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mitchell-lab.bsky.social
Regulation of transcription, stem cells, and trying to figure out the regulatory code. The Mitchell Lab at the U of Toronto.
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As you scroll through our skeets, you’ll see that women scientists are vital to discoveries made at CSB. For International Day of Women & Girls in Science, we’ve highlighted some recent impressive accomplishments #IDWGS2025 #WomenInScience csb.utoronto.ca/supporting-t...

submitted 15 days ago • 0 comments

Supporting the talented women scientists of CSB on IDWGS csb.utoronto.ca/supporting-t...

submitted 15 days ago • 0 comments

Our work on the enhancers regulating Sox2 in neural stem cells is published! This one has been a long time in the works. We found a cluster of downstream enhancers, including the more well studied SRR2, are required to maintain Sox2 expression and anterior neural identity. doi.org/10.1093/g3jo...

submitted 28 days ago • 1 comment

Career achievement unlocked - two publications come out on the same day! Great collaboration with Tom Sexton doi.org/10.1126/scia... And fantastic work by Tiegh Taylor and Mitchell lab colleagues journals.plos.org/plosgenetics...

submitted 74 days ago • 0 comments

Out now in @ScienceAdvances A great team effort, spearheaded by Angeliki, showing that promoter and enhancer dynamics become homogenized on transcriptional activation, and that loop extrusion and transcription compete to put brakes on chromatin doi.org/10.1126/scia...

submitted 74 days ago • 0 comments

The cells are all-right: Regulation of the Lefty genes by separate enhancers in mouse embryonic stem cells. How are 2 genes separately regulated even though they are fairly close to each other in the genome, we find a primary role for gene separation distance. journals.plos.org/plosgenetics...

submitted 74 days ago • 0 comments

Beautiful walk at #AsilomarChromatin this afternoon. Looking forward to the evening session.

submitted 75 days ago • 0 comments

Always been amazed how cells actually INTENTIONALLY cause double strand breaks. At @asilomarchroma last night, Cheyenne Sadeghi @FrockLab @Stanford showed evidence supporting that during #meiosis, #ATM kinase can suppress translocations after #SPO11 induces the meiotic double strand break.

submitted 75 days ago • 0 comments

Kicking off the 2024 @asilomarchromatin meeting with Maria Aristizabal Queen’s Univ drilling down on cancer-derived #histone mutations in budding yeast. Affect #genome integrity, transcription, and chromatin compaction! So cool that her first talk was THIS conference when she was an undergrad!

submitted 76 days ago • 0 comments

Students in our Stem Cell & Developmental Biology Focus are attending the Medicine by Design Symposium today. A great opportunity to learn about the latest developments in Regenerative Medicine! #MbDSymposium @mitchell-lab.bsky.social

submitted 79 days ago • 0 comments

In studies of transcriptional regulation, the Mitchell Lab @mitchell-lab.bsky.social found that redundant systems protected genome integrity no matter what they removed or added to the folded structure linking the essential Sox2 gene with distant regulators csb.utoronto.ca/mitchell-lab...

submitted 103 days ago • 1 comment