markusmukenhirn.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

🔥 New Fraticelli lab publication🔥 “Pre-existing stem cell heterogeneity dictates clonal responses to the acquisition of leukemia driver mutations” Now at Cell Stem Cell, with two new figures, in vivo, and sequential mutagenesis data. Performed with the support of Cris Cancer and @erc.europa.eu

submitted 18 hours ago • 4 comments

Automatic cell analysis using #AI Researchers retrained existing AI-based software on over 17,000 microscopy images with over 2 million structures to develop this new model - Segment Anything for Microscopy: www.uni-goettingen.de/en/3240.html... #NatureMethods research: doi.org/10.1038/s415...

submitted 1 day ago • 0 comments

Guillamat, P., Blanch-Mercader, C., Pernollet, G., Kruse, K., & Roux, A. (2022). Integer topological defects organize stresses driving tissue morphogenesis. Nature Materials, 21(5) #EpithelialMechanics https://buff.ly/41cHclL

submitted 2 days ago • 0 comments

Totally agree. The election result is no surprise according to the latest predictions but that the far right party got double the votes they got last time is a very concerning outcome.

submitted 2 days ago • 0 comments

I'm thrilled that our paper is now online: www.nature.com/articles/s41... describing an elegant pH-triggered CIE. Thanks to everyone who made it an exciting and successful project @ewanmacdonald.bsky.social @cessvala.bsky.social @christianwunder.bsky.social #fluorescencefriday #microscopymonday

submitted 2 days ago • 1 comment

Science is for everyone. docs.google.com/forms/d/e/1F...

submitted 9 days ago • 9 comments

Just voted for the new German parliament. Go democracy!

submitted 3 days ago • 0 comments

Worst. Episode. EVER.

submitted 4 days ago • 889 comments

Use this form to tell us how the new US administration is affecting your research, or suggest future coverage https://go.nature.com/3EYNA8C

submitted 4 days ago • 4 comments

If we had to pick a favorite 👇 "Geometry-driven asymmetric cell divisions pattern cell cycles and zygotic genome activation in the zebrafish embryo" from @heisenbergcplab.bsky.social et al. 🔗 to preprint: www.biorxiv.org/content/10.1... 🔗 to full list: focalplane.biologists.com/2025/02/21/m...

submitted 4 days ago • 0 comments

Our preprints list is now up on FocalPlane! This week we focus on research that has applied microscopy to answer questions in biology. As always, let us know if there are any recent preprints that you think we should highlight. focalplane.biologists.com/2025/02/21/m...

submitted 4 days ago • 1 comment

Bravo @plos.org! US exec orders "stand in direct conflict with our core values, our mission, edit policies" "PLOS will not compromise on issues of scientific rigor & editorial integrity... we seek diversity because more expert voices make for better science" theplosblog.plos.org/2025/02/plos...

submitted 4 days ago • 2 comments

I started my lab more then 4 years ago, and we have endured some very challenging times ever since.…I am very excited to share the first paper from my lab, published now in @naturemethods.bsky.social www.nature.com/articles/s41...

submitted 5 days ago • 10 comments

Der neue US-Energieminister Chris Wright hat in seiner Antrittsrede scharfe Kritik an der deutschen Energiewende geäußert. Doch die entscheidenden Zahlen, mit denen er argumentiert hat, sind frei erfunden. Ein Faktencheck im Climate.Table von @table.media (€): table.media/climate/anal...

submitted 6 days ago • 117 comments

HHMI, CZI your local grad group’s DEI committee (?) - the fear of retaliation is causing scientists across scales to abandon justice, morality and humanity. Fear is real - our response to the threat is in our control - we cower or confront. Your choice.

submitted 6 days ago • 1 comment

How do cells find their place in a developing embryo? Scientists have long wondered. A new study by the Hiiragi group uncovers how embryos achieve precise cell organization. Curious what breadcrumbs have to do with this? @prachitimoghe.bsky.social explains it here: www.hubrecht.eu/breadcrumb-t...

submitted 8 days ago • 0 comments

Delighted to share that my PhD work from the Hiiragi Lab is now published in Nature Cell Biology! We uncover the cellular mechanisms underlying pattern formation and how patterning robustness can be ensured during embryo development. Check out the full story: nature.com/articles/s41556-025-01618-9

submitted 8 days ago • 0 comments

Visualizing RNA in live cells using CRISPR nature.com/articles/s41...

submitted 7 days ago • 0 comments

I'm looking for a talented+motivated person to join my team at the #MechanobiologyInstitute @NUS for a #postdoc. If you're interested in investigating collective cell behavior during 3D tissue #morphogenesis with me, please apply here or PM for Qs. Please RT! careers.nus.edu.sg/job/Research...

