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maxperutzlabs.bsky.social
The Max Perutz Labs are a joint venture of @univienna.bsky.social and the Medical University of Vienna, dedicated to a mechanistic understanding of fundamental biomedical processes.
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🎉 Perutz group leader and @embl.org alumna Irma Querques received the John Kendrew Award for her groundbreaking research in genome editing 🏆 Named after John Kendrew, who won the 1962 Nobel prize in chemistry alongside Max Perutz, this award carries a special significance ➡️ tinyurl.com/4ep7vzhb

🤔 Ever wondered how top-quality monoclonal antibodies are made? In the fourth part of our facilities series, we take you inside the Monoclonal Antibody facility, where experts produce tailor-made antibodies ➡️ tinyurl.com/mt29aac5 @univie.ac.at

Another tenured professor at the Perutz - congrats to @sebastianfalk.bsky.social! 👏 His lab, established in 2019, explores how small RNAs control gene expression through the RNA interference pathway 🔎 More ➡️ tinyurl.com/4c86dmr5 @univie.ac.at

You are passionate about mobile DNA, structural biology, and genome engineering? 👀 Exciting #postdoc opportunity ahead! @irmaquerques.bsky.social's lab is seeking a postdoctoral researcher with a background in biochemistry and structural biology (cryo-EM) 🥼 More ➡️ tinyurl.com/nd9zbmt6

💻 Are you an IT enthusiast and problem solver who enjoys tackling tech challenges and helping people? Then this opportunity is for you! The Max Perutz Labs are looking for an IT support allrounder to maintain IT services and provide first-level support. More (in German) ➡️ tinyurl.com/y46uderk

❕Master's thesis opportunity! The Martens lab is offering a Master's project to investigate how Parkinson's disease aggregates impact the human brain 🧠 Don't miss this chance to dive into cutting-edge research ➡️ tinyurl.com/22epxz4r

Long before the Max Perutz Labs were officially founded in 2005, a group of ambitious young molecular biologists - some of them shown below - dreamed of creating a research institute that would unite the strengths of scientists in a cross-university initiative 🙌 #MaxPerutzLabs20Years @univie.ac.at

👩‍🎓 Paulina Kettel (Karagöz lab) defended her thesis titled "Deciphering the early activation mechanisms of the unfolded protein response by proteotoxic endoplasmic reticulum stress" and earned her hat! Congrats, Paulina 🤩🎉 @univie.ac.at

👏 Congrats to Irene Schwartz from the Versteeg lab on completing her PhD with her project "Protection from endogenous cancer-associated APOBEC3 deaminases through proteasomal degradation"! 🙌 #phdone @univie.ac.at

‪We're excited to announce that registration for the "Tiles of Life" Student Symposium is now open! With a fantastic lineup of guest speakers, complemented by SMICH student talks, we’re set for two inspiring days. Don’t miss out—register now! 🚀🎓✨ #TilesofLife #studentsymposium #SMICH

📑 New study out now! The Kovarik lab uncovers a novel mechanism for eliminating pro-inflammatory pre-mRNAs in the nucleus - preventing the overproduction of cytokines published in Molecular Cell ➡️ tinyurl.com/m8p87k6k @univie.ac.at

Did you miss the Vienna BioCenter Climate Lecture with Philipp Weber? Or maybe you want to revisit the interesting discussions? Then you are in luck, because the lecture just went online on the YouTube Channel of the Climate Group: youtube.com/watch?v=sTk1... #vbcclimatelecture

Congrats to Perutz group leaders Elif Karagöz and @shotarootsuka.bsky.social on becoming tenured professors 🎉 Since 2019, the Karagöz lab has been uncovering how cells maintain protein homeostasis, while the Otsuka lab explores how the ER and nucleus communicate ➡️ tinyurl.com/2phzhprj

Don’t miss the next @crc1430.bsky.social seminar tomorrow, January 28. We're excited to welcome Sascha Martens (@maxperutzlabs.bsky.social @univie.ac.at) as he explores the 'Mechanisms of Selective #Autophagy.'

