lsajournal.org - Profile | ThreadSky | a Reddit-style client for Bluesky

In this study, the authors identify genes putatively causal for ADHD and show how their biological pathways link to co-occurring traits and biomarkers in a tissue and time-dependent manner https://buff.ly/4kiGdZW

submitted 22 hours ago • 0 comments

By Abdelnaser et al. Identification of TNFAIP2 as a unique cellular regulator of CSF-1 receptor activation https://buff.ly/4hV7hwy

submitted 6 days ago • 0 comments

A biallelic variant in GORASP1 causes a novel Golgipathy with glycosylation and mitotic defects https://buff.ly/4b3VMk3

submitted 7 days ago • 0 comments

in vivo, phage display combined with microdialysis can be used for the discovery of vascular homing peptides capable of extravasation and tissue penetration in the target organ https://buff.ly/3QAjRFX

submitted 7 days ago • 0 comments

Epigenetic regulation affects the capacity of stem cells to proliferate and differentiate, with canonical PRC1 being particularly important for neural stem cell fate @mareikealbert.bsky.social @crtd-tud.bsky.social https://buff.ly/3CM7q6t

submitted 7 days ago • 0 comments

Visualization of Euglena gracilis Organelles and Cytoskeleton Using Expansion Microscopy @sciencecharles.bsky.social https://buff.ly/3Ew7WWM

submitted 9 days ago • 0 comments

LSA ❤️ Reviewers! Thank you to all Reviewers for sharing their time and expertise while reviewing manuscripts. Reviewers that assisted LSA in 2024: https://buff.ly/4b2ry10

submitted 9 days ago • 0 comments

Take a look at this recently published study in LSA: FGF7 as an essential mediator for the onset of ankylosing enthesitis related to psoriatic dermatitis https://buff.ly/4aWYPuu

submitted 9 days ago • 0 comments

PICH impacts the Spindle Assembly Checkpoint via its DNA translocase and SUMO-interaction activities https://buff.ly/42QmCdf

submitted 9 days ago • 0 comments

This study demonstrates the molecular mechanism and biological significance of the formation of large CSF-1 receptor aggregates in macrophages https://buff.ly/4hV7hwy

submitted 13 days ago • 0 comments

Beckröge et al. Impaired primitive erythropoiesis and defective vascular development in Trim71-KO embryos @wkolanus.bsky.social https://buff.ly/3QaRM7y

submitted 13 days ago • 0 comments

A growing number of studies suggest that the Golgi apparatus plays specific roles during neurodevelopment. This study identifies the first human loss-of-function mutation in the Golgi protein GRASP65 and reveals resulting defects in glycosylation and mitosis https://buff.ly/4b3VMk3

submitted 14 days ago • 0 comments

A combination of in vivo phage display and microdialysis identifies homing peptides capable of cell and tissue penetration https://buff.ly/3QAjRFX

submitted 14 days ago • 0 comments

https://buff.ly/42Pztwe Salamanders display remarkable starvation resistance. The Authors show that newt cells maintain constitutive activation of autophagy during prolonged starvation. This may underlie the high starvation resistance of newts and may contribute to the development of novel therapies

submitted 14 days ago • 0 comments

Epigenetic mechanisms regulate the capacity of stem cells to proliferate and differentiate. This study dissects the role of canonical and non-canonical PRC1 in neural stem cell fate specification @mareikealbert.bsky.social @crtd-tud.bsky.social https://buff.ly/3CM7q6t

submitted 14 days ago • 0 comments

The authors show HCAR1 has a nuclear localization where it promotes cancer malignancy through chromatin regulation, DNA damage repair, translational regulation, and intra-nuclear signaling https://buff.ly/3CrZasj

submitted 14 days ago • 0 comments

New article by Eudenbach et al: Assessment of PRMT6-dependent alternative splicing in pluripotent and differentiating NT2/D1 cells https://buff.ly/4jJCXq7

submitted 15 days ago • 0 comments

Peroxisome-mediated cholesterol trafficking is essential for the ciliary localization of the Polycystin complex to prevent the occurrence of polycystic kidney https://buff.ly/4hiVoAs

