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mstortz.bsky.social
🇦🇷Biólogo bohemio en el exilio virtual. 🇺🇸Cell nucleus biologist in the virtual exile. 🔬Transcription factors, genome structure, nuclear architecture, biomolecular condensates. 🗣️Views are my own.
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Posts 14 Comments 36

How do transcription compartments form — and does phase separation drive gene expression? I enjoyed discussing these questions with @akispapantonis.bsky.social a lot, and we put our thoughts together for @naturerevgenet.bsky.social, now out at rdcu.be/erP1u

submitted 3 days ago • 1 comment

In the nucleus, many intrinsically disordered proteins (IDPs) form condensates. What IDP sequence features drive this behavior? We developed CondenSeq, a high-throughput approach to measure nuclear condensate formation, and applied it to ~14,000 IDPs to find out! rdcu.be/eq975

submitted 6 days ago • 3 comments

If heterochromatin is really a liquid-like condensate, why is it not spherical? We investigated whether mechanical interactions between a condensate and a fiber network can explain the variety of morphologies seen in phase-separated nuclear compartments www.biorxiv.org/content/10.1...

submitted 6 days ago • 5 comments

Springer-Nature launched a series of "Discover" journals that closely mimic MDPI titles -- sharing *identical* journal names, and likely similar business model. What is going on, and why researcher will - as always - fall for it? A 🧵 the-strain-on-scientific-publishing.github.io/website/post...

submitted 7 days ago • 9 comments

We’ve pioneered a disease-agnostic screening platform for aberrant biomolecular condensates—cellular structures linked to incurable neurological diseases. We screened genes and FDA-approved drugs that modulate disease-relevant nuclear condensates: www.biorxiv.org/cgi/content/...

submitted 13 days ago • 0 comments

Thrilled to share that my first #micropublication is out! 🧬🔬 I created a user-friendly ImageJ/FIJI plugin for nuclear segmentation and multi-channel fluorescence analysis that doesn't require programming skills. www.micropublication.org/journals/bio...

submitted 15 days ago • 2 comments

www.nature.com/articles/s41... From Denis Hnisz lab

submitted 18 days ago • 1 comment

Dear colleagues, Science in Argentina is under siege. Government funding has stopped and the system is about to collapse. Please help us spread the word to stop the exodus of our best human resources. youtu.be/76tYd-QRIfI?... www.nature.com/articles/d41...

submitted 22 days ago • 0 comments

Great to see this published @genesdev.bsky.social. Evidence that enhancers can activate a bystander gene in an adjacent TAD, and that cohesin facilitates this. @uoe-igc.bsky.social. pubmed.ncbi.nlm.nih.gov/40436628/

submitted 23 days ago • 1 comment

@science.org Expansion in situ genome sequencing links nuclear abnormalities to aberrant chromatin regulation | Science www.science.org/doi/10.1126/... @jbuenrostro.bsky.social @eboyden3.bsky.social + al @broadinstitute.org @harvard.edu #ExIGS #Chromatin #Lamin #Progeria #Aging #ExpansionMicroscopy

submitted 24 days ago • 0 comments

#spatialbiology #RNAbiology www.nature.com/articles/s41...

submitted 28 days ago • 0 comments

Excited our paper is out in Cell @cp-cell.bsky.social! 🧬⚡ DNA photo-crosslinking proteomics in living cells 🎯 Pinpoints protein-DNA interactions to single amino acids 🌎 Globally quantifies DNA binding for >1800 proteins at a timescale of minutes 🔗 www.cell.com/cell/fulltex... 🧵

submitted 30 days ago • 3 comments

Our new paper is out in iScience. Congratulations for Belen! We have found new evidence that supports the involvement of glucocorticoid receptor condensates in transcription control.

submitted 34 days ago • 0 comments

Extensive differences observed in 3D genome structure between homologous heterozygous chromosomes revealed by Genome Architecture Mapping #GAM in the @apombo1.bsky.social lab ➡️ www.embopress.org/doi/full/10....

submitted 38 days ago • 0 comments