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Study shows azithromycin effectively treats typhoid fever even with low plasma levels, highlighting its potential against drug-resistant strains: https://doi.org/10.1093/jacamr/dlaf015 #JACAMRNews

submitted 4 hours ago • 0 comments

First detection of VIM-1 producing E. coli from a fattening calf at slaughter within the German #AMR monitoring The blaVIM-1 gene is located on a small 16 kb plasmid within a class 1 integron https://doi.org/10.1093/jacamr/dlaf009 #JACAMRNews

submitted 8 hours ago • 0 comments

This study audited the prescribing of antibiotics, using patient medical charts at a tertiary-level public hospital, in preparation for the implementation of an #AntimicrobialStewardship programme: https://doi.org/10.1093/jacamr/dlae219 #JACAMRNews #IDSky

submitted 1 day ago • 0 comments

How long should bacterial infections be treated with antibiotics? Review summarizing key RCTs & international consensus for a holistic guide to antibiotic durations, highlighting important caveats: more evidence needed for severe infections & in LMICs doi.org/10.1093/jaca... #JACAMRNews

submitted 1 day ago • 0 comments

Liu et al. characterized bacteria and their drug resistance in samples collected from pet hospitals in 30 provinces of China during October 2022 through 2023, enhancing understanding of the current #AMR situation in pet populations in China: https://doi.org/10.1093/jacamr/dlaf007 #JACAMRNews

submitted 2 days ago • 0 comments

Defining & responding to contextual drivers for #AntimicrobialStewardship implementation in SA neonatal units enabled a multidisciplinary team approach to develop & optimise #AMS, with potential for other low resource settings: https://doi.org/10.1093/jacamr/dlae222 @neleshg.bsky.social #JACAMRNews

submitted 2 days ago • 0 comments

IV to oral antibiotic switch in patients with uncomplicated E. faecalis BSI showed shorter length of hospital stay and no significant increase in the risk of treatment failure—this could be a promising strategy for selected patients: https://doi.org/10.1093/jacamr/dlaf004 #JACAMRNews

submitted 3 days ago • 0 comments

ICYMI: this adapted UK AWaRe list reached through consensus will support national #AntimicrobialStewardship and usage targets of the UK 2024–29 NAP https://doi.org/10.1093/jacamr/dlae218 @dianeashiru.bsky.social @raseaton66.bsky.social @aliciad3.medsky.social #JACAMRNews

submitted 3 days ago • 0 comments

Although treatment success rates for drug-resistant TB have improved in Namibia, they are still below the WHO global target With children aged under 15 years and women at higher risk of treatment failure, targeted interventions are needed: https://doi.org/10.1093/jacamr/dlae211 #JACAMRNews

submitted 6 days ago • 0 comments

New: patterns of antibiotic use by age/sex + implications for stewardship and AMR! I’m particularly fond of the plots! See next post for the headlines or the paper for the stories the antibiotics tell... Co-authors: Tom Ashfield + @gmknght.bsky.social, part of Gwen's fellowhip on age/sex on AMR!

submitted 14 days ago • 1 comment

Despite global surveillance efforts, antibiotic resistance (ABR) is hard to address in LMICs Médecins Sans Frontières conducted this review hoping to use pooled findings to inform treatment where local ABR data are unavailable Standardized antibiograms are needed

submitted 6 days ago • 0 comments

Successful use of ceftazidime/avibactam for an XDR K. pneumoniae empyema secondary to a pleural-biliary fistula: 🔥 New #AMRrounds article just published 👇 https://doi.org/10.1093/jacamr/dlaf019 @inyourfaecium.bsky.social @wwrighid.bsky.social #JACAMRNews #IDSky #AntimicrobialResistance

submitted 7 days ago • 0 comments

In this systematic review, Raju et al. show the proportion of non-typhoidal Salmonella isolated from patients in Bangladesh, India, Sri Lanka and Vietnam and highlight the need for better surveillance and a One Health approach: https://academic.oup.com/jacamr/article/6/6/dlae190/7908600 #JACAMRNews

submitted 8 days ago • 0 comments

In urinary tract infection, antimicrobial therapy matching with in vitro susceptibility predicts a clinical cure better than mismatching predicts a failure https://doi.org/10.1093/jacamr/dlae188 #JACAMRNews

submitted 9 days ago • 0 comments

Nitroxoline showed excellent in vitro activity against uropathogens isolated from China & may be a good option for uncomplicated UTIs caused by A. baumannii that are more challenging & have few clinical options Further in vivo efficacy studies needed doi.org/10.1093/jaca... #JACAMRNews

submitted 9 days ago • 0 comments

Al Mohajer et al. found that medical school ranking did not impact the rate of antibiotic days supplied per 100 beneficiaries Students and providers with over 20 years of experience had the highest days supplied rate: https://doi.org/10.1093/jacamr/dlae191 #JACAMRNews

submitted 10 days ago • 0 comments

This article addresses the issue of #AntimicrobialResistance in Enterobacterales in the East of England, providing data to guide the empirical treatment of UTIs: https://doi.org/10.1093/jacamr/dlaf003 #JACAMRNews