submitted 8 days ago • 0 comments

We are hiring! If you are curious to understand how the mechanical integrity of epithelia is maintained without the tissue tearing, apply now! Phd and post-doctoral funding available

submitted 8 days ago • 0 comments

What Europe should do RIGHT NOW: Make it extremely easy for US scientists to get long-term visa, create as many additional research jobs in key areas as possible, create new, generous science and research funds. People are losing their jobs over there NOW. Let‘s welcome them.

submitted 8 days ago • 30 comments

ATTENTION (PLEASE SHARE) If anyone has or knows of any positions that might be appropriate for the NIH staff members who were terminated, please post the information in this thread. There are lots of talented and accomplished people who may be looking for new opportunities.

submitted 10 days ago • 92 comments

It is my first Bluesky post: I am thrilled that our work on MemGraft probes for “permanent” fluorescent labelling of plasma membranes is finally out in JACS Au! We established a concept of lipid-directed covalent labeling of plasma membranes. Open access article: pubs.acs.org/doi/10.1021/...

submitted 12 days ago • 5 comments

“The world’s a shit show, so why not put 💩 on a chip? Scientists created an iPSC-derived intestine-on-a-chip with fecal microbiota—uncovering epithelium-specific biomarkers & microbial factors linked to melanoma outcomes. Cutting-edge #OrganOnChip tech! #ImmunoSky #MedSky”

submitted 12 days ago • 2 comments

Cool stuff from Andrey Klymchenko's lab. These plasma membrane labels are a pretty smart design. Check it out! pubs.acs.org/doi/10.1021/...

submitted 12 days ago • 1 comment

Mechanics of Single Cytoskeletal Filaments - Annual Reviews just out from @romet-jegou-lab.bsky.social @cecileleduc.bsky.social @hugowioland.bsky.social: www.annualreviews.org/content/jour...

submitted 13 days ago • 0 comments

Schoenit, A., Monfared, S., Anger, L., Rosse, C., Venkatesh, V., Balasubramaniam, L., Marangoni, E., Chavrier, P., ..., Doostmohammadi, A., & Ladoux B. (2024). Force transmission is a master regulator of mechanical cell competition. bioRxiv. #EpithelialMechanics www.biorxiv.org/content/10.1...

submitted 13 days ago • 0 comments

Clinical applications of human organoids www.nature.com/articles/s41...

submitted 13 days ago • 0 comments

The self-driving multiscale microscope from @daetwylerstephan.bsky.social is out. It can image an entire zebrafish embryo longitudinally and follow a volume of interest over time with high resolution. We used it to study cancer-immune cell interactions. www.nature.com/articles/s41...

submitted 13 days ago • 5 comments

We present: Direct-view oblique plane microscopy www.biorxiv.org/content/10.1...

submitted 13 days ago • 4 comments

This is awesome! The next evolution in mesoscopic OPM. Lamb et al dispense with the tertiary imaging system and put a camera directly into the remote space. Involves some modification of the imaging sensor - very cool!

submitted 13 days ago • 1 comment

After a long journey, Segment Anything for Microscopy is now published in Nature Methods! We significantly improve SAM for interactive and automatic segmentation in light and electron microscopy and build a user-friendly tool. www.nature.com/articles/s41...

submitted 13 days ago • 12 comments

Excited to share our new work with Frank Jülicher on noise control & concentration buffering in intracellular condensates! There has been confusion about these concepts, which we aim to address in this paper. www.cell.com/cell-systems...

submitted 14 days ago • 1 comment

Learn about the differences of noise buffering and noise reduction mediated by biomolecular condensates. A report from our former colleague Chris Zechner and Frank Jülicher from the MPI-PKS @zechnerlab.bsky.social @mpipks.bsky.social @poldresden.bsky.social

submitted 14 days ago • 0 comments

Making intrabodies from antibodies just got easier! Learn how we made 𝟭𝟵 intrabodies to bind and light up peptides and histone modifications in live cells. And thanks to Academia, all sequences are freely available. (video credit: Yuko Sato @YukoSatoT2) (1/15) www.biorxiv.org/content/10.1...

submitted 14 days ago • 12 comments

ÅNGSTRÖM-RESOLUTION IMAGING OF CELL-SURFACE GLYCANS 🧬🎨🍬 The glycocalyx, our cells' sugar coat, holds secrets in immunology, cancer, viral infections, and more. Visualizing its molecular architecture was impossible… until now. #glycotime #microscopy www.biorxiv.org/content/10.1...

submitted 16 days ago • 15 comments

New publication from the Krieg lab on programmable hydrogels and cell polarity switching:

submitted 16 days ago • 0 comments

Another beautiful tight junction. This time with scale bar :)

submitted 19 days ago • 0 comments

New publication from the Krieg lab on programmable hydrogels and cell polarity switching:

submitted 16 days ago • 0 comments

"Die USA sind ein neuer Talentpool für uns."

submitted 17 days ago • 0 comments

Integrin Trafficking, Fibronectin Architecture, and Glomerular Injury upon AdipoR1 Depletion journals.lww.com/jasn/abstrac...

submitted 17 days ago • 0 comments