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krhornberger.bsky.social
med chem @ Arvinas | PhD @ Columbia | hiker | cocktail enthusiast | he/him/huz/dad | dreaming of Sedona | while I have a connection to Arvinas, all opinions expressed are my own and do not represent the views, opinions, or positions of the company
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McKinley’s Delight 2 oz rye 1 oz sweet vermouth 1 barspoon cherry Heering 1 dash absinthe lemon twist

submitted 5 days ago • 1 comment

Really enjoying Alessio Ciulli’s talk at #AACR25 this afternoon

submitted 8 days ago • 1 comment

Undisclosed location

submitted 9 days ago • 1 comment

One of my favorite things about conferences is connecting with colleagues and friends from across the years — here’s a smattering of connections from this week #AACR25

submitted 9 days ago • 4 comments

Next up at #AACR25 New Drugs on the Horizon, AZ just unveiled their KRAS-G12D inhibitor

submitted 9 days ago • 0 comments

The last New Drugs on the Horizon session is underway at #AACR25. GSK & Ideaya just dropped the structure of their WRN helicase inhibitor

submitted 9 days ago • 0 comments

Spotted in the #AACR25 exhibit hall “Excuse me, sir, where is your badge?” 🐦

submitted 10 days ago • 1 comment

New KRAS-G12V inhibitor RMC-5127 from Revolution Medicines next up at #AACR25 New Drugs on the Horizon

submitted 10 days ago • 5 comments

New Helios degrader from BMS at #AACR25 New Drugs on the Horizon

submitted 10 days ago • 1 comment

New dual-targeting (PSMA & STEAP1) ADC from AbbVie just unveiled at #AACR25 New Drugs on the Horizon

submitted 10 days ago • 0 comments

New Drugs on the Horizon is underway at #AACR25. Brian Lanman from Amgen kicks it off with a new pan-KRAS inhibitor

submitted 10 days ago • 1 comment

A couple of snippets from the #AACR25 educational sessions today: some perhaps counterintuitive ADC insights from Greg Thurber and Raffaele Colombo, new roads into Myc from the Moellering lab, and the latest from the Nomura lab. Great first day!

submitted 11 days ago • 1 comment

The walking… it begins

submitted 11 days ago • 1 comment

Let’s goooo I’m in the air and on my way to Chicago for #AACR25 Roll call: who’s going?

submitted 12 days ago • 0 comments

Probing the E3 Ligase Adapter Cereblon with Chemical Biology

submitted 13 days ago • 0 comments

We’re just a few days out from the start of #AACR25 - a big conference highlight of the year for me. As usual, the centerpiece for the chemists will be the New Drugs on the Horizon sessions, with an exciting lineup of first-time clinical candidate disclosures. Check it out, and see you in Chicago!

submitted 15 days ago • 0 comments

Deubiquitinase-Targeting Chimeras (DUBTACs) as a Potential Paradigm-Shifting Drug Discovery Approach

submitted 16 days ago • 0 comments

Discovery of a VHL molecular glue degrader of GEMIN3 by Picowell RNA-seq

submitted 17 days ago • 0 comments

Spring break trip is in the bag. Most important stop was on the way home, now enjoying on the deck since it’s our first decent day of the year

submitted 18 days ago • 0 comments

Boston/Cambridge friends get a bonus point if they know where I took this from

submitted 18 days ago • 4 comments

Diversity Synthesis Using Glutarimides as Rhodium Carbene Precursors in Enantioselective C–H Functionalization and Cyclopropanation

submitted 22 days ago • 0 comments

Discovery of a Series of Covalent Ligands That Bind to Cys77 of the Von Hippel–Lindau Tumor Suppressor Protein (VHL)

submitted 24 days ago • 0 comments

Good morning from my backyard in Connecticut, where it’s currently Saturday, February 72nd

submitted 26 days ago • 0 comments

Identification of a non-inhibitory aptameric ligand to CRL2ZYG11B E3 ligase for targeted protein degradation

submitted 27 days ago • 0 comments

This closing of the talent spigot will reverberate for years to come - so disheartening all around

submitted 28 days ago • 0 comments

Linker-Determined Folding and Hydrophobic Interactions Explain a Major Difference in PROTAC Cell Permeability

submitted 28 days ago • 1 comment

One of these days, I’m going to do some forensics and find patient zero for the inclusion of “importantly” in scientific manuscripts. It’s like an endemic disease today. I guarantee we’re gonna find one or a few founder labs that had PIs full of themselves somewhere in the musty past.

submitted 33 days ago • 1 comment

Size-Dependent Target Engagement of Covalent Probes

submitted 34 days ago • 1 comment