submitted 10 days ago • 0 comments

Nursing home nurses’ opinion on the potential evolution of their role in #AntimicrobialStewardship: three profiles of nurses identified, which could assist healthcare managers and policymakers tailoring the implementation of these changes in nursing homes: doi.org/10.1093/jaca... #JACAMRNews

submitted 13 days ago • 0 comments

Nursing home nurses’ opinion on the potential evolution of their role in antimicrobial stewardship: three profiles of nurses identified, which could assist healthcare managers and policymakers tailoring the implementation of these changes in nursing homes: doi.org/10.1093/jaca... #JACAMRNews

submitted 13 days ago • 0 comments

This meta-analysis found an overall pooled prevalence of human intestinal carriage of ESBL E. coli of 25.4%: https://doi.org/10.1093/jacamr/dlaf001 #JACAMRNews

submitted 13 days ago • 0 comments

Treatment with ivacaftor does not alter S. aureus burden in the cystic fibrosis rat but led to the formation of tolerant SCVs, suggesting that development of an SCV phenotype may allow S. aureus to persist in the cystic fibrosis lung during ivacaftor therapy: doi.org/10.1093/jaca... #JACAMRNews

submitted 14 days ago • 0 comments

Akbar et al. outline a prospective audit and feedback approach where pharmacists evaluate antifungal prescriptions, monitor drug use, and provide recommendations for antifungal therapy optimization in a cancer care hospital: https://doi.org/10.1093/jacamr/dlae184 #JACAMRNews

submitted 15 days ago • 0 comments

Incorrect penicillin allergy (penA) labels are common and impede the use of first line narrow spectrum penicillin antibiotics This review highlights the negative impact penA has on antimicrobial resistance: https://doi.org/10.1093/jacamr/dlaf002 #JACAMRNews

submitted 15 days ago • 0 comments

In this review, Petermann et al. explore the benefits of personalized TB treatment through therapeutic drug monitoring of rifampicin in resource-limited settings: https://doi.org/10.1093/jacamr/dlae182 #JACAMRNews

submitted 16 days ago • 1 comment

This study examined the country of origin and price of antibiotics in Vietnam: although most antibiotics were domestically produced, the availability of Reserve group antibiotics depended on imports from high-income countries: https://doi.org/10.1093/jacamr/dlae221 #JACAMRNews

submitted 16 days ago • 0 comments

Veterinarians’ antibiotic prescribing behaviour is dynamic and changes with different contextual situations: priorities and pressures, uncertain field conditions, systemic challenges, and an enabling environment https://doi.org/10.1093/jacamr/dlae177 #JACAMRNews

submitted 17 days ago • 0 comments

Diagnosis & antibiotic prescribing in nursing homes often lacked interprofessional collaboration & involved 2 distinct organization types—institutional vs private practices Future stewardship should improve the connection between these 2 organizations: doi.org/10.1093/jaca... #JACAMRNews

submitted 17 days ago • 0 comments

Knudsen et al. developed and validated a real-time PCR-assay detecting the sequence bridging the vanB trans-poson (Tn1549) and the E. faecium to rapidly and accurately diagnose vanB vancomycin-resistant E. faecium in rectal screening samples: https://doi.org/10.1093/jacamr/dlae180 #JACAMRNews

submitted 20 days ago • 0 comments

This point prevalence survey conducted at the CHUZ/AS in Benin found high antibiotic use in hospitalized patients, indicating the need for more PPS and antibiotic use monitoring as well as instigation of AMS programmes in hospitals in Benin: https://doi.org/10.1093/jacamr/dlae220 #JACAMRNews #IDSky

submitted 20 days ago • 0 comments

A multistep #AntimicrobialStewardship programme has proven feasible and sustainable in improving antibiotic prescriptions in a paediatric setting: https://doi.org/10.1093/jacamr/dlae181 #JACAMRNews #IDSky

submitted 21 days ago • 0 comments

This study explores TB prevalence in conflict-affected northeastern Ethiopia, revealing alarming rates of rifampicin-resistant strains: https://doi.org/10.1093/jacamr/dlae206 #JACAMRNews #IDSky

submitted 21 days ago • 0 comments

CRE surveillance by Tsui et al. discovered two MDR clinical isolates of E. coli ST1193 with plasmids harbouring NDM-type carbapenemase genes from Qatar: https://doi.org/10.1093/jacamr/dlae166 #JACAMRNews #IDSky

submitted 22 days ago • 0 comments

Antifungal resistance is increasing globally, with more patients at risk of invasive fungal disease There is an urgent need to standardise antifungal stewardship (AFS) in the UK—this position paper sets out the UK’s current AFS landscape: https://doi.org/10.1093/jacamr/dlae209 #JACAMRNews #IDSky

