leokiss.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

Such a fun collaboration with @michaelnadbio.bsky.social! Check out the latest form of #ubiquitin modification- MARUbylation!

submitted 1 day ago • 2 comments

I'm super excited to share our study in collaboration with @jnpruneda.bsky.social, published today in @embojournal.org! We show that PARPs are modified with a non-canonical ester-linked mono-ADP-ribosylated ubiquitin species for the first time in cells: www.embopress.org/doi/full/10....

submitted 1 day ago • 4 comments

sequencing.roche.com/global/en/ar... Really cool stuff by Roche! Sequencing by Expansion Nanopore Sequencing! www.biorxiv.org/content/10.1...

submitted 1 day ago • 0 comments

Open #positions‼️ I am looking for: 📌2 Postdocs 📌 1 Research Assistant to join our new research group at the University of Milan. We’ll study #RSV viral replication factories and pioneer new protein degradation technologies #TPD as #antiviral strategies. If interested, drop me a message here 📩 🦠 RT

submitted 7 days ago • 0 comments

Congratulations to Arno Alpi and Peter Murray for the FEBS Letters Award 2025. 🎉 ❕ Further information: febs.onlinelibrary.wiley.com/hub/journal/... ❕ Award-winning publication: febs.onlinelibrary.wiley.com/doi/10.1002/...

submitted 8 days ago • 0 comments

Today in @nature.com we share our back-to-back stories with Ning Zheng’s lab revealing chemical-genetic convergence between a molecular glue degrader & E3 ligase cancer mutations. 1/5

submitted 14 days ago • 5 comments

🎉 Thrilled to announce that after 5 years in Cambridge, I’m returning to Italy to start my own lab at the University of #Milan!🇮🇹 Funded by the Italian Science Fund, we’ll study viral replication factories for new antiviral strategies🦠🧬🔬 Postdoc positions openings soon🌟 Want to join? Get in touch! 📩

submitted 22 days ago • 2 comments

Soooo excited to share this, just published. www.nature.com/articles/s41.... It started as a crazy ‘Friday afternoon’ experiment and just… worked. And kept on working. We fused a #nanobody to a #thioesterase. This delivers the thioesterase to a target and specifically depalmitoylates this protein

submitted 19 days ago • 2 comments

Happy to see that our Cell wall integrity #CWI & #ATG8ylation #preprint found a home @natureplants www.nature.com/articles/s41... Congrats Jose, Peng, Alessia & everyone involved. Stay tuned for exciting updates on this story…

submitted 19 days ago • 8 comments

Fantastic job opportunities with an outstanding virologist in Milan! Highly recommended!!!

submitted 22 days ago • 0 comments

🎉Super excited to share our story on how the substrate receptor FBXO31 functions as a quality control factor by recognizing amides. This has been an amazing collaboration between Bode lab and @jcornlab.bsky.social. Special shutout goes to @matthiasmuhar.bsky.social www.nature.com/articles/s41...

submitted 28 days ago • 3 comments

Cells are filled with toxic stuff that damages healthy proteins. Is that garbage just left to rot on the curb? No way! Ubiquitin ligases have evolved to recognize chemical damage and clean it up! www.nature.com/articles/s41...

submitted 27 days ago • 2 comments

Super exiting new work revealing a novel quality control pathway for c-terminal amides!

submitted 28 days ago • 0 comments

Happy to share the first preprint from my lab by @indrabekere.bsky.social and Veronika Merold! We solved the cryo-EM structure of the RNA immune sensor OAS2 and revealed how dimerization and subcellular localization regulate its activity! Check out Indra’s thread for a summary:

submitted 28 days ago • 1 comment

From Dorothea Fiedler's lab: Protein polyphosphorylation as a new post-translational modification www.biorxiv.org/content/10.1...

submitted 34 days ago • 0 comments

🆕 #preprint by @gekaragoz.bsky.social lab & us on the crosstalk between #UFMylation & #RQC (ribosome-associated quality control) www.biorxiv.org/content/10.1... As always let us know what you think!

submitted 37 days ago • 0 comments

In a great collaboration with @hummerlab.bsky.social and the Kräusslich lab: HIV capsid doesn't break at the NPC; instead, it cracks open the NPC itself! Details in Cell: authors.elsevier.com/sd/article/S... @mpibp.bsky.social @uniheidelberg.bsky.social A thread below:

submitted 40 days ago • 7 comments

By my reckoning, yesterday marked the 50th anniversary of ubiquitin's discovery! 🎈🎉🎁🥂 www.pnas.org/doi/10.1073/...

