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jbrandmdphd.bsky.social
Physician-Scientist at Univ of Penn, treating/studying Castleman Disease, histiocytic disorders, and lymphoma. Stroma sleuth. Storming castles. I love immunology! Views are my own, and not medical advice.
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Prolific Poster

Today is the AACR Early-Career Hill Day, and we're calling on early-career scientists, trainees, students, and supporters to contact Congress and ask them to prioritize NIH funding. Now more than ever, it's important to take action: AACR.org/NIH #AACRontheHill #FundNIH

STAT story is up about study section restart. www.statnews.com/2025/02/24/s...

This! We need help to keep medical research going!! Anyone?

Yes! Is anyone able to help?

🚨This should be amplified!! Study sections and council meetings are still being cancelled despite the court order unblocking NIH freezes, effectively halting any new research grant from being funded: www.thetransmitter.org/funding/fede...

The AACR is deeply concerned that the Administration’s recent actions are threatening NIH and its mission to accelerate progress for patients with cancer and other diseases that afflict millions of Americans. Read our statement: https://buff.ly/4gRXNB8

YES!

It's not unicentric or multicentric: It's OLIGOcentric Castleman!! @bloodjournal.bsky.social

Harold Varmus is an American hero. We should listen.

Statement at #Tandem25 thanking NIH contributors not able to join the meeting took me aback: #OncSky

This is outstanding. All academic scientists should be required to watch this.

I believe that most of our society values science and scientists. We need to continue to communicate our findings and value to the public and advocate for increased research funding, especially for young investigators->they are the future.

Apparently last week's NHLBI advisory council was cancelled. Worried for my K08 application and hoping for order to return to NIH.

The NIH Notice about the new indirect cost rate "plan"

Asking hard questions and pushing the boundaries of medical science to develop new cures is hard. I worry that Friday night's new NIH rules will only further disincentivize universities to support medical research.

“I think the American people need to understand how devastating it would be if this goes through,” Dr. Lefkowitz said. “A lot of research would just have to stop; I can’t imagine that the shortfall could be met from other sources.”

1. Today the NIH director issued a new directive slashing overhead rates to 15%. I want to provide some context on what that means and why it matters. grants.nih.gov/grants/guide...

Exciting to have more treatments for rare disease patients!

Congratulations to the 7 @pennmedicine.bsky.social physician-scientists recently elected to the American Society for Clinical Investigation (@the-asci.bsky.social)! Please check back as we profile each new member tinyurl.com/2p9jdkdt

Congratulations Joe! #UpliftingAthletes #Raredisease #CureCastleman

Congratulations to all!!!

Kim Rathmell to step down as NCI Director January 20. Hope that we can benefit from her leadership at the NCI again in the future.

Large-scale changes in the genome inherited from parents are significant risk factors for pediatric solid tumors, a new Science study finds. The results provide new insights into the genetic underpinnings of pediatric cancers.

Ccl19-Cre+ fibroblasts use Dll1 Notch ligands to control MZBs!! www.sciencedirect.com/science/arti...

Cancer-specific innate and adaptive immune rewiring drives resistance to PD-1 blockade in classic Hodgkin lymphoma www.nature.com/articles/s41...

What an incredibly moving story! Scientists and doctors should do all they can to help these patient leaders!

Let's make it easier to diagnose Castleman Disease! Read about my work presentes at ASH to try to make this happen!! ash.confex.com/ash/2024/web...

Let's make it easier to diagnose Castleman Disease! Here's some of what I've been doing on this front!! reachmd.com/programs/pro...

Already loving #ASH24

Max deserves a Nobel. In the meantime, you can nominate someone for the Max Cooper Prize, deadline is April 1st. "Nomination letters of up to 3 pages must articulate how their research has led to advances in immunology research that will have a lasting impact." #Immunology

Wow. This is a big deal. Dr. Druker again leads the way.

I love any chance to work with Burkhard Ludewig's lab. This paper from his group is so exciting!

I have enjoyed following the work from Jonathan Bromberg's lab and am looking forward to reading this paper!

US leadership in the funding of medical research is something we as taxpayers can be proud of. At a simpler, economic-only, level it is just an incredible return on investment.

JOSH!!

Immune cells change in proportions with age - naive go down, effector go up. www.science.org/doi/10.1126/...

More women are entering MD-PhD programs but does their training result in similar career trajectories as men? https://insight.jci.org/articles/view/184715 The latest Physician-Scientist Development article from ASCI member Lawrence F. Brass delves into this question.

Tabelecleucel R/R EBV+ PTLD #ASH24: - off-the-shelf EBV allo CTL - 75 pts, 24% ECOG 2+, all prior R+/-chemo - ORR 51%, CR 28%, mDOR 23 mo - 1-yr OS 56% (responders 79%) - no G5 TEAEs, no CRS/ICANS, GVHD, organ rejection Important option in pts with otherwise very poor OS. #lymsm

Thank you @landau.bsky.social for an engaging and impressive talk @pennmedicine.bsky.social /CHOP today!

Sectarianism in immunology. (highly specific for immunologists, all credit to @pedromics on X) 1/8

#reviewoftheweek An interesting revisit of Polly Matzinger’s danger theory of immunity, by Guido Kroemer & Co 🦠 www.nature.com/articles/s41....

Academics in their forties

This could be sooo helpful.