jimjohnsonsci.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

Have you already checked out our #EISG2025 program? Fresh off the press! Download it here: eisg2025.se/scientific_p...

submitted 16 days ago • 0 comments

Professor Charlotte Ling, from the #eisg2025 steering committee, introduces this year’s European Islet Study Group event in Malmö, Sweden. Lund University Diabetes Centre is the host of this year's meeting, and we are happy to see that over 250 researchers have registered for the meeting 👏

submitted 3 days ago • 0 comments

Estrogen-related receptor alpha promotes skeletal muscle regeneration and mitigates muscular dystrophy www.biorxiv.org/content/10.1...

submitted 8 days ago • 0 comments

AKT-mediated phosphorylation of TSC2 controls stimulus- and tissue-specific mTORC1 signaling and organ growth www.sciencedirect.com/science/arti...

submitted 8 days ago • 0 comments

nice paper by a large team led by @paulwfranks.bsky.social showing in humans what we showed in mice - reducing insulin production completely prevents liver fat accumulation www.cell.com/cell-metabol.... Insulin hypersecretion causes fatty liver in the IMI cohort. www.medrxiv.org/content/10.1...

submitted 8 days ago • 0 comments

New data on #BCAA metabolism in #T2D: although exercise has an insulin-sensitising effect, this does not appear to occur in tandem with improved BCAA clearance #DiabetesResearch #Endocrinology #MedSky

submitted 9 days ago • 0 comments

Earth will warm 1.5 degrees Celsius above preindustrial levels in just two years, new data shows. Irreversible tipping points — like the melting of Arctic ice sheets or the collapse of coral reefs — are closer at hand than previously believed.

submitted 10 days ago • 408 comments

VCHRI research summit day.

submitted 12 days ago • 0 comments

90% of doing science is being open to new ideas.

submitted 14 days ago • 2 comments

Latent EBV enhances the efficacy of anti-CD3 mAb in Type 1 diabetes @natcomms.nature.com www.nature.com/articles/s41...

submitted 15 days ago • 0 comments

Musk should be asked about this in every interview he does now and forever. To ignore it is a dereliction of duty. www.nytimes.com/2025/05/30/o...

submitted 15 days ago • 1300 comments

Microbiome metabolism of dietary phytochemicals controls the anticancer activity of PI3K inhibitors www.cell.com/cell/fulltex... @cellcellpress.bsky.social @asaelroichman.bsky.social

submitted 26 days ago • 1 comment

Excellent point

submitted 27 days ago • 0 comments

Going with a local hero: Southern Resident Killer Whale! Only about 70 of them left in the Pacific Northwest, mainly due to their preferred diet being Chinook salmon. Pollution (including noise), are also factors. They are culturally iconic, and spiritually important to PNW Indigenous peoples.

submitted 29 days ago • 2 comments

Glad to report that this tour de force from our collaborator Caroline Alexander (with a bit of assistance from our lab in the form of Michaela Trautman) is now out: "Dietary lipids are largely deposited in skin and rapidly affect insulating properties" www.nature.com/articles/s41...

submitted 29 days ago • 0 comments

Long-term cytokine exposure of human islet micro tissues created a type 1 diabetes-like phenotype with impaired low-glucose-induced glucagon secretion, with attenuation by GIP @diabetologiajnl.bsky.social link.springer.com/article/10.1...

submitted 29 days ago • 0 comments

Role of the translation factor EIF2A in protecting #BetaCells during #ERStress #DiabetesResearch #Isets #MedSky @jimjohnsonsci.bsky.social @bruceverchere.bsky.social

submitted 33 days ago • 0 comments

New study on novel translation factor EIF2A led by Panzhinskiy as a collaboration between @jimjohnsonsci.bsky.social lab, Jan lab & @bruceverchere.bsky.social lab UBC Life Sciences Institute. Thanks Breakthrough T1D Canada for funding this project #DiabetesResearch link.springer.com/article/10.1...

submitted 37 days ago • 0 comments

Light and sex modify Snord116 genotype effects on metabolism, behavior, and imprinted gene networks following circadian entrainment https://www.biorxiv.org/content/10.1101/2025.05.01.651733v1

submitted 38 days ago • 0 comments

"The turbines spew NOx at an estimated rate of 1,200 to 2,000 tons a year — far more than the gas-fired power plant across the street or the oil refinery down the road." I don't see how ppl rationalize any use for AI when the costs so clearly outweigh the benefits. It's a health-destroying machine.

