lcpilling.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

New paper from my team describing a new prognostic tool in prostate cancer! doi.org/10.1002/1878...

submitted 6 days ago • 0 comments

A great opportunity to join us in Exeter as a Lecturer in Health Data Science: tinyurl.com/2sy7w2y5. Please get in touch if you're interested!

submitted 19 days ago • 0 comments

So frustrating to still need separate login details for each journal in "Manuscript Central"... How has this not been streamlined yet? I end up resetting my password and (re)entering my details every time

submitted 19 days ago • 0 comments

The first major output from the MRC funded GEMINI sites.exeter.ac.uk/gemini/Multi... consortium. We bring together genetic and primary care data from multiple sources to compare 2546 pairs of traits based on 72 long term chronic heritable conditions: www.sciencedirect.com/science/arti...

submitted 20 days ago • 1 comment

Another day, another review for a superficial two-sample MR paper. These are wasiting an enormous amount of editor/review time. I rarely accept unless within my (very specific) area of special interest. The two below commentaries are timely and worth a read (by authors and editors alike!)

submitted 23 days ago • 1 comment

submitted 26 days ago • 0 comments

Next week the DEMON biomarkers working group are hosting Dr Sofia Toniolo who will be talking about the opportunities and pitfalls from digital and plasma biomarkers in Alzheimer’s Disease. 📅 Thursday 6th Feb 10am GMT. All welcome - PM for details.

submitted 27 days ago • 0 comments

Added functions for quick genetic analysis in UK Biobank RAP R package {ukbrapR} v0.3.0 - extract_variants() to pull Bulk genotypes straight into R (imputed or WGS) - create_pgs() to create a polygenic score (pull Bulk genotypes, create score, and load straight into R) github.com/lcpilling/uk...

submitted 27 days ago • 1 comment

Quick way to get extreme p-values in R is to return them as strings! log_pvalue = log(2) + pnorm(abs(z),lower.tail=FALSE,log.p=TRUE) log10_pvalue = log_pvalue/log(10) ## from LN to log10 mantissa = 10^(log10_pvalue %% 1) exponent = log10_pvalue %/% 1 sprintf("%1.2fe%d",mantissa,exponent)

submitted 36 days ago • 2 comments

🚨PLEASE SHARE: Senior reseach post: come and work at the IEU with Gib Hemani and @mendelrandom.bsky.social on Mendelian randomization, become my co-worker :) – research posts with closing date 5th February 2025.

submitted 44 days ago • 0 comments

Minor-ish update to {ukbrapR} to v0.2.9 to fix 2 bugs and improve behaviour of some internal functions github.com/lcpilling/uk...

submitted 44 days ago • 0 comments

My blood 🩸 made it all the way to University Hospital, Birmingham where it helped to save or improve someone's life Love getting these e-mails. Consider signing up to donate blood, if you don't already www.blood.co.uk @givebloodnhs.bsky.social

submitted 48 days ago • 0 comments

On submitting papers in December ☃️ Two schools of thought: 1) submit it before going on leave, to have it off your desk 2) no-one will review it before January anyway, so might as well wait What do you reckon?

submitted 71 days ago • 2 comments

jobs.exeter.ac.uk/hrpr_webrecr... Interested in data management? Want a permanent position working in beautiful Devon and work collaboratively to support the work of lots of genomics team? Apply!!

submitted 71 days ago • 0 comments

Great talk on how ChatGPT x Mendelian randomisation (but really any open data) leads to mass scientific production void of thought. It's not a new phenomena, this happened to art. I just reread: "The Work of Art in the Age of Mechanical Reproduction" which is absolutely prescient wrt us now.

submitted 72 days ago • 1 comment

Daniel Williamson at the UK Biobank scientific conference explaining his study of MRI-estimed cortical brain iron and incident dementia risk @ukbiobank.bsky.social #UKBSC24

submitted 78 days ago • 0 comments

So much anticipation for this session at the UK Biobank scientific conference tomorrow #UKBSC24 If any of you are going, reach out: let's meet and chat! @ukbiobank.bsky.social #AcademicSky

submitted 79 days ago • 1 comment

🌟Post-doc available in Exeter with the superb @janemasoli.bsky.social researching cardiovascular ageing using health data science approaches This is part of a wider NIHR-funded project studying cardiovascular frailty in routine health data Join us! 🤩

submitted 84 days ago • 0 comments

So many awesome tools for complex trait genetics! 🧬 Great idea @michelnivard.bsky.social to create a repository listing them. I am learning about new ones every day at the moment, as people add to the repo Add yours! 🤩 github.com/MichelNivard...

submitted 85 days ago • 0 comments

It's not my favourite bias (what, you don't have a favourite bias?) but collider bias is important and for some reason harder to wrap your head around than other bias' #stats #epidemiology #bias #academicsky

submitted 90 days ago • 2 comments

The historic distinction between diseases impacted by common vs. rare variants is increasingly shown to not always apply Love this study on how common genetic variants modify neurodevelopmental disease risk, differentiating direct effects (transmitted to offspring) and indirect effects (on parents)

submitted 96 days ago • 0 comments

To my new followers, hello! Nice to meet you 👋 I have a few niche #Rstats packages 📦 you may find useful 😄 Short thread 🧵 lcpilling.github.io

submitted 96 days ago • 1 comment

So excited to have #AcademicSky and #ScienceSky But I don't think I will ever bring myself to say 'skeet' ... I will only ever 'post' on here I think 😂

submitted 97 days ago • 0 comments

🚨NEW PREPRINT! Interested in Mendelian randomization and proteomics? 🧬 We created a comprehensive multi-ancestry proteome-phenome-wide atlas of protein-disease associations in European, African, and East Asian ancestries! Preprint: www.medrxiv.org/content/10.1... Website: broad.io/protein_mr_a...

submitted 99 days ago • 1 comment

I reviewed a paper yesterday and it was brilliant! Such a pleasure to be able to write a really positive review, highlighting the bits I liked most There were a couple of minor things to clear up but honestly it made my day #AcademicSky

submitted 102 days ago • 0 comments

So happy that "it" is happening... it's like everyone is reconvening after the summer Academic twitter is dead ... long live #AcademicSky!

submitted 102 days ago • 0 comments

PhD opportunity with myself, Jane Masoli and Jack Bowden Aim is to study how cardiovascular genetic risks vary with age to improve mechanistic understanding and clinical risk prediction Funded for 3.5 years - deadline 3-Dec Please share with recent MSc students! www.exeter.ac.uk/study/fundin...

submitted 103 days ago • 0 comments

Really enjoying the biological science sessions at #GSA2024 - room 4C-3 is where it is at! Current fascinating talk is by Patricia Opresko on how oxidative damage to #telomeres promotes #senescence

submitted 103 days ago • 0 comments

Stimulating first day at #GSA2024 - I especially enjoyed back-to-back geroscience and 'drug repurposing for ageing' sessions Looking forward to catch up with old friends and meeting new collaborators. Reach out if you are here in #Seattle and want to connect

submitted 104 days ago • 0 comments

Happy grant rejection Friday to those of you who observe it #AcademicChatter #AcademicTwitter

submitted 138 days ago • 1 comment