jrichardalbert.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

Delighted to share our latest work deciphering the landscape of chromatin accessibility and modeling the DNA sequence syntax rules underlying gene regulation during human fetal development! www.biorxiv.org/content/10.1... Read on for more: 🧵 1/16 #GeneReg 🧬🖥️

submitted 12 days ago • 2 comments

In this study, Hermant et al. describe the evolution of the retrotransposon MERVL and its cis-regulatory transcription factor binding motifs, highlighting the phyloregulatory adaptation at play during early embryogenesis. Learn more here: ➡️ tinyurl.com/gd352270

submitted 22 days ago • 0 comments

Australia is populated with marsupial equivalents of placental mammals, but this might be the cutest: the honey possum or noolbenger (Tarsipes rostratus), found only in southwest Australia. They're pollen and nectar-eating, with prehensile tails (📷: Simon Colenutt, iNaturalist)

submitted 90 days ago • 2 comments

New preprint from the @arnausebe.bsky.social lab! 💐 Here @crisnava.bsky.social, @seanamontgomery.bsky.social & collaborators develop a novel ChIPseq protocol, and demonstrate its huge potential to study the evolution of chromatin function and regulation across the eukaryotic tree of life.

submitted 57 days ago • 3 comments

🚨New preprint from @bonevlab.bsky.social 🚨: What are the key epigenetic mechanisms that drive species-specific gene regulation during primate neurogenesis - and how do they contribute to the evolution of the human neocortex? Here’s what we discovered 👇 www.biorxiv.org/content/10.1...

submitted 63 days ago • 3 comments

We are featuring Amanda Haage as an extraordinary biologist this week. Amanda was the first to post on @prelights.bsky.social and is a Kaess Endowed Professor of Anatomy & Cell Biology at the University of North Dakota, USA. #100biologists

submitted 58 days ago • 1 comment

Important work unraveling how restoring DNA methylation loss affects cellular differentiation, transposon restriction and genomic imprinting (!!!) in mouse. Congrats to all the authors!

submitted 64 days ago • 1 comment

Feeling extremely grateful for this transition of bioRxiv into an independent nonprofit. The tonic to predatory, smash & grab journals. www.cshl.edu/the-natural-...

submitted 64 days ago • 0 comments

Big news: we are setting up a new non-profit organization to run bioRxiv and medRxiv. It's called openRxiv [no it's not a new preprint server; it's dedicated organization to oversee the servers] openrxiv.org 1/n

submitted 65 days ago • 55 comments

Help 🚨 science Bluesky. We'd like an #GFP/#FluorescentProtein construct with an intron in the middle of the coding sequence for an experiment (not before the coding sequence). Does anyone know of anything that fits? We haven't turned up anything suitable from a quick search so far. Please repost 🙏

submitted 65 days ago • 1 comment

The realignment of research in our group @fmiscience.bsky.social is beginning to bear fruit. Proud of our captain @merleskribbe.bsky.social and the whole team! www.sciencedirect.com/science/arti...

submitted 77 days ago • 0 comments

Paper out !!🥳big thanks to all authors @marliesoomen.bsky.social @diego-rt.bsky.social @kaessmannlab.bsky.social @jonathangoeke.bsky.social @lorenzamottes.bsky.social & 'bluesky-less' Lots of interesting new TE (& genes) biology Data fully browsable💻 👉 embryo.helmholtz-munich.de/shiny_embryo/

submitted 83 days ago • 8 comments

A vaccine skeptic was just elected Health Secretary of the USA. Reminds me of when the Largest Man in Quebec was elected Health Minister and fucked our entire health care system. But much worse.

submitted 90 days ago • 0 comments

💥The @elife.bsky.social special issue on #ReproductiveHealth just dropped💥 It includes our story (soon to be updated) about the erosion of sperm/testis genes in gorillas coincident with the #Evolution of a polygamous mating system #RepoductiveBiology 🧪 💻🧬 elifesciences.org/collections/...

submitted 104 days ago • 0 comments

NEW PAPER ALERT! In this paper that was posted today on @biorxivpreprint.bsky.social, Felix Simon from our lab at @ijmonod.bsky.social (with important contributions by Isabel Holguera and a small contribution from yours truly) completed the trifecta. www.biorxiv.org/content/10.1...

