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mrclmb.bsky.social
The MRC Laboratory of Molecular Biology aims to understand biological processes at the molecular level to help tackle human health problems and disease.
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Prolific Poster

Join us on Monday 19th May at 11am (BST) for an #LMBSeminar from James Turner. James is based at the Francis Crick Institute and will discuss ‘Blueprints of Life: Understanding the Sex Chromosomes’ More info: www2.mrc-lmb.cam.ac.uk/news-and-eve...

How does a fly’s nervous system differ by sex? 🧠🪰 Led by Tomke Stürner & Paul Brooks, Greg Jefferis’ group, the Drosophila Connectomics group (University of Cambridge) & global colleagues publish a new atlas, revealing sex-specific neurons driving distinct behaviours. www.nature.com/articles/s41...

Great to share the impact of our LMB AstraZeneca Blue Sky Collaboration with the AstraZeneca Board this month! A prime example is Sortera Bio, a spinout from our partnership. It’s all about teamwork and combining strengths to advance science together. #BlueSkyResearch #Collaboration #Innovation

To celebrate this year's #EarthDay, a group of LMB members went for a walk to local #RSPB nature reserve Fen Drayton. ☀️ 🍃 🐦 We witnessed a red kite fighting a crow in the air & saw a beautiful family of Egyptian geese with 7 cute chicks! Looking forward to our next trip! #EarthDay2025 #GreenLMB

#ICYMI you can now watch last week’s excellent Milstein Lecture from David Pellman on our YouTube channel: youtu.be/NN0uWbFb990

Uncovering the hidden complexity behind the brain’s master clock. New research led by @nsmyllie.bsky.social, in Michael Hastings’s group, reveals that body clock proteins PER2 & CRY1 act more independently than previously thought: www2.mrc-lmb.cam.ac.uk/uncovering-t... #LMBResearch 🧪 🕙 🧠

🏅Medal reveal!🏅 Celebrating scientific breakthroughs and world-class care, we’re delighted to share the design for the medal you’ll get for completing our 10k, 5k or Fun Run on 18 May! Free for u17s. Find out more and book your spot now: cambridge-biomedical.com/event/campus...

We’re hiring TWO Maintenance Technicians to join the LMB’s Estates & Facilities Team, with a focus on electrical or mechanical systems. Apply by 18th May for a permanent role in a state-of-the-art building. www.jobs.ac.uk/job/DMS340/m... #CambridgeJobs #Hiring

Finally in peer-reviewed form: Mapping the ultrastructural topology of the corynebacterial cell surface. @bupbuse.bsky.social @vikramalva.bsky.social Please also see concurrent beautiful work from @adriasogues.bsky.social and Han Remaut.

Latest paper from the lab @cellbiol-mrclmb.bsky.social, Anna's PhD work hot off the press @plosbiology.org ! Using single cell genomics to understand tube morphogenesis, and why it's as important to switch things off as it is to switch them on!

A colder frontier in cryo-EM 🧪🔬 Chris Russo’s group, inc. Joshua Dickerson, adapted #cryoEM to work at liquid helium temperatures (13 kelvins), where every frame captured contains more information than the equivalent using liquid nitrogen (81 kelvins). Read more: tinyurl.com/mwwcunkc #LMBResearch

David Pellman, from the Dana-Farber Cancer Institute and Harvard University, will be joining us TOMORROW to deliver the 2025 César Milstein Lecture on ‘Mechanisms driving the rapid evolution of genomes’ Join us from 10am (BST)! More info: www2.mrc-lmb.cam.ac.uk/news-and-eve... #LMBSeminar

To mark #DyingMattersWeek, we've partnered with @cuhnhs.bsky.social to run a Dying Matters Cafe - a safe space (inc free tea and coffee) to chat about all aspects of death and dying. Facilitated by Tina O’Hara, Lead Nurse for End of Life Care. cambridge-biomedical.com/event/dying-...

Check out this great video with Samia Mohinta (@mohintasamia.bsky.social), Data Scientist in the LMB’s Neurobiology Division to hear about how she uses AI to help map neurons in the brain! 🧠 Video: @acceleratescience.bsky.social youtu.be/68fQ7ZGTxAQ?...