Paper alert! 📢 RNA-protein interactions are well-documented, but their relationship with biological coding has remained elusive - until now 🔎 In @pnas.org, the Žagrović lab uncovered specific examples of RNA-protein interactions embedded within the genetic code ➡️ tinyurl.com/3t33hrzm @univie.ac.at

Der Chemiker Markus Muttenthaler und der Biophysiker @jonasries.bsky.social erhalten je einen Proof of Concept Grant des ERC - wir gratulieren! 🥳 🧪 Mit dem Programm des @ercresearch.bsky.social wird grundlagenorientierte Pionierforschung mit hohem Innovationspotenzial ermöglicht. 👨‍🔬 👩‍🔬 Mehr dazu: ⤵

🎉 Congratulations to @jonasries.bsky.social on receiving an ERC Proof of Concept grant! With his project 'PhaseFLUX', Jonas is working on a microscope prototype to enhance the MINFLUX technology 🔬 #ERCPoC ➡️ tinyurl.com/yc4yww3k

Honored to announce our partnership with @marcoyannic.bsky.social! Check out the link below 🎉

🎉 Congrats to @marcoyannic.bsky.social on securing a WWTF grant! Partnering with Irene Görzer from the Medical University of Vienna, Marco will delve into the largely unexplored world of anelloviruses - ubiquitous, commensal members of the human virome 🦠 Read more ➡️ tinyurl.com/yk5zfcmh

Time to share our organelle proteome paper out in @cellcellpress.bsky.social: doi.org/nzwz We created a spatial map of human cells using organelle immunoprecipitation at scale. Locate your fav protein among the 7,600 we mapped across 19 subcellular compartments: organelles.sf.czbiohub.org/ 1/3 🧪

🫵 You are interested in recombinant protein purification, quantitative biochemistry and structural biology? Great Master's project ahead! 🤩 The Leonard lab offers a project to elucidate the mechanism(s) by which the ISR kinases specifically recruit eIF2 📶 Read more ➡️ tinyurl.com/238r7rkb

The Vienna BioCenter Summer School 2025 call is now open for applications from talented undergrads. It is the perfect preparation for students who are interested in graduate study in the life sciences arena. 9-week research project, accommodation and stipend for successful candidates.

2025 marks an incredible milestone: it is the 20th anniversary of the Max Perutz Labs! 🎉 This is a chance not only to celebrate how far we’ve come but also to be inspired by the bold vision that started it all and to carry that energy forward into the next 20 years. Stay tuned! #MaxPerutzLabs20Years

🚨 Out now! @marcoyannic.bsky.social and his former colleagues at the Chan Zuckerberg Biohub have unveiled a new study in Cell. The team led by Manuel Leonetti mapped the subcellular distribution of thousands of proteins to create an atlas of the human proteome ➡️ tinyurl.com/ypn65duk @univie.ac.at

The Vienna BioCenter Summer School 2025 call is now open for talented undergrads, it's a great opportunity for students who are interested in the life sciences. Check out Peter's group: training.vbc.ac.at/summer-school/

The Max Perutz Labs wishes everyone a relaxing holiday season filled with joy and a 2025 filled with success, new ideas, and groundbreaking science! 🎄🎁🌟 Stay curious, stay inspired, and see you in the new year! 🎊

🔬 Microscopes are a cornerstone of any life science lab - and at the Perutz, the BioOptics Light Microscopy and Histology facilities have you covered! ✨ In the third part of our Perutz facilities series, we spotlight these two essential hubs 🧫🧠 Watch their video here ➡️ tinyurl.com/2jyr3cer

👀 Exciting Master's project in the Karagöz lab open! The team explores how cells respond to proteotoxic stress and is now diving into a new project to uncover how ER chaperones regulate the unfolded protein response (UPR) 💡 Don't miss the chance ➡️ tinyurl.com/3wjedm5b

Master's thesis opportunity❕ The Bachmair lab offers a project about the biochemical and cell biological analysis of protein turnover driven by amino-terminal degradation signals in plants 🌱 More information ➡️ tinyurl.com/bddmb97y

✨ Are you creative, critical, and communicative? Passionate about science and ready to make an impact? 💪 The Querques lab is looking for a research technician! Apply here ➡️ tinyurl.com/ak8b5zhw

Great news from the Slade lab! Postdoc Lisa Appel and PhD student Johannes Benedum have been named Researchers of the Month from the Medical University of Vienna, celebrating their outstanding publications in Nature Communcations last year 🏆👏 ➡️ tinyurl.com/42kybvsb

Congratulations to four Vienna BioCenter Researchers on receiving ERC Grants! Read more: www.viennabiocenter.org/about/news/f... #viennabiocenter #ERCCoG #ERCSyG

Paper alert! 📢 The inner nuclear membrane is a hub for the lipid metabolism. In a new @natureportfolio.bsky.social Comms study, the Köhler lab uncovers Seipin as a key regulator in maintaining lipid balance and nuclear envelope integrity 🌟 Read more ➡️ tinyurl.com/ycy7pjkh @univie.ac.at

I am extremely excited to share that I have been awarded the ERC Consolidator grant! In our project GENE-TUNE, we will build regulatory landscapes and study how enhancer distance and enhancer cooperativity shapes genes expression levels!

