Profile avatar
kaipohl.bsky.social
Postdoc in translational vaccine research @Charité - University Medical Center, Berlin. PhD from JCSMR @ANU, Canberra. Interested in Innate immunity and T cells. Mostly here for science and some politics.
3 posts 378 followers 328 following
Getting Started
Posts 7 Comments 2

The strain on scientific publishing: we set out to characterise the remarkable growth of the scientific literature in the last few years, in spite of declining growth in total scientists. What is going on? direct.mit.edu/qss/article/... A 🧵 1/n #AcademicSky #PhDchat #ScientificPublishing #SciPub

submitted 99 days ago • 48 comments

🤯

submitted 76 days ago • 0 comments

Did you know that Germany has its own large-scale population-based biobank? The German National Cohort or NAKO❗ If not, let me tell you why👇

submitted 86 days ago • 4 comments

To get the ball rolling here on Bsky I'll post this recent preprint that I never posted on X because... you know... ick. We find that B cells take bites out of parasites to obtain antigens for presentation to T cells. www.biorxiv.org/content/10.1...

submitted 96 days ago • 1 comment

My first Skeetorial! 💻🧬TCR-TRANSLATE - A new framework for thinking about the TCR:pMHC specificity problem. TLDR: We pretrained LLMs on ~8M TCR & pMHC seqs Finetuned on sparse pMHC->TCR pair data Validated CDR3b sequences to unseen antigens >> random performance on IMMREP2023 "private" antigens

submitted 98 days ago • 1 comment

Here is out first attempt to understand #TCR #repertoire in human tissues -Tissue determinants of the human T cell receptor repertoire Around 6 million T cells profiled at #single #cell #level www.biorxiv.org/content/10.1...

submitted 103 days ago • 1 comment

LLMs are fantastic learners of arbitrary sequence to sequence mappings. Text summarization, Q&A, and machine translation, etc. So what happens if you apply them to the many-to-many mapping of the TCR cross reactivity landscape? Turns out, some pretty cool things. Check it out 😏

submitted 105 days ago • 0 comments