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ludwigcancer.bsky.social
We fund cutting-edge scientific research across multiple Branches and Centers to better understand cancer and eliminate the suffering caused by the disease.
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Check out the latest issue of eLudwigNews conta.cc/41ynrGB and sign up for our newsletter to stay up to date on all Ludwig news bit.ly/LCRnews #CanSky #OncoSky

The Ludwig Princeton Branch is tackling fascinating and difficult problems in cancer research. We’ll be sharing videos from the Branch’s principal investigators about their work, beginning with this excellent overview from Branch Director Josh Rabinowitz. youtu.be/JnPvr9qxMz4 #CanSky #OncoSky

Ludwig @harvard.edu's Rakesh Jain tells us a bit about his life’s work on manipulating conditions of the tumor microenvironment to improve responses to cancer therapy and what he most appreciates about the Center’s community. youtu.be/i-PdxvLcei8

Ludwig @harvard.edu’s Jia-Ren Lin, researcher in Peter Sorger’s lab at the Center, shares how partnership with Sandro Santagata and others at the Center has supercharged their work on the high-dimensional imaging of cancerous tissues. @harvardlab.bsky.social #CanSky youtu.be/IPDZ_Eq_Wug

Check out the latest issue of eLudwigNews conta.cc/3EvkhdW and sign up for our newsletter to stay up to date on all Ludwig news bit.ly/LCRnews

Ludwig @harvard.edu’s Sandro Santagata discusses what drew him to cancer research and how the Ludwig Institute’s support enabled his collaboration with Peter Sorger to develop a new platform for the molecular profiling of tumors. youtu.be/Ycr7sNbP0yU

Ludwig Johns Hopkins’ Jacqueline Douglass, a clinician and scientist, spoke to us about her work and the challenges of balancing family and career. bit.ly/4gwAvRh

Check out this Q&A from the latest Ludwig Link, in which Ludwig @harvard.edu’s @jennyhogstrom.bsky.social tells us about her vocational and avocational passions: bit.ly/40ZYmnH

Researchers led by Ludwig @harvard.edu’s Rakesh Jain report that dasatinib, a leukemia drug, potently inhibits the growth of a subtype of the pediatric brain cancer ependymoma (EPN) in mouse models. Dasatinib induced a complete regression of tumors of this subtype in 78% of mice. bit.ly/4heMuUt

Team led by Ludwig Lausanne's Matteo Massara & @johannajoyce.bsky.social finds that gut bacteria of genus Alistipes promote metastasis in a breast-to-brain model of metastasis and identifies a bacterially regulated metabolite the disrupts cancer-blood vessel interactions in the brain. bit.ly/4aIhiL8

Ludwig Stanford’s Quenton Rashawn Bubb sat down with us for an engaging conversation about his life, scientific studies and career. Check it out: bit.ly/3Cvh2T1 #CancerChat #CancerSky #ResearchSky

Hear from Ludwig @harvard.edu’s Conor Evans, who specializes in photomedicine, about why he feels like “a kid in a candy store” collaborating with colleagues at the Center to solve problems in cancer research and diagnostics. #CancerSky #CancerChat youtu.be/Bb-YqB-5QdM

We spoke with Ludwig @harvard.edu’s Kornelia Polyak about her research on the molecular biology of breast cancer and how the Ludwig Harvard community excels in building collaborations to accelerate discovery. youtu.be/0mlv9UXpx1I

Three Ludwig Center trainees took a few minutes out of their very busy schedules to tell us about their lives, scientific fascinations, avocational passions and views on a variety of issues. bit.ly/4fQLQLr #ImmunoSky #CancerSky #CancerChat

Check out the latest issue of eLudwigNews conta.cc/3C01hDm and sign up for our newsletter to stay up to date on all Ludwig news bit.ly/LCRnews

Ludwig @harvard.edu’s @alextoker.bsky.social discusses his work, what drew him into a life of science and what compels him to contribute to cancer research. youtu.be/IIG5VD8EHB8 #CancerResearch #CancerChat #ImmunoSky

