lillemeier-lab.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

Exciting news! Our latest manuscript is out! Really happy to report on the development of synthetic chimeric TCRs with enhanced antigen sensitivity and capable of bispecificity to successfully overcome tumor heterogeneity in pre-clinical models. Check it out: rdcu.be/edRwJ

submitted 1 day ago • 1 comment

LAG3 is an inhibitory receptor that can be blocked to increase anti-tumor immune responses. What is the molecular mechanisms of LAG3 inhibition? A new paper in Cell shows that ligand-induced ubiquitination activates LAG3 by releasing its tail from the membrane. www.cell.com/cell/fulltex...

submitted 13 hours ago • 0 comments

Just kicked off the Tri-Regio #AI Networking Symposium! Looking forward to a day of #MachineLearning, #NeuralNetworks & computational biology – and more! Bringing together top research expertise from the Upper Rhine region & beyond, right here in #Freiburg: deeplearning.uni-freiburg.de

submitted 1 day ago • 0 comments

If you are looking for a research position, PhD studentship or technical role, we have a number of #JobOpportunities on our website: www.cruk.manchester.ac.uk/careers/ Current three #postdoctoral #fellowships, one #FlowCytometry technician role & a #PhD position available #NewJob #CanSky #OncoSky

submitted 1 day ago • 0 comments

Check out this latest study by CIBSS researcher Stephan Ehl and colleagues, which provides new insights into the clinical manifestations, trajectories and penetrance of the #RareDisease of #SOCS1 insufficiency, as well es a better understanding of the effect of Janus kinase (JAK) inhibition.

submitted 4 days ago • 0 comments

Fixing killer identity. Shin and colleagues found that TCR signals suppressed characteristic features of IL-15-induced human memory CD8+ T-cell activation, including increased NKG2D expression and upregulation of genes related to NK cytotoxicity and IFN response. www.biorxiv.org/content/10.1...

submitted 4 days ago • 0 comments

Killers are made, not born? Rudd and colleagues identify GSK-3 as a key regulator of CD4+ T-cell help in generating highly cytotoxic CD8+ T cells, suggesting a promising therapeutic strategy for cancer treatment. @biorxiv-immuno.bsky.social www.biorxiv.org/content/10.1...

submitted 4 days ago • 0 comments

Fantastic opportunity to work in a great lab. Highly recommended!

submitted 4 days ago • 0 comments

PD-1 transcriptomic landscape across cancers and implications for immune checkpoint blockade outcome doi.org/10.1038/s415...

submitted 5 days ago • 0 comments

Save the Date: In next week's CIBSS seminar, Dr. Anupama Hemalatha (@fmiscience.bsky.social) will discuss metabolic rewiring at the interphase of oncogenesis and homeostasis. Tuesday, March 18, 2025, 12:00–13:00 Institute of Biology I, Hauptstr. 1 Join in person or via livestream: kurzlinks.de/dkt6

submitted 5 days ago • 0 comments

New review in @eurjimmunol.bsky.social exploring the current landscape of single-cell and spatial multi-omics technologies, the application of generative AI in data analysis and modelling and their impact on our understanding of autoimmune diseases. onlinelibrary.wiley.com/share/RURZSM...

submitted 5 days ago • 0 comments

Gads mediates TCR signals by interacting with SLP-76 and LAT. Yablonski and colleagues investigate Gads in thymocytes. Gads promotes passage through TCR-driven checkpoints, but represses the progression of unselected DN and DP cells. @eurjimmunol.bsky.social onlinelibrary.wiley.com/share/RURZSM...

submitted 5 days ago • 0 comments

More data, fewer animals: Validating multiparametric single-cell cytokine analysis. Spectral flow cytometry panels for cytokine expression analyses in mouse immune and joint cells. Animal testing replaced by co-cultures. @eurjimmunol.bsky.social onlinelibrary.wiley.com/share/EBQWKK...

submitted 5 days ago • 0 comments

Sugar coating. Excellent review on how altered tumor glycosylation modulates immune response. onlinelibrary.wiley.com/share/RDIKVN...

submitted 5 days ago • 0 comments

Our spring round of PhD recruitment closes in one week. We’re looking for researchers of any nationality with backgrounds in biological or biomedical sciences, physics, chemistry, maths or computer science. Find out more and apply by midday, 19 March: www.crick.ac.uk/careers-and-...

submitted 6 days ago • 0 comments

REGISTRATIONS ARE NOW OPEN!🚨 conferences.unibas.ch/frontend/ind... Date: June 23-25, 2025 Venue: ZLF Hörsaal, University of Basel Early bird registration: 300 CHF Registration with abstract submission: 100 CHF Deadline April 28th⏳ Join us to stay updated on the latest advancements in #organoids!