submitted 44 days ago • 1 comment

Data centers are the new sacrifice zones

submitted 44 days ago • 7 comments

Analysis of increased platelet activation in people with #T1D @diabetologiajnl.bsky.social link.springer.com/article/10.1...

submitted 44 days ago • 0 comments

EIF2A is a novel target for beta cell protection and the circumvention of EIF2S1-mediated translational repression #islets #diabetes @jimjohnsonsci.bsky.social @diabetologiajnl.bsky.social link.springer.com/article/10.1...

submitted 44 days ago • 0 comments

It’s my pleasure to speak (twice) at the Australian Islet Study Group meeting in beautiful Adelaide. Great science and company :)

submitted 44 days ago • 0 comments

Intracellular metabolic gradients dictate dependence on exogenous pyruvate www.nature.com/articles/s42... Congrats to @lydiafinley.bsky.social Lab!

submitted 47 days ago • 1 comment

This is a must read article on Poilievre and Trump. bruce728.substack.com/p/trump-show...

submitted 48 days ago • 44 comments

WSJ: No confidence. Worst April since the Great Depression. www.wsj.com/finance/inve...

submitted 54 days ago • 47 comments

Good job team America www.nbcnews.com/news/us-news...

submitted 54 days ago • 227 comments

The euro and every other major currency is surging against the dollar

submitted 54 days ago • 115 comments

A Lancet preprint estimates that if US funding is cut and not replaced, from 2025-2040 there will be 15.2 mil add'l AIDS deaths, 2.2 mil add'l TB deaths, 7.9 mil add'l child deaths from other causes, and 40-55 mil add'l unplanned pregnancies. @altusaid.altgov.info papers.ssrn.com/sol3/papers....

submitted 54 days ago • 33 comments

A host-pathogen metabolic synchrony that facilitates disease tolerance @natcomms.nature.com @sebariquelme.bsky.social www.nature.com/articles/s41...

submitted 55 days ago • 1 comment

Targeting CD38 immunometabolic checkpoint improves metabolic fitness and cognition in a mouse model of #Alzheimer’s disease @natcomms.nature.com www.nature.com/articles/s41...

submitted 55 days ago • 1 comment

An organ-wide spatiotemporal transcriptomic and cellular atlas of the regenerating zebrafish heart www.nature.com/articles/s41...

submitted 54 days ago • 0 comments

We have and will continue to fail America's youth until we can get serious about gun control.

submitted 54 days ago • 85 comments

Phosphoproteomics Uncovers Exercise Intensity-Specific Skeletal Muscle Signaling Networks Underlying High-Intensity Interval Training in Healthy Male Participants link.springer.com/article/10.1...

submitted 54 days ago • 0 comments

genomebiology.biomedcentral.com/articles/10.... Quite an indictment of some of the current single cell "virtual cell" foundation models. Even for the relatively mundane applications, cell labeling, batch correction etc, they are poor compared to much simpler & cheaper methods.

submitted 55 days ago • 6 comments

Thanks for @laura-babcock.bsky.social taking up this issue. I write about Poilievre's plan to suspend laws protecting the rights of people before the courts. He boasts he will target universities and deport students. This is the MAGA/FASCIST playbook. charlieangus.substack.com/p/book-burne...

submitted 56 days ago • 18 comments

Just spoke with my CDC sources. They were in tears. Budgets cut. RFJK has ordered them not to publicize bird flu symptoms in exposed workers. Not to test them. Not to speak. They know people are getting sick. And they’re being forced to stay silent. This is not just a cover-up. It's cruelty.

submitted 56 days ago • 409 comments

"Weaponized oversight. Intimidation dressed up as transparency" <- Something to watch for in the scholarly communications space.

submitted 56 days ago • 2 comments

The BC-subset of polls are consistently showing the NDP around 12-17% of the vote in this province. In 2021, the NDP got 29% of the vote in B.C. So if NDP candidates lose half their vote in every riding in B.C., even a candidate like Davies that historically averages 50% of the vote is in trouble

submitted 56 days ago • 10 comments