lindavsinclair.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

Fine-tuning tumor immunogenicity with mitochondrial complex I Our views on a very cool paper from @ppuigserverb.bsky.social we hope you like it! www.nature.com/articles/s43...

submitted 40 days ago • 1 comment

Delighted to have had the opportunity to write this spotlight with @juanquintana.bsky.social and the lab, on the recent @lydialynch.bsky.social paper, showing rhythmicity of IL-17 expression in adipose! Fascinating paper, which raises loads of cool questions #immunosky www.cell.com/immunity/ful...

submitted 43 days ago • 5 comments

Our Communication and Engagement Grant is open to all BSI members who want to take part in #PublicEngagement 🌟 Share your passion, build skills, and make a difference to the world of #immunology 💪 Application deadline: 1 Feb 2025 🗓️ Apply now 👉 bit.ly/3Y9j8gm

submitted 41 days ago • 1 comment

Elegant work by Jason Cyster's group "Our study demonstrates that the canonical chemoattractant receptor-ligand systems well-established for lymphocyte homeostatic trafficking to LNs are no longer the major contributors in the inflamed setting." #ImmunoSky

submitted 52 days ago • 2 comments

Thank you Drs. Dan Klionsky and Dimitra Dialynaki for your commentary on our work: www.tandfonline.com/doi/epdf/10....

submitted 52 days ago • 0 comments

Michael J Fox has had tremendous influence on people with Parkinson's Disease (PD), their carers, families and those working on PD. He is a shining example of what a single person is capable of. Well deserved recognition.

submitted 52 days ago • 0 comments

Organelles meets dinos! 🦖🔬 Featuring Mitosaur, ERsaur, Golgisaur, Lysosaur, and others, it's such a creative take on the cellular world we know and love. 💚 Which dino-organelle is your favorite? Let us know below! 👇

submitted 60 days ago • 0 comments

LPS stimulates dynamic changes in B cell metabolism to promote proliferation https://www.biorxiv.org/content/10.1101/2024.12.16.628649v1

submitted 68 days ago • 0 comments

A proteomic map of B cell activation and its shaping by mTORC1, MYC and iron https://www.biorxiv.org/content/10.1101/2024.12.19.629506v1

submitted 66 days ago • 0 comments

Here is link to Shixin's new paper: www.science.org/doi/epdf/10....

submitted 74 days ago • 5 comments

T cells get hungry! Check out Shixin Ma's new paper showing nutrient switching controls T cell exhaustion. Nutrients metabolized in the nucleus by ACSS2 and ACLY direct histone acetylation at key loci via binding to specific HATs, indicating a metabolic code guides our histone code. @science.org

submitted 74 days ago • 1 comment

Just recently I wrote an opinion piece with Shingo Kajimura, based around the idea that adipocytes, besides having energy storage/endocrine function, also act as immune hubs #Immunosky 🧪 1/🧵 febs.onlinelibrary.wiley.com/doi/10.1111/...

submitted 81 days ago • 4 comments

Can you explain your doctoral research through interpretive dance? The 17th annual #DanceYourPhD competition is open! Submit by 28 March for a chance to win $2000: scim.ag/3BcKi0e

submitted 83 days ago • 3 comments

Our annual Dance Your Ph.D. contest is open for submissions until March 28 💃 The entry form is here (plus more details in the article linked below): www.science.org/content/page...

submitted 83 days ago • 1 comment

Hello BlueSky! Looking forward to sharing all things #Immunology, #Host-pathogen and #hematology! As we are heading towards the end of 2024, I'll post highlights published @science.org so far this year - and hot-of-the press research from our December issues!

submitted 86 days ago • 3 comments

🎉 I'm a #newPI , and I'm so excited to share our new paper out in Nature Comms today! 🧵 rdcu.be/d2gBV Quick intro for the new followers: I'm from Monash Uni in Melbourne, and we study T and B cell responses to viruses, bacteria & parasites with the goal of improving vaccines. #ImmunoSky #MicroSky

submitted 85 days ago • 17 comments

A starter pack for PhD students and Postdocs in Immunology to connect 🔽 Drop a 🧬 and I'll add you to the list. Let's build the upcoming immuno community! #ImmunoSky 🧪 go.bsky.app/RABVXY4

submitted 84 days ago • 75 comments

Fascinating new paper about how commensal #fungi can promote #type2 responses in mice, a process involving fungal induction of #IL-33 🍄 🧪 #ImmunoSky www.nature.com/articles/s41...

