matsen.bsky.social
I ♥ evolution, immunology, math, & computers. Professor at Fred Hutch & Investigator at HHMI. http://matsen.fredhutch.org/
10 posts
397 followers
81 following
Getting Started
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Next stop: postdoc with @wsdewitt.bsky.social working on BCRs. Look out, antibody people!
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Plus, she's taught tons, including for Coding for Cancer www.fredhutch.org/en/education..., @girlswhocode.bsky.social, and I handed off my teaching slot in the MCB Tools for Computational Biology course.
She is a kind and genuine soul.
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Bonus paper: dx.doi.org/10.1371/jour... Maggie designs a multilevel model to estimate time of HIV infection in infants. This was her rotation project, and how she taught herself probability / Bayesian inference.
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Paper 3: doi.org/10.1101/2024... (in revision for NAR.) Clear evidence for the effects of microhomology in VDJ recombination: if there is a little homology between the two trimmed ends, then the sequence is more likely to ligate. This was a very challenging project; Maggie crushed it!
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Paper 2: dx.doi.org/10.7554/eLif... Sequence determinants of VDJ recombination trimming. VDJ trimming distributions have all these crazy shapes yet are consistent between individuals. Why? Maggie modeled sequence dependence with a handful of parameters and got a model that fits beautifully (orange)
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Paper 1: dx.doi.org/10.7554/eLif... . GWAS finding first examples of trans genetic variants associated with VDJ recombination outcome. Look, there's Artemis (DCLRE1C), providing an independent line of evidence for Artemis being the agent of VDJ recombination trimming.
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Love it. The NSF has "broader impacts" as part of grant applications. It would be neat to see the NIH reward this sort of work.
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Agree, but in what mode of communication?