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libuchauer.bsky.social
Computational Biologist. Mathematical models, omics methods and data analysis for immunology and infection research at Charité Berlin. https://libuchauer.github.io/lab/
26 posts 699 followers 883 following
Prolific Poster

See you in Dublin in October for the ICSB2024! Early registration is open at: ICSB2025.com. I will chair an exciting session on "Cell Engineering & Pathway Engineering".

Thank you to Stiftung Charité for featuring me and my group in the FACES interview series! www.stiftung-charite.de/en/news-in-d...

Was bringt der Wandel? Wie gehen wir in Wissenschaft und Gesellschaft damit um? Wie verändern sich Wissenschaft und Gesellschaft selbst? Reisen Sie beim #SalonSC durch #Metamorphosen in Geschichte und Gegenwart - am 18.1.25 ab 18 Uhr in der BBAW. salon.bbaw.de/start

Freue mich drauf, heute Abend als neues Mitglied der Jungen Akademie beim Salon Sophie Charlotte salon.bbaw.de/start der BBAW dabei zu sein! Kommt vorbei und lernt unsere Forschung durch ein besonderes Quartett-Spiel kennen 🃏🃏🃏🃏. Raum 230, 19/20/21 Uhr!

This! Also well put in this editorial in PLOS Comp Biol: Putting benchmarks in their rightful place: The heart of computational biology doi.org/10.1371/jour...

Learn how to analyze spatial omics data! Join our computational genomics course in 2025. Application deadline 30th January. compgen.mdc-berlin.de 🖥️ 🧬 🧪

How to do differential expression with scRNAseq data? State of the art is "pseudo-bulk" analysis with RNA-seq methods like edgeR or DESeq2, where "cell type" is encoded as discrete categories. Biologically, discrete categories are not always the most appropriate concept.(1/3) doi.org/10.1038/s415...

Petition der Gewerkschaft der Polizei #GdP für ein bundesweites „Böllerverbot“

🧬 🖥️ Need help for investigating tissue complexity from #spatial #transcriptomics data? Try out our #spacedeconv R package! 💻 Code: github.com/omnideconv/s... 📝 Preprint: www.researchsquare.com/article/rs-5...

Nach den neusten RKI-Zahlen sinken die Impfquoten gegen verschiedene ansteckende Krankheiten wie Polio (Kinderlähmung). Gerade in Kreisen mit ohnehin niedrigeren Polio-Impfquoten (Beispiele Main-Tauber und Deggendorf in der Grafik) ging es drastisch nach unten; deutlich weniger Veränderungen wo…

Impfquoten für Grippe & Pneumokokken sind miserabel in Deutschland. Beides sind günstige, gut verträgliche, sichere Impfstoffe & stellen eine der wirksamsten & einfachsten Präventionsmaßnahmen gegen schwerwiegende Erkrankungen wie Lungenentzündung, ARDS & Sepsis dar! www.rki.de/DE/Content/I...

A few days left to apply if you would like to work on spatial multi-omics modeling in an interdisciplinary team!

HIV - Heilung in Sicht? Sehr informativer und differenzierter Artikel in der @taz.de über die Fortschritte und Herausforderungen in der HIV-Forschung & Therapie und der Lange Weg zur Heilung. @cgaebler.bsky.social gibt spannende Einblicke in seine Forschung an der Klinik f. Infektiologie #Charité

Not checking nuclear markers like MALAT1 or intronic reads in your scRNA-seq data?🚨 We show their power to flag low-quality cells—even in top public datasets. It’s time to prioritize better QC for cleaner, more reliable genomics research! Read more: bmcgenomics.biomedcentral.com/articles/10.... 1/8

Hiring! I'm looking for a postdoc in machine learning of spatial single-cell data. Exciting project to develop methods for modelling cellular circuits in disease and regeneration of heart, liver and bone marrow using Xenium data from our lab. tinyurl.com/ymkvk7vn

Join us for a World Aids day Fundraiser special event at Moviemento Berlin featuring short films curated by Xposed, and short introductions into our research work as well as valuable insights from representatives of TransSe*works and Deutsche Aidshilfe moviemento.de/film/world-a...

Every year, >200K newborns die from sepsis. Our team used machine learning to develop a set of genes that can predict neonatal sepsis risk using at birth blood samples. www.thelancet.com/journals/ebi...

