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lkrsh89.bsky.social
Interested in how proteins are made and maintained in cells | #Membraneprotein, #ERAD, #molecularchaperones, #ubiquitin #signalling | Now: Postdoc @MRC-PPU, Dundee | Prev. Postdocs: LKC-NTU, SG and Dunn School @Oxford | BSc and PhD: WEHI, UniMelb, AUS.
7 posts 595 followers 1,264 following
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Posts 18 Comments 3

New to #ubiquitin? Been with it for a while? Either way this review may be for you 🤩 Excited to share our review article in @molcell.bsky.social, diving deep into everything #ubiquitin Read here 👉: kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F... @cellpress.bsky.social @wehi-research.bsky.social

submitted 40 days ago • 1 comment

Nikita Sergejevs, Pedro Carvalho and colleagues find that that the intramembrane protease SPP conducts topology surveillance of CYP51A1 by initiating quality control of incorrectly inserted molecules. Highlight: journals.biologists.com/jcs/article/... Article: journals.biologists.com/jcs/article/...

submitted 69 days ago • 1 comment

🚨 Our latest study, "Yeast Knowledge Graphs Database for Exploring Saccharomyces cerevisiae and Schizosaccharomyces pombe," has just been deposited in @biorxivpreprint.bsky.social ! We’re thrilled to share our work with the world! #KnowledgeGraphs www.biorxiv.org/content/10.1101/2024.12.04.626523v1

submitted 78 days ago • 2 comments

Waves of new BlueSky arrivals in last few days! I’ve been tracking starter packs relevant to molecular/mechanistic/genetic/cellular…etc biology Hope it’s helpful but warning: now a v long thread! Probably the last time I can do this...

submitted 105 days ago • 15 comments

If you are interested in doing cutting-edge molecular #neurobiology research, I can highly recommend the opportunity to work with @adamgrieve.bsky.social, whom not only will ensure you an exciting scientific journey, but will also be a great mentor, guiding you through the ups and downs of a #PhD.

submitted 79 days ago • 1 comment

Amazing PhD opportunity to join an exciting new lab at Bristol Biochemistry - send your best students in Ferdos’ direction!

submitted 90 days ago • 1 comment

This study has it all! A truly structure-to-function study on two #deubiquitinases that were thought to be pseudoenzymes and providing insights into disease mutations. Congratulations to @gallantkai.bsky.social, Kim and the team!

submitted 81 days ago • 1 comment

Since I read about AKIRIN2 in 2021 in their earlier paper in Nature, I have always been fascinated by this protein. This follow-up preprint is aimed at unraveling the mechanistic aspects of its functions! Just excited at the fact that we have so much more to learn about the world of #proteostasis!

submitted 81 days ago • 0 comments

It was a treat to hear this story when @micharapelab.bsky.social visited University of Dundee and continuation of the story at the EMBO #ubiquitin and #ubiquitin-like proteins meeting in Cavtat, a couple months ago! Very elegant and informative mechanistic and functional works on #stresssignalling!

submitted 81 days ago • 1 comment

Excited to reveal specific reactive oxygen species as sentinel molecules that control localized protein degradation at #mitochondria to adjust electron transport chain abundance, with many implications for the role of ROS in development and disease. www.cell.com/molecular-ce...

submitted 82 days ago • 6 comments

The second of our two new preprints addresses the question of how proteasomes can be kept dormant for instance in oocytes. This study was spearheaded by first author Sascha Amann. biorxiv.org/cgi/content/... (1/6)🧵

submitted 82 days ago • 3 comments

A humbling reminder that we've only scratched the surface of life's complexity. www.science.org/content/arti...

submitted 87 days ago • 2 comments

SAVE THE DATE 🗓️Ubiquitin & Friends Symposium: 8-9 May 2025 in Vienna! Registration will open🔜 Keep an eye out for the announcement 👀 ✨guest speaker lineup👇🧵 +talks from abstracts! Great chance for #ECRs to meet with peers & experts in a friendly setting! 🔗 www.protein-degradation.org/symposium/

submitted 88 days ago • 1 comment

Excited to report our discovery of an important component of the oxidative stress response: the E3 ligase TRIP12. It acts as a chain elongation factor that amplifies CUL3-KEAP1 activity to drive NRF2 degradation as cells recover from stress. www.biorxiv.org/content/10.1...

submitted 91 days ago • 5 comments

The dark side of fluorescent protein tagging: the impact of protein tags on biomolecular condensation www.biorxiv.org/content/10.1...

submitted 92 days ago • 10 comments

For people interested in chaperones, protein quality control, proteostasis and cellular homeostasis, here is the link of the webinars we (P. Goloubinoff, A. Barducci, N. Nillegoda and I) hosted during the COVID pandemics. A lot of material! tinyurl.com/27y5wpzy

submitted 100 days ago • 2 comments

Hello! As a new user, I thought I would introduce myself. I am a postdoc in the lab of @kulathu.bsky.social at MRC-PPU, Dundee, UK. Fascinated by #molecularchaperones and #proteinqualitycontrol. Find me on pubmed pubmed.ncbi.nlm.nih.gov?term=Logesva... or here scholar.google.com/citations?us...

submitted 100 days ago • 0 comments

We are still considering postdoc candidates for the post advertised below. A 2-year contract beginning in 2025 to work on protein SUMO E3 ligases and the nucleosome.

submitted 102 days ago • 0 comments