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mlacyphd.bsky.social
#OpenScience supporter, I work @Addgene.bsky.social curating DNA and web content. Previously worked at ASCB, publishing, Yale Biophysics PhD. He/him
125 posts 1,057 followers 1,018 following
Prolific Poster

Nominate a colleague or yourself for the WICB @ascbiology.bsky.social Sandra K. Masur Senior Leadership Award for late career scientists with outstanding scientific achievements, coupled with leadership in mentoring women and underrepresented groups. Deadline, June 30th. www.ascb.org/award/sandra...

90% of you probably don’t need to read this. But maybe some of you are curious & 10% will feel seen. Or a little less alone. This isn’t about seeking sympathy. It’s about sharing something hard to say out loud; partly to heal, partly in case someone needs to hear it too. (1/3) tinyurl.com/DudinO

🚨Interdisciplinary perspectives needed🚨 Have you worked across disciplines in research? We want to hear from you! Take part in the Healthier Science through Collaboration (HxC) survey. Help shape better, more inclusive research environments. app.onlinesurveys.jisc.ac.uk/s/edinburgh/... Please RT.

Excited to share our Science paper on HaloDA1.0-the first genetically encoded far-red dopamine sensor! 🥳It enables powerful multiplex imaging in neurons, brain slices, and live animals.🧠🔬 #GRABsensors #Dopamine www.science.org/doi/10.1126/...

Check out what's new and hot in our collection! 👀 🧬 A new CRISPR/retrotransposon system 🏷️ TurboCas for dynamic protein labeling 🛠️ Addgene's own lentiviral backbones 🧪 Antibodies from our partners at ‪@ipiproteins.bsky.social‬ 🔥 and more! blog.addgene.org/hot...

When it comes to creating plots of your data, are you team 'web apps' or 'vibe coding' with genAI-based tools? 📊 In this post, Joachim Goedhart @joachimgoedhart.bsky.social‬ discusses the potentials and pitfalls of both approaches in data visualization:

FlyBase, a crucial resource for drosophila research, has lost its funding because its grant is awarded to Harvard. The team is scrambling to find other sources of funds, including donations from labs. Read more: www.thetransmitter.org/community/fl... @flybase.bsky.social

One of my favorite parts of my job is learning about all the fantastic tools folks are developing and sharing! Check out what's new and hot from the past few months, and learn how you can use them 👇 (and not just plasmids... antibodies and viral preps too!)

🧪Source request: Are you a father in academia trying your best to be an equal partner in parenting? Do you want to tell me about why you think that is important? If so, please reach out! I'll only be able to speak to 1 source (it's a short piece), but tell me about your situation & it could be you!

URGENT: FlyBase has lost practically all its funding overnight; even user fees are tied up in denied grant funding. 🤬🤯 Any lab using @flybase.bsky.social please donate using the link in post below. This incredible community, on whose backs our #Drosophila labs depend, can't be left out to dry.

🎉 We’ve hit a major milestone — 2 MILLION plasmids shared worldwide! Thank you to our incredible community of scientists driving discovery and collaboration every day. Here’s to the next million! 💡🧬🌍 #ScienceForAll #PlasmidPower #OpenScience

We are looking for a postdoc to study biomolecular condensates and/or mechanosensitive membrane proteins. Please help spread the news 🙏 sites.rutgers.edu/shi-lab/look...

Say we want to transduce something-GFP that will label the presynapses in cultured hippocampal neurons. Which fusion protein is the best for specific labeling with minimal effect by itself? Current guesses are synaptophysin (p38), synapsin, RIM (Bassoon is too big) but most refs are old

I appreciate the offers from other scientists to help Harvard (students, labs, etc) through this attack, but what would be most helpful is for you to use your position to contact your elected representatives and make it clear this fight isn't just Harvard, it will affect you, and their districts too

Applications are now open for our fall internship program! This is an excellent opportunity for a beginning science journalist to report and write about the fast-moving field of neuroscience. Apply now: simonsfoundation.wd1.myworkdayjobs.com/en-US/simons...

Shout out to all the amazing scientists who worked on these 8 studies - your work will accelerate neuroscience research globally! We're grateful to play a part in helping these tools reach labs worldwide. www.addgene.org/collections/...

In the battle against brain disease, researchers can now rely on a new arsenal of genetic tools – The Armamentarium. Together with scientists from across the NIH BRAIN Initiative, we’ve created and published over 1000 new enhancer AAV vectors. 🧠📈

New Neuron issue! Discover methods for accessing neuronal and non-neuronal cell types in the CNS from the BRAIN Armamentarium Consortium. 🧠🔧 Read insights from Bosiljka Tasic & @gordfishell.bsky.social: www.cell.com/neuron/fullt... Explore the full issue here: www.cell.com/neuron/current

Are you (or a recent grad or tech/lab manager) looking for an awesome, mission-driven job? Come join us @addgene.bsky.social! Put your lab skills to work making impact for thousands of scientists around the world 💪🧬🧪

*Paid internship opportunity* @biologists.bsky.social is looking for a 3-month intern this summer to work across the Node, @prelights.bsky.social and @focalplane.bsky.social If you're interested in #SciCommm & #publishing, and have the right to work in the UK, apply by 5 June 👇

Are you (or a recent grad or tech/lab manager) looking for an awesome, mission-driven job? Come join us @addgene.bsky.social! Put your lab skills to work making impact for thousands of scientists around the world 💪🧬🧪

Love Addgene? Come work with us! We are hiring a Plasmid Production Manager - come find out why Addgene is recognized as a Top Place to Work by the Boston Globe (8 years running), BuiltIn, and NABR! addgene.applytojob.c...

