marcotrizzino.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

On this day May 13th, 1985 the city of Philadelphia dropped a bomb on the Move Home at 6221 Osage Avenue killing 11 people including 5 children. collaborativehistory.gse.upenn.edu/stories/move...

submitted 19 hours ago • 25 comments

We had previously shown that TBX3 and #WNT cooperate in limb #DevBio We now have a shocking finding, just published in @pnas.org TBX3 physically engages with β-catenin to drive metastasis genes in #ColorectalCancer (CRC) www.pnas.org/doi/epub/10....

submitted 1 day ago • 6 comments

The Parkinsons disease associated Leucine-rich repeat kinase 2 affects expression of Transferrin receptor 1 and phosphorylation of key signaling proteins in human iPSC-derived dopaminergic neurons https://www.biorxiv.org/content/10.1101/2025.05.06.652393v1

submitted 2 days ago • 0 comments

New notice on NIH foreign awards Perhaps some useful clarity and information grants.nih.gov/news-events/...

submitted 6 days ago • 8 comments

And just like that, overnight our lab loses two 5-year R01s (both of which just started) because of the new NIH rules about foreign co-PIs. This is so painful.

submitted 6 days ago • 21 comments

🧬🎉Thrilled to share our new chromatin remodeling study! We reveal three states of human CHD1 and identify a novel "anchor element" that interacts with the acidic patch—conserved among remodelers. Our structures clarify mechanisms of remodeler recruitment! Link: authors.elsevier.com/a/1l2ik3vVUP...

submitted 7 days ago • 4 comments

I am excited to share our lab's first review out with in Blood Cancer Journal. We discuss the impact of transposable elements on genome regulation and variation in both normal haematopoietic processes and haematological cancers. www.nature.com/articles/s41...

submitted 7 days ago • 0 comments

📣 Imperial College Research Fellowships! Prestigious 4yr fellowship ✔️ Salary from £48k ✔️ Up to £45k for research ✔️ A supportive, inclusive research environment ✔️ UK or international ✔️ <4 yrs post-PhD Drop me a pm if you are interested in bee/microbe related research! tinyurl.com/mr3k5a93

submitted 8 days ago • 0 comments

This is quite amazing, the team identified some exceptionally powerful neutralizing antivenom antibodies and are working toward a universally protective cocktail. Brilliant, and all it took was for a single person to get bitten by snakes some 200 times.... www.cell.com/cell/fulltex...

submitted 10 days ago • 2 comments

Remember when you first learned about genetics at school? All those fascinating examples of human traits that are each apparently determined by just a single gene? Time to check in on some of your favourites to see how they’re doing. 🧬🧵🧪 1/n

submitted 11 days ago • 55 comments

NIH’s new director, Jayanta “Jay” Bhattacharya, dismissed the report as “rumors” in an interview with Science on Thursday morning, hours before he announced the new policy. www.science.org/content/arti...

submitted 11 days ago • 2 comments

New from @statnews.com on internal memos to halt NIH-funded international collaboration that go beyond what was reported in the NIH guidance from May 1. a 🧵 www.statnews.com/2025/05/02/n...

submitted 11 days ago • 3 comments

A cluster of neural crest cell migrating on some micro patterns (📹 Kai Weißenbruch). Also congratulations to former postdoc Adam Shellard, Kai Weißenbruch, and PhD student Peter A. E. Hampshire on their recent paper on friction-based migration. www.nature.com/articles/s41...

submitted 11 days ago • 0 comments

Masterpiece!

submitted 11 days ago • 0 comments

So the way I read the guidance, foreign institutions would still be allowed as long as they are directly awarded and not subwarded? grants.nih.gov/grants/guide....

submitted 11 days ago • 0 comments

NIH announced it will no longer allow subawards to foreign institutions, as part of a national security-minded overhaul to how it manages research funding

submitted 11 days ago • 1 comment

RFK Jr: "We found that there's a direct inverse correlation between fluoride exposure and low IQ in children. So the more you get, the stupider you are."