submitted 15 days ago • 0 comments

A functional single-cell metabolic survey identifies Elovl1 as a target to enhance CD8+ T cell fitness in solid tumors @natmetabolism.bsky.social www.nature.com/articles/s42... www.nature.com/articles/s42...

submitted 8 days ago • 0 comments

@benjbroom.bsky.social et al. @groomlab.bsky.social show that early type I interferon blockade alters CXCR3 chemokine regulation & cell location to promote an antigen-dependent CD8+ T cell transition of precursor of exhausted T cells to stem cell–like memory CD8+ T cells rupress.org/jem/article/...

submitted 8 days ago • 0 comments

@brownlab1.bsky.social kicking off 🎓 Immunoschool 🎓 with the history, importance & evolution of vaccines, and how the current deadly, avoidable US measles outbreak emphasizes how crucial it is that we communicate the value of what scientific advances can do to the public. Educate your immune system!

submitted 8 days ago • 1 comment

🚨 New EJI-EFIS Prize for ECRs! 🚨 🏆 €5,000 award for the best research article in EJI by an Early Career Researcher! 🎤 Winner presents at ECI + receives an EFIS–EJI travel grant! 🔗 Apply now: onlinelibrary.wiley.com/page/journal... #ECR #Immunology #EJI #EFIS #ScienceFunding

submitted 10 days ago • 0 comments

Regulatory T cells constrain T cells of shared specificity to enforce tolerance during infection | Science www.science.org/doi/10.1126/...

submitted 10 days ago • 0 comments

Want to know more about how to prepare a successful European grant? Save the date & register for our next FCYI webinar in April: tinyurl.com/yc8z5348 @yefis-immunology.bsky.social @sfi-immunologie.bsky.social

submitted 12 days ago • 0 comments

Now in #Science #Immunology: @ejohnwherry.bsky.social & al use Tox-inducible KO mice to show that continuous #TOX expression in established exhausted #CD8 #Tcells (Tex cells) acts as enduring epigenetic control to reinforce Tex cell fate. Findings suggest TOX might be useful therapeutic target!

submitted 11 days ago • 1 comment

Specific MBP-derived self-peptides promote immune tolerance in the CNS and induce an unconventional regulatory T cell response www.science.org/doi/10.1126/... highlights in @sciimmunology.bsky.social on @nature.com @jonykipnis.bsky.social doi.org/10.1038/s415...

submitted 11 days ago • 0 comments

TOX safeguards exhaustion biology in established Tex cells and restrains fate conversion to Teff cells www.science.org/doi/10.1126/... @sciimmunology.bsky.social @ejohnwherry.bsky.social

submitted 11 days ago • 1 comment

Collaboration between interleukin-7 and -15 enables adaptation of tissue-resident and circulating memory CD8+ T cells to cytokine deficiency: Immunity www.cell.com/immunity/ful...

submitted 11 days ago • 0 comments

Hitting two targets with one arrow. Integrated computational analysis identifies therapeutic targets with dual action in cancer cells and T cells. These key immuno-oncology target include TNFAIP3, SOCS1 and PTPN2. www.cell.com/immunity/ful...

submitted 11 days ago • 0 comments

Only 10 days left to apply! We are looking for a passionate protein biochemist for the reconstitution of lipid kinases. We have long term funding and you will be trained in the use of supported lipid bilayers. If you are interested just get in touch or apply directly!

submitted 11 days ago • 0 comments

Monitoring mRNA vaccine antigen expression in vivo using PET/CT @naturecomms.bsky.social www.nature.com/articles/s41...

submitted 12 days ago • 0 comments

We are recruiting #postdoctoral scientists to join @giampazolias.bsky.social and our Cancer Immunosurveillance group 🧪🥼🧫🦠 For full details of the position, please visit our website: www.cruk.manchester.ac.uk/career/mi-24... Closing date: 4th April #OncoSky #CanSky #CancerResearch #microbiome

submitted 12 days ago • 0 comments

Just 3 days left to sign up for 👇 spread the word and repost please

submitted 11 days ago • 0 comments

Flow Cytometry Operator/Specialist at the FACS Core Facility (FCF) of the Biozentrum, University of Basel (60-80%) www.biozentrum.unibas.ch/open-positio... @biozentrum @unibas.ch #Biozentrum #Basel #research #science #joboffer #hiring #cytometry #operator

submitted 11 days ago • 0 comments

Aspirin slow cancer metastasis by decrease platelet TXA2 and releasing T cells from suppression. www.nature.com/articles/s41...

