naturebiotech.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

In Brief: Gene and cell therapies from Bayer subsidaries AskBio & BlueRock Therapeutics make headway in trials for Parkinson's nature.com/articles/s41... rdcu.be/ebozG

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SVision-pro enables pairwise genome comparison and improves de novo and somatic structural variant calling go.nature.com/4a49VMU rdcu.be/ebg4V

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Redefining antibody patent protection using paratope mapping and CDR-scanning go.nature.com/4gYpZ5i

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An innovative challenge-based and research-driven educational model immerses groups of undergraduate students in the discovery stages of biotech industry research go.nature.com/43j2fWH rdcu.be/eaNtd

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Human respiratory airway progenitors derived from pluripotent cells generate alveolar epithelial cells and model pulmonary fibrosis - @columbiamed.bsky.social go.nature.com/4hQa5eI

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Hello Bluesky! Let’s try a first post…here’s my latest story for @naturebiotech.bsky.social on @vertexpharma.bsky.social non-opioid pain killer and next-gen NaV1.8 inhibitors in the pipeline rdcu.be/ealj0

submitted 8 days ago • 0 comments

Thanks @naturebiotech.bsky.social for covering our work building the world’s largest foundational biological database for training AI. 🔬 What does this mean? Smarter AI, deeper insights & innovations that aid both biodiversity and drug discovery. Read the article: www.nature.com/articles/s41...

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Research Highlight: Engineering adipocytes for cancer treatment, via @naturerevendo.bsky.social www.nature.com/articles/s41...

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CycleHCR uses a unified barcode system to image both RNA and protein in deep tissue contexts #NBTHighlight science.org/doi/10.1126/...

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In Brief: Top biopharma companies join forces to conduct UK Biobank Pharma Proteomics Project, aimed at understanding how fluctuations in protein levels influence disease www.nature.com/articles/s41... rdcu.be/eaLsO

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Startup grows egg proteins in potato fields www.nature.com/articles/s41...

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Internal cap-initiated translation for efficient protein production from circular mRNA - @nagoyauniversity.bsky.social go.nature.com/4b37Thj

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AI biotechs launch bioprospecting expeditions with Indigenous groups, agree to share benefits www.nature.com/articles/s41...

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Society, patients and clinicians welcome a much-needed non-opioid pain medication. Vertex’s first-in-class analgesic Journavx could soon be followed by a new generation of addiction-free pain drugs acting at NaV1.8 sodium channels www.nature.com/articles/s41...

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In Brief: Real-life Jurassic Park startup Colossal BioSciences has raised $200 million to bring back three extinct animals: the woolly mammoth, the Tasmanian tiger and the dodo bird www.nature.com/articles/s41... rdcu.be/eaosC

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Single-molecule live-cell RNA imaging with CRISPR–Csm - @doudna-lab.bsky.social @qb3-berkeley.bsky.social @innovativegenomics.bsky.social go.nature.com/3EJPKsM

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Sustained in situ protein production and release in the mammalian gut by an engineered bacteriophage go.nature.com/4jWgRAW

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Undergraduate education as catalyst for public–private partnership in biotechnology go.nature.com/43j2fWH

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The first clinical results in patients with a genetic form of frontotemporal dementia show that enhancing progranulin in the brain may halt disease progression www.nature.com/articles/s41...

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@vertexpharma.bsky.social 's opioid-free drug for acute pain wins FDA approval www.nature.com/articles/s41...

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The reverse transcriptase domain of prime editors contributes to DNA repair in mammalian cells - @rti-umasschan.bsky.social go.nature.com/3X6mOBv

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Excited to share our latest work, now out in @NatureBiotech ! We introduce SEED-Selection, a powerful method that enables high-efficiency enrichment of T cells edited at multiple loci in a single step 🧵👇 www.nature.com/articles/s41...

submitted 20 days ago • 1 comment

Tumors need a lot of nutrients to grow. By engineering and implanting fat cells to outcompete cancers for nutrients we can suppress them. Novel cancer therapy called Adipose Manipulation Transplantation (AMT). AMAZING work led by and dedicated to Hai Nguyen. www.nature.com/articles/s41...

submitted 22 days ago • 2 comments

Sound healing and beyond Ultrasound neurotechnologies are moving quickly into clinical trials in a wide variety of applications, and initiatives to open-source their manufacture will make them more accessible go.nature.com/3Q5rNOY

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The February issue is live nature.com/nbt/volumes/... On our cover, Dockerill et al. describe a peptide nucleic acid–based approach to creating drugs with on-demand reversibility go.nature.com/3JGbxRu

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A newly discovered microbial enzyme efficiently breaks down cellulose, leading to enhanced glucose release from biomass when expressed in engineered fungi #NBTHighlight nature.com/articles/s41...

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Tumor-reactive T cell receptors are rapidly identified from lymphocyte scRNA-seq data go.nature.com/49O5INm rdcu.be/d8L1u

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Gains in early-onset dementia with progranulin open new paths for drug discovery www.nature.com/articles/s41...

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A new tool checks the quality of gene annotations in genome sequences go.nature.com/4bH5OaF rdcu.be/d8L05

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Precise RNA targeting with CRISPR–Cas13d - @nevillesanjana.bsky.social go.nature.com/4gEn95x

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Disease-related premature stop codons are efficiently corrected by harnessing near-cognate tRNAs go.nature.com/3ToILdE rdcu.be/d8L0t

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🚨 Deadline extended! 🚨 We’ve extended our submission deadline to February 13th AoE! Join us at @iclr-conf.bsky.social 2025 in Singapore 🇸🇬, compete for a seed grant, and get a chance to have your paper fast-tracked to @naturebiotech.bsky.social Find all the details here 👉: www.gembio.ai

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New online in @naturebiotech.bsky.social: Lipid nanoparticles carrying plasmid DNA and an inflammation inhibitor enable longer transgene expression than mRNA nanoparticles-by Manthan N. Patel, Jacob S. Brenner et al.

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New online in @naturebiotech.bsky.social: Primary T cells with multiple genetic modifications are rapidly isolated by negative selection. -by Christopher R. Chang, Brian R. Shy, Justin Eyquem et al.

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The program of the CiRT2025 meeting is out: meeting2025.cirt-net.org/program.html. I will be sharing my top 10 tips on publishing with @naturebiotech.bsky.social. See you there?

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Happy to appear in #BNNBloomberg TV talking about our recent research paper in @naturebiotech.bsky.social about #ai and #quantum for KRAS binder discovery. With @akshatai.bsky.social @elonverse.bsky.social Igor Staglar @cgorgulla.bsky.social @ghazivakili.bsky.social and others #chemsky

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A library of fluorogenic dyes enables the measurement of protein unfolding for a large range of proteins go.nature.com/4ajNRNp rdcu.be/d8LZH

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RNA structures are built from cryogenic electron microscopy maps using deep learning and backbone tracing go.nature.com/3URIilo rdcu.be/d8LZg

submitted 18 days ago • 0 comments