lucagiorgetti.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

Fun collaboration with @gebhardtlab.bsky.social and @akispapantonis.bsky.social: CTCF and cohesin bind increasingly efficiently to chromatin and instruct the establishment of chromosome structure in zebrafish embryos

submitted 7 days ago • 0 comments

An image analyst position is available in our microscope facility. Please share!

submitted 17 days ago • 0 comments

Want to start an independent research group? ...with core funding, outstanding facilities & a curiosity-driven culture? Join us at @embl.org We are recruiting across research themes, inc (epi)genomics, human dev bio, predictive modelling & neurobiology👇 embl.wd103.myworkdayjobs.com/en-US/EMBL/d...

submitted 17 days ago • 2 comments

Now out in @science.org w/ @jshendure.bsky.social we present 'Genome-shuffle-seq': a method to shuffle mammalian genomes and characterize the impact of structural variants (SVs) with single-cell resolution in one experiment. www.science.org/doi/10.1126/...

submitted 29 days ago • 3 comments

Together with @smandrup.bsky.social and Minna Kaikkonen we are happy to announce the 3rd Edition of the EMBO Workshop on #Enhancers and #Enhanceropathies. This time we will meet during the beautiful Danish summer (June 16-21). Book the dates and register soon!!! meetings.embo.org/event/25-enh...

submitted 29 days ago • 0 comments

Come join us for this very first conference on single molecule approaches (both omics et imaging) to understand gene expression regulation. Lots of slots for young selected speakers!

submitted 42 days ago • 0 comments

Very cool collaboration with @andersshansen.bsky.social's lab on how to calibrate Micro-C using our labs' previous live-cell estimates of looping probability!

submitted 43 days ago • 1 comment

Two great articles in Mol Cell about enhancer cooperativity & long-range enhancer activation by @chribue.bsky.social & Wysocka labs: www.sciencedirect.com/science/arti... www.sciencedirect.com/science/arti... Dimitra and I had the pleasure to write a Preview: www.sciencedirect.com/science/arti...

submitted 43 days ago • 0 comments

We are happy to share our enhancer scramble story, a strategy to create hundreds of stochastic deletions, inversions, and duplications within mammalian gene regulatory regions and associate these new architectures with gene expression levels 🧵 www.biorxiv.org/content/10.1...

submitted 45 days ago • 3 comments

Excited to share James Jusuf's preprint: By integrating Micro-C with SuperRes Live-Imaging we can calibrate genomics&imaging to perform absolute quantification of looping (e.g. this loop is present 3%) We quantify mESC 36k loops: <loops> are generally rare (2.3%) www.biorxiv.org/content/10.1...

submitted 44 days ago • 6 comments

Our IT (at @fmiscience.bsky.social) group is looking for a Linux Systems Engineer. This is an interesting opportunity to work in a diverse research environment. www.fmi.ch/education-ca...

submitted 45 days ago • 0 comments

Single molecule approaches across the central dogma! Genomics, imaging and theory! Very excited to host the first edition of Gene regulation, one molecule at a time this July @embl.org! Great lineup and many abstract selected talks!

submitted 45 days ago • 1 comment

We made a photoswitchable HaloTag (psHaloTag), which can reversibly turn-on fluorogenic dyes upon illumination 💡. Congrats to Franzi, Bego and all co-authors, check out our preprint below 👇 www.biorxiv.org/content/10.1...

submitted 53 days ago • 1 comment

Our new paper showing how loss of the nuclear pore protein TPR leads to activation of an inflammatory gene expression programme in senescence is now published in eLife: bit.ly/4h1VcFi @wbickmor.bsky.social @uoe-igc.bsky.social @elife.bsky.social

submitted 53 days ago • 0 comments

How to test the functional impact of non-coding variants in vivo? We developed a new method called dual-enSERT, which can quantitatively compare the effects of enhancer variants in live mouse embryos in under two weeks. www.nature.com/articles/s41... 1/n

submitted 54 days ago • 4 comments

Are you interested in studying enhancer biology/3D genome organization in my lab at the University of Tokyo? This Biohub Network program would be a great opportunity for you! Feel free to reach out if you're interested!! www.czbiohub.org/program-ssfc...

