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jitendrakmeena.bsky.social
Studying RNA degradation mechanisms, ribonucleotide homeostasis, their role in human diseases, and investigating therapeutic strategies to target these processes.
8 posts 26 followers 226 following
Getting Started
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Check out our new & improved V2 manuscript for RiboNN, with new analyses to further sharpen the results!! www.biorxiv.org/content/10.1...

submitted 37 days ago • 0 comments

mRNA 5'UTR functions, large scale, and feature detection to predict effect on translation - IN VIVO 🔥 awesome work from the awesome Madalena Reimão-Pinto & Alex Schier and colleagues 👏 MPRAs in multicellular organisms translation specificity 🤝 cell type specificity www.cell.com/developmenta...

submitted 42 days ago • 0 comments

#1 Happy to share our last work published in @NatureCellBio about a new cell cycle checkpoint that senses nuclear shape & mechanics to guarantee genome integrity www.nature.com/articles/s41.... Great work from @sol-herve.bsky.social & Andrea Scelfo in close collaboration with @katemiro.bsky.social

submitted 49 days ago • 10 comments

How do 250k regulatory sequences coordinate 15k genes in mammalian development? Just out: A genomic evidence board to decode the chaos by mapping enhancer-gene interactions across embryonic mouse tissues New resource with Miao Yu, Ming Hu, Bing Ren, and more. www.nature.com/articles/s41...

submitted 71 days ago • 1 comment

My first first-author paper was published this morning! Did you know eye lenses grow in layers throughout life and can be analyzed to study movement and foraging ecology. But eye lenses differ in bio molecular composition across fish taxa, especially for sharks! 🧪🌎🦑 link.springer.com/article/10.1...

submitted 71 days ago • 12 comments

"We report that numerous “miRNAs” previously reported in EMT and cancer contexts are not incorporated into RISC and are not capable of endogenously silencing target genes, despite the fact that hundreds of publications in the cancer field describe their roles" www.biorxiv.org/content/10.1...

submitted 76 days ago • 5 comments

🧪 #RNASky #RNABiology Our paper is now on bioRxiv. A short thread. This is the work of 2 former students (& me) - Sandipan dasgupta and Anand Ravi The whole project originated more than a decade ago during my postdoc days. I found that mRNAs can transfer between mammalian cells, not by exosomes>>

submitted 111 days ago • 6 comments

What are the consequences of excessive RNA production? We found that MYC hyper activation that increases RNA synthesis, also accelerates RNA decay, resulting in a new type of oncogenic stress- RNA catabolic stress. Happy to share this work was featured on the cover. aacrjournals.org/cancerdiscov...

submitted 105 days ago • 1 comment