mikelove.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

RNA xkcd.com/3056

submitted 23 hours ago • 147 comments

🚨 10 Days Until Stand Up for Science, and some HUGE NEWS! - Take Action With Us! 🚨 We’re excited to announce 32 official Stand Up for Science events happening across the country on March 7th! 🧵⬇️

submitted 1 day ago • 5 comments

Took a trip to the NC Legislative Branch yesterday to meet with Rep. Allen Buansi to talk about how we can @standupforscience.bsky.social ! Science 🤝🏽 science policy 🤝🏽 science communication

submitted 1 day ago • 1 comment

Submit your abstract now and be part of the conversation at #ISMBECCB2025! Deadline: Thursday, April 17, 2025 📥Submit here: https://s.mtrbio.com/asuvfrsmsy

submitted 1 day ago • 0 comments

📢 Thrilled to see this out, an atlas of e/sQTL across multiple tissues and diverse ancestries in 14,324 TOPMed participants: www.medrxiv.org/content/10.1... Grateful to the #TOPMed #Omics WG for giving me an opportunity to learn and contribute to this important work 🧬

submitted 1 day ago • 1 comment

Delighted to tell you about the newest preprint from our lab, from the amazing @sugansivaguru.bsky.social - ever wondered what dyes are the right dyes for image based profiling? Hop into a 🧵 to learn more about "Alternate dyes for image-based profiling assays" (1/x) www.biorxiv.org/content/10.1...

submitted 2 days ago • 2 comments

@thejohnnyyu.bsky.social, @therealnima.bsky.social, and I, are excited to tell you about Tahoe-100M! The largest publicly available single-cell dataset that measures the effect of 1200 genes on 50 cell line models. The Vevo team has outdone itself. #Tahoe100M www.biorxiv.org/content/10.1...

submitted 2 days ago • 1 comment

One of the remarkable things about #NIH is how rigorously its grants, research, and employees are reviewed. NIH science and scientists are held to a high standard by external reviewers — via study sections and councils, or BSC/site visit reviewers. And the reviews have teeth. 🧪

submitted 2 days ago • 8 comments

Research budgets have been flat in decline in real dollars for more than a decade. The system is already function on bare minimums - want more efficiency? more stable funding and more stable budgets so we're not resubmitting grants over and over

submitted 2 days ago • 1 comment

Another loss for #science & the next generation of researchers. The 28-year running NIDA summer internship program is cancelled for this year. @altnih4science.bsky.social #SavetheNIH

submitted 2 days ago • 2 comments

You in the Triangle area and thinking about standing up for science? Come to my beloved 2nd workplace and make a sign 😊🍻 supplies provided! You can leave a sign w me and i can bring it up to DC! @standupforscience.bsky.social

submitted 2 days ago • 3 comments

Anyone (like me!) who has launched a startup knows that bench space, access to utilities, trash collection, etc. cost money. 'Indirect cost' funding from the NIH is what helps pay these costs at universities. This is a great article explaining this: www.princeton.edu/news/2025/02...

submitted 2 days ago • 0 comments

#Science

submitted 2 days ago • 4 comments

NEWS: In USDA, multiple people have been asked to report the names of LGBTQ employee resource group leaders to higher-ranking officials, according to interviews with workers and a document reviewed by Mother Jones. + similar in the Department of the Interior

submitted 2 days ago • 118 comments

Our new paper describing a scalable approach for training sequence-to-function models on personal genomes ("personal genome training"), includes our observations on when this works and its limitations. www.biorxiv.org/content/10.1... Congrats: Anna, @xinmingtu.bsky.social , @lxsasse.bsky.social

submitted 3 days ago • 0 comments

I am happy to announce our new paper "Univariate-guided sparse regression". It's a new lasso that leverages the signs and magnitude of univariate coefficients . Sparser and more interpretable than the lasso. We're excited! arxiv.org/abs/2501.18360 R: github.com/trevorhastie...

submitted 3 days ago • 1 comment

And these 2 PhD students are ready to go, the 3 other scientists are cranking and we love them 🥺♥️, but we NEED more support! From volunteers, to org support, we’re calling on the scientific community! JOIN US! SEE YOU IN DC Y’ALL 🫡 @standupforscience.bsky.social

submitted 4 days ago • 1 comment

It's @scipyconf.bsky.social submission time again! This year I am running the Bioinf/Comp Bio/Neuroscience track, covering how Python is advancing science and problem-solving in those fields. Let me know if y'all have questions, and looking forward to the submissions!

submitted 47 days ago • 1 comment

The entire business model of American R1 universities is not viable without restoration of federal funding, & every individual institution pretending it can solve this problem alone is also not viable. University presidents need to be speaking out, collectively & loudly about this, in DC, right now.

submitted 5 days ago • 40 comments

Probabilistic and machine-learning methods for predicting local rates of transcription elongation from nascent RNA sequencing data academic.oup.com/nar/article/...

submitted 4 days ago • 0 comments

I cannot wait to this event to happen! We will have 3 days of great scientific discussions, planning for collaborators and networking with old friends and new colleagues! Programme: iscb.org/3dbioinfo202... You can still register: iscb.org/3dbioinfo202...