submitted 15 days ago • 0 comments

Genome-edited cell lines for PICH-depletion or replacement to loss of function mutants revealed an unidentified PICH function impacting SAC activity through modulating Bub1 association at kinetochores https://buff.ly/42Uudrz

submitted 15 days ago • 0 comments

Lysosome targeting nanoparticles, loaded with mefloquine, inhibit coronavirus infection in mouse MHV-A59 and human OC43 coronavirus model systems as well as SARS-CoV-2-WA1 and its Omicron variant in a human lung epithelium model @reviewcommons.org https://buff.ly/3EpgxKK

submitted 15 days ago • 0 comments

https://buff.ly/4aWYPuu This study sheds light on the pathogenic association between the skin and joint in psoriatic arthritis. The authors indicated that IL-17A, which is produced in the skin, induces joint manifestations via FGF7 signaling in the pathology of psoriatic arthritis.

submitted 16 days ago • 0 comments

https://buff.ly/3Ew7WWM The authors @sciencecharles.bsky.social applied expansion microscopy to visualize the cytoskeleton, mitochondria, and chloroplasts of Euglena gracilis which enabled high-resolution imaging, revealing cellular structures and organelle development.

submitted 16 days ago • 0 comments

The authors provide cryo-EM structures of Drosophila INDY in diverse functional states at near-atomic resolution. Their structures reveal its conformational cycle, sodium-independent H+/citrate co-transport, and phospholipid effects on stability. https://buff.ly/3WCRlXq

submitted 19 days ago • 0 comments

This report investigates the effect of 21 variants in the hSLC39A8 gene experimentally on protein expression, localization, and uptake of metal ions, and computationally on dimerization stability RESOLUTE and REsolution the @supertifurgalab.bsky.social at CeMM https://buff.ly/4aHOzG3

submitted 19 days ago • 0 comments

The authors report that Trim71-KO leads to decreased embryonic primitive erythropoiesis and impaired vascular development and provide evidence for direct repression of Eomes via Trim71-mediated mRNA binding @wkolanus.bsky.social https://buff.ly/3QaRM7y

submitted 20 days ago • 0 comments

New article by Eudenbach et al: Assessment of PRMT6-dependent alternative splicing in pluripotent and differentiating NT2/D1 cells https://buff.ly/4jJCXq7

submitted 21 days ago • 0 comments

Newts exhibit remarkable starvation resistance, facilitated by sustained autophagosome levels in fibroblasts during extended nutrient deprivation, and retain an evolved mechanism that balances regeneration and autophagy-mediated survival under starvation https://buff.ly/42Pztwe

submitted 21 days ago • 0 comments

PRMT6, through its methyltransferase activity, contributes to alternative splicing in both pluripotent and neuronally differentiating NT2/D1 cells, affecting primarily cassette exons https://buff.ly/4aNui1R

submitted 21 days ago • 0 comments

This new article by Mohammad Nezhady et al, shows lactate GPCR, HCAR1, has a nuclear localization in cancer cells and it drives cancer malignancy by multiple location-biased activities in the nucleus https://buff.ly/3CrZasj

submitted 21 days ago • 0 comments

Ciliary cholesterol prevents polycystic kidney https://buff.ly/42BRfmP

submitted 22 days ago • 0 comments

Lysosome targeting nanoparticle treatment for SARS-CoV-2 @reviewcommons.org https://buff.ly/4b20Qpj

submitted 22 days ago • 0 comments

Mitochondrial dysfunction induces mutant VAPB inclusions via ER-mitochondrial contacts in ALS8, providing a mechanism for age-related disease manifestation/progression in this genetic ALS form #ALS #VAPB #Mitochondria https://buff.ly/40vw03r

submitted 22 days ago • 0 comments

Using a concept called graph pangenome for many individual genomes as the baseline can improve the identification and characterization of large-sized genomic variations for disease genomics study https://buff.ly/3PQdNIZ