David Pellman will give the 2025 César Milstein Lecture at 10am on Thursday 24th April. Read more about his research & upcoming lecture ‘Mechanisms driving the rapid evolution of genomes’ here: www2.mrc-lmb.cam.ac.uk/2025-cesar-m... #LMBNews #LMBSeminar

Emmanuel Derivery (@deriverylab.bsky.social in @cellbiol-mrclmb.bsky.social) speaks to @jcellsci.bsky.social about the motivations behind his career, the exciting field of protein design & advice for new Group Leaders. Full interview: journals.biologists.com/jcs/article/... #LMBintheNews

Excellent opportunity available for a motivated #postdoc to join @kellythd-nguyen.bsky.social’s group investigating the roles of histones in regulating telomerase using a multi-disciplinary approach. More details: www.nature.com/naturecareer... Apply by 04 MAY #PostdocJobs #ScienceJobs

Congrats to #LMBAlumni Spyros Artavanis-Tsakonas, Iva Greenwald & Gary Struhl on receiving the 2025 Canada Gairdner International Award! Their groundbreaking work on Notch signalling, with key contributions from their time at the LMB, has had a lasting impact on developmental biology research.

Last week, some of the LMB had the exciting opportunity to visit Cambridge South station, our new neighbours on @cambridgebiocampus.bsky.social! 🚉 We’re looking forward to the station opening in 2026 & providing a new, green travel option for our staff & visitors. #CambridgeSouth #SustainableTravel

We’re looking for motivated Cleaning Assistant to join our Domestic Services Team who provide an amazing cleaning service to the LMB, allowing our staff to work in a clean and safe environment! Apply by 21 APR mrc.tal.net/vx/lang-en-G... #CambridgeJobs #CleaningJobs

“I’ve been interested in science as long as I can remember” From his earliest memories of science, to what drew him to studying the sensory pathways in C. elegans, check out this interview with William Schafer (@schaferlab.bsky.social) in the LMB’s Neurobiology Division. youtu.be/BOqyWD5ZpCA

Are you an organised, detail-oriented person, motivated by working closely with diverse groups of people? We’re looking for a Senior Administrator to manage HR, finances and provide key support to 150+ researchers! More info: www.jobs.ac.uk/job/DMP221/s... Apply by 24 APR! #AdminJobs #CambridgeJobs

Excellent opportunity for a #postdoc to join Kate McDole’s group in @cellbiol-mrclmb.bsky.social, where you’ll get to investigate how cells form tissue during early organogenesis in developing mice. More details: mrc.tal.net/vx/lang-en-G... #Postdocjobs #ScienceJobs

Several opportunities for #postdocs to join @annebertolotti.bsky.social's group in the LMB’s Neurobiology Division to study kinases and phosphatases in stress signalling pathways and diseases. More info: www.nature.com/naturecareer... Apply by 01 MAY #PostdocJobs #ScienceJobs

How do cytosol-invading bacteria evade LPS ubiquitylation by the host's defence machinery? @felixrandow.bsky.social's group determined that Shigella flexneri uses IpaH1.4 to degrade the LPS ligase RNF213, inhibiting the cell's ubiquitylation abilities. Read more: tinyurl.com/3y4kv2bp #LMBResearch🧪

Great opportunity to join the LMB as our new Domestic Services Manager! This is a complex, hands-on management role, overseeing our Domestic Services department to deliver high-quality cleaning and waste disposal services. More info: mrc.tal.net/vx/lang-en-G... Apply by 21st April

Congratulations to LMB Group Leader Benjamin Ryskeldi-Falcon, who has been awarded The Colworth Medal from @biochemsoc.bsky.social! Read more about the award & Benjamin’s research into neurodegenerative diseases here: www2.mrc-lmb.cam.ac.uk/benjamin-rys... #LMBNews #BiochemAwards

We’re looking for a multi-skilled Fluidic Automation Bioengineer to join John O’Neill’s group in the LMB’s Cell Biology Division, to develop novel platforms for drugging the circadian clock in cultured cells and tissues over many days. www.nature.com/naturecareer... Closes 24 APR #ScienceJobs

What a great experience, loved every second of it! Thank you for having me and giving me a platform to talk about my research in octopus vision @cambridgefestival.bsky.social #CamFest2025

We’re looking for an organised Support Officer to join our IT department. As the lead on a data management & cybersecurity audit project, you will work closely with people across the LMB to make sure the project runs smoothly. www.cambridgenetwork.co.uk/jobs/it-supp... Apply by 20 APR #ITJobs

Join us TODAY at 3pm (BST) to learn all about Jue Chen’s research on ‘How small molecules rescue a folding disease: principles learned from the ion channel CFTR.’ See our website for more info: www2.mrc-lmb.cam.ac.uk/news-and-eve... #LMBSeminar

