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jgezelle.bsky.social
Columbia PhD studying viral RNA structure and degradation
5 posts 159 followers 399 following
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Posts 12 Comments 3

ICE can enter anyone’s home, and abduct and deport them to a foreign prison indefinitely because the DOJ says they can ignore the 4th, 5th and 15th amendments. If there’s no due process or protections against illegal search and seizures, none of us are safe.

submitted 18 days ago • 991 comments

A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome www.nature.com/articles/s41...

submitted 46 days ago • 0 comments

Hey #RNAsky check out our new preprint! we solved a new nuclease-blocking viral #RNA structure and found some illuminating similarities across diverse viral families. Thread below ⬇️ biorxiv.org/content/10.110…

submitted 144 days ago • 2 comments

submitted 152 days ago • 0 comments

Amazing work revealing the mechanisms by which mRNAs are delivered to the bacterial ribosome! 🤯 Congrats to the Weixlbaumer lab and their collaborators in the Walter and Rappsilber labs! 🍾

submitted 164 days ago • 0 comments

I'm excited to share the preprint for the first chunk of my PhD work! We combined DMS structure probing with nascent RNA enrichment to report high-resolution, dynamic structures of transcripts just after synthesis - inside cells. @karlaneugebauer.bsky.social www.biorxiv.org/content/10.1...

submitted 167 days ago • 1 comment

Our latest paper, a fantastic collaboration with the Mendell Lab, is out. Great work by Xiaoqiang Zhu and Victor Cruz. We uncover how tRNA structural features in the ribosomal P-site modulate co-translational mRNA decay by the CCR4-NOT complex. #RNAsky #RNAbiology #translation #ribosome #cryoEM 1/5

submitted 173 days ago • 6 comments

My first post! #mRNA translation initiation and its regulation in eukaryotes. #Ribosomes #cryoEM #RNABiology #Translation #Science

submitted 175 days ago • 5 comments

New preprint on our method aa-tRNA-seq: chemically capturing aminoacylated tRNA molecules & pulling them through nanopores. It’s been a blast working with my collaborator Aleks Radakovic to take this from idea to promising pilot data to some looking exciting biology to chase down in future work.

submitted 175 days ago • 6 comments

LARP1 directly binds non-translating ribosomes and TOP mRNAs www.embopress.org/doi/full/10....

submitted 181 days ago • 0 comments

One of the most ancient sequences in biology, the peptidyl transferase center of the ribosome, is not as conserved as we might have thought. #RNA #Ribosomes www.biorxiv.org/content/10.1...

submitted 181 days ago • 1 comment

Let's make a thread of RNA-related conferences in 2025 🧵 (add missing!)

submitted 181 days ago • 12 comments