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I loved reading about Barrett's rigorous empirical research on insect sentience, its ethical implications, and how to mitigate insect suffering within industries that make heavy use of these remarkable invertebrates! 80000hours.org/podcast/epis...

submitted 6 hours ago • 0 comments

Two remarkable innovations coming together to tackle prion disease: AAVs that leverage human receptors to cross the blood-brain-barrier + a way of epigenetically silencing the gene encoding prions. I recall reading those cited papers and both are amazing! www.prnewswire.com/news-release...

submitted 14 hours ago • 0 comments

"Poetry is only secondarily about words. Primarily, it is about truth." -- Martin Silenus, one of the seven pilgrims in the novel Hyperion by Dan Simmons.

submitted 1 day ago • 0 comments

I've lately been thinking about similar philosophical ideas to those described in this article. Very interesting read! nautil.us/is-everyone-...

submitted 3 days ago • 0 comments

Super cool paper where Jeppesen et al. discover and characterize a new type of large extracellular vesicle (EV): blebbisomes! These blebbisomes have active mitochondria, RNAs, and other organelles (except nucleus) and secrete and take up smaller EVs! www.nature.com/articles/s41...

submitted 3 days ago • 0 comments

There are strong ethical reasons and practical human-centered reasons to embrace synthetic alternatives to horseshoe-crab blood for endotoxin detection. #bioethics #pharmaceuticals #biotech www.nature.com/articles/d41...

submitted 5 days ago • 0 comments

A nice paper where Xia et al. present a useful new tool for molecular biology, a way of using CRISPR-Csm complexes to track the movements of single RNA molecules in living cells while minimally interfering with their function. #biochemistry #cellbiology #genetics www.nature.com/articles/s41...

submitted 5 days ago • 0 comments

An interesting glimpse into the adventurous world of neutrino research in Antarctica! www.symmetrymagazine.org/article/a-ha...

submitted 7 days ago • 0 comments

My top 10 favorite science fiction novels in rough order. In the case of Hyperion, I am counting "Hyperion" and its sequel "The Fall of Hyperion" as one book. Note that I'm not including standalone short stories, though certain ones would rank very highly if they were here.

submitted 7 days ago • 2 comments

An article providing a nice glimpse into the NeuroAI efforts from the Amaranth Foundation. More detail can be found in their preprint: arxiv.org/abs/2411.18526 www.thetransmitter.org/neuroai/does...

submitted 7 days ago • 0 comments

Super interesting profile of Alex Zhavoronkov, founder of Insilico Medicine, which is among the most successful biotech companies applying AI to drug discovery and design for longevity and more. proto.life/2022/11/alex...

submitted 8 days ago • 1 comment

Great article from Asimov Press on the history of mouse models and where they came from, the benefits and drawbacks of current laboratory mice, and possibilities for the future of mice and other model systems. #history #biotech #biomedicine press.asimov.com/articles/mou...

submitted 10 days ago • 0 comments

Have you ever been curious about how we might map entire mammalian brains with sufficient resolution to capture synaptic connections between neurons? Check out my newly published perspective journal article in Cell Reports Methods!

submitted 10 days ago • 1 comment

Magnificent paper (link: www.sciencedirect.com/science/arti...) on the remarkable ladderlike organization of endoplasmic reticulum in dendrites and how such structures contribute to neuronal computations. #neuroscience #neurobiology #brain #neurons #biology

submitted 14 days ago • 0 comments

Excellent paper by Chuapoco et al. from Viviana Gradinaru's group on developing blood-brain-barrier crossing AAV vectors for nonhuman primates with high potential for clinical translation. #genetherapy www.nature.com/articles/s41...

submitted 16 days ago • 0 comments

I presented these slides at the Workshop on Philosophy and Ethics of Brain Emulation at the Mimir Center for Long Term Futures Research in Stockholm. I discussed how various biological phenomena may exert effects on computations underlying subjective experiences. logancollinsblog.com/2025/02/11/r...

submitted 17 days ago • 0 comments

An interesting study where Kravčenko et al. use cryoET to examine the proteins associated with synaptic vesicles, how these proteins change over the life cycles of synaptic vesicles, and possible functional implications of their findings. #structuralbiology www.pnas.org/doi/10.1073/...

submitted 19 days ago • 0 comments

Realistic model of the structure of a single synaptic vesicle from: Takamori, S. et al. Molecular Anatomy of a Trafficking Organelle. Cell 127, 831–846 (2006).

