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A 𝐡𝐲𝐩𝐞𝐫𝐢𝐦𝐦𝐮𝐧𝐞 𝐚𝐜𝐮𝐭𝐞 𝐫𝐞𝐣𝐞𝐜𝐭𝐢𝐨𝐧 is a rejection of a transplanted graft within 48 hours after transplantation, owing to preexisting cytotoxic antibodies in the recipient that bind antigen on the graft, which leads to coagulation, ischemia, and necrosis. #MedSky #ScienceSky

submitted 6 hours ago • 1 comment

A 37-year-old man presented with a 10-month history of dry cough, fatigue, and dry mouth. Chest radiography showed reticular opacities at the lung bases and cystic lucencies in both lungs. Read the full case details: nej.md/42OwR1U #MedSky #PulmSky

submitted 11 hours ago • 0 comments

If people are interested in learning about the ACIP and its decades of contributions to US vaccine policy successes, here’s a short 2014 piece I wrote in NEJM with Adel Mahmoud (timed with its 50th anniversary) www.nejm.org/doi/full/10....

submitted 2 days ago • 1 comment

Use of antiarrhythmic drugs or catheter ablation to suppress recurrent ventricular tachycardia is often warranted, but studies comparing the two approaches are limited. Research findings from a randomized trial are summarized in a new Quick Take video. youtu.be/nLHewmck0zo #MedSky #CardioSky

submitted 1 day ago • 0 comments

Commercial influences in health care #AI risks misaligning care with patient and societal needs. A new Perspective advocates for comprehensive oversight and regulatory frameworks to protect care while fostering innovation and competition. nejm.ai/4hyjmYB #MedSky #MLSky

submitted 1 day ago • 1 comment

An analysis of published studies suggests that a longer duration of immune checkpoint inhibitor therapy is associated with a higher incidence of complete response among patients with mismatch repair–deficient cancers. Full correspondence: nej.md/3EXiEpe #MedSky #Oncology

submitted 1 day ago • 0 comments

A previously healthy 44-year-old woman presented to the oral medicine clinic with an 11-month history of mouth ulcers and blistered lips. The lesions had caused pain while eating, with resultant unintentional weight loss. 1/4 #MedSky #DermSky

submitted 2 days ago • 2 comments

NEJM Editorial Fellow Christos Kotanidis, MD, DPhil, summarizes the FINEARTS-HF trial examining the efficacy and safety of finerenone in patients with heart failure with mildly reduced or preserved ejection fraction. Full trial results: nej.md/470x4ix #MedSky #CardioSky

submitted 2 days ago • 0 comments

New in the February 20, 2025, issue of NEJM: Catheter Ablation for Ventricular Tachycardia (VANISH2 trial) nej.md/3Z5ECOD Acalabrutinib Combinations in Untreated CLL (AMPLIFY phase 3 trial) nej.md/3Q55fOs Microvascular Inflammation of Kidney Allografts nej.md/4hiFoyJ #MedSky

submitted 2 days ago • 1 comment

Tubal ectopic pregnancy can be life-threatening. Management strategies include surgical treatment (salpingectomy or salpingostomy), medical treatment (methotrexate), or, in selected cases, expectant management. Learn more: nej.md/4bejU3x #MedSky #OBGYN

submitted 3 days ago • 1 comment

Although the yellow fever vaccine is highly effective, supply is limited. In a trial in Africa, lower doses of vaccine were noninferior to a standard dose for producing seroconversion within 28 days. Full NIFTY trial results: nej.md/3D9rAY9 #MedSky #IDSky

submitted 3 days ago • 0 comments

The alternate splicing small molecule risdiplam, administered to a fetus with spinal muscular atrophy, had an apparent ameliorating effect on the disorder through 30 months. Learn more: nej.md/3XbEg7J #MedSky #Neurology #PedSky

submitted 3 days ago • 0 comments

Cabozantinib, as compared with placebo, doubled median progression-free survival in patients with extrapancreatic neuroendocrine tumors and tripled it in those with pancreatic neuroendocrine tumors. Full CABINET trial results and Research Summary: nej.md/3AYuEoI #MedSky #Oncology