submitted 89 days ago • 0 comments

Our latest paper reveals an intriguing and essential role for the class III #PI3K VPS34 in Treg homeostasis and function. Selective deletion of VPS34 in Treg led to a scurfy-like phenotype, suggesting an essential role for VPS34 in Treg-suppression. doi.org/10.3389/fimm... #immunosky

submitted 91 days ago • 1 comment

#Immunosky #neuroskyence our team is expanding and we’re recruiting a colleague with a strong background in neuroscience (PhD level) to conduct curiosity-driven research into the role of adaptive immunity in controlling sleep. Details & how to apply here: www.jobs.manchester.ac.uk/Job/JobDetai...

submitted 91 days ago • 1 comment

1/23 Big news for the #ObenaufLab! So excited to finally share our new study providing another puzzle piece, why immunotherapy fails in many tumors, now out in @Nature 🧵👇 www.nature.com/articles/s41...

submitted 91 days ago • 49 comments

PhD opportunity in my lab together plus collaborative placement with Jenny Mjosberg's group at Karolinska. Looking for someone with a passion to learn and develop spatial 'omics pipelines in the gut. Deadline end of the week! Spread the word: www.findaphd.com/phds/project...

submitted 93 days ago • 1 comment

New PhD opportunity in the lab with @profjudiallen.bsky.social and @douglaspdyer.bsky.social looking at interactions between ILCs and the extracellular matrix. Application deadline Jan 10th 2025 - spread the word Bluesky immunologists! www.findaphd.com/phds/project...

submitted 90 days ago • 0 comments

ICYMI: earlier this year in #Science #Immunology, Josh Gray, Donna Farber & al. analyzed the phenotype, transcriptome, function, & repertoire of #gdTcells in mucosal & lymphoid tissues & blood from 176 #human donors across the life span! Subjects ranged in age from just a few days to over 80 years!

submitted 91 days ago • 0 comments

Mice and humans develop intestinal inflammation when PI3Kdelta is inhibited. Lyn Lim, Shimon Sakaguchi and colleagues provide evidence this is secondary to defects in the differentiation and maturation of pTreg:

submitted 97 days ago • 0 comments

🎓 Exciting #PhD opportunity in our lab at @mcbleicester.bsky.social and @leicstructbio.bsky.social. Join the BBSRC-funded MIBTP programme for a 4-year fully funded studentship with comprehensive training in year 1 + research project years 2-4. #PhDSky #AcademicSky Details: tinyurl.com/4fhavzxh

submitted 97 days ago • 0 comments

Very proud of this one. Sarah Hamoudi, PhD student in the lab, developed autologous cocultures between mucosal T cells and epithelial organoids from control or from patients with Crohn's disease. www.biorxiv.org/content/10.1...

submitted 102 days ago • 2 comments

Another lactate dependent immunosuppressant mechanism, here in Glioblastoma #GBM #Lactate #CD47 #HistoneLactylation JCI - Lactate reprograms glioblastoma immunity through CBX3-regulated histone lactylation www.jci.org/articles/vie...

submitted 98 days ago • 0 comments

The bad news: Many people don’t get enough iron in their diet. The good news: One ounce of dark chocolate has 3.37 mg of iron Ladies, that’s 5.5 ounces a day that you clearly need. Sorry guys, you’ll get your daily allotment with 2.5.

submitted 100 days ago • 245 comments

Obesity imprints adipose tissue even after weight loss - promoting regain and progression. Same is observed with GLP-1 therapies were we see regain in the majority of individuals who stop TX www.nature.com/articles/s41...

submitted 100 days ago • 0 comments

Metabolism starter pack now full with 150 contacts! go.bsky.app/VavECSX

submitted 99 days ago • 5 comments

We have plenty of exciting events to look forward to next year including the #SIGNET2025 joint symposium⭐ This popular event connects #immunologists from across Scotland and champions the work of #ECRs! Register and submit your abstract here 👉 bit.ly/4euIWLO

submitted 100 days ago • 0 comments

‼️ The brilliant @giampazolias.bsky.social is hiring #postdocs (ERC funded!) to join his group - apply now to be a part of this stellar team solving BIG ☄️ questions in #Microbiome and #CancerImmunology @cruk-mi.bsky.social 📣 Deadline 1st Dec. See more below

submitted 99 days ago • 0 comments

I made a starter pack for those of us interested in or working on T cells. Let me know if you would like to be added or know somebody that should be added. Looking forward to scientific discussions and updates on our favorite immune cell type!