New AAV Enhancer Collection available from the Allen Institute for Brain Science! This AAV Enhancer Collection features the best-in-class enhancers to visualize different brain regions with high specificity. www.addgene.org/depo...

Any guesses for how often our QC team identifies sequence errors in incoming samples? <10% 😄 20% 😅 30% 😖 40% 😫 >50% 😱 Don't worry - @addgene.bsky.social's amazing QC team makes sure everything that goes online for distribution is 💯 verified and error-free! Read and find out 👇

🧪Hello! are you a scientist who started your PhD in 2020 and are now wrapping up? I want to know how your life is and how you're feeling about your prospects in 2025 for a story in @nature.com. DM me or find me on Signal at aheidt.16. Tell yo friends! (Also seeking international sources.)

A non-toxic, user-friendly buffer that enhances green fluorophore performance in conventional and super-resolution imaging by Wim Vandenberg and team: www.biorxiv.org/content/10.1...

Would you like to be @the-node.bsky.social's new Community Manager? Find out here what this exciting role involves and how you can apply to join the team. thenode.biologists.com/would-you-li... Application deadline 19 May #SciComm #DevBio #StemCell

Recipients of these F31s should ABSOLUTELEY be contacting their research administrators and Office of Sponsored Projects to initiate appeal processes. The cancellation of these contracts may even be illegal. I've heard some institutions even have templates to help w/ the first steps of this process

"I would not have dared to dream that metastatic melanoma would become a treatable disease in my lifetime. Yet here we are today, with 43% of people diagnosed with metastatic melanoma living 10 years or more, due to treatments that we broadly refer to as cancer immunotherapy." Barry P. Sleckman, UAB

In this post I collated my "academic software stack". Tried-and-tested, mostly FOSS, and geared towards Mac. For anyone that's looking for software for scientific research. 🧪 quantixed.org/2025/04/29/s...

We are reviving the #scholcommlab newsletter now that we have a lab manager again! Plan is to share smaller updates around once per month. We were letting months and months go between messages, but we have far too much going on! Sign up here: www.scholcommlab.ca/stay-up-to-d...

📢Tell us what you think about the Node and help us shape the Node's future! Please spare around 5 minutes to fill in our survey: www.surveymonkey.com/r/7QHYQCW Participants of the survey can enter a prize draw for a chance to win a bag of goodies from @biologists.bsky.social 🎁 #DevBio #StemCells

Interested in using chemogenetic tools to control and study neuronal activity? Check out our recently updated Chemogenetics Plasmid Collection, with over 100 new plasmids added to the page! www.addgene.org/coll...

New at Can We Still Govern: An anonymous NIH employee maps out the GOP budget gameplan to permanently gut our most important science agency. Impoundment, delay and red tape will create artificial "savings" that become the new benchmark for NIH budgets. donmoynihan.substack.com/p/the-nih-bu...

I'm heartbroken that the MOSAIC K99/R00 is being terminated, and I'm angry that many of my peers are facing uncertainy with the early cancellation of their grants. I hope you'll take time to read their stories.

Momentum is growing. Key debrief items: - 500+ university presidents standing together - NSF director Panch resigns amidst huge budget cuts. The Lancet calls for RFK to resign. - updates on student visas, Women’s Health Initiative & so much more This was Week 14 - buttondown.com/liminalcreat...

I've just blogged in @scholarlykitchen.bsky.social about why explaining research to a rubber duck could be the secret to clearer thinking and better communication. Thanks to my husband for introducing me to this brilliant concept! scholarlykitchen.sspnet.org/2025/04/24/r...

In just 4 days I'll be running the Boston Marathon! It's such an honor to do it for Boston Children's Hospital, I'm so grateful & inspired by everyone there. I passed my original fundraising goal of $12,000 but every $ counts, can you spare a few bucks? secure.childrenshospital.org/goto/Mike-Lacy.

🚨 Preprint alert 🚨 Excited to share our work on "Ab-trapping," an antibody artifact causing misleading peripheral ("rim") staining in imaging & genomics (IF, CUT&Tag, CUT&RUN). Antibodies fail to penetrate structures, accumulating at the periphery. A 🧵👇 doi.org/10.1101/2025...

New from Addgene: Retroviral backbone plasmids built for your favorite gene! We’ve designed a flexible set of retroviral vectors ready for easy cloning and stable gene expression. Tested with EGFP ✔️ Stable cell line protocol included ✔️ Ready to power your next experiment ✔️ Grab yours today!

We’re thrilled to announce the expansion of Addgene’s management team and Board of Directors! These key appointments support Addgene’s growth strategy and illustrate our responsiveness to the evolving needs of the life sciences community. Read our full press release: www.addgene.org/news...

My quote of the day …But without scientific progress no amount of achievement in other directions can insure our health, prosperity, and security as a nation in the modern world. Vannevar Bush Science: The Endless Frontier

A follow-up to my quote of the day this morning: A short Bluetorial about Vannevar Bush and his legacy

Are you graduating this Spring with a BS or MS and interested in Mechanobiology? Join the Berro lab as Postgraduate Associate! More information and applications here: shorturl.at/3xmjx

Plasmids can be found here! www.addgene.org/browse/artic...

Here we share our opinions on "Practical considerations for data exploration in quantitative cell biology" journals.biologists.com/jcs/article/... Joanna, Hanna and I worked quite a bit on this piece and I hope you find it useful Many thanks to @jcellsci.bsky.social for publishing it