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matteo-fiorenza.bsky.social
Assistant Professor in Clinical Translational Metabolism at the University of Copenhagen | #Physiology #Metabolism #Mitochondria #Diabetes #Obesity #Exercise #Muscle
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Reducing the mitochondrial oxidative burden alleviates lipid-induced muscle insulin resistance in humans In our latest study, we provide mechanistic evidence implicating mitochondrial ROS in the development of muscle insulin resistance in hyperlipidemic states such as obesity. 1/7 🧵👇

Kicking off 2025 with a highlight from our 2024 study in #CellReportsMedicine @cellpress.bsky.social We uncovered the potential role of a metabokine-sphingolipid axis in sustaining weight loss in humans with #obesity. 1/10 🧵👇

Views about the causes of obesity have polarised. Characterised by low carb and energy balance models. Last year NovoNordisk invited the protagonists of these models to Copenhagen to discuss commonalities and differences. The resultant paper has now been published in Nature Metabolism rdcu.be/dZryb

Reducing the mitochondrial oxidative burden alleviates lipid-induced muscle insulin resistance in humans In our latest study, we provide mechanistic evidence implicating mitochondrial ROS in the development of muscle insulin resistance in hyperlipidemic states such as obesity. 1/7 🧵👇

A mechanism for why durable weight loss is so difficult: epigenetic memory of fat cells www.nature.com/articles/s41...

Hello @bsky.app #science community! I'll be sharing papers on #physiology, #metabolism, #diabetes, #obesity, #mitochondria, #muscle, and #exercise. If you are working in these areas, reach out and connect.

New preprint! We show that GLP1RA semaglutide increases skeletal muscle OXPHOS efficiency in mice. Improved energy efficiency would be predicted to lower energy expenditure and may contribute to propensity for weight regain. www.biorxiv.org/content/10.1...

People working on #cancermetabolism, #mitochondrialbiology, #metabolism, please reach out! Share this so I can follow who is here! I will share paper on cancer metabolism, but anything else related to mitochondria and metabolism.