LMB scientists showcased their work at the @cambridgefestival.bsky.social with a hands-on activity about the scale of biology and an artistic piece about body clocks. Read about the event here: www2.mrc-lmb.cam.ac.uk/lmb-highligh... #LMBNews #CamFest @nsmyllie.bsky.social

Join us at 11am (BST) on Monday 7th April for an #LMBSeminar from Rod MacKinnon of Rockefeller University. He will be discussing ‘Higher order transient structures and the principles of dynamic connectivity in membrane signaling.’ More details: www2.mrc-lmb.cam.ac.uk/news-and-eve...

Spring has definitely arrived on Campus! have you spotted anything else blooming?

“If you’re really curious about science, then you should do it.” We recently caught up with David Barford, Group Leader in the LMB’s Structural Studies Division, to learn more about his career, what inspires him and his group’s research into kinetochore complexes. youtu.be/qaudt961iMU

Don’t miss the 2025 César Milstein Lecture, by David Pellman from the Dana-Farber Cancer Institute and Harvard University. Join us at 10am (BST) on Thu 24th April to learn about “Mechanisms driving the rapid evolution of genomes” More details: www2.mrc-lmb.cam.ac.uk/news-and-eve... #LMBSeminar

Find out what @anna-neuro.bsky.social got up to during her masters in the Schafer lab @mrclmb.bsky.social

How do SMC complexes capture DNA? 🧪 Led by Frank Bürmann, Jan Löwe’s & Mark Dillingham’s groups have identified the directional loading mechanism the bacterial SMC complex MukBEF uses to capture & ingest DNA, & found a phage inhibitor to this pathway. Read more: tinyurl.com/4s8nrrkk #LMBResearch

We love seeing our beautiful daffodils in bloom outside the LMB! 🌼

Want to know more about the transmission of misfolded proteins in neurodegenerative diseases? Don’t miss the #LMBSeminar from Virginia Man-Yee Lee from the University of Pennsylvania at 11:30am on Tuesday 8th April. Visit our website for further details: www2.mrc-lmb.cam.ac.uk/news-and-eve...

Did you know the LMB has an Exhibition Room? Don’t miss our current display all about scientific models! Come and learn how and why researchers make models, and the integral role they’ve played in several LMB discoveries. #LMBExhibition

LMB spinout TRIMTECH Therapeutics, co-founded by Leo James & Will McEwan, will leverage the unique properties of TRIM21 to develop targeted protein degraders to treat neurodegenerative conditions. Read more: www2.mrc-lmb.cam.ac.uk/lmb-spinout-... #LMBNews #drugdiscovery #spinout

Cracking the Code of Protein Degradation: Led by #LMBalumni @leokiss.bsky.social, the Schulman Lab @mpibiochem.bsky.social in collaboration with Leo James's group at the LMB has developed new 🧪 science tech #UbiREAD to decipher the ubiquitin protein degradation code within cells.

Earlier this year, Chris Johnson retired after 30+ years at the MRC, including supporting LMB research as the Head of the Biophysics Facility. Before he retired, he shared reflections on his varied career and how science and his role evolved: www2.mrc-lmb.cam.ac.uk/about-lmb/lm... #LMBAlumni

LMB @cambridgefestival.bsky.social engagement team ready to go! Join us at CAST today 11-4 to explore the tiny scale of our research, play our mutant matching game & see @nsmyllie.bsky.social Sci-Art collaboration. More details: www.festival.cam.ac.uk/events/molec...

Heading to @cambridgefestival.bsky.social tomorrow? Don’t miss us at CAST between 11AM-4PM (GMT). Discover the importance of molecular biology by matching mutated microscopic worms to the mutated gene that they contain! No booking needed—just come! More info: www.festival.cam.ac.uk/events/molec...

📢 Calling all undergraduates looking for hands-on academic research experience! There’s still time to apply for the LMB’s Student Placement Scheme. Visit our website to learn more and get your applications in by 30th March. www2.mrc-lmb.cam.ac.uk/students/stu...

Don’t miss this upcoming #LMBSeminar from Jue Chen of Rockefeller University! Join us at 3pm (BST) on Monday 7th April to hear all about ‘How small molecules rescue a folding disease: principles learned from the ion channel CFTR.’ Further details: www2.mrc-lmb.cam.ac.uk/news-and-eve...