submitted 7 days ago • 0 comments

Updated from the preprint, our paper, "Spatiotemporal analysis of gene expression in the human dentate gyrus reveals age-associated changes in cellular maturation and neuroinflammation" is now published. www.cell.com/cell-reports...

submitted 5 days ago • 5 comments

I'm so happy that I can finally share the results of my first postdoc paper with @baym.lol!!! Turns out plasmids are an amazing system to study multi-scale evolution and we can track within-cell and between-cell dynamics! (1/n) www.biorxiv.org/content/earl...

submitted 5 days ago • 9 comments

Pitt to pause PhD admissions, following Vanderbilt and USC, because of uncertainty of NIH funding to academic universities. Who will teach and train US scientists for pharma and biotech? Should we import them from countries that do? www.wesa.fm/health-scien...

submitted 5 days ago • 8 comments

I wrote up an FAQ about the recent federal grant cuts. A few points: 🧵

submitted 7 days ago • 2 comments

First blog post! An overview and context of our work on distances between phylogenetic trees using BHV extension spaces statdivlab.github.io/blog/article...

submitted 7 days ago • 0 comments

If the admin wanted more US-born scientists, telling them at the last minute that they can't come to graduate school is probably not the best way to do it. www.statnews.com/2025/02/19/t...

submitted 7 days ago • 6 comments

New preprint w/ @soumyakundu.bsky.social @sbmontgom.bsky.social @anshulkundaje.bsky.social ! Using deep learning & scATAC-seq, we studied context-specific variants in disease & evolution, and introduce FLARE for de novo mutations—w/ application to autism-affected families. doi.org/10.1101/2025...

submitted 8 days ago • 0 comments

Wow, this would be heartbreaking. Many people working on CHIPS left long-term positions at NIST to work on what they rightly viewed as a consensus national security issue. link: news.bloomberglaw.com/bloomberg-go...

submitted 7 days ago • 1 comment

The latest ISCB newsletter is here! This issue honors Black contributions to #computationalbiology, celebrates the 2025 ISCB Award winners, and explores trends in Proceedings submissions. Find it here: https://s.mtrbio.com/zqzgnzmjew

submitted 7 days ago • 0 comments

Excited to share that PROTRIDER, our method to call outliers on mass spectrometry-based proteomics data, is out now!! #proteomics #massspectrometry #raredisease doi.org/10.1101/2025...

submitted 8 days ago • 1 comment

Excited to share our MicrobiomeBenchmarkData preprint, addressing compositional data analysis for microbiome DA. This Bioconductor package features 3 datasets with biological ground truths. Spoiler: simple methods like LEfSe, Wilcoxon, RNA-seq methods performed well www.biorxiv.org/content/10.1...

submitted 8 days ago • 1 comment

One of the coolest and most novel findings I’ve seen in years. This is why I work in worms. To find things no one even really knew to look for. Like a conserved system that splices transposons out of mRNAs to prevent otherwise lethal insertions in essential genes! - www.biorxiv.org/content/10.1...

submitted 9 days ago • 0 comments

I figured today was as good a day as any to introduce myself over here! My lab combines stem cell models and genome engineering to study how the interactions between genes and environments contributes to brain disease. The only thing I find more rewarding than scientific discovery is mentoring…

submitted 30 days ago • 1 comment

1/ When using observational data for #causalinference, emulating a target trial helps solve some problems... but not all problems. In a new paper, we explain why and when the #TargetTrial framework is helpful. www.acpjournals.org/doi/10.7326/... Joint work with my colleagues @causalab.bsky.social

submitted 9 days ago • 3 comments

ICYMI: a post about why the firings at NIH this weekend devastated cancer research. And other biomedical research too. Building a science lab is like building a new company: it takes years to put together the right team. Many lab groups are now broken. altnih4science.subst...

submitted 9 days ago • 12 comments

A few updates and clarifications A slow but steady stream of NoAs are being reported to me. NIH grants management specialists are clearly back to work getting awards out the door, both for scientist's sake and for their own. 1/n

submitted 9 days ago • 3 comments

NA: Discussing regulatory approaches as therapeutics - reminding on haploinsufficiency - generally this is just fine - but 660 genes lead to diseases when haploinsufficiency - some other known genes where there are no homozygous variants may also be related to haploinsufficiency #LorneGenome25

submitted 9 days ago • 0 comments

Fascinating functional genomics session at #lorneGenome25 - covering humans, bats, jellyfish, and snakes 🦇🐍 Live posting from the wonderful @lizworthey.bsky.social if you would like to follow along (now or later) 🌟

submitted 9 days ago • 1 comment

This is the preprint write up of my sabbatical work with Dave Kelley’s group at Calico. We tried out several transformer replacements for multi-task learning in functional genomics (i.e. what Borzoi does). Mamba, in particular, seems to outperform a mini version of Borzoi, especially when “striped”.

submitted 9 days ago • 1 comment

Please don’t stop sharing and posting your science because of the current attack on it, it is still valuable and reminds us what the fight is for

submitted 9 days ago • 3 comments

If you are a journalist--this should be your biggest story. Musk is denying hope to patients who have exhausted all other options 🧪

submitted 9 days ago • 3 comments