submitted 13 days ago • 5456 comments

☕Han et al. report the existence of #neural #StemCells (NSCs) outside the central nervous system and show that these peripheral NSCs display features similar to brain NSCs, including the ability to differentiate into mature #neurons. bit.ly/4jmyN6G

submitted 12 days ago • 1 comment

NIH has cancelled its participation in Safe to Sleep, a 30-year campaign to prevent babies from dying in their sleep www.statnews.com/2025/04/30/n...

submitted 12 days ago • 40 comments

Piwi and piRNAs repress transcription of aberrant rRNA genes containing retrotransposon fragments https://www.biorxiv.org/content/10.1101/2025.04.30.651568v1

submitted 13 days ago • 0 comments

Check out our latest preprint, led by Dr. Siyu Chen, that brings together an amazing team of scientists from several labs ( @vram142.bsky.social, Tavazoie, and Navickas) to tackle a fundamental problem in biology: how do cells regulate expression of their tRNAs? www.biorxiv.org/content/10.1...

submitted 13 days ago • 2 comments

💥🥳 At long last, our latest paper is out! Gag proteins of endogenous retroviruses are required for zebrafish development www.pnas.org/doi/10.1073/... Led heroically by Sylvia Chang & @jonowells.bsky.social A study which has changed the way I think of #transposons! No less! 🧵 1/n

submitted 13 days ago • 14 comments

Our latest manuscript (7 years in the works) tackles the question of how diurnal ground squirrels evolved a cone-dominant retina, in contrast to the ancestral rod-dominant retina retained by virtually all other mammals./1 www.biorxiv.org/content/10.1...

submitted 14 days ago • 6 comments

Familial Alzheimer disease mutation identifies novel role of SORLA in release of neurotrophic exosomes https://www.biorxiv.org/content/10.1101/2025.04.22.649924v1

submitted 14 days ago • 0 comments

SoxB1 family members inhibit Wnt signaling to promote maturation and deposition of stable neuromasts by the zebrafish Posterior Lateral Line primordium https://www.biorxiv.org/content/10.1101/2025.04.23.650055v1

submitted 14 days ago • 0 comments

Inhibiting SOX18 with propranolol restores vascular integrity in NR2F2-driven malformations https://www.biorxiv.org/content/10.1101/2025.04.25.650344v1

submitted 14 days ago • 0 comments

If you're a new PI within 5 years of your first faculty position, here are two fantastic grants to help develop your research: the Kickstart Travel Grant & ECR Visiting Fellowships Find out more at biologists.com/grants/#jeb The next application deadline is 6 June Please repost to spread the word

submitted 15 days ago • 0 comments

Our primate T2T paper came out in Nature yesterday! It was a huge effort and I'm so grateful that I got the opportunity to work with this amazing group of scientists over the first two years of my PhD! www.nature.com/articles/s41...

submitted 33 days ago • 0 comments

New preprint! We have discovered that the splicing factor Sex lethal (Sxl - well known for its role in sex determination) binds to chromatin and regulates tRNA synthesis in neurons by interacting with RNA Pol III! Highlighting Sxl as a novel modulator of neuronal homeostasis. tinyurl.com/s44s2z95

submitted 17 days ago • 3 comments

We released our preprint on the CREsted package. CREsted allows for complete modeling of cell type-specific enhancer codes from scATAC-seq data. We demonstrate CREsted’s robust functionality in various species and tissues, and in vivo validate our findings: www.biorxiv.org/content/10.1...

submitted 40 days ago • 1 comment

The rest of Mendel's alleles characterized! So, out of 7 traits, 3 caused by TE insertions!!! (though apparently there are two different green alleles, one cause by a TE insertion, but another a promoter deletion allele) www.nature.com/articles/s41...

submitted 18 days ago • 1 comment

Wait, what? Point centromeres are direct descendants of retrotransposons 🤯!!

submitted 18 days ago • 1 comment

This is just an amazing discovery! TE co-option as centromeres in yeast.

submitted 18 days ago • 0 comments

Would you like to be the Node’s new Community Manager? #JobOpportunity If you're interested in #SciComm and passionate about #DevBio, consider applying to this job to join the @dev-journal.bsky.social @biologists.bsky.social team! Find out more about what the role entails:

submitted 19 days ago • 0 comments