submitted 100 days ago • 66 comments

Friends, the second #immunology starter pack filled in 3 days! I started a third to help folks new to BlueSky rebuild their network Below are the links If you're an immunologist and I have missed you so far, let me know 🧪 go.bsky.app/PY5tCas go.bsky.app/FmERUoD go.bsky.app/6aT6qDS

submitted 100 days ago • 91 comments

Making a starter pack of LGBTQ+ immunologists and need 8 people to create the pack. Don’t want to add people who haven’t requested to be added, so please let me know if you’d like including #Immunosky #PrideInSTEM 🏳️‍🌈🏳️‍⚧️

submitted 101 days ago • 8 comments

🔬 Curious about #mitochondria #imaging but unsure where to begin? Our review might help! 🚀📜🧪 www.annualreviews.org/content/jour... #Quantitative #Microscopy #SuperResolution #AcademicSky #ScienceSky #CellBiology #mtDNA

submitted 101 days ago • 7 comments

Some useful starter packs 👍 Cancer Immunology: bsky.app/starter-pack... A repertoire of immunologists II: bsky.app/starter-pack... Immunometabolism: bsky.app/starter-pack... A repertoire of immunologists: bsky.app/starter-pack...

submitted 100 days ago • 1 comment

We strongly suggest that academic publishers and other platforms that host research rapidly implement a Share to Bluesky button for their articles. Here's how: docs.bsky.app/docs/advance... #AcademicSky #HigherEd #Altmetrics

submitted 100 days ago • 176 comments

We had a great time today at this fantastic event. So many great science presentations, alongside interesting and thought-proving talks on the progressive history of Manchester and how to build and maintain positive and inclusive research culture in the lab. Thanks all for bringing it together!

submitted 100 days ago • 2 comments

📢Last weeks #immunometabolism discoveries @Bims_BiomedNews⬇️⬇️⬇️ biomed.news/bims-imicid/... A lot of interesting articles within but highlighting a study I hadn't come across yet: I) Functional identification of soluble uric acid as an endogenous inhibitor of CD38

submitted 100 days ago • 0 comments

It was great to work with Kendle Maslowski’s group @mmimic.bsky.social and others on this project, interrogating the curious question of why T cells aren’t engaged by bacterial cancer therapy, and how to make them so! It’s all down to metabolism of course 😉…

submitted 100 days ago • 0 comments

Asparaginase expression impedes T cell responses but is required for anti-tumour efficacy during salmonella CRC therapy. More evidence for importance of Asn for T cells! Great work Kendle and colleagues!

submitted 100 days ago • 0 comments

Check it out!!! Our work delineating why T cells aren't needed for Salmonella colorectal cancer therapy, and how to get them on board is out 😅🧪🦠. @cruk-si.bsky.social Collab with @bendinglab.bsky.social @sarahdimeloe.bsky.social #Immunosky #Microsky #metabolism www.embopress.org/doi/full/10....

submitted 100 days ago • 2 comments

Proud of @thestemvillage.bsky.social and @lydiabeckeriii.bsky.social to be hosting a great meeting today showcasing the LGBTQ+ immunology community! Great job to organisers @mcsinton.bsky.social @juanquintana.bsky.social @franzeprogatzky.bsky.social @drtesutherland.bsky.social and the team!

submitted 100 days ago • 1 comment

Can colleagues amplify this appeal to journals and journal editors to open accounts on Bluesky, please? @MicrobioSoc @TrendsMicrobiol @CellCellPress @JBacteriology @jbiolchem @Nature @ScienceMagazine @PNASNews @MolMicroEditors @NAR_Open @NatureMicrobiol @NatureComms @ASMicrobiology 🙏 🦠🧪🧫🧬

submitted 108 days ago • 18 comments

Study argues glutamine diminishes activation and recruitment of neutrophils #Neutrophils #glutamine #mitochondria #glutathione #transglutaminase2 “Glutamine modulates neutrophil recruitment and effector functions during sterile inflammation” doi.org/10.1093/jleu...

submitted 101 days ago • 1 comment