submitted 106 days ago • 1 comment

Our #Paramecium artwork is featured on the cover of #NAR! doi.org/10.1093/nar/...

submitted 122 days ago • 1 comment

At 17 I thought this was the coolest thing ever. 17 years later: it still is!! CRISPR and RNA vaccines are neat and all but... www.youtube.com/watch?v=B38C...

submitted 130 days ago • 0 comments

Discover the wonders of 𝘗𝘦𝘳𝘬𝘪𝘯𝘴𝘶𝘴 🤩 This parasitic protist undergoes rapid #CellDivision : from a single sporangium to hundreds of motile zoospores. A stunning glimpse into the speed and precision of microbial life! 🌊🔬 Stay tuned for more 𝘗𝘦𝘳𝘬𝘪𝘯𝘴𝘶𝘴 insights! #CellBiology #ProtistsOnSky

submitted 133 days ago • 2 comments

🔬Decoding Silencing: How Heterochromatin Transcribes to Silence Itself! 🧬 Discover how a pioneer transcription factor-like complex infiltrates repressive heterochromatin, producing transcripts with hidden introns that kickstart RNAi-mediated heterochromatin formation www.nature.com/articles/s41...

submitted 132 days ago • 1 comment

Centrophilic retrotransposon integration via CENH3 chromatin in Arabidopsis from Tetsuji Kakutani & colleagues - beautiful insights into control of transposon insertion into the centromeres www.nature.com/articles/s41...

submitted 133 days ago • 2 comments

Thanks @cnrs.bsky.social for highlighting our recent work on "la méthylation de l'ADN" 🤗 (in French) @ijmonod.bsky.social www.insb.cnrs.fr/fr/cnrsinfo/...

submitted 150 days ago • 0 comments

After a year of extra work and edits with @joncahn.bsky.social, I am overjoyed to share the final version of our work: Characterization of DNA methylation reader proteins of Arabidopsis thaliana Published in Genome Research @genomeresearch.bsky.social genome.cshlp.org/content/earl...

submitted 157 days ago • 1 comment

After 60 years, scientists finally know why ginger, calico, and tortoiseshell #cats look the way they do. scim.ag/3BpxRxY

submitted 162 days ago • 7 comments

Following up on Nat. Commun. 2018, we analyzed the relationship between TE transcription and expression levels of genes involved in TE silencing in somatic and germline tissues across vertebrates. doi.org/10.1093/gbe/...

submitted 159 days ago • 1 comment

Happy to see our research on SMC Wadjet published in Molecular Cell. We showed DNA loop extrusion (LE) by a bacterial SMC, confirming LE is conserved across all life forms. Wadjet's LE activity is crucial for recognizing and restricting foreign plasmids, serving as a defense mechanism. 🧬🔬🧪

submitted 164 days ago • 5 comments

I feel like I'm onto something

submitted 168 days ago • 1 comment

Very excited that our paper describing a critical role for the PNUTS-PP1 phosphatase complex in transcription pause release is up online! This was a massive team effort with @edimitrova.bsky.social and the rest of the @robklose.bsky.social lab www.cell.com/molecular-ce... A short thread: (1/8)

submitted 170 days ago • 2 comments

📢 Preprint! How does the environment of a father before conception influence offspring? Even more, how do paternal genetics & ages interact with exposures to affect F1 outcome? We tested this systematically, with intriguing findings & some cautionary tales🧵... www.biorxiv.org/content/10.1...

submitted 170 days ago • 12 comments

Cursed protein 🫣

submitted 170 days ago • 0 comments

For my first post here, I am happy to share that our latest paper is out at #NAR. Thanks for the smooth and constructive reviewing process and the highlight #RNAbiology #TEsky #smallRNAs (1/8) doi.org/10.1093/nar/...

submitted 171 days ago • 6 comments

Another go-to graph for "AHA!" moments: phylogenetic trees. This @embl.org hosted interactive tree viz tool is intuitive and so so so customizable.

submitted 172 days ago • 1 comment