submitted 12 days ago • 0 comments

Resident responses. Panzer and colleagues show that tissue resident memory T cells store cytokine mRNAs, but their translation is suppressed by the integrated stress response (ISR) pathway. After activation, the ISR regulator eIF2α is dephosphorylated resulting in cytokine production. rdcu.be/ecugd

submitted 12 days ago • 0 comments

Join SITC for the Research & Development Career Path Webinar on March 27 at 3 p.m. CST. Hear from Panelists such as Dmitry Gabrilovich, MD, PhD, Priti Hegde, PhD, & Ira Mellman, PhD, FAACR, FAIO. Register today for free! sitcancer.org/biotech-virtual-programs#webinars

submitted 12 days ago • 0 comments

The molecular reach of antibodies crucially underpins their viral neutralisation capacity Our work on measuring and understanding the role of molecular reach on antibody function is now part of a list of editor's pick manuscripts: www.nature.com/collections/...

submitted 12 days ago • 0 comments

Great project in a great lab! Check it out!

submitted 12 days ago • 0 comments

5 days left to join us in Freiburg for a #PhD position through the [email protected] funded program. Consider applying and join me or @kleinevehnlab.bsky.social and our amazing @dompsfr.bsky.social @biologyunifreiburg.bsky.social community. www.sgbm.uni-freiburg.de/node/1847

submitted 14 days ago • 1 comment

Brilliant new paper from Jie Yang @jieyang437.bsky.social and Rahul Roychoudhuri @roychoudhurilab.bsky.social linking aspirin to immune-mediated prevention of cancer metastasis. www.nature.com/articles/s41...

submitted 13 days ago • 2 comments

📢 We are recruiting group leaders! We seek researchers who address fundamental questions in biology, including the development, the function, and the dynamics of complex biological systems. APPLY before March 30th 2025 👉 www.ibdm.univ-amu.fr/we-are-recru... #ScienceCareers #Marseille

submitted 56 days ago • 0 comments

Register for tomorrow's Updated Results on Cis-targeted IL-2s Webinar. Clinical benefits of the T #cell activating #cytokine IL-2 have not been fully realized, due to the potential of T cell-mediated off-target toxicities & other safety concerns. Register: ow.ly/Bl9v50V9xZX

submitted 15 days ago • 0 comments

T cells on the right path? Cancer-associated fibroblasts (CAF) co-opt chemokines for immunosuppression. Expression of atypical chemokine receptor ACKR2 on bystander cells protects primary murine cytotoxic T lymphocytes from CAF-mediated chemoattraction. onlinelibrary.wiley.com/share/IZF6QW...

submitted 15 days ago • 0 comments

Francis Collins, the NIH Director for 12 years, led the Human Genome Project and other NIH efforts for 32 years, resigned today. Key words from his resignation letter www.nytimes.com/2025/03/01/u...

submitted 17 days ago • 65 comments

We are recruiting a #postdoctoral researcher for our Leukaemia Biology group headed by Prof Tim Somervaille For all the details of this exciting project, the research questions on #AML & #epigenetics and information on the position itself, please visit: www.cruk.manchester.ac.uk/career/mi-25...

submitted 15 days ago • 0 comments

A precision cellular immunotherapy shows potential to deplete only autoimmune B cells in AChR-seropositive myasthenia gravis www.science.org/doi/10.1126/...

submitted 18 days ago • 0 comments

We are recruiting a #postdoctoral researcher for our Cancer Inflammation and Immunity group headed by @santiagozelenay.bsky.social For all the project details, research background, information about the position and the Institute, please visit: www.cruk.manchester.ac.uk/career/mi-25...

submitted 18 days ago • 0 comments

Choi and colleagues describe a subpopulation of naive CD4 T cells with high levels of IL-7R, CD97, IL18R, and Ly6C. The cells show Th1 characteristics and contribute to tumor control in mice. In cancer patients, IL-7Rhi CD97+ CD4 population correlate with the responses to anti-PD-1. rdcu.be/ebIjX

submitted 18 days ago • 0 comments

Optical #nanoscopy without “ON/OFF” – Stefan Hell, @thomas-hensel.bsky.social, and co-workers have increased the resolution in fluorescence #microscopy 🔬 by a factor of 30 without having to sequentially switch fluorescent molecules between light & dark states. ⬇️ www.mpinat.mpg.de/4938925/pr_2...

submitted 19 days ago • 1 comment

TCR catch bonds nonlinearly control CD8 cooperation to shape T cell specificity www.nature.com/articles/s41...

submitted 19 days ago • 0 comments