submitted 3 days ago • 1 comment

Dr. @emilyalsentzer.bsky.social, a Stanford faculty member and expert in clinical #AI, discusses the evolution of natural language processing, the challenges of AI in clinical settings, and what the future holds for open-source medical AI. Full episode: nejm.ai/4gOGeSo #MedSky #MLSky

submitted 3 days ago • 0 comments

An asymptomatic 17-year-old boy who had emigrated from El Salvador was found to have a pleural effusion on a chest radiograph. A small number of parasite eggs were seen in the pleural fluid. Full case details from @stanfordmedicine.bsky.social: nej.md/3CGzRTg #MedSky #PulmSky #IDSky

submitted 3 days ago • 0 comments

In a large trial involving patients with acute myocardial infarction, 95% of whom had ST-segment elevation myocardial infarction, spironolactone did not reduce the risk of cardiovascular events. Read the full CLEAR trial results and Research Summary: nej.md/4ftkpIc #MedSky #CardioSky

submitted 4 days ago • 0 comments

Cardiorespiratory fitness is an indicator of future cardiac, metabolic, and health events and is a strong predictor of all-cause mortality. Brazile et al. review the basics of the cardiorespiratory response to exercise. Full article in NEJM Evidence: eviden.cc/3Pe9Ay8  #MedSky #CardioSky #PulmSky

submitted 4 days ago • 0 comments

In the CLEAR trial involving patients with acute myocardial infarction, colchicine did not decrease the risk of major adverse cardiovascular events over a median follow-up period of 3 years. Full trial results and Research Summary: nej.md/4i2U6dV #MedSky #CardioSky

submitted 5 days ago • 0 comments

An 84-year-old man with a history of metastatic melanoma of the scalp who was undergoing immunotherapy presented with new, multiple blue-gray macules on the scalp. Read the full case details: nej.md/3EwbkAN #MedSky #DermSky #Oncology

submitted 5 days ago • 0 comments

Maternal platelet-activating anti–platelet factor 4 antibodies led to cerebral venous sinus thrombosis, thrombocytopenia, hyperfibrinolysis, and cerebral bleeding in a neonate. Read the full correspondence: nej.md/3QbmHkt #MedSky #Neurology

submitted 6 days ago • 0 comments

A 𝐬𝐲𝐧𝐭𝐡𝐞𝐭𝐢𝐜 𝐩𝐫𝐨𝐦𝐨𝐭𝐞𝐫 consists of genetic sequences composed of regulatory elements not usually found together in nature that drive the expression of an adjacent gene. Full definition of this NEJM Illustrated Glossary term: nej.md/4hyvxob #ScienceSky

submitted 7 days ago • 1 comment

Case Record of the MGH: A 30-year-old woman was admitted to the hospital because of headache and dysesthesia. She had recently traveled to Asia and Hawaii. A diagnosis was made. Read the full case details: nej.md/3EsnpHd #MedSky #Neurology

submitted 7 days ago • 1 comment

Most patients with extrapancreatic neuroendocrine tumors or pancreatic neuroendocrine tumors eventually have disease progression with available therapies, and new treatments are needed. Research findings are summarized in a new Quick Take video. youtu.be/v4VemREn1QM #MedSky #Oncology

submitted 8 days ago • 1 comment

Simultaneous measurements in children revealed overestimation of arterial saturation by pulse oximetry that was attributable to spectrophotometric measures of skin tone. Learn more: nej.md/4hyuZ1B #MedSky #PedSky

submitted 8 days ago • 0 comments

A 19-year-old man presented with a 3-week history of an asymptomatic rash on his neck. He worked as a beach lifeguard in southern California and reported no recent international travel. 1/3 #MedSky #DermSky

submitted 9 days ago • 5 comments

GPT-4–based translation substantially improved patient comprehension of discharge summary notes, especially in populations that historically have low health literacy. Further research is needed. Read the full article by A. Kumar and colleagues: nejm.ai/4avSdTw #MedSky #AI #MLSky

submitted 10 days ago • 0 comments

New in the February 13, 2025, issue of NEJM: Colchicine in Acute Myocardial Infarction (CLEAR trial) nej.md/4i2U6dV Routine Spironolactone in Acute Myocardial Infarction (CLEAR trial) nej.md/4ftkpIc Cabozantinib in Advanced Neuroendocrine Tumors (CABINET trial) nej.md/3AYuEoI #MedSky