submitted 41 days ago • 0 comments

🎄 xmas preprint 🎄 we are excited to share our cryo-EM structure of UBR4 in complex with KCMF1 and CALM1. the PQC ligase forms a massive ubiquitination arena, primed to amplify ubiquitin chains (E4 activity) and boost degradation of defective proteins. www.biorxiv.org/content/10.1...

submitted 67 days ago • 4 comments

Starter pack here for protein modifications! All PTMs, enzymes, biochemistry, protein fate and function, cell signaling +++ go.bsky.app/HqEcaCw

submitted 76 days ago • 9 comments

The first paper from our lab is online! A wonderful collaboration with @scottbscience.bsky.social lab. We discover that Pol II is extensively regulated by Ubiquitin at the beginning of the transcription cycle! www.cell.com/molecular-ce...

submitted 77 days ago • 7 comments

New week, updated starter pack. Now with 81 profiles to follow if you are interested in anything #ubiquitin or #Ubl: signalling, structure and biochemistry, biology, mechanisms, proteostasis, TPD, chemical biology, etc. Let me know if you or anyone else is missing.

submitted 79 days ago • 1 comment

The second of our two new preprints addresses the question of how proteasomes can be kept dormant for instance in oocytes. This study was spearheaded by first author Sascha Amann. biorxiv.org/cgi/content/... (1/6)🧵

submitted 82 days ago • 3 comments

We are very excited to share our recent preprint on the nuclear import mechanism of the proteasome, driven by the multivalent adaptor AKIRIN2! www.biorxiv.org/content/10.1... 🧵 1/6

submitted 83 days ago • 2 comments

Very excited to present the structural and mechanistic basis for stress response silencing by the monster E3 ligase SIFI. www.biorxiv.org/content/10.1...

submitted 86 days ago • 8 comments

SAVE THE DATE 🗓️Ubiquitin & Friends Symposium: 8-9 May 2025 in Vienna! Registration will open🔜 Keep an eye out for the announcement 👀 ✨guest speaker lineup👇🧵 +talks from abstracts! Great chance for #ECRs to meet with peers & experts in a friendly setting! 🔗 www.protein-degradation.org/symposium/

submitted 89 days ago • 1 comment

Excited to report our discovery of an important component of the oxidative stress response: the E3 ligase TRIP12. It acts as a chain elongation factor that amplifies CUL3-KEAP1 activity to drive NRF2 degradation as cells recover from stress. www.biorxiv.org/content/10.1...

submitted 92 days ago • 5 comments

Excited to share my first paper as a postdoc with @KaHochberg @mpi_marburg! We've made some fascinating discoveries about the evolution of animal stem cells in colab with @jauchr and @deMendoza_Alex. 🧬🔬 Link: www.nature.com/articles/s41... (1/n)

submitted 103 days ago • 1 comment

Could't think of a better inaugural post here. Very excited to share that our manuscript on the "Discovery and mechanism of K63-linkage-directed deubiquitinase activity in USP53" was published today at Nature Chemical Biology. Congratulations Kim, Kai, and all authors! www.nature.com/articles/s41...

submitted 93 days ago • 6 comments

and a late-breaking "bacterial ubiquitination" preprint from last week: some chlamydia encode an E3 ligase - SneRING - that assembles K63/K11 ubiquitin chains, interacts with mitochondrial & ER proteins, and may remodel organelles for intracellular survival. www.biorxiv.org/content/10.1...

submitted 93 days ago • 0 comments

go.bsky.app/HqEcaCw

submitted 97 days ago • 14 comments

As more and more scientists come here, I've made a chaperonologists/ PQC and Proteostasis starter pack. If you would like to be added, feel free to ask and share. go.bsky.app/Co7Tuub

submitted 97 days ago • 5 comments

www.nature.com/articles/s41...

submitted 99 days ago • 0 comments

There are now 50 Ub/Ubl signalling profiles in this starter pack. Go follow them! Hopefully more will follow. Let me know if I’m missing you or any others on the list.

submitted 99 days ago • 0 comments

It seems no starter pack exists yet for the migrated #TPD community - here is an attempt at one: go.bsky.app/FreGFDW

submitted 100 days ago • 2 comments

After much excitement about seeing our paper: “ Pathogenic proteotoxicity of cryptic splicing is alleviated by ubiquitination and ER-phagy ” published in @ScienceMagazine, it’s time to summarize our discoveries here! 😊 1/20 www.science.org/doi/10.1126/...

submitted 100 days ago • 2 comments

📯📯 Chemical Biology starter pack 📯📯 140 PIs & groups posting primary research in chemical biology. Please reskeet (?) & reply to this post if you want to be added! go.bsky.app/KLrTWoj Let's make ChemBioSky even greater again! #realtimechem #FluorescenceFriday #chemsky #chemtwitter #AgentOrange

submitted 101 days ago • 48 comments