submitted 22 days ago • 0 comments

In Atlanta, USA, living in a high-income neighborhood is associated with significantly lower risk of harbouring a urinary pathogen that is non-susceptible to first-line treatments, compared with living in a low-income neighborhood: https://doi.org/10.1093/jacamr/dlae179 #JACAMRNews

submitted 23 days ago • 0 comments

High antibiotic resistance in daycare centres in Nigeria highlights the urgent need for better infection control and #AntimicrobialStewardship strategies: https://doi.org/10.1093/jacamr/dlae213 #JACAMRNews

submitted 23 days ago • 0 comments

Last chance to sign up for the FREE Antimicrobial Chemotherapy Conference 2025, which starts at 1300GMT today! This two-day, free-of-charge virtual conference is jointly organised by BSAC and @gardp.bsky.social. Register your complimentary place here: acc-conference.com #ACC2025

submitted 23 days ago • 0 comments

This retrospective multicentre investigation of infective endocarditis caused by Enterococcus faecalis demonstrated that the MIC of amoxicillin was not associated with mortality: https://doi.org/10.1093/jacamr/dlae167 #JACAMRNews

submitted 24 days ago • 0 comments

Maruri-Aransolo et al. found a non-significant reduction in MRSA prevalence among people with cystic fibrosis in Spain between 2013 & 2021 The high genotypic & phenotypic diversity and impact on CF severity indicates a need for continued surveillance: https://doi.org/10.1093/jacamr/dlae160 #JACAMRN…

submitted 24 days ago • 0 comments

Antibiotic prescription rates are high in tertiary hospitals in Niger—most were used empirically & less than 1/4 antibiotics prescribed had a stop/review date recorded Only 4.2% of prescribed antibiotics had cultures & susceptibility testing requested https://doi.org/10.1093/jacamr/dlae175 #JACAMRN…

submitted 27 days ago • 0 comments

The UK Health Security Agency (UKHSA) has published an updated antimicrobial stewardship tool to support healthcare professionals across the UK prescribe the most appropriate antibiotics for patients, while protecting their future effectiveness. www.gov.uk/government/n...

submitted 27 days ago • 0 comments

This register-based study on lower UTI in men in primary healthcare shows lower antibiotic resistance in E. coli than national surveillance data, highlighting the need for ongoing surveillance in order to choose the right empirical treatment: https://doi.org/10.1093/jacamr/dlae214 #JACAMRNews #IDSky

submitted 27 days ago • 0 comments

This single-centre retrospective study describes the real-world experience of expanded use of oritavancin and associated adverse reactions: https://doi.org/10.1093/jacamr/dlae174 #JACAMRNews #IDSky

submitted 28 days ago • 0 comments

Mentorship is a progressive approach to knowledge & skills transfer, promoting sustainable local expertise in antimicrobial use surveillance Valuable insights into the learning needs & mentorship experiences of Australian mentors & mentees from 4 LMICs:

submitted 28 days ago • 0 comments

#AntimicrobialStewardship programmes have been implemented around the world to optimally manage antimicrobial use to attenuate antimicrobial resistance Community pharmacies can benefit from antimicrobial stewardship programmes: https://doi.org/10.1093/jacamr/dlae176 #JACAMRNews

submitted 29 days ago • 0 comments

In the West Bank AMR is increasingly and alarmingly common Efforts are being made to expand #AntimicrobialStewardship programmes (ASPs) This study explores doctors’ perceptions of AMR and ASPs at a critical point in national ASP development: https://doi.org/10.1093/jacamr/dlae198 #JACAMRNews

submitted 29 days ago • 0 comments

Among febrile cancer patients in sub-Saharan Africa, malaria and MDR Gram negative bacteria are important infectious agents: https://doi.org/10.1093/jacamr/dlae173 @davidvanduin.bsky.social #JACAMRNews

submitted 30 days ago • 0 comments

Based on PK/PD assessment in ELF, SUL 1g q6h 0.5h infusion provided >90% PTA for A. baumannii isolates with SUL MIC up to 2 mg/L only 3g q8h 4h infusion achieved higher PTA & conferred additional benefit against SUL-susceptible/intermediate isolates https://doi.org/10.1093/jacamr/dlae203 #JACAMRNews

submitted 30 days ago • 0 comments

Elizabethkingia are rare human pathogens that cause serious infections in vulnerable hosts MDR emerging during treatment limits antimicrobial options & makes treatment difficult Multi-drug and optimally dosed regimens are required for good outcomes: https://doi.org/10.1093/jacamr/dlae161 #JACAMRNews

submitted 31 days ago • 0 comments

The abstracts from #Infection2024 BSAC Winter Conference are now online! 👇 https://academic.oup.com/jacamr/issue/7/Supplement_1 @bsacandjac.bsky.social #JACAMRNews #IDSky

submitted 31 days ago • 0 comments

A new model explains self-medication with antibiotics in LMICs where antibiotics are available to buy over the counter High prescribing by doctors means people think antibiotics are a good treatment and commercial interests promote sales: https://doi.org/10.1093/jacamr/dlae165 #JACAMRNews

submitted 34 days ago • 0 comments