👏 Big congrats to Perutz group leader Christa Bücker @chribue.bsky.social on receiving the prestigious ERC Consolidator Grant! With GENE-TUNE, the Buecker lab will take a bottom-up approach to decode the complexities of gene regulatory landscapes ➡️ tinyurl.com/ybhucz3u #ERCCoG @univie.ac.at

By definition, enhancers can activate from a distance. But with increased distance between enhancer and promoter, the activation drops. To study this systematically, we build a synthetic locus: www.cell.com/molecular-ce... 1/12

🆕 publication! 🧬 How do enhancers, located far away in the genome, communicate with their target genes? In Molecular Cell, the lab of @chribue.bsky.social shows how different enhancers cooperate to drive gene expression using a novel synthetic platform ➡️ tinyurl.com/yckubbjb @univie.ac.at

👩‍🎓 Claudia Pachinger (Dammermann lab) defended her thesis with the title “Novel insights into centriolar satellites as regulators of centrosome and cilium function” and earned her hat 🎉 Congratulations! @univie.ac.at

Congrats, Claudia! 🤩👏

Congratulations to Alex Stockinger from the Raible lab @tessmarraiblelabs.bsky.social on successfully defending his thesis and earning his hat “The cellular sources and molecular profiles of stem cells during regeneration of a marine annelid”! 🪱🎓 #phdone @univie.ac.at

Excited to share our latest preprint (@biorxivpreprint) on brain organoid development. Lead by Julia Naas and Meritxell Balmaña (@txellbalmana) with Arndt von Haeseler, Christopher Esk (@christopher-esk.bsky.social) and colleagues across Vienna. @maxperutzlabs.bsky.social, @IMBA_Vienna, @CeMM_News.

🤔 Is it worth taking on a challenging experiment during your PhD? For Eva Krötenheerdt (Leonard lab) and Julia Kober (Ramundo lab, GMI), the answer is yes! Their proposal earned them the 'Out of the box' award at this year’s Vienna BioCenter PhD Symposium 🚀#SuccessStory @univie.ac.at

Paper alert! 📢 Why can some organisms regenerate lost tissue while others can’t? In @natureportfolio.bsky.social Communications, the Raible lab @tessmarraiblelabs.bsky.social reveal how specialized marine worm cells de-differentiate into stem cells to repair lost tissue➡️ tinyurl.com/5f7cncym

Exciting news! ✨ Sascha Martens and his lab are proud to continue the journey with the Aligning Science Across Parkinson’s Initiative (ASAP), as their funding has been extended! Since 2020, this global collaboration has been exploring the crucial link between mitophagy and PD ➡️ tinyurl.com/fzbht8jd

👏🎉 Congratulations to Perutz alumna Laura Santini on receiving the Vienna BioCenter PhD Award! Her outstanding thesis focuses on a crucial cell state transition during early embryonic development 🧫➡️ tinyurl.com/yc24bus3

🚨 Out now! Bernd Bauer and the Martens lab reveal in EMBO Journal how the cargo receptor TAX1BP1 faciliates the switch from cargo collection to autophagosome formation, a process crucial for successful aggrephagy - the cell's way of recycling aggregated proteins ♻️ More ➡️ tinyurl.com/35ev5pvv

📢 Paper alert from the Karagöz lab! Published in Nature Comms, first author Harald Hornegger reveals that phosphorylation of IGF2BP1 impacts the size and number of stress granules 🫧 Their study shows how cells can fine-tune transcription💡Read more ➡️ tinyurl.com/3dwzc4yd

What’s been going on the MINFLUX field? Lukas Scheiderer, Jonas Ries and I have it summarized in our new review article, written at @maxperutzlabs.bsky.social. Check it out at arxiv.org/abs/2410.15902.

🆕 publication! The Foisner lab has uncovered how LAP2α plays a crucial role in cell differentiation by regulating the distribution of lamins on chromatin 💡 Their findings in Nucleic Acids Research shed light on the gene-regulatory functions of lamins 💪 More insights ➡️ tinyurl.com/bddyu4x3