submitted 9 days ago • 2 comments

A new review by Danielle Gallegos, PhD, addresses the dimensions and mechanisms of food and nutrition insecurity, as well as assessment, populations at highest risk, and health consequences across diverse contexts. Read the full review: nej.md/4aXZ8Vz #MedSky #GastroSky

submitted 10 days ago • 0 comments

Two patients with refractory myeloma who had excellent antitumor responses to cilta-cel CAR T-cell therapy later had T-cell lymphomas that contained the lentivirus construct used to generate the CAR T-cell product. Brief Report on the CARTITUDE-4 trial: nej.md/4gA6G27 #MedSky #Hematology

submitted 10 days ago • 0 comments

Patients with a prothrombotic clinical course often associated with thrombocytopenia may have a monoclonal paraprotein, even at low levels, that activates platelets by binding to platelet factor 4. Read the Brief Report: nej.md/4gKmrUs #MedSky #Hematology

submitted 10 days ago • 0 comments

#Obesity often develops in childhood. In children with obesity, treatment with liraglutide for 56 weeks + lifestyle interventions induced a greater mean change in BMI than lifestyle interventions alone. Full SCALE Kids phase 3a trial results: nej.md/3MBP1uc #MedSky #PedSky

submitted 10 days ago • 1 comment

Primary aldosteronism is characterized by dysregulated and relatively nonsuppressible aldosterone production that persists independent of its dominant regulators, renin and angiotensin II. Learn more: nej.md/3Wsvi5L #MedSky #CardioSky #OBGYN

submitted 10 days ago • 0 comments

Perspective by Eleanor R. Menzin, MD: With U.S. politics threatening to erase the gains of science, reduce access to vaccines, and undermine their vast public health benefit, what is a conscientious pediatrician to do? Read the full Perspective: nej.md/4iZNHQW

submitted 10 days ago • 0 comments

A 29yo man with well-controlled HIV infection presented with a 1-week history of a painful, whitish discoloration on his tongue. Smooth, pink, guttate macules were present on the tongue within a white coating. Full case from @aidshealthcare.bsky.social : nej.md/4jNuAdw #MedSky #IDSky

submitted 10 days ago • 2 comments

In a prespecified interim analysis of a phase 3, randomized, controlled trial, the selective endothelin type A receptor antagonist atrasentan reduced proteinuria in patients with IgA nephropathy, without apparent safety issues. Full ALIGN trial results: nej.md/3NzvISW #MedSky #Nephrology

submitted 11 days ago • 0 comments

The rise in patient demand for mental and behavioral health services since the Covid-19 pandemic has proven difficult for many #HealthCare organizations. Join NEJM Catalyst on March 13, 2025, to learn how to make the progress needed. Register now: nej.md/3WJVxoy #MedSky

submitted 11 days ago • 1 comment

Among patients with IgA nephropathy, treatment with iptacopan, which inhibits the alternative complement pathway, resulted in a significant reduction in proteinuria as compared with placebo. Full APPLAUSE-IgAN trial results and Research Summary: nej.md/3UmrOkh #MedSky #Nephrology

submitted 12 days ago • 0 comments

Did you know there are multiple types of #hunger? From physical to emotional triggers, learn more about what drives your appetite in this latest @nejm.org article doi.org/10.1056/NEJM...

submitted 16 days ago • 0 comments

“In this trial … using store-bought, home-measured peanut versus peanut avoidance in high-threshold peanut allergy, those treated achieved significantly higher rates of desensitization with a durable response off treatment.” Full trial results in NEJM Evidence: eviden.cc/3WMQwLF #MedSky

submitted 12 days ago • 0 comments

A 35-year-old man presented with a 2-year history of proximal muscle weakness with intermittent muscle cramping. Physical examination showed macroglossia and enlargement of the muscles in both calves. Read the full case details: nej.md/3CjmTec #MedSky #EndoSky

submitted 12 days ago • 0 comments

A 29-year-old man who reported having male sex partners and using injection drugs presented with a 2-day history of fever, chills, and elbow pain and swelling, followed by the appearance of a diffuse rash. Read the full case details: nej.md/4gnM3Gd #MedSky #IDSky

submitted 13 days ago • 2 comments