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jimjohnsonsci.bsky.social
Physiologist, Mentor, Collaborator. Posts =/= employers’ views.
194 posts 2,979 followers 6,702 following
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Have you already checked out our #EISG2025 program? Fresh off the press! Download it here: eisg2025.se/scientific_p...

Professor Charlotte Ling, from the #eisg2025 steering committee, introduces this year’s European Islet Study Group event in Malmö, Sweden. Lund University Diabetes Centre is the host of this year's meeting, and we are happy to see that over 250 researchers have registered for the meeting 👏

Estrogen-related receptor alpha promotes skeletal muscle regeneration and mitigates muscular dystrophy www.biorxiv.org/content/10.1...

AKT-mediated phosphorylation of TSC2 controls stimulus- and tissue-specific mTORC1 signaling and organ growth www.sciencedirect.com/science/arti...

nice paper by a large team led by @paulwfranks.bsky.social showing in humans what we showed in mice - reducing insulin production completely prevents liver fat accumulation www.cell.com/cell-metabol.... Insulin hypersecretion causes fatty liver in the IMI cohort. www.medrxiv.org/content/10.1...

New data on #BCAA metabolism in #T2D: although exercise has an insulin-sensitising effect, this does not appear to occur in tandem with improved BCAA clearance #DiabetesResearch #Endocrinology #MedSky

Earth will warm 1.5 degrees Celsius above preindustrial levels in just two years, new data shows. Irreversible tipping points — like the melting of Arctic ice sheets or the collapse of coral reefs — are closer at hand than previously believed.

VCHRI research summit day.

90% of doing science is being open to new ideas.

Latent EBV enhances the efficacy of anti-CD3 mAb in Type 1 diabetes @natcomms.nature.com www.nature.com/articles/s41...

Musk should be asked about this in every interview he does now and forever. To ignore it is a dereliction of duty. www.nytimes.com/2025/05/30/o...

Microbiome metabolism of dietary phytochemicals controls the anticancer activity of PI3K inhibitors www.cell.com/cell/fulltex... @cellcellpress.bsky.social @asaelroichman.bsky.social

Excellent point

Going with a local hero: Southern Resident Killer Whale! Only about 70 of them left in the Pacific Northwest, mainly due to their preferred diet being Chinook salmon. Pollution (including noise), are also factors. They are culturally iconic, and spiritually important to PNW Indigenous peoples.

Glad to report that this tour de force from our collaborator Caroline Alexander (with a bit of assistance from our lab in the form of Michaela Trautman) is now out: "Dietary lipids are largely deposited in skin and rapidly affect insulating properties" www.nature.com/articles/s41...

Long-term cytokine exposure of human islet micro tissues created a type 1 diabetes-like phenotype with impaired low-glucose-induced glucagon secretion, with attenuation by GIP @diabetologiajnl.bsky.social link.springer.com/article/10.1...

Role of the translation factor EIF2A in protecting #BetaCells during #ERStress #DiabetesResearch #Isets #MedSky @jimjohnsonsci.bsky.social @bruceverchere.bsky.social

New study on novel translation factor EIF2A led by Panzhinskiy as a collaboration between @jimjohnsonsci.bsky.social lab, Jan lab & @bruceverchere.bsky.social lab UBC Life Sciences Institute. Thanks Breakthrough T1D Canada for funding this project #DiabetesResearch link.springer.com/article/10.1...

Light and sex modify Snord116 genotype effects on metabolism, behavior, and imprinted gene networks following circadian entrainment https://www.biorxiv.org/content/10.1101/2025.05.01.651733v1

"The turbines spew NOx at an estimated rate of 1,200 to 2,000 tons a year — far more than the gas-fired power plant across the street or the oil refinery down the road." I don't see how ppl rationalize any use for AI when the costs so clearly outweigh the benefits. It's a health-destroying machine.

Data centers are the new sacrifice zones

Analysis of increased platelet activation in people with #T1D @diabetologiajnl.bsky.social link.springer.com/article/10.1...

EIF2A is a novel target for beta cell protection and the circumvention of EIF2S1-mediated translational repression #islets #diabetes @jimjohnsonsci.bsky.social @diabetologiajnl.bsky.social link.springer.com/article/10.1...

It’s my pleasure to speak (twice) at the Australian Islet Study Group meeting in beautiful Adelaide. Great science and company :)

Intracellular metabolic gradients dictate dependence on exogenous pyruvate www.nature.com/articles/s42... Congrats to @lydiafinley.bsky.social Lab!

This is a must read article on Poilievre and Trump. bruce728.substack.com/p/trump-show...

WSJ: No confidence. Worst April since the Great Depression. www.wsj.com/finance/inve...

Good job team America www.nbcnews.com/news/us-news...

The euro and every other major currency is surging against the dollar

A Lancet preprint estimates that if US funding is cut and not replaced, from 2025-2040 there will be 15.2 mil add'l AIDS deaths, 2.2 mil add'l TB deaths, 7.9 mil add'l child deaths from other causes, and 40-55 mil add'l unplanned pregnancies. @altusaid.altgov.info papers.ssrn.com/sol3/papers....

A host-pathogen metabolic synchrony that facilitates disease tolerance @natcomms.nature.com @sebariquelme.bsky.social www.nature.com/articles/s41...

Targeting CD38 immunometabolic checkpoint improves metabolic fitness and cognition in a mouse model of #Alzheimer’s disease @natcomms.nature.com www.nature.com/articles/s41...

An organ-wide spatiotemporal transcriptomic and cellular atlas of the regenerating zebrafish heart www.nature.com/articles/s41...

We have and will continue to fail America's youth until we can get serious about gun control.

Phosphoproteomics Uncovers Exercise Intensity-Specific Skeletal Muscle Signaling Networks Underlying High-Intensity Interval Training in Healthy Male Participants link.springer.com/article/10.1...

genomebiology.biomedcentral.com/articles/10.... Quite an indictment of some of the current single cell "virtual cell" foundation models. Even for the relatively mundane applications, cell labeling, batch correction etc, they are poor compared to much simpler & cheaper methods.

Thanks for @laura-babcock.bsky.social taking up this issue. I write about Poilievre's plan to suspend laws protecting the rights of people before the courts. He boasts he will target universities and deport students. This is the MAGA/FASCIST playbook. charlieangus.substack.com/p/book-burne...

Just spoke with my CDC sources. They were in tears. Budgets cut. RFJK has ordered them not to publicize bird flu symptoms in exposed workers. Not to test them. Not to speak. They know people are getting sick. And they’re being forced to stay silent. This is not just a cover-up. It's cruelty.

"Weaponized oversight. Intimidation dressed up as transparency" <- Something to watch for in the scholarly communications space.

The BC-subset of polls are consistently showing the NDP around 12-17% of the vote in this province. In 2021, the NDP got 29% of the vote in B.C. So if NDP candidates lose half their vote in every riding in B.C., even a candidate like Davies that historically averages 50% of the vote is in trouble