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jamesbriscoe.bsky.social
Developmental Biologist working at the Francis Crick Institute. Neural tube, morphogens, and gene regulatory networks. Editor-in-chief, Development. London · briscoelab.org
149 posts 4,733 followers 507 following
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Good to see this from @kichevalab.bsky.social in final journal format BMP signalling drives neural tube patterning through a temporal relay mechanism Lmx1a connects fast negative feedback and slow positive regulation www.cell.com/developmenta...

Congratulations Laura Avinyo! @lauavinyo.bsky.social and Heura Cardona! First paper of your PhD 🎉. doi.org/10.1242/dev.... Beautiful quantified trajectory of how the skeletal pattern of the gene Sox9 emerges during limb development. @embl.org @barcelonacollaboratorium.com

Breakimg: Ian Chapman appointed as next UKRI chief executive. Current UKAEA head tasked with leading public research funder into “refreshed mission” targeting economic growth. www.researchprofessionalnews.com/rr-news-uk-r...

"Genes are... the easy part" @philipcball.bsky.social argues biologists need to embrace complexity from the start, rather than beginning with oversimplified "one gene, one trait" models +1 www.cell.com/cell-systems...

Want to add novel developmental biology and biophysics methods to your research? Have a look at #EMBLDevBio, where you'll learn all about highly multiplexed RNA fluorescent in situ hybridisation, quantitative imaging, and more 🥼 📥 Apply by 26 Mar 🔗 s.embl.org/ptd25-01-bl #quantitativebiology

Our latest in @dev-journal.bsky.social: an in vivo CRISPR screening approach in chick embryos to study neural cell specification from the caudal lateral epiblast (CLE) Identifies role for super elongation complex component MLLT3 A thread... journals.biologists.com/dev/article/...

Happy Valentine’s Day. ❤️ This image shows a section of a human trunk organoid, precursor to the spine and nervous system, grown from human stem cells. The green spot is a notochord, a rod-shaped tissue that acts as a kind of GPS system. Credit: Tiago Rito.

An in vivo CRISPR screen in chick embryos reveals a role for MLLT3 in specification of neural cells from the caudal epiblast Read this Techniques & Resources Article by Ashley Libby, @jamesbriscoe.bsky.social and colleagues: https://journals.biologists.com/dev/article/152/3/DEV204591/365644/

Do you want one of the most influential jobs in dev bio? Would you like to work with the best group of editors & publishing professionals in the business? Are you interested in leading the premier not for profit community focussed journal in the field? Come be Development's next Executive Editor

Very sorry to hear of the passing of Professor Roger Pedersen, whose visionary leadership helped establish the @scicambridge.bsky.social. I will never forget how Roger personally taught my group how to dissect early post-implantation mouse embryos; watching him at the microscope was truly inspiring

Our latest in @dev-journal.bsky.social: an in vivo CRISPR screening approach in chick embryos to study neural cell specification from the caudal lateral epiblast (CLE) Identifies role for super elongation complex component MLLT3 A thread... journals.biologists.com/dev/article/...

Calling all students. The registration for the European Summer School on Stem Cell Biology and Regenerative Medicine is now open.

Here’s a story about actual Nazis, the Original Gastruloid, and the lengths scientists will go for other scientists and for science itself. Welcome to Episode Two of the #LongBibliography #DevBiol #SciHist 🧵. 1/13

To accompany the Biologists @ 100 conference, we're launching an image competition together with @focalplane.bsky.social! Enter your best biological research images 🧪🔬 Shortlisted images will be presented at the #Biologists100 conference in March. Details: thenode.biologists.com/enter-the-no...

New work from my @crick.ac.uk colleagues in @jpvincentlab.bsky.social Brinker only present in winged insects & acts to extend the range of BMP signalling in wing discs This genetic innovation might have been crucial for wing development & insect flight evolution www.biorxiv.org/content/10.1...

I agree with @economist.com that the "Oxbridge arc" has huge potential But realising this isn't just about planning regulations People are crucial. This means increasing, not cutting, PhD training & easing skilled worker visas www.economist.com/leaders/2025...

Saddened to hear of John Reinitz's death Reliably contrarian and argumentative but razor sharp, original and inspirational His approach to dev bio was a decade and more ahead of the field biologicalsciences.uchicago.edu/news/john-re...

Really important article and approach!