submitted 21 days ago • 0 comments

An interesting paper where Schuette et al. develop a generative diffusion-based AI model for predicting chromatin 3D structure. The model takes chromatin accessibility sequence data as input and outputs a statistical distribution of predicted chromatin structures. www.science.org/doi/10.1126/...

submitted 22 days ago • 0 comments

Fascinating study where Sarfatis et al. developed an expansion microscopy spatial transcriptomics method for bacteria to spatially visualize and quantify up to 80% of the microbial transcriptome at once. Bacteria were enlarged up to 11.1x for this process! www.science.org/doi/10.1126/...

submitted 22 days ago • 1 comment

My drawing of the glucose-alanine cycle, a part of amino acid metabolism. I made this diagram with Affinity Designer. #biochemistry #metabolism

submitted 27 days ago • 0 comments

Evo is an extremely impressive paradigm shift for biological research. Its abilities suggest generative AI will likely play a central role in most future biotech. We may regularly use such AI to design new biomolecular processes at the press of a button. www.science.org/doi/10.1126/...

submitted 29 days ago • 1 comment

Very interesting paper by Lindley et al. showing that two mRNAs can be spliced together with extremely high efficiency using an optimized ribozyme system, allowing expression of large genes after dual-AAV delivery for treatment of muscular dystrophies. #genetherapy www.science.org/doi/10.1126/...

submitted 29 days ago • 0 comments

A blog webpage written by entrepreneur Matt Krisiloff which offers helpful advice to scientific founders of biotechnology companies on how to fundraise and manage relations with investors. mattkrisiloff.com/2025/01/07/f...

submitted 36 days ago • 0 comments

Cool biophysical modeling of the endoplasmic reticulum! "In their paper, the team calls the peripheral ER an 'active liquid network'... to capture not only the liquid-like sliding of the junctions but also the growth of new tubules from existing ones." www.czbiohub.org/life-science...

submitted 38 days ago • 0 comments

The Common Coordinate Framework is a complete, high-resolution 3D atlas of the mouse brain meant to serve as a common reference for the neuroscience community. Learn how to navigate it and use it in your research: alleninstitute.org/science-reso... 🧠📈

submitted 38 days ago • 0 comments

I love that Microdrop Technologies (www.microdrop.de) has developed tools for dispensing arrays of droplets with volumes as small as 20 picoliters - which is one 50,000th of a microliter! #biotech #nanotech #instrumentation

submitted 38 days ago • 0 comments

Great paper on how perineuronal nets influence electrophysiology, plasticity, memory, and more. Exemplifies just how many crazy layers of regulation there are to the brain's computations besides just the connectome and neuronal spiking patterns. #brain www.nature.com/articles/s41...

submitted 38 days ago • 0 comments

Excellent article proposing a new large-scale institution for deciphering biological intelligence which would commercialize its discoveries in the forms of AI, computing, and microscopy technologies. www.thetransmitter.org/neuroai/solv...

submitted 38 days ago • 1 comment

As time goes on, we see more and more empirical evidence for capacity of animals to experience emotions like love, fear, pain, etc. I'd suggest assuming animals are sentient unless proven otherwise and aim to mitigate their suffering as much as possible. www.nbcnews.com/science/scie...

submitted 40 days ago • 0 comments

"The five basic neuro-rights are: mental privacy, fair access to mental augmentation, preserving personal identity, protection from bias and maintaining free will." english.elpais.com/science-tech...

submitted 40 days ago • 1 comment

I've updated my list of exciting biotechnology companies to watch! It now includes 139 companies along with logos, links to the websites, subtype of biotech, and sets of key facts about each. Enjoy! #biotech #biotechnology logancollinsblog.com/2021/05/10/l...

submitted 40 days ago • 1 comment

Maybe one reason most people don't see the value in transhumanism is that they have a hard time conceptualizing how something like widely available neural interfaces could lead to a dramatically more abundant future - most focus only on near-term solutions to specific problems.

submitted 41 days ago • 0 comments

SMILES represents molecular structures in String data format. With the proliferation of LLMs, it will be awesome to watch how 'chemical linguistics' explodes as a field! en.wikipedia.org/wiki/Simplif...

submitted 43 days ago • 1 comment

Did you know that you can download Wikipedia articles as PDFs? I recently started using this feature and it feels really nice to collect eclectic knowledge of interest in an easily accessible place.

submitted 43 days ago • 0 comments

Love the innovative vision of this startup. Sounds to me like they are on point with their ethics too. Excited to see them progress further! #developmentalbiology #tissueengineering #biotechnology www.technologyreview.com/2022/08/04/1...

submitted 44 days ago • 0 comments