🚨 One week left to apply! 🚨 Don’t miss the chance to join the Gaebler & Ibrahim Labs for a cutting-edge postdoc position at the intersection of viral immunology, virology & gene regulation. 👉Apply here charite.hrpuls.de/de/job-offer...

ConvexGating allows to turn labeled groups/clusters (e.g. those derived with graph based algorithms) of highdim cytometry data into interpretable gating strategies with potential for marker discovery cell sorting -- congrats Maren & team and we will give it a try!

well if this isn't what we're here for 🤩

MYCOPLASMA PNEUMONIAE This cheeky little intracellular bacteria seems to be up to mischief with kids in the USA at the moment A quick thread on this bug, what's going on, and what to do (or not do!) about it #IDSky #PedSky #PedsIDSky 🧪 1/🧵

🧬 🖥️ If you are looking for more tools, resources, and insights about next-generation #deconvolution, have a look at our #omnideconv website: omnideconv.org

35 years after the Berlin wall came down. Signs drawn by people from Berlin were put up along 5 kms of where the former wall was standing. Extremely impressive and it somehow gives a tiny bit of hope how many people wrote about democracy.

📢 New preprint alert: Excited to share our deep dive into the role of tandem repeats (TRs) in single-cell gene expression across the immune system, using WGS and scRNA-seq data from 1,790 individuals and over 5 million blood cells! 🧬 🧵👇 #repeats #SingleCell 1/9

Intricate shape of a dendritic cell, guardians of the immune system.

I'm looking for a postdoctoral researcher for a 3-year position on the predictability of evolution using computational modelling: vacatures.uva.nl/UvA/job/Post... Please share!

Bicoid over Paris !

Very thorough deconvolution review, addressing many super relevant problems which are annoyingly often swept under the carpet, e.g. mRNA bias, annotation resolution, sc/bulk tech differences. Thanks @itisalist.bsky.social @francescafinotello.bsky.social and team!

Eric Engelbrecht in my lab showing us that we have much to discover in the human IGK locus! Gene conversions, novel inversions, SVs, SNVs, genes and alleles...oh my! rdcu.be/dJ8mL

Register before 22 April: Ascona Workshop 8-13 Sep 2024 Spatial and Temporal Statistical Modeling in Molecular Biology Statistical, computational and ML methods & applications to spatial biological data, from cells, tissues to planetary-scale spatialbio.net

Join me in 1.5h at the scverse community call (connection details at scverse.zulipchat.com#narrow/strea... ) to learn about LEMUR, differential geometry for single-cell, and get a sneak peek of an upcoming Python package! pylemur.readthedocs.io/en/latest/in...

Thanks for the shout out! Mike is among our faculty along with @wkhuber.bsky.social, Charlotte Soneson, Vince Carey, Robert Gentleman and many others! Come for the data science stay for the Dolomites! (Or the other way around! 🙃)

Und noch einer:

@maxplanck.bsky.social invites applications for three positions as Max Planck Foundation Research Group Leader in the area of #carbon #capture technologies. www.mpg.de/21509921/car...

It takes, er....big ball, and lots of them, to publish AI generated nonsense art in a scientific paper. Also I don't ever want to hear that Frontiers is not a predatory publisher. www.frontiersin.org/articles/10....

Announcing the call for fully funded 2 year postdoc positions for Clinician Scientists @dkfz.bsky.social. For more information visit www.dkfz.de/en/clinician...

Journal Club candidate 👀👀

Meine Mama 💪💪💪

#CharitéBerlin 🤝 Gegen Hass, Verfolgung und Ausgrenzung. Zusammen für die Demokratie.

Take these polls with a grain of salt, but it looks as if the recent upward trend of the extreme-right AfD (blue) has been stymied in the wake of mass protests against their ideology. Black line is the center-right CDU which has been trying to court AfD voters recently by toying with similar ideas

Three more weeks to apply for the PhD position on mathematical modelling of microbial evolution in my group! vacatures.uva.nl/UvA/job/PhD-... Now also announced on my new website 🖥️: meikewortel.com Contact me if you are interested or forward to someone who might be. Thanks!

Normally I’d suspect this to be an urban legend, but this is directly from a source that I trust: right-wing stickers in Germany rigged with razor blades to hurt the reasonable Germans that will be trying to take them down. Be careful out there, folks. The Nazis are giving zero f*cks these days.