ICYMI: Commentary on "mechanism" in dev bio Ozpolat et al argue for diverse approaches to mechanism - from molecular to systems level journals.biologists.com/dev/article/...

I can highly recommend the YEN 2025 meeting for students and postdocs working on 'anything embryo' - a fantastic meeting organized by students and postdocs for you!

Registration open for this year's Young Embryologist Network meeting 19 May, The Francis Crick Institute, London thenode.biologists.com/yen-2025-con...

Did you get a Travelling Fellowship between 1990-2010? Please tell us about it!

🧪Two more days to apply to @dev-journal.bsky.social's Pathway to Independence programme. Apply by 31 January. #ECR #DevBio

Agree. Cuts in UKRI funded PhD places, is about government funding and prioritisation. We need work force planning with joined up thinking A PhD is not about an academic career, its an apprenticeship for the knowledge economy. "Europe's Silicon Valley" will not exist without PhDs

Sorry to hear this about @cardiffuni.bsky.social Losing 400 faculty means Cardiff Uni is now mostly employing administrators (they currently have 3660 admin to 3410) academics according to their website). At what point do you stop being an academic institution? www.theguardian.com/education/20...

New from @crick.ac.uk Briefing note on what we're doing for #OpenScience & data sharing, including hiring specialist staff, mandatory archiving & enhanced training Result: Data availability statements up to 89% & better quality deposits in our institutional Figshare www.ijdc.net/index.php/ij...

Excited to announce new editorial leadership with Professor Andrew Dillin as Editor-in-Chief and Dr. Eric Sawey as Executive Editor, expanding the journal’s scope to include exciting new areas of molecular and cellular biology. bit.ly/genesdevpr

Beautiful work from my colleagues in the @lab-turner.bsky.social Systematically deleting Y chr genes in mice reveals their crucial roles in sperm development from stem cell establishment to X-Y pairing in meiosis and sperm cell formation www.science.org/doi/10.1126/...

A week left to apply to @dev-journal.bsky.social Pathway to Independence programme Deadline 31 January The programme supports postdocs going on the academic job market in 2025 We offer training, mentorship, profile-raising and networking opportunities journals.biologists.com/dev/pages/pi...

🧪 Did you know that our founder held the record for the oldest message in a bottle as part of his research into ocean currents? As part of our 100-year celebrations, we would like to hear stories from you on how The Company of Biologists has impacted your careers. bit.ly/4hsN40W #biologists100

"How being a scientist helped me to be a good mother" In this new "Honest conversations" blog post, Felicity Davis @davislab.bsky.social discusses gender inequalities in academia and shares her experience of becoming a mother-scientist: thenode.biologists.com/how-being-a-...

A couple of weeks left to apply to join Development's *Pathway to Independence* programme Support & mentoring for post-docs on the academic job market Deadline: January 31 journals.biologists.com/dev/pages/pi...

Our latest: how to generate the notochord "Timely TGFβ signalling inhibition induces notochord" A thread: www.nature.com/articles/s41...

This year, the Company of Biologists @biologists.bsky.social publisher of Development, J. Cell Science, Disease Models & Mechs... celebrates its *100* year anniversary From little acorns, mighty oaks grow Find out about some of the centenary activities: thenode.biologists.com/celebrating-...

Important work from Placzek & Blackshaw labs: Fate mapping developing chick forebrain Suggests hypothalamus develops ventral to telencephalon/prethalamus not anterior to diencephalon New 'tripartite hypothalamus' idea challenges the prevailing prosomere model www.biorxiv.org/content/10.1...

📢Still time to vote for the 2024 Development cover image of the year! Of the 24 cover images featured in @dev-journal.bsky.social in 2024, which one is your favourite? Browse through the images and vote by 13 Jan: thenode.biologists.com/vote-for-the... #DevBio 🧪

That @biologists.bsky.social has been extremely influential in my career is not an exaggeration. Most of my fav science is in the Company's journals + I've been constantly & generously supported via conference grants, participation in workshops and a recent fellowship to visit another lab. Thank u 🥰

Catching up after the break Salutary study from Badia-i-Mompel & co systematically comparing GRN inference methods There's a long way to go: "methods have limited robustness, yield substantially different outcomes & are affected by the type of data" www.biorxiv.org/content/10.1...

New year! New social media! And new job opening!! Join us on a programme leader track to start your group @mrc-lms.bsky.social! Supportive colleagues, wonderful new building and outstanding facilities! #cellidentity #sexdifferences #genesenvironment