midgut precursors via DPP pathway. Exp Cell Res, 439(1):114092 www.sciencedirect.com/science/arti...

submitted 11 days ago • 0 comments

Verma, D., Singh, A., Singh, J., Mutsuddi, M., Mukherjee, A. (2024). Regulation of Notch signaling by non-muscle myosin II Zipper in #Drosophila. Cell Mol Life Sci, 81(1):195 link.springer.com/article/10.1...

submitted 11 days ago • 0 comments

Sui, L., Dahmann, C. (2024). A cellular tilting mechanism important for dynamic tissue shape changes and cell differentiation in #Drosophila. Dev Cell, 59(14):1794-1808 www.cell.com/developmenta...

submitted 11 days ago • 0 comments

Yuan, Y., Chen, Q., Brovkina, M., Clowney, E. J., Yadlapalli, S. (2024). Clock-dependent chromatin accessibility rhythms regulate circadian transcription. PLoS Genet, 20(5):e1011278 journals.plos.org/plosgenetics...

submitted 12 days ago • 0 comments

Narbey, R., Mouchel-Vielh, E., Gibert, J. M. (2024). The H3K79me3 methyl-transferase Grappa is involved in the establishment and thermal plasticity of abdominal pigmentation in #Drosophila melanogaster females. Sci Rep, 14(1):9547 www.nature.com/articles/s41...

submitted 12 days ago • 0 comments

Bujosa, P., Reina, O., Caballé, A., Casas-Lamesa, A., Torras-Llort, M., Perez-Roldan, J., Nacht, A. S., Vicent, G. P., Bernues, J., Azorin, F. (2024). Linker histone H1 regulates homeostasis of heterochromatin-associated cRNAs. Cell Rep, 43(5):114137 www.cell.com/cell-reports...

submitted 12 days ago • 0 comments

Snedeker, J., Davis, B. E. M., Ranjan, R., Wooten, M., Blundon, J., Chen, X. (2024). Reduced Levels of Lagging Strand Polymerases Shape Stem Cell Chromatin. bioRxiv, www.biorxiv.org/content/10.1...

submitted 12 days ago • 0 comments

Brown, J. L., Zhang, L., Rocha, P. P., Kassis, J. A., Sun, M. A. (2024). Polycomb protein binding and looping in the ON transcriptional state.. Sci Adv, 10(17):eadn183 www.science.org/doi/10.1126/...

submitted 12 days ago • 1 comment

Vizjak, P., Kamp, D., Hepp, N., Scacchetti, A., Gonzalez Pisfil, M., Bartho, J., Halic, M., Becker, P. B., Smolle, M., Stigler, J., Mueller-Planitz, F. (2024). ISWI catalyzes nucleosome sliding in condensed nucleosome arrays. Nat Struct Mol Biol, www.nature.com/articles/s41...

submitted 12 days ago • 0 comments

New! 15y after the classic Aigouy et al "Cell Flow Reorients the Axis of Planar Polarity in the Wing Epithelium..." from lab of much missed Suzanne Eaton, we provide our take from post-doc Sara Tan "Tissue shear as a cue for aligning planar polarity in the developing Drosophila wing". rdcu.be/d81Vn

submitted 16 days ago • 1 comment

Bereda, C. C., Dewey, E. B., Nasr, M. A., Sekelsky, J. (2024). Functions of the Bloom Syndrome Helicase N-terminal Intrinsically Disordered Region. bioRxiv www.biorxiv.org/content/10.1...

submitted 13 days ago • 0 comments

Watase, G. J., Yamashita, Y. M. (2024). DNA polymerase II-mediated rDNA transcription mediates rDNA copy number expansion in #Drosophila. PLoS Genet, 20(5):e1011136 journals.plos.org/plosgenetics...

submitted 13 days ago • 0 comments

Camp, D., Venkatesh, B., Solianova, V., Varela, L., Goult, B. T., Tanentzapf, G. (2024). The actin binding sites of talin have both distinct and complementary roles in cell-ECM adhesion. PLoS Genet, 20(4):e1011224 journals.plos.org/plosgenetics...

submitted 13 days ago • 0 comments

Park, K., Choi, H., Han, I. J., Asefa, W. R., Jeong, C., Yu, S., Jeong, H., Choi, M., Yoon, S. E., Kim, Y. J., Choi, M. S., Kwon, J. Y. (2024). Molecular and cellular organization of odorant binding protein genes in #Drosophila.. Heliyon, 10(9):e29358 www.cell.com/heliyon/full...

submitted 13 days ago • 0 comments

Mukherjee, A., Fallacaro, S., Ratchasanmuang, P., Zinski, J., Boka, A., Shankta, K., Mir, M. (2024). A fine kinetic balance of interactions directs transcription factor hubs to genes. bioRxiv, www.biorxiv.org/content/10.1...

submitted 13 days ago • 0 comments

Sun, Z., Inagaki, S., Miyoshi, K., Saito, K., Hayashi, S. (2024). Osiris gene family defines the cuticle nanopatterns of #Drosophila. Genetics, 227(2) academic.oup.com/genetics/art...

submitted 13 days ago • 0 comments

Jia, Q., Yang, L., Wen, J., Liu, S., Wen, D., Luo, W., Wang, W., Palli, S. R., Sheng, L. (2024). Cyp6g2 is the major P450 epoxidase responsible for juvenile hormone biosynthesis in #Drosophila melanogaster. BMC Biol, 22(1):111 bmcbiol.biomedcentral.com/articles/10....

submitted 14 days ago • 0 comments

Liu, M., He, L. (2024). Dietary cysteine and methionine promote peroxisome elevation and fat loss by induction of CG33474 expression in #Drosophila adipose tissue. Cell Mol Life Sci, 81(1):190 link.springer.com/article/10.1...

submitted 14 days ago • 0 comments

Jin, L., Tian, X., Ji, X., Xiao, G. (2024). The expression of Catsup in the hindgut is essential for zinc homeostasis in #Drosophila melanogaster. Insect Mol Biol, resjournals.onlinelibrary.wiley.com/doi/10.1111/...

submitted 14 days ago • 0 comments