submitted 72 days ago • 0 comments

Only two days left to apply to the joint Epigenetics and Chromatin Architecture & Transcription Regulation meeting 👇 We're looking forward to seeing you in Banff!

submitted 53 days ago • 0 comments

Did you know CTCF has a life outside cohesin loop extrusion and 3D genome folding? Here is a short review of these molecular activities by Aaron Corin and with @vram142.bsky.social www.sciencedirect.com/science/arti...

submitted 69 days ago • 2 comments

We often speak about chromatin as being accessible or inaccessible, but what does it mean? We wrote a short review on this, 🔬 focused: sciencedirect.com/science/arti... A big thank you to Tom Fillot for his efforts on this and to @hansen_lab @marcelonollmann for their help as editors.

submitted 71 days ago • 4 comments

Please check out our new paper showing that the supposed looping factor ZNF143 has no role in chromatin looping: www.cell.com/molecular-ce... And also check out the companion paper from @andersshansen.bsky.social: www.cell.com/molecular-ce...

submitted 71 days ago • 2 comments

Finally out! We present EXTRA-seq, a new EXTended Reporter Assay to quantify endogenous enhancer-promoter communication at kb scale! www.biorxiv.org/content/10.1... A 🧵about what it can do: #SynBio #DeepLearning #GeneRegulation

submitted 75 days ago • 5 comments

Out now in @ScienceAdvances 👇 science.org/doi/10.1126/... A great team effort, spearheaded by Angeliki, showing that promoter and enhancer dynamics become homogenized on transcriptional activation, and that loop extrusion and transcription compete to put brakes on chromatin

submitted 75 days ago • 2 comments

Join us at FMI as a Junior Group Leader! A unique opportunity to set up your lab in a vibrant international research institute with world-class research groups and facilities, generous core funding, a collegial and inclusive culture - and great colleagues 🤓!

submitted 75 days ago • 1 comment

Registrations are open for the first edition of 'Gene regulation, one molecule at a time'! Very excited to bring #SingleMoleculeGenomics and #SingleMoleculeImaging community together @embl.org ! www.embl.org/about/info/c...

submitted 78 days ago • 0 comments

Incredible day for the lab with @mattiaubertini.bsky.social and Verena Mutzel both being awarded EMBO fellowships to pursue their postdoctoral projects! We're so proud of them and grateful to the EMBO community for supporting our science.

submitted 80 days ago • 0 comments

Here it is! Congratuations to @jesskelley.bsky.social @edimitrova.bsky.social @neilblackledge.bsky.social @aleksszczurek.bsky.social and the rest of the team (Maciej, Amy, and Hieu). This was a fab collaboration with Arminja Kettenbach. Also see a lovely complementary paper from Fei Chen's group.

submitted 95 days ago • 8 comments

Join us in Banff for the Keystone Interplay of Chromatin Architecture and Transcriptional Regulation meeting next spring (joint with Epigenetics in Development and Disease): www.keystonesymposia.org/conferences/... Short talk abstract coming up - Jan 9

submitted 85 days ago • 0 comments

Gene regulation is more complex than you think, even in bacteria! Check out the preprint from the PhD work of Luca Galbusera. TLDR: Within single cells, transcription factor (TF) levels can undergo large transient changes that occur on the same time-scale as 1/n www.biorxiv.org/content/10.1...

submitted 87 days ago • 1 comment

two excellent papers on enhancer-promoter distance. Revisiting a classic unsolved problem. www.cell.com/molecular-ce... www.cell.com/molecular-ce... Wysocka and @chribue.bsky.social labs

submitted 89 days ago • 1 comment

We are live on Bluesky too!

submitted 87 days ago • 2 comments