We caught up with Ludwig @harvard.edu’s Marcia Haigis to discuss her work on cancer metabolism, what drives her research and what makes the Ludwig Harvard community so special. Check it out: www.youtube.com/watch?v=8rwa... #CancerResearch #CancerChat #ImmunoSky

Celebrate the holiday season with the December 2024 issue of the Ludwig Link, featuring our usual lineup of exciting research, news of a research initiative at Ludwig @unil.bsky.social and Q&As with three early-career researchers from our Ludwig Centers. bit.ly/4007AP6 #CancerChat

Many thanks to The Scientist for covering our recent paper on fibrotic scarring and brain tumor recurrence 🙏 Here's the #openaccess link for our original paper in Cancer Cell led by Watson*, Zomer* et al: www.cell.com/cancer-cell/... #scicomm 🧪🔬 www.the-scientist.com/blocking-sca...

Night-shift immune cells keep your body's fat management on track while you sleep. @lydialynch.bsky.social @ludwigcancer.bsky.social www.nature.com/articles/s41...

At last week’s stimulating Ludwig Harvard retreat, we caught up with the Center’s Co-directors George Demetri & Joan Brugge to ask them about the thinking behind the Harvard Center’s extraordinarily collaborative structure. Check out this short video to find out what they said: youtu.be/kP_uPcnfC94

35 Ludwig investigators across our branches and centers have been recognized on the #HighlyCited2023 list from Clarivate. Congratulations to all! clarivate.com/highly-cited...

Check out the latest issue of eLudwigNews conta.cc/3C9mZoc and sign up for our newsletter to stay up to date on all Ludwig news bit.ly/LCRnews

Check out the latest issue of eLudwigNews conta.cc/3Ubkho4 and sign up for our newsletter to stay up to date on all Ludwig news bit.ly/LCRnews

Scientists led by Ludwig @unil.bsky.social's Florian Huber & Michal Bassani-Sternberg report NeoDisc, a computational pipeline that integrates molecular/genetic analyses of tumors + targets of T cells and harnesses AI to design personalized cancer vaccines. bit.ly/4eFqe59

A Ludwig Oxford study punctures a longstanding assumption about the source of the genome's most common type of mutation. Its findings have implications for our understanding of not only cancer biology but also carcinogenic risk & drug resistance. bit.ly/3Y4bDsZ

Team led by Ludwig Harvard's Karen Cichowski has identified in preclinical studies a 2-drug combo that could treat #TNBC. It kills cancer cells by hijacking naturally occurring signals that eliminate certain breast cells after the cessation of lactation. bit.ly/3ZWFRQW

Check out the latest issue of eLudwigNews conta.cc/3Y6F2DY and sign up for our newsletter to stay up to date on all Ludwig news bit.ly/LCRnews

Check out the latest issue of eLudwigNews conta.cc/4eskWsZ and sign up for our newsletter to stay up to date on all Ludwig news bit.ly/LCRnews

The September 2024 issue of Ludwig Link is here! Read a brief biography of our founder and catch up on our recent contributions to cancer research. bit.ly/3ZnLgR4

Excited to share our new study on #scarring, recurrence, and brain tumors 🧠 We discovered a fibrotic scar response, following a range of different therapies - that promotes cancer cell survival - & ultimately tumor #relapse 👏👏 Watson* Zomer* et al: www.cell.com/cancer-cell/... 🔬🧪⚕️🩺 🧵 1/

Study led by Ludwig @unil.bsky.social's @johannajoyce.bsky.social, Spencer Watson & alumnus Anoek Zomer shows recurrent #GBM tumors grow out of fibrous scars of tumors destroyed by therapy, explains why & tests a therapy in animal models to scuttle the process. bit.ly/3zfKOcL

Check out the latest issue of eLudwigNews conta.cc/3AMSZxO and sign up for our newsletter to stay up to date on all Ludwig news bit.ly/LCRnews

Study led by Ludwig @unil.bsky.social's Ping-Chih Ho & Alessio Bevilacqua identifies a cellular metabolic switch essential to generating memory T cells for lasting immunity as well as a subtype of T cells in tumors that drives responses to cancer #immunotherapy. bit.ly/4dVOFue

Ludwig @unil.bsky.social's Melita Irving, former grad student Evangelos Stefanidis & team report a two-pronged attack strategy to simultaneously drive T cell & macrophage attack on tumors. Adding therapeutic antibodies to the mix boosts cancer cell targeting. bit.ly/3X4fjMb

Team led by Ludwig @unil.bsky.social's Alexandre Harari & Rémy Pétremand reports in Nature Biotechnology an AI-based predictive model, TRTpred, that when used with other algorithms vastly improves selection of potent T cells for personalized cancer immunotherapy. bit.ly/4b8vuMJ

The Spring 2024 edition of the Ludwig Link is live! Check it out for a deep dive into a 3-year team science initiative focused on immunometabolism, a Q&A with three early-career scientists, and our usual round up of science, awards and news from Ludwig researchers. bit.ly/ll24s

Team led by Ludwig @unil.bsky.social's Matteo Morotti, Alizee Grimm, Denarda Dangaj Laniti & George Coukos reports in Nature a new mechanism of immune evasion employed by tumors & shows how it can be disabled to improve the efficacy of a cancer immunotherapy. bit.ly/4aFpF9n

Ludwig @unil.bsky.social's Spencer Watson & @johannajoyce.bsky.social developed HIFI, an open-source method to simultaneously capture the dynamic structural & cellular architecture of tumors & used it to analyze changes in brain tumors subjected to radiotherapy: rdcu.be/dELus

Congratulations to Ludwig Oxford’s Francesco Boccellato on receiving the Lee Placito Research Fellowship! The Lee Placito Medical Fund seeks to advance research on cancers and other diseases of the gastrointestinal tract. bit.ly/4cKjCSq

Celebrating the seven early-career researchers awarded Ludwig-supported travel awards to this year’s AACR Annual Meeting through the Scholars-in-Training program! bit.ly/43Q7viL

The AACR Annual Meeting begins today, and we’ve compiled a list of the presentations and posters by Ludwig researchers this year. Check out the link and consider these excellent additions to your itinerary! #AACR24 bit.ly/4aqCWme

Ludwig Johns Hopkins team led by Tushar Nichakawade, Jiaxin Ge, Bert Vogelstein and Suman Paul has shown that an anti-TRBC1 antibody linked to a cancer drug can effect a cure in mouse models of human T cell cancers, for which few viable therapies exist. bit.ly/3vuq8Mr

Folks at New York office sporting their swank Ludwig Cancer Research hats. Some people say it’s the hippest, hottest look out there this spring.

Check out this important “Perspective” in Cell on unravelling the complexity of cancer as a systemic disease. Its co-authors include Ludwig Lausanne's Douglas Hanahan & @johannajoyce.bsky.social, Ludwig Princeton’s Eileen White & Scientific Advisor Karen Vousden. bit.ly/3TSsD4q

Check out this excellent article from Ludwig @unil.bsky.social’s @johannajoyce.bsky.social on the twists and turns of the early stages of her extraordinary career, and her advice for young researchers facing the same questions today. go.nature.com/4as68bV

Don’t miss this commentary co-authored by Ludwig @unil.bsky.social's @johannajoyce.bsky.social on why the gender gap widens on the higher rungs of the academic ladder—depicted graphically as a scissor-shaped curve—and how the disparity might be remedied. bit.ly/490p2pn

Team co-led by Ludwig @unil.bsky.social's Michal Bassani-Sternberg reports a method to identify peptides encoded by RNAs once thought to be noncoding that are presented to immune cells & finds 54 such potential cancer antigens in lung & melanoma tumor samples. bit.ly/3x3rKgA