submitted 23 days ago • 0 comments

The February issue includes articles showing that m6A modification promotes the nuclear retention of mRNAs that contain intact 5′ splice site motifs, vinculin–Arp2/3 interaction inhibits actin assembly in membrane protrusions, & much more! https://buff.ly/4g9TvVp

submitted 23 days ago • 0 comments

Cryo-EM structures of Drosophila INDY https://buff.ly/3WCRlXq

submitted 26 days ago • 0 comments

Within RESOLUTE and REsolution, the @supertifurgalab.bsky.social at CeMM studied variants of the human SLC39A8 (ZIP8) metal transporter to better understand links to diseases involving disrupted metal ion homeostasis https://buff.ly/40CFb1R

submitted 26 days ago • 0 comments

Centromeres contain two physically distinct CENP-A nucleosomes, one of which associates with the CENP-C complex and regulating CENP-C levels is critical for accessibility of the centromeric chromatin fiber for transcriptional machinery @dpmelters.bsky.social https://buff.ly/40LsByD

submitted 26 days ago • 0 comments

ALS8, caused by a VAPB mutation, involves ER inclusions. Mitochondrial damage and ER-mitochondrial contacts drive this, accelerating disease progression, as shown in yeast and motoneuron models #ALS #VAPB #Mitochondria https://buff.ly/40vw03r

submitted 28 days ago • 0 comments

Scientists show that using graph pangenome, a way to represent genomes from many individuals, can improve the identification of big sized mutations in the disease genomics study https://buff.ly/3PQdNIZ

submitted 28 days ago • 0 comments

Researchers discover that NME7, a lesser-studied protein, is required for cilium assembly and Hedgehog signaling, impacting cilia microtubule stability. This study advances our understanding of primary cilia assembly and functions https://buff.ly/4amZF36

submitted 30 days ago • 0 comments

CENP-C is critical in regulating centromere homeostasis by supporting a unique higher-order structure of centromeric chromatin and altering the accessibility of the centromeric chromatin fiber for transcriptional machinery @dpmelters.bsky.social https://buff.ly/40LsByD

submitted 33 days ago • 0 comments

The Authors achieve in-toto single-cell observation in a whole hemisphere of an E5.5 embryo for 12 h, optimizing their microscope system, including an incubator, and refining the observation protocol https://buff.ly/4hAHzxh

submitted 34 days ago • 0 comments

Inhibiting UNC119 in primary T cells alters LCK location and function without affecting its phosphorylation state. This inhibition also slows cancer cell growth, making UNC119 a potential therapeutic target for T acute lymphocytic leukemia @cruk-si.bsky.social https://buff.ly/4hiouj3

submitted 34 days ago • 0 comments

TFEB promotes TNBC self-renewal and protects TNBC stem cells against metabolic stress via unfolded protein response and autophagy, revealing vulnerabilities that could be therapeutically exploited https://buff.ly/4hiJhmI

submitted 34 days ago • 0 comments

A nucleoside diphosphate kinase family protein NME7 regulates cilium assembly and Hedgehog signaling https://buff.ly/4amZF36

submitted 37 days ago • 0 comments

embryonic development / single-cell tracking / SPIM microscope / trans-scale / live-imaging https://buff.ly/4hAHzxh

submitted 41 days ago • 0 comments

Transcription Factor EB (TFEB) protects breast cancer stem cells from metabolic stress by inducing the Unfolded Protein Response and autophagy https://buff.ly/4hiJhmI

submitted 41 days ago • 0 comments

Ciliary proteins regulate TCR signalling in unciliated T cells. Inhibition of UNC119 also can inhibit T acute lymphocytic leukemia cell growth @cruk-si.bsky.social https://buff.ly/3Wofpx1

submitted 41 days ago • 0 comments

The January issue includes work showing that PTPN1/2 inhibition promotes muscle stem cell differentiation in Duchenne muscular dystrophy, an ex vivo model allows visualization of emergent metastatic features, & much more! https://buff.ly/4jc7CMD

submitted 48 days ago • 0 comments