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maxx.living.tech
Founder of Solt DB (@living.tech) | Bioprocess engineer + MatSci engineer | Day job at Emerald Cloud Lab Solt DB is a public benefit company helping investors understand science, and scientists understand business. https://www.living.tech/
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Oakland. Bayard Street at Melwood Ave. Multiple callers say that they see a dumpster fire. If you end up missing this neighborhood dumpster fire, Panthers host Georgia Tech Tuesday night at the Pete.

Who benefits from US funding uncertainty? Hours after posting this, I got an email inviting me to China with a “package to support my research for 20 years.” Apparently, generous offers are available to all good scientists!🧪🧠

For decades, the US government has painstakingly kept American science #1 globally—and every facet of American life has improved because of it. The internet? Flu shot? Ozempic? All grew out of federally-funded research. Now all that's being dismantled. 1/ www.technologyreview.com/2025/02/21/1...

Will Exact Sciences $EXAS write off billions in intangibles and goodwill in Q4 2024? We'll find out this afternoon when it announces earnings. 🤞🧬

Pockets of bubbly are spreading across biotech stocks. Recursion Pharma $RXRX is now valued at $4.6 billion without efficacy data for a single drug candidate. GRAIL $GRAL up 245% since the start of the year. GeneDx $WGS 2025 revenue will shrink from Q4 run rate, stock up 25%. CRISPR stocks are up.

As outcry builds over Trump cuts to NIH payments, drugmakers are MIA On last night's earnings call, $VRTX CEO Reshma Kewalramani said nothing about the NIH, yet Vertex owes some of that $11B in cystic fibrosis drug sales to foundational biomedical research funded by NIH....

'Some chapters read like a scientific whodunnit. In one, Mr Piller has to work hard to earn the trust of a reluctant whistleblower. In another, he travels to Prague for a private meeting with a group of image detectives with cryptic pseudonyms.' www.economist.com/culture/2025... archive.ph/bXMr4

Cutting funding for "useless research" is killing us. Every breakthrough started as pointless: • CRISPR was bacteria defending itself • mRNA was too unstable to work • Penicillin was mold

GigSlave Goes Public With $84 Billion Valuation. The popular slave-hailing app made its Wall Street debut today with a highly anticipated IPO that could grow the slave sharing company's value by more than 80%.

Why would Pennsylvania, home to academic hubs Pittsburgh and Philadelphia, not join this group in court?

Super Bowl Confetti Made Entirely From Shredded Concussion Studies theonion.com/super-b...

It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.

My car hit 100,000 miles this morning while traversing the Liberty Tunnel. Is there a more yinzer milestone than that?

Exact Sciences $EXAS made a lot of acquisitions at inflated prices in recent years. As a result, 63% (!!) of assets are intangibles + goodwill. I would use Q4 2024 to write off as much of that as possible. By the time the non-cash charge rolls off 12-month metrics the business could be profitable.

NEW: Health agencies are being told to rank thousands of workers as fears of layoffs grow CDC managers must identify 40% of staff on probationary periods who aren’t “mission-critical” — by today Similar efforts underway across HHS Cuts expected With @lenasun.bsky.social @emilydavies.bsky.social

"Of course it’s important to stay informed, and journalists can still provide the valuable information we need... But this process has been short-circuited by tech platforms and a media environment built around seeking reaction for its own sake." www.404media.co/you-cant-pos...

I am one of these NSF postdocs. NSF has frozen everyone’s access to their salaries and research stipends (that were already awarded) with no information about when they might be expected to be unfrozen. It still appears like we are expected to continue doing our work though.

We donate 6% of all membership revenue to public benefit projects, including decarbonization efforts through Stripe Climate. Check out some of the new projects for 2025! frontierclimate.com/portfolio

Ah man. Smithfield Foods, the largest pork producer in the United States, went public today with the boring ticker "SFD." The tickers "BAKN" and "BACN" are also available. Missed opportunity. 🥓

There are lessons in DeepSeek for biotech. When drug developers say they need high selling prices in the U.S. to fund global innovation, that's not entirely true. Constraints can spur innovation, too. Thread 🧵👇

NVIDIA $NVDA is on pace to lose more market value today ($330 billion) than all but three drug developers globally are worth total (Eli Lilly $LLY , Johnson & Johnson $JNJ , Novo Nordisk $NVO ).

Pittsburgh Regional Transit, assemble!

I’m all for imagining a future where we have powerful AIs that can do things we currently can’t. But I implore you to try to imagine them *solving actual problems* not extracting the joy out of living.

Pepfar, which is estimated to have delivered lifesaving treatment as many as 25 million people in 54 countries, faces a funding delay of as long as 180 days. Story by @apoorvanyt.bsky.social [Gift link] www.nytimes.com/2025/01/24/u...

Can TechBio fix a radio?

The difference between #techbio and #biotech is hubris. Where #techbio believes biological mystery can be overcome by more data and that the underlying mechanism is unimportant, #biotech (and it's children #synbio #engbio) believes that the mechanism itself will lead to new wonders

My lab has a tradition that each week one person contributes edits to a Wikipedia page relevant to their scientific work, and then presents it briefly at lab meeting (and we clap). A few of my favorites: en.wikipedia.org/wiki/Proprio... en.wikipedia.org/wiki/Chionea en.wikipedia.org/wiki/Femoral...

The United States wants to exit the World Health Organization (WHO). How is WHO funded? Is funding unfair? Does the United States pay "too much"? It's important to lean on primary sources when possible to cut through the noise. (It's usually always possible, we just don't value it.) Thread 🧵👇

Normal cities during winter: "Let's plow and salt to make the roads safe." Pittsburgh during winter: "Eh, screw it, this road is now closed."

Although AI tools like AlphaFold get all the hype in drug discovery, ADMET models are where most of the value is created before molecules enter the clinic. We rarely hear about that. Because that's more difficult to hype up.