madhurbsingh.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

New preprint🌍 Our trans-ancestry GWAS in UK Biobank uncovers novel risk loci for major depression, improving genetic insights across populations. 🔗: www.medrxiv.org/content/10.1... @madhurbsingh.bsky.social @gentyae.bsky.social @pbb319.bsky.social timbigdeli.bsky.social @roseannpeterson.bsky.social

submitted 22 hours ago • 0 comments

Many thanks to all of the collaborators and funders (esp @wellcometrust.bsky.social & @ukri.org) who made this DNA methylome-wide study of antidepressant exposure possible www.nature.com/articles/s41...

submitted 5 days ago • 1 comment

Excited to share a couple of new items (links below): 1. Our work on gene-environment interactions in the UKBiobank is up at the American Journal of Human Genetics 2. Our work on modeling ancient human population size history is up at Molecular Biology and Evolution

submitted 11 days ago • 1 comment

🚨NEW PAPER! Together with Wuno Akingbuwa (@wonuola.bsky.social) we developed a way to estimate non-linear genetic correlations. It didnt sit well with us that known non-linear relations (e.g. BMI and MDD with a famous U shaped ) are poorly captured in statistical genetics. 🧵

submitted 15 days ago • 2 comments

Incredibly proud to see our latest work out in Nature Genetics: www.nature.com/articles/s41... Here we share our FLAMES framework, which predicts the effector genes in GWAS loci with state-of-the-art precision🔥 Special thanks to @daniposthu.bsky.social A full thread describing findings below!

submitted 18 days ago • 1 comment

New paper! Led by Kirsten J. M. van Hooijdonk & Jacqueline Vink, this study finds no bidirectional causal link between diet/physical activity & depression/anxiety using triangulation. No strong causal evidence! @zoereed.bsky.social @madhurbsingh.bsky.social 📖 doi.org/10.1017/S003...

submitted 23 days ago • 0 comments

Nice paper showing ~1/540 people have a sex chromosome trisomy from 3 large biobanks (UKB, FinnGen, MVP) comprising 1.5 million individuals along with their phenotypic impact. www.medrxiv.org/content/10.1...

submitted 23 days ago • 1 comment

Are mental disorders extreme manifestations of continuous traits or genetically distinct entities? We present Genomic Taxometric Analysis of Continuous and Case-Control data (GTACCC) for evaluating genetic continuity and differentiation of traits across the severity spectrum. Tweetorial coming soon.

submitted 24 days ago • 2 comments

Modern GWAS can identify 1000s of significant hits but it can be hard to turn this into biological insight. What key cellular functions link genetic variation to disease? I'm very excited to present our new work combining associations and Perturb-seq to build interpretable causal graphs! A 🧵

submitted 34 days ago • 6 comments

King's College London launches the Atlas of Longitudinal Datasets, in partnership with @wellcometrust.bsky.social / @mqmentalhealth.bsky.social, a free platform with over 1,600 datasets, to support mental health research worldwide. 🌍 Read more and learn how to access: www.kcl.ac.uk/news/kings-l...

submitted 37 days ago • 1 comment

🚀 New paper by @madhurbsingh.bsky.social on smoking & DNA methylation via twin-based MR using @ntrbiopsy.bsky.social data! Supervised by Mike Neale, @jennyvandongen.bsky.social, & Conor Dolan. Co-authors: @dlapato.bsky.social, @charlesbreeze.bsky.social. 🔗 doi.org/10.1007/s106...

submitted 43 days ago • 0 comments

Thrilled to share some amazing news— @madhurbsingh.bsky.social, supervised by Roseann Peterson, PhD, and Michael C. Neale, PhD, has been awarded VCU VIPBG's Kenneth S. Kendler Award for Excellence in Predoctoral Research!

submitted 43 days ago • 0 comments

1/n Our multi-ancestry #GWAS meta-analysis of major depression is now published in @cellpress.bsky.social. www.cell.com/cell/fulltex... A thread 🧵:

submitted 45 days ago • 4 comments

🚨 This will become a curated list of awesome tools for complex trait genetics, add yours! it may become a review in which case those who contribute are invited as co-authors.

submitted 93 days ago • 7 comments

Tidyplots empowers life scientists with easy code-based data visualization https://www.biorxiv.org/content/10.1101/2024.11.08.621836v1 #rstats

submitted 99 days ago • 6 comments

New here? or logged back in recently? Find your old friends in statistical and psychiatric genetics in this starter pack, ill try to update frequently, let me know if you want to be added: go.bsky.app/9643dwo

submitted 114 days ago • 5 comments

Excited about this work from my PhD being presented by my advisor, Roseann Peterson, at #WCP2024 in MEX🇲🇽 “Empowering Genomic Discovery for Major Depression: A GWAS Workflow Across Ancestries”! 🌎🧬🧠 11/17, 12-1 PM, Station 1. Advancing trans-ancestry GWAS for genetic insights!💡 #Genetics #Psychiatry

submitted 106 days ago • 0 comments

@ent3c.bsky.social suggested we need a behaviour genetics starter pack, let me know who to add!

submitted 108 days ago • 9 comments

I couldn't spot a starter pack for rare disease / clinical genomics, so I started one: go.bsky.app/SUWZ9Hw Very much a work in progress, and biased by who I have already found here, so please suggest people to add! Self-nominations encouraged. #ClinicalInformatics #genomics #bioinformatics 🖥️🧬

submitted 106 days ago • 38 comments

Excited about this work from my PhD being presented by my advisor, Roseann Peterson, at #WCP2024 in MEX🇲🇽 “Empowering Genomic Discovery for Major Depression: A GWAS Workflow Across Ancestries”! 🌎🧬🧠 11/17, 12-1 PM, Station 1. Advancing trans-ancestry GWAS for genetic insights!💡 #Genetics #Psychiatry

submitted 106 days ago • 0 comments

Bluesky servers...

submitted 106 days ago • 0 comments

Don’t miss our poster at #WCP2024! 📊 Dive into “Exploring Depression Phenotypes Across Latin American Genomes” with the LAGC-MDD Working Group 🌎 on 11/16, 12-1 PM at Station 03. Join us to explore GWAS insights on MDD in Latin America! #Genomics #Psychiatry

submitted 106 days ago • 1 comment

We must stand against the arbitrary categorization of continuous variables! ... and that's why I'm proud to announce my support of abolishing time zones in favor of the time gradient

submitted 107 days ago • 27 comments

🧬The Genetic Links to Anxiety and Depression @GLADStudy is on the #CatalogueMHM! 🧠 The study looks at the #riskfactors for #depression and #anxiety. Check it out here-> buff.ly/3Al8exO @thaliaeley.bsky.social @psychgenomics.bsky.social @kcl.ac.uk @nihr.bsky.social

submitted 121 days ago • 0 comments

I have been (foolishly?) searching for peak 2015-2017 twitter "science on socials" magic... In an experiment to recapture that excitement, I talked to @eikofried.bsky.social , in what might veer into podcast territory(?), about a new GWAS of Depression (N > 5 million) www.youtube.com/watch?v=vHvB...

submitted 297 days ago • 1 comment

Our attempt at studying the psychiatric epidemiology of the (potentially causal) relation between educational attainment and psychiatric diagnosis, while triangulating across different methods, led by the amazing @perlinedemange.bsky.social when she was a PhD student with me in Amsterdam..

submitted 303 days ago • 1 comment

Two new chapters from my open-access textbook in human population genetics are now online: - Population structure: I. Ancestry estimation - Population structure: II. More about admixture web.stanford.edu/group/pritch...

submitted 315 days ago • 1 comment

The International Statistical Genetics Workshop, annually held in Boulder, has its video lectures and practicals organized on a user-friendly website, which will be further expanded as the field evolves 🧬📏 www.colorado.edu/ibg/isgw-onl...

submitted 364 days ago • 0 comments

Great job students and faculty of the International Statistical Genetics Workshop 2024 in Boulder, what an amazing week it was, as always 🧬❤️🍻 Next year it's GWAS and sequence data analysis again, see you then: colorado.edu/ibg/workshop